scholarly journals Increased Endocannabinoid Signaling Reduces Social Motivation in Intact Rats and Does Not Affect Animals Submitted to Early-Life Seizures

2020 ◽  
Vol 14 ◽  
Author(s):  
Fernanda Teixeira Ribeiro ◽  
Marcia Ivany Silva de Serro-Azul ◽  
Fernanda Beraldo Lorena ◽  
Bruna Pascarelli Pedrico do Nascimento ◽  
Alexandre José Tavolari Arnold ◽  
...  
Keyword(s):  
Early Life ◽  
Negative Impact ◽  
Endocannabinoid System ◽  
Social Motivation ◽  
Social Stimulus ◽  
Social Discrimination ◽  
The Social ◽  
Male Wistar Rats ◽  
Vehicle Treated Control ◽  
Intact Rats

The early life status epilepticus (SE) causes high anxiety and chronic socialization abnormalities, revealed by a low preference for social novelty and deficit in social discrimination. This study investigated the involvement of the endocannabinoid system on the sociability in this model, due to its role in social motivation regulation. Male Wistar rats at postnatal day 9 were subjected to pilocarpine-induced neonatal SE and controls received saline. From P60 the groups received vehicle or JZL195 2 h before each behavioral test to increase endocannabinoids availability. In the sociability test, animals subjected to neonatal SE exhibited impaired sociability, characterized by social discrimination deficit, which was unaffected by the JZL195 treatment. In contrast, JZL195-treated control rats showed low sociability and impaired social discrimination. The negative impact of JZL195 over the sociability in control rats and the lack of effect in animals subjected to neonatal SE was confirmed in the social memory paradigm. In this paradigm, as expected for vehicle-treated control rats, the investigation toward the same social stimulus decreased with the sequential exposition and increased toward a novel stimulus. In animals subjected to neonatal SE, regardless of the treatment, as well as in JZL195-treated control rats, the investigation toward the same social stimulus was significantly reduced with no improvement toward a novel stimulus. Concerning the locomotion, the JZL195 increased it only in control rats. After behavioral tests, brain tissues of untreated animals were used for CB1 receptor quantification by Elisa and for gene expression by RT-PCR: no difference between control and experimental animals was noticed. The results reinforce the evidence that the early SE causes chronic socialization abnormalities, revealed by the low social interest for novelty and impaired social discrimination. The dual FAAH/MAGL inhibitor (JZL195) administration before the social encounter impaired the social interaction in intact rats with no effect in animals subjected to early-life seizures.

Individual differences, social attention, and the history of the social motivation hypotheses of autism

2019 ◽  
Vol 42 ◽  
Author(s):  
Peter C. Mundy
Keyword(s):  
Individual Differences ◽  
Early Development ◽  
Emotional Development ◽  
Social Motivation ◽  
Social Attention ◽  
Social Emotional Development ◽  
Social Emotional ◽  
Precise Understanding ◽  
The Social ◽  
History Of

Abstract The stereotype of people with autism as unresponsive or uninterested in other people was prominent in the 1980s. However, this view of autism has steadily given way to recognition of important individual differences in the social-emotional development of affected people and a more precise understanding of the possible role social motivation has in their early development.

Challenges to the social motivation theory of autism: The dangers of counteracting an imprecise theory with even more imprecision

2019 ◽  
Vol 42 ◽  
Author(s):  
Mirko Uljarević ◽  
Giacomo Vivanti ◽  
Susan R. Leekam ◽  
Antonio Y. Hardan
Keyword(s):  
Empirical Evidence ◽  
Social Motivation ◽  
Motivation Theory ◽  
The Social

Abstract The arguments offered by Jaswal & Akhtar to counter the social motivation theory (SMT) do not appear to be directly related to the SMT tenets and predictions, seem to not be empirically testable, and are inconsistent with empirical evidence. To evaluate the merits and shortcomings of the SMT and identify scientifically testable alternatives, advances are needed on the conceptualization and operationalization of social motivation across diagnostic boundaries.

Energy Markets and Trading

2018 ◽  
Author(s):  
David Mares
Keyword(s):  
Fossil Fuels ◽  
Negative Impact ◽  
Adjustment Costs ◽  
Institutional Context ◽  
Energy Markets ◽  
Energy Resources ◽  
Trade Offs ◽  
The Social ◽  
Impact Risk

This chapter discusses the role of energy in economic development, the transformation of energy markets, trade in energy resources themselves, and the geopolitical dynamics that result. The transformation of energy markets and their expansion via trade can help or hinder development, depending on the processes behind them and how stakeholders interact. The availability of renewable, climate-friendly sources of energy, domestically and internationally, means that there is no inherent trade-off between economic growth and the use of fossil fuels. The existence of economic, political, social, and geopolitical adjustment costs means that the expansion of international energy markets to incorporate alternatives to oil and coal is a complex balance of environmental trade-offs with no solutions completely free of negative impact risk. An understanding of the supply of and demand for energy must incorporate the institutional context within which they occur, as well as the social and political dynamics of their setting.

scholarly journals Pharmacological modulation of AMPA receptors rescues specific impairments in social behavior associated with the A350V Iqsec2 mutation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Renad Jabarin ◽  
Nina Levy ◽  
Yasmin Abergel ◽  
Joshua H. Berman ◽  
Amir Zag ◽  
...  
Keyword(s):  
Social Behavior ◽  
Ampa Receptors ◽  
Emotional State ◽  
Social Discrimination ◽  
Glutamatergic Synapses ◽  
Behavioral Deficits ◽  
Pharmacological Modulation ◽  
The Social ◽  
State Preference ◽  
Molecular Pathophysiology

AbstractIn this study we tested the hypothesis that pharmacological modulation of glutamatergic neurotransmission could rescue behavioral deficits exhibited by mice carrying a specific mutation in the Iqsec2 gene. The IQSEC2 protein plays a key role in glutamatergic synapses and mutations in the IQSEC2 gene are a frequent cause of neurodevelopmental disorders. We have recently reported on the molecular pathophysiology of one such mutation A350V and demonstrated that this mutation downregulates AMPA type glutamatergic receptors (AMPAR) in A350V mice. Here we sought to identify behavioral deficits in A350V mice and hypothesized that we could rescue these deficits by PF-4778574, a positive AMPAR modulator. Using a battery of social behavioral tasks, we found that A350V Iqsec2 mice exhibit specific deficits in sex preference and emotional state preference behaviors as well as in vocalizations when encountering a female mouse. The social discrimination deficits, but not the impaired vocalization, were rescued with a single dose of PF-4778574. We conclude that social behavior deficits associated with the A350V Iqsec2 mutation may be rescued by enhancing AMPAR mediated synaptic transmission.

Usurpers of Technology: Train Robbery and Theft in Egypt, 1876–1904

2021 ◽  
pp. 1-18
Author(s):  
Xiaoyue Li
Keyword(s):  
Negative Impact ◽  
Centralized Control ◽  
Informal Networks ◽  
Grassroots Activism ◽  
Late 19Th Century ◽  
State Regulations ◽  
Colonial State ◽  
The Social ◽  
Social Wealth ◽  
Everyday Knowledge

Abstract This article examines banditry, embezzlement, and other insider crimes along Egyptian railway lines during a period when British officials exerted centralized control over the Egyptian railway and financial austerity had a negative impact on the rail sector. By exploring the motives and tactics of railway crimes, I posit that criminals, by making claims on and use of the technology outside the purview of state regulations, expressed their heterogeneous desires to redistribute social wealth, repurpose the technological promise of modern railways, and confound intentions of colonial governance. Using new archival materials, this article utilizes a bottom-up approach to examine grassroots activism, everyday knowledge, informal networks, and the social mores and norms that criminals harnessed to discern infrastructural vulnerabilities and elude surveillance from the colonial state. Ultimately, I contend that criminal acts uncovered social crises otherwise hidden under the shadow of the exterior prosperity and stability of late 19th-century Egypt.

scholarly journals Calcium isotopic patterns in enamel reflect different nursing behaviors among South African early hominins

2019 ◽  
Vol 5 (8) ◽  
pp. eaax3250 ◽  
Author(s):  
Théo Tacail ◽  
Jeremy E. Martin ◽  
Florent Arnaud-Godet ◽  
J. Francis Thackeray ◽  
Thure E. Cerling ◽  
...  
Keyword(s):  
Breast Milk ◽  
South African ◽  
Early Life ◽  
Tooth Enamel ◽  
Biological Evolution ◽  
Milk Consumption ◽  
Interbirth Interval ◽  
Australopithecus Africanus ◽  
The Social ◽  
Life Behavior

Nursing is pivotal in the social and biological evolution of hominins, but to date, early-life behavior among hominin lineages is a matter of debate. The calcium isotopic compositions (δ44/42Ca) of tooth enamel can provide dietary information on this period. Here, we measure the δ44/42Ca values in spatially located microsized regions in tooth enamel of 37 South African hominins to reconstruct early-life dietary-specific variability in Australopithecus africanus, Paranthropus robustus, and early Homo. Very low δ44/42Ca values (<−1.4‰), indicative of milk consumption, are measured in early Homo but not in A. africanus and P. robustus. In these latter taxa, transitional or adult nonmilk foods must have been provided in substantial quantities relative to breast milk rapidly after birth. The results suggest that early Homo have continued a predominantly breast milk–based nursing period for longer than A. africanus and P. robustus and have consequently more prolonged interbirth interval.

scholarly journals Observational Fear Learning in Rats: Role of Trait Anxiety and Ultrasonic Vocalization

2021 ◽  
Vol 11 (4) ◽  
pp. 423
Author(s):  
Markus Fendt ◽  
Claudia Paulina Gonzalez-Guerrero ◽  
Evelyn Kahl
Keyword(s):  
Trait Anxiety ◽  
Conditioned Fear ◽  
Ultrasonic Vocalization ◽  
Fear Learning ◽  
Anxiety State ◽  
Learning Procedure ◽  
The Social ◽  
Medium Level ◽  
Male Wistar Rats

Rats can acquire fear by observing conspecifics that express fear in the presence of conditioned fear stimuli. This process is called observational fear learning and is based on the social transmission of the demonstrator rat’s emotion and the induction of an empathy-like or anxiety state in the observer. The aim of the present study was to investigate the role of trait anxiety and ultrasonic vocalization in observational fear learning. Two experiments with male Wistar rats were performed. In the first experiment, trait anxiety was assessed in a light–dark box test before the rats were submitted to the observational fear learning procedure. In the second experiment, ultrasonic vocalization was recorded throughout the whole observational fear learning procedure, and 22 kHz and 50 kHz calls were analyzed. The results of our study show that trait anxiety differently affects direct fear learning and observational fear learning. Direct fear learning was more pronounced with higher trait anxiety, while observational fear learning was the best with a medium-level of trait anxiety. There were no indications in the present study that ultrasonic vocalization, especially emission of 22 kHz calls, but also 50 kHz calls, are critical for observational fear learning.

scholarly journals Social environment influences the relationship between genotype and gene expression in wild baboons

2013 ◽  
Vol 368 (1618) ◽  
pp. 20120345 ◽  
Author(s):  
Daniel E. Runcie ◽  
Ralph T. Wiedmann ◽  
Elizabeth A. Archie ◽  
Jeanne Altmann ◽  
Gregory A. Wray ◽  
...  
Keyword(s):  
Gene Expression ◽  
Individual Differences ◽  
Social Environment ◽  
Group Size ◽  
Early Life ◽  
Social Connectedness ◽  
Dominance Rank ◽  
Social Stressors ◽  
The Social ◽  
Wild Baboons

Variation in the social environment can have profound effects on survival and reproduction in wild social mammals. However, we know little about the degree to which these effects are influenced by genetic differences among individuals, and conversely, the degree to which social environmental variation mediates genetic reaction norms. To better understand these relationships, we investigated the potential for dominance rank, social connectedness and group size to modify the effects of genetic variation on gene expression in the wild baboons of the Amboseli basin. We found evidence for a number of gene–environment interactions (GEIs) associated with variation in the social environment, encompassing social environments experienced in adulthood as well as persistent effects of early life social environment. Social connectedness, maternal dominance rank and group size all interacted with genotype to influence gene expression in at least one sex, and either in early life or in adulthood. These results suggest that social and behavioural variation, akin to other factors such as age and sex, can impact the genotype–phenotype relationship. We conclude that GEIs mediated by the social environment are important in the evolution and maintenance of individual differences in wild social mammals, including individual differences in responses to social stressors.

Early postnatal overnutrition impairs VO2max gains with moderate exercise and increase post-exercise muscle damage in adult male rats

2021 ◽  
pp. 1-5
Author(s):  
Douglas Lopes Almeida ◽  
Gabriel Sergio Fabricio ◽  
Laize Peron Tófolo ◽  
Tatiane Aparecida Ribeiro ◽  
Camila Cristina Ianoni Matiusso ◽  
...  
Keyword(s):  
Early Life ◽  
Male Rats ◽  
Moderate Intensity ◽  
Moderate Exercise ◽  
Moderate Intensity Exercise ◽  
Post Exercise ◽  
Reduced Body ◽  
Male Wistar Rats ◽  
The Impact ◽  
Adaptation To Exercise

Abstract Exercise counteracts obesity effects, but information on how early-life obesity may affect long-term adaptation to exercise is lacking. This study investigates the impact of early-life postnatal overfeeding (PO) on animals’ adaptation to exercise. Only male Wistar rats were used. On postnatal day (PN) 30, rats from control (NL-9 pups) or PO (SL-3 pups) litters were separated into four groups: NL-sedentary (NL-Se), NL-exercised (NL-Ex), SL-sedentary (SL-Se), and SL-exercised (SL-Ex). Exercised groups performed moderate-intensity exercise, running on a treadmill, from PN30 to PN90. Further experiments were carried out between PN90 and PN92. PO promoted obesity in SL versus NL rats (P < 0.05). Exercise reduced body weight (P < 0.001), body fat (P < 0.01), and improved glucose homeostasis in SL-Ex versus SL-Se. SL-Ex presented lower VO2max (P < 0.01) and higher post-exercise LDH (P < 0.05) compared to NL-Ex rats. Although moderate exercise counteracted obesity in SL rats, early-life overnutrition restricts fitness gains in adulthood, indicating that early obesity may impair animals’ adaptation to exercise.

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