scholarly journals Case Report: Auditory Neuropathy and Central Auditory Processing Deficits in a Neuro-Otological Case-Study of Infratentorial Superficial Siderosis

2021 ◽  
Vol 11 ◽  
Author(s):  
Natallia Kharytaniuk ◽  
Peter Cowley ◽  
David J. Werring ◽  
Doris-Eva Bamiou
Keyword(s):  
Magnetic Resonance ◽  
Auditory Processing ◽  
Auditory Pathway ◽  
Magnetic Resonance Images ◽  
Auditory Neuropathy ◽  
Self Report ◽  
Response To Treatment ◽  
Superficial Siderosis ◽  
Central Auditory Processing ◽  
Processing Deficits

Hearing and balance impairment are the most frequently reported features of infratentorial (classical) superficial siderosis (iSS). There are few comprehensive descriptions of audiovestibular function in iSS and therefore limited understanding of the affected segment(s) of the audiovestibular pathway. In addition, monitoring disease progression and response to treatment is challenging and currently mainly guided by subjective patient reports and magnetic resonance imaging. To the best of our knowledge, there have been no previous reports assessing central auditory function in iSS. We describe such findings in a patient with iSS in an attempt to precisely localize the site of the audiovestibular dysfunction, determine its severity and functional impact. We confirm the presence of (asymmetrical) auditory neuropathy and identify central auditory processing deficits, suggesting involvement of the central auditory pathway beyond the brainstem. We correlate the audiological and vestibular findings with self-report measures and the siderosis appearances on brain magnetic resonance images.

scholarly journals Speech Evoked Auditory Brainstem Response in Stuttering

Scientifica ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Ali Akbar Tahaei ◽  
Hassan Ashayeri ◽  
Akram Pourbakht ◽  
Mohammad Kamali
Keyword(s):  
Auditory Processing ◽  
Auditory Pathway ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses ◽  
Control Group ◽  
Central Auditory Processing ◽  
Significant Group ◽  
Speech Stimuli ◽  
Brainstem Response ◽  
Processing Deficits

Auditory processing deficits have been hypothesized as an underlying mechanism for stuttering. Previous studies have demonstrated abnormal responses in subjects with persistent developmental stuttering (PDS) at the higher level of the central auditory system using speech stimuli. Recently, the potential usefulness of speech evoked auditory brainstem responses in central auditory processing disorders has been emphasized. The current study used the speech evoked ABR to investigate the hypothesis that subjects with PDS have specific auditory perceptual dysfunction.Objectives. To determine whether brainstem responses to speech stimuli differ between PDS subjects and normal fluent speakers.Methods. Twenty-five subjects with PDS participated in this study. The speech-ABRs were elicited by the 5-formant synthesized syllable/da/, with duration of 40 ms.Results. There were significant group differences for the onset and offset transient peaks. Subjects with PDS had longer latencies for the onset and offset peaks relative to the control group.Conclusions. Subjects with PDS showed a deficient neural timing in the early stages of the auditory pathway consistent with temporal processing deficits and their abnormal timing may underlie to their disfluency.

scholarly journals Speech Processing Disorder in Neural Hearing Loss

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Joseph P. Pillion
Keyword(s):  
Speech Processing ◽  
Auditory Processing ◽  
Neurological Disorders ◽  
Auditory Neuropathy ◽  
Central Auditory Processing ◽  
Temporal Lobes ◽  
Electrophysiological Tests ◽  
Bilateral Lesions ◽  
Clinical Conditions ◽  
Inferior Colliculi

Deficits in central auditory processing may occur in a variety of clinical conditions including traumatic brain injury, neurodegenerative disease, auditory neuropathy/dyssynchrony syndrome, neurological disorders associated with aging, and aphasia. Deficits in central auditory processing of a more subtle nature have also been studied extensively in neurodevelopmental disorders in children with learning disabilities, ADD, and developmental language disorders. Illustrative cases are reviewed demonstrating the use of an audiological test battery in patients with auditory neuropathy/dyssynchrony syndrome, bilateral lesions to the inferior colliculi, and bilateral lesions to the temporal lobes. Electrophysiological tests of auditory function were utilized to define the locus of dysfunction at neural levels ranging from the auditory nerve, midbrain, and cortical levels.

scholarly journals Impaired Subcortical Detection of Auditory Changes in Schizophrenia but Not in Major Depression

2019 ◽  
Vol 46 (1) ◽  
pp. 193-201 ◽  
Author(s):  
Arnim Johannes Gaebler ◽  
Jana Zweerings ◽  
Jan Willem Koten ◽  
Andrea Anna König ◽  
Bruce I Turetsky ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Major Depression ◽  
Auditory Processing ◽  
Region Of Interest ◽  
Auditory Pathway ◽  
Consistent Finding ◽  
Healthy Control ◽  
Patient Groups ◽  
Processing Deficits ◽  
Cortical Dysfunction

Abstract The mismatch negativity is a cortical response to auditory changes and its reduction is a consistent finding in schizophrenia. Recent evidence revealed that the human brain detects auditory changes already at subcortical stages of the auditory pathway. This finding, however, raises the question where in the auditory hierarchy the schizophrenic deficit first evolves and whether the well-known cortical deficit may be a consequence of dysfunction at lower hierarchical levels. Finally, it should be resolved whether mismatch profiles differ between schizophrenia and affective disorders which exhibit auditory processing deficits as well. We used functional magnetic resonance imaging to assess auditory mismatch processing in 29 patients with schizophrenia, 27 patients with major depression, and 31 healthy control subjects. Analysis included whole-brain activation, region of interest, path and connectivity analysis. In schizophrenia, mismatch deficits emerged at all stages of the auditory pathway including the inferior colliculus, thalamus, auditory, and prefrontal cortex. In depression, deficits were observed in the prefrontal cortex only. Path analysis revealed that activation deficits propagated from subcortical to cortical nodes in a feed-forward mechanism. Finally, both patient groups exhibited reduced connectivity along this processing stream. Auditory mismatch impairments in schizophrenia already manifest at the subcortical level. Moreover, subcortical deficits contribute to the well-known cortical deficits and show specificity for schizophrenia. In contrast, depression is associated with cortical dysfunction only. Hence, schizophrenia and major depression exhibit different neural profiles of sensory processing deficits. Our findings add to a converging body of evidence for brainstem and thalamic dysfunction as a hallmark of schizophrenia.

scholarly journals Overview of Central Auditory Processing Deficits in Older Adults

2015 ◽  
Vol 36 (03) ◽  
pp. 150-161 ◽  
Author(s):  
Naveen Nagaraj ◽  
Sarah Kennett ◽  
Meredith Levisee ◽  
Samuel Atcherson
Keyword(s):  
Older Adults ◽  
Auditory Processing ◽  
Central Auditory Processing ◽  
Processing Deficits

scholarly journals Acquired Central Auditory Processing Disorder in Service Members and Veterans

2020 ◽  
Vol 63 (3) ◽  
pp. 834-857 ◽  
Author(s):  
Victoria Tepe ◽  
Melissa Papesh ◽  
Shoshannah Russell ◽  
M. Samantha Lewis ◽  
Nina Pryor ◽  
...  
Keyword(s):  
Risk Factors ◽  
Auditory Processing ◽  
Military Service ◽  
Service Members ◽  
Central Auditory Processing ◽  
Knowledge Gaps ◽  
Personnel Assessment ◽  
Processing Deficits ◽  
Blast Neurotrauma ◽  
State Of The Science

Purpose A growing body of evidence suggests that military service members and military veterans are at risk for deficits in central auditory processing. Risk factors include exposure to blast, neurotrauma, hazardous noise, and ototoxicants. We overview these risk factors and comorbidities, address implications for clinical assessment and care of central auditory processing deficits in service members and veterans, and specify knowledge gaps that warrant research. Method We reviewed the literature to identify studies of risk factors, assessment, and care of central auditory processing deficits in service members and veterans. We also assessed the current state of the science for knowledge gaps that warrant additional study. This literature review describes key findings relating to military risk factors and clinical considerations for the assessment and care of those exposed. Conclusions Central auditory processing deficits are associated with exposure to known military risk factors. Research is needed to characterize mechanisms, sources of variance, and differential diagnosis in this population. Existing best practices do not explicitly consider confounds faced by military personnel. Assessment and rehabilitation strategies that account for these challenges are needed. Finally, investment is critical to ensure that Veterans Affairs and Department of Defense clinical staff are informed, trained, and equipped to implement effective patient care. Infographic https://doi.org/10.23641/asha.12071232

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