scholarly journals Disruption in Surface-Based Functional Connectivity in the Right Posterior Hippocampal CA3 Subfield: A Probable Neural Basis of Visuospatial Working Memory Impairment in Patients With Right Temporal Lobe Epilepsy

2021 ◽  
Vol 12 ◽  
Author(s):  
Zongxia Lv ◽  
Zirong Chen ◽  
Wei Ye ◽  
Xiaomin Pang ◽  
Liluo Nie ◽  
...  
Keyword(s):  
Working Memory ◽  
Functional Connectivity ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Right Hemisphere ◽  
Anterior Cingulate ◽  
Visuospatial Working Memory ◽  
Neural Basis ◽  
Right Temporal Lobe Epilepsy ◽  
The Right

Visuospatial working memory (VSWM) impairment is common in patients with right temporal lobe epilepsy (rTLE). The posterior hippocampus is critical for spatial memory, but the contributions of the different subfields to VSWM deficits remain unclear. Forty-six rTLE patients and 42 healthy controls (HCs) were recruited. Resting-state fMRI (rsfMRI) and structural MRI scans were administered, followed by a VSWM_Nback test. The right posterior hippocampus was automatically segmented, and the surface-based functional connectivity (SBFC) of the subiculum (Sub), CA1, CA3, dentate gyrus (DG), hippocampal tail, and right entorhinal cortex (EC) were compared between groups. Correlation analysis was performed between the altered SBFC and VSWM_Nback scores for rTLE patients. The results showed that rTLE patients underperformed in the VSWM_Nback test, with longer mean reaction time of accurate response (ACCmeanRT) in 0back and 2back condition, lower hit rate (HR) and higher false alarm rate (FAR) in 2back condition. Compared with HCs, the rCA3 in the rTLE group exhibited decreased SBFC with inferior parietal cortex (IPC), temporal lateral cortex (TLC), and posterior visual cortex (PVC) in the right hemisphere as well as the bilateral dorsolateral prefrontal cortex (DLPFC). The SBFC of the rEC and right anterior cingulate cortex (rACC) increased in the rTLE group. Within the rTLE group, the decreased SBFC of the rCA3-rIPC and rCA3-rLTC were correlated with worse VSWM performance. Therefore, the decreased SBFC of the rCA3-rIPC and rCA3-rLTC might be the critical aberrant FC pattern reflecting VSWM impairment in rTLE patients. The mechanism might involve functional disruption between the core subsystem and the medial temporal subsystem of the default mode network (DMN).

Aberrant cerebral intrinsic activity and cerebro-cerebellar functional connectivity in right temporal lobe epilepsy

Neuroreport ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Xia Zhou ◽  
Jinping Liu ◽  
Zhao Zhang ◽  
Lu Qin ◽  
Xiaomin Pang ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Intrinsic Activity ◽  
Right Temporal Lobe Epilepsy

scholarly journals Anterior cingulate cortex differently modulates fronto-parietal functional connectivity between resting-state and working memory tasks

2019 ◽  
Author(s):  
Xin Di ◽  
Heming Zhang ◽  
Bharat B Biswal
Keyword(s):  
Working Memory ◽  
Functional Connectivity ◽  
Anterior Cingulate Cortex ◽  
Resting State ◽  
Cingulate Cortex ◽  
Task Demands ◽  
Anterior Cingulate ◽  
Functional Coupling ◽  
The Right ◽  
State 1

AbstractThe brain fronto-parietal regions and the functional communications between them are critical in supporting working memory and other executive functions. The functional connectivity between fronto-parietal regions are modulated by working memory loads, and are shown to be modulated by a third brain region in resting-state. However, it is largely unknown that whether the third-region modulations remain the same during working memory tasks or were largely modulated by task demands. In the current study, we collected functional MRI (fMRI) data when the subjects were performing n-back tasks and in resting-state. We first used a block-designed localizer to define the fronto-parietal regions that showed higher activations in the 2-back than the 1-back condition. Next, we performed physiophysiological interaction (PPI) analysis using left and right middle frontal gyrus (MFG) and superior parietal lobule (SPL) regions, respectively, in three continuous-designed runs of resting-state, 1-back, and 2-back conditions. No regions showed consistent modulatory interactions with the seed pairs in the three conditions. Instead, the anterior cingulate cortex (ACC) showed different modulatory interactions with the right MFG and SPL among the three conditions. While increased activity of the ACC was associated with decreased functional coupling between the right MFG and SPL in resting-state, it was associated with increased functional coupling in the 2-back condition. The observed task modulations support the functional significance of the modulations of the ACC on fronto-parietal connectivity.

scholarly journals Differences in graph theory functional connectivity in left and right temporal lobe epilepsy

2014 ◽  
Vol 108 (10) ◽  
pp. 1770-1781 ◽  
Author(s):  
Sharon Chiang ◽  
John M. Stern ◽  
Jerome Engel ◽  
Harvey S. Levin ◽  
Zulfi Haneef
Keyword(s):  
Graph Theory ◽  
Functional Connectivity ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Left And Right ◽  
Right Temporal Lobe Epilepsy

scholarly journals Decreased Resting-State Functional Connectivity of Periaqueductal Gray in Temporal Lobe Epilepsy Comorbid With Migraine

2021 ◽  
Vol 12 ◽  
Author(s):  
Long Wang ◽  
Xin-Ting Cai ◽  
Mei-Dan Zu ◽  
Juan Zhang ◽  
Zi-Ru Deng ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Resting State ◽  
Periaqueductal Gray ◽  
Retrograde Tracing ◽  
Comorbid Condition ◽  
Resting State Functional Connectivity ◽  
Excitatory Transmission ◽  
The Right

Objective: Patients with temporal lobe epilepsy (TLE) are at high risk for having a comorbid condition of migraine, and these two common diseases are proposed to have some shared pathophysiological mechanisms. Our recent study indicated the dysfunction of periaqueductal gray (PAG), a key pain-modulating structure, contributes to the development of pain hypersensitivity and epileptogenesis in epilepsy. This study is to investigate the functional connectivity of PAG network in epilepsy comorbid with migraine.Methods: Thirty-two patients with TLE, including 16 epilepsy patients without migraine (EwoM) and 16 epilepsy patients with comorbid migraine (EwM), and 14 matched healthy controls (HCs) were recruited and underwent resting functional magnetic resonance imaging (fMRI) scans to measure the resting-state functional connectivity (RsFC) of PAG network. The frequency and severity of migraine attacks were assessed using the Migraine Disability Assessment Questionnaire (MIDAS) and Visual Analog Scale/Score (VAS). In animal experiments, FluoroGold (FG), a retrograde tracing agent, was injected into PPN and its fluorescence detected in vlPAG to trace the neuronal projection from vlPAG to PPN. FG traced neuron number was used to evaluate the neural transmission activity of vlPAG-PPN pathway. The data were processed and analyzed using DPARSF and SPSS17.0 software. Based on the RsFC finding, the excitatory transmission of PAG and the associated brain structure was studied via retrograde tracing in combination with immunohistochemical labeling of excitatory neurons.Results: Compared to HCs group, the RsFC between PAG and the left pedunculopontine nucleus (PPN), between PAG and the corpus callosum (CC), was decreased both in EwoM and EwM group, while the RsFC between PAG and the right PPN was increased only in EwoM group but not in EwM group. Compared to EwoM group, the RsFC between PAG and the right PPN was decreased in EwM group. Furthermore, the RsFC between PAG and PPN was negatively correlated with the frequency and severity of migraine attacks. In animal study, a seizure stimulation induced excitatory transmission from PAG to PPN was decreased in rats with chronic epilepsy as compared to that in normal control rats.Conclusion: The comorbidity of epilepsy and migraine is associated with the decreased RsFC between PAG and PPN.

scholarly journals Hippocampal Functional Connectivity Patterns During Spatial Working Memory Differ in Right Versus Left Temporal Lobe Epilepsy

2013 ◽  
Vol 3 (4) ◽  
pp. 398-406 ◽  
Author(s):  
Gaëlle Doucet ◽  
Karol Osipowicz ◽  
Ashwini Sharan ◽  
Michael R. Sperling ◽  
Joseph I. Tracy
Keyword(s):  
Working Memory ◽  
Functional Connectivity ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Spatial Working Memory ◽  
Left Temporal Lobe ◽  
Connectivity Patterns

Graph theory application with functional connectivity to distinguish left from right temporal lobe epilepsy

2020 ◽  
Vol 167 ◽  
pp. 106449
Author(s):  
Saba Amiri ◽  
Jafar Mehvari-Habibabadi ◽  
Neda Mohammadi-Mobarakeh ◽  
Seyed Sohrab Hashemi-Fesharaki ◽  
Mehdi M. Mirbagheri ◽  
...  
Keyword(s):  
Graph Theory ◽  
Functional Connectivity ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Theory Application ◽  
Right Temporal Lobe Epilepsy

scholarly journals Distinct Associations of Cognitive Impairments and Reduced Gray Matter Volumes in Remitted Patients with Schizophrenia and Bipolar Disorder

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Ting Sun ◽  
Pengfei Zhao ◽  
Xiaowei Jiang ◽  
Yifang Zhou ◽  
Chao Li ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Working Memory ◽  
Gray Matter ◽  
Right Hemisphere ◽  
Cognitive Impairments ◽  
Anterior Cingulate ◽  
First Episode ◽  
Temporal Pole ◽  
The Right ◽  
Gray Matter Volumes

Background. Cognitive impairments are documented in schizophrenia (SZ) and bipolar disorder (BD) and may be related to gray matter volumes (GMVs). Thus, this study is aimed at exploring whether the association between cognitive impairments and GMV alterations is similar in patients with SZ and BD and understanding the underlying neurobiological mechanisms. Methods. A total of 137 adult subjects (46 with SZ, 35 with BD, and 56 age-, sex-, and education-matched healthy controls (HC)) completed the MATRICS Consensus Cognitive Battery (MCCB) and structural magnetic resonance imaging scanning. We performed group comparisons of the cognitive impairments, the GMV alterations, and the association between them. Results. Compared with HC, the patients with SZ and BD showed shared deficits in 4 cognitive domains (i.e., processing speed, working memory, problem solving, and social cognition) and the composite. SZ and BD had commonly decreased GMVs, mainly in the insula, superior temporal pole, amygdala, anterior cingulate, and frontal cortices (superior, middle, opercular inferior, and orbital frontal gyrus). No correlation between MCCB scores and GMVs was detected in SZ. However, for BD, working memory was relevant to the right hemisphere (i.e., right insula, amygdala, superior temporal pole, and medial and dorsolateral superior frontal gyrus). Limitations. The major limitations were that not all patients were the first-episode status and no medication. Conclusions. The association was mainly limited to the BD group. Thus, the underlying pathophysiology of the cognitive deficits, in terms of GMV alterations, may be diverse between two disorders.

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