scholarly journals Intrinsic Brain Activity in Temporal Lobe Epilepsy With and Without Depression: Insights From EEG Microstates

2022 ◽  
Vol 12 ◽  
Author(s):  
Yueqian Sun ◽  
Guoping Ren ◽  
Jiechuan Ren ◽  
Qun Wang
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Brain Activity ◽  
Comorbid Depression ◽  
Diagnostic And Statistical Manual ◽  
Eeg Topography ◽  
State Frequency ◽  
Microstate Analysis ◽  
Common Pathogenesis ◽  
Intrinsic Brain Activity

Background: Depression is the most common psychiatric comorbidity of temporal lobe epilepsy (TLE). In the recent years, studies have focused on the common pathogenesis of TLE and depression. However, few of the studies focused on the dynamic characteristics of TLE with depression. We tested the hypotheses that there exist abnormalities in microstates in patients with TLE with depression.Methods: Participants were classified into patients with TLE with depression (PDS) (n = 19) and patients with TLE without depression (nPDS) (n = 19) based upon the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V). Microstate analysis was applied based on 256-channel electroencephalography (EEG) to detect the dynamic changes in whole brain. The coverage (proportion of time spent in each state), frequency of occurrence, and duration (average time of each state) were calculated.Results: Patients with PDS showed a shorter mean microstate duration with higher mean occurrence per second compared to patients with nPDS. There was no difference between the two groups in the coverage of microstate A–D.Conclusion: This is the first study to present the temporal fluctuations of EEG topography in comorbid depression in TLE using EEG microstate analysis. The temporal characteristics of the four canonical EEG microstates were significantly altered in patients with TLE suffer from comorbid depression.

scholarly journals Intrinsic brain activity changes in temporal lobe epilepsy patients revealed by regional homogeneity analysis

Seizure ◽  
2020 ◽  
Vol 81 ◽  
pp. 117-122
Author(s):  
Baotian Zhao ◽  
Bowen Yang ◽  
Zhongjian Tan ◽  
Wenhan Hu ◽  
Lin Sang ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Brain Activity ◽  
Regional Homogeneity ◽  
Homogeneity Analysis ◽  
Intrinsic Brain Activity

A pioneering FreeSurfer volumetric study of a series of patients with mesial temporal lobe epilepsy and hippocampal sclerosis with comorbid depression

2021 ◽  
pp. 111281
Author(s):  
Nathália Stela Visoná de Figueiredo ◽  
Larissa Botelho Gaça ◽  
Idaiane Batista Assunção-Leme ◽  
Lenon Mazetto ◽  
Maria Teresa Fernandes Castilho Garcia ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Hippocampal Sclerosis ◽  
Mesial Temporal Lobe Epilepsy ◽  
Comorbid Depression ◽  
Volumetric Study ◽  
Mesial Temporal Lobe

Reading, listening and memory-related brain activity in children with early-stage temporal lobe epilepsy of unknown cause-an fMRI study

2015 ◽  
Vol 19 (5) ◽  
pp. 561-571 ◽  
Author(s):  
Katariina Mankinen ◽  
Pieta Ipatti ◽  
Marika Harila ◽  
Juha Nikkinen ◽  
Jyri-Johan Paakki ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Early Stage ◽  
Brain Activity ◽  
Fmri Study

Regulation of TWIK-related K+ channel 1 in the anterior hippocampus of patients with temporal lobe epilepsy with comorbid depression

2021 ◽  
Vol 121 ◽  
pp. 108045
Author(s):  
Xiao-Li Li ◽  
Chong-Yang Tang ◽  
Shu Wang ◽  
Meng Zhao ◽  
Xiong-Fei Wang ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
K Channel ◽  
Comorbid Depression

scholarly journals Alterations in regional homogeneity of resting-state brain activity in mesial temporal lobe epilepsy

Epilepsia ◽  
2013 ◽  
Vol 54 (4) ◽  
pp. 658-666 ◽  
Author(s):  
Hongwu Zeng ◽  
Ricardo Pizarro ◽  
Veena A. Nair ◽  
Christian La ◽  
Vivek Prabhakaran
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Resting State ◽  
Brain Activity ◽  
Mesial Temporal Lobe Epilepsy ◽  
Regional Homogeneity ◽  
Mesial Temporal Lobe

scholarly journals Do Hippocampal Neurons Really Count for Comorbid Depression in Patients With Mesial Temporal Lobe Epilepsy and Hippocampal Sclerosis? A Histopathological Study

2021 ◽  
Vol 15 ◽  
Author(s):  
Nathália Stela Visoná de Figueiredo ◽  
Anaclara Prada Jardim ◽  
Lenon Mazetto ◽  
Jeana Torres Corso Duarte ◽  
Sandra Mara Comper ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Hippocampal Neurons ◽  
Hippocampal Sclerosis ◽  
Mesial Temporal Lobe Epilepsy ◽  
Histopathological Study ◽  
Comorbid Depression ◽  
Neuronal Density ◽  
Mesial Temporal Lobe ◽  
Patients With Epilepsy

Depression is the most frequent psychiatric comorbidity seen in mesial temporal lobe epilepsy (MTLE) patients with hippocampal sclerosis (HS). Moreover, the HS is the most frequent pathological hallmark in MTLE-HS. Although there is a well-documented hippocampal volumetric reduction in imaging studies of patients with major depressive disorder, in epilepsy with comorbid depression, the true role of the hippocampus is not entirely understood. This study aimed to verify if patients with unilateral MTLE-HS and the co-occurrence of depression have differences in neuronal density of the hippocampal sectors CA1–CA4. For this purpose, we used a histopathological approach. This was a pioneering study with patients having both clinical disorders. However, we found no difference in hippocampal neuronal density when depression co-occurs in patients with epilepsy. In this series, CA1 had the lowest counting in both groups, and HS ILAE Type 1 was the most prevalent. More studies using histological assessments are needed to clarify the physiopathology of depression in MTLE-HS.

scholarly journals Depression and Temporal Lobe Epilepsy: Expression Pattern of Calbindin Immunoreactivity in Hippocampal Dentate Gyrus of Patients Who Underwent Epilepsy Surgery with and without Comorbid Depression

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Luciana D’Alessio ◽  
Hector Konopka ◽  
Patricia Solís ◽  
Laura Scévola ◽  
Mónica Fernandez Lima ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Dentate Gyrus ◽  
Temporal Lobe ◽  
Epilepsy Surgery ◽  
Verbal Learning ◽  
Granular Cell ◽  
Cell Loss ◽  
Comorbid Depression ◽  
Hippocampal Dentate Gyrus ◽  
Dsm Iv

Purpose. Changes in calbindin (CB) expression have been reported in patients with temporal lobe epilepsy (TLE) with controversial implications on hippocampal functions. The aim of this study was to determine the CB immunoreactivity in hippocampal dentate gyrus of patients who underwent epilepsy surgery for drug-resistant TLE with and without comorbid depression and/or memory deficits. Methods. Selected hippocampal samples from patients with TLE who underwent epilepsy surgery were included. Clinical and complementary assessment: EEG, video-EEG, MRI, psychiatric assessment (structured clinical interview, DSM-IV), and memory assessment (Rey auditory verbal learning test, RAVLT; Rey-Osterrieth complex figure test, RCFT), were determined before surgery. Hippocampal sections were processed using immunoperoxidase with the anti-calbindin antibody. The semiquantitative analysis of CB immunoreactivity was determined in dentate gyrus by computerized image analysis (ImageJ). Results. Hippocampal sections of patients with TLE and HS (n=24) and postmortem controls (n=5) were included. A significant reduction of CB+ cells was found in patients with TLE (p<0.05, Student’s t-test). Among TLE cases (n=24), depression (n=12) and memory deficit (n=17) were determined. Depression was associated with a higher % of cells with the CB dendritic expression (CB-sprouted cells) (F1,20=11.81, p=0.003, hp2=0.37), a higher CB+ area (μm2) (F1,20=5.33, p=0.032, hp2=0.21), and a higher optical density (F1,20=15.09, p=0.001, hp2=0.43) (two-way ANOVA). The GAF scale (general assessment of functioning) of DSM-IV inversely correlated with the % of CB-sprouted cells (r=−0.52, p=0.008) and with the CB+ area (r=−0.46, p=0.022). Conclusions. In this exploratory study, comorbid depression was associated with a differential pattern of CB cell loss in dentate gyrus combined with a higher CB sprouting. These changes may indicate granular cell dysmaturation associated to the epileptic hyperexcitability phenomena. Further investigations should be carried out to confirm these preliminary findings.

scholarly journals Reduced expression of the glucocorticoid receptor in the hippocampus of patients with drug‐resistant temporal lobe epilepsy and comorbid depression

Epilepsia ◽  
2020 ◽  
Vol 61 (8) ◽  
pp. 1595-1605
Author(s):  
Luciana D’Alessio ◽  
Lucia Mesarosova ◽  
Jasper J. Anink ◽  
Silvia Kochen ◽  
Patricia Solís ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Drug Resistant ◽  
Comorbid Depression
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