scholarly journals DISCOHAT: An Acronym to Describe the Spectrum of Symptoms Related to Bilateral Vestibulopathy

2021 ◽  
Vol 12 ◽  
Author(s):  
Sophie Paredis ◽  
Lisa van Stiphout ◽  
Eva Remmen ◽  
Michael Strupp ◽  
Marie-Cecile Gerards ◽  
...  
Keyword(s):  
Case Control Study ◽  
Wide Spectrum ◽  
Head Movements ◽  
Tertiary Referral ◽  
Bilateral Vestibulopathy ◽  
Tertiary Referral Center ◽  
Vestibular Symptoms ◽  
Unilateral Vestibulopathy ◽  
Uniform Assessment ◽  
Control Study

Objective: To assess the prevalence of each symptom listed in the acronym DISCOHAT (worsening of symptoms in Darkness and/or uneven ground, Imbalance, Supermarket effect, Cognitive complaints, Oscillopsia, Head movements worsen symptoms, Autonomic complaints, and Tiredness) in patients with bilateral vestibulopathy (BVP), compared to patients with unilateral vestibulopathy (UVP).Methods: A descriptive case-control study was performed on BVP and UVP patients who were evaluated for their vestibular symptoms by two of the authors (RvdB, MCG) at a tertiary referral center, between 2017 and 2020. During history taking, the presence of each DISCOHAT symptom was checked and included in the electronic health record. Presence of a symptom was categorized into: “present,” “not present,” and “missing.”Results: Sixty-six BVP patients and 144 UVP patients were included in this study. Prevalence of single DISCOHAT symptoms varied from 52 to 92% in BVP patients and 18–75% in UVP patients. Patients with BVP reported “worsening of symptoms in darkness,” “imbalance,” “oscillopsia,” and “worsening of symptoms with fast head movements” significantly more than UVP patients (p ≤ 0.004).Conclusion: The DISCOHAT acronym is able to capture a wide spectrum of symptoms related to vestibulopathy, while it is easy and quickly to use in clinic. Application of this acronym might facilitate a more thorough and uniform assessment of bilateral vestibulopathy, within and between vestibular clinics worldwide.

Antiphospholipid antibodies may be associated with uveitis

2020 ◽  
pp. 112067212096872
Author(s):  
Yinon Shapira ◽  
Yael Ben-Arie-Weintrob ◽  
Boris Gilburd ◽  
Sandra Reuter ◽  
María Sánchez-Castañón ◽  
...  
Keyword(s):  
Antiphospholipid Antibodies ◽  
Case Control Study ◽  
Case Control ◽  
Healthy Controls ◽  
Tertiary Referral ◽  
Tertiary Referral Center ◽  
Nuclear Antigens ◽  
Infectious Uveitis ◽  
Unselected Population ◽  
Control Study

Purpose: To evaluate the prevalence of a spectrum of autoantibodies in adult patients with non-infectious uveitis compared to healthy controls. Methods: This is a case-control study conducted in a tertiary referral center. Serum positivity to auto-antibodies directed at membranous phospholipids (aPL), nuclear antigens, and cytoplasmic (ANCA) antigens were assessed in sera from 63 non-infectious uveitis patients, and 78 healthy controls. Uveitis patients’ demographic and clinical data were collected retrospectively from their medical charts. Results: Of the spectrum of antibodies evaluated only aPL were linked with uveitis (OR 11.2, CI 1.4–92.1), as 13 (20.6%) uveitis patients were positive to at least one of the screened aPL, namely either anti-cardiolipin (aCL), anti-β2-glycoprotein (aβ2GPI), or anti-phosphatidylserine/prothrombin (aPS/PT). aCL antibodies were detected in 5/63 (7.9%) of uveitis patients and in none of controls ( p = 0.016). Positivity to either aCL or aβ2GPI was noted in 8/63 (12.7%) of uveitis patients and in 1 (1.3%) of the controls ( p = 0.011). Of the 13 uveitis patients positive to any of the aPL antibodies, 8 (62%) had exclusively anterior uveitis, 9 (69%) were idiopathic, and none had evidence of posterior vaso-occlusive involvement or systemic thrombotic manifestations. Conclusion: An association between aPL and uveitis among an unselected population of patients with no evidence of thrombosis or presence of the antiphospholipid syndrome was documented in this study. This link was observed, alike the general population of uveitis patients, mainly in patients with anterior eye inflammation. A possible interaction between aPL and uveitis, mediated by non-thrombotic mechanisms, requires further studies.

scholarly journals Influence of autoimmune biomarkers on interstitial lung diseases: A tertiary referral center based case-control study

2015 ◽  
Vol 109 (3) ◽  
pp. 397-405 ◽  
Author(s):  
Philippe R. Bauer ◽  
Sanjay Kalra ◽  
Thomas G. Osborn ◽  
Jennifer St. Sauver ◽  
Andrew C. Hanson ◽  
...  
Keyword(s):  
Lung Diseases ◽  
Case Control Study ◽  
Case Control ◽  
Interstitial Lung Diseases ◽  
Tertiary Referral ◽  
Tertiary Referral Center ◽  
Referral Center ◽  
Control Study

scholarly journals Allium vegetables intake and endometrial cancer risk

2009 ◽  
Vol 12 (9) ◽  
pp. 1576-1579 ◽  
Author(s):  
Carlotta Galeone ◽  
Claudio Pelucchi ◽  
Luigino Dal Maso ◽  
Eva Negri ◽  
Maurizio Montella ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Wide Spectrum ◽  
Protective Role ◽  
Case Control ◽  
Endometrial Cancer Risk ◽  
Allium Vegetables ◽  
Control Study

AbstractObjectiveThe potential role of allium vegetables on endometrial cancer risk has been scarcely investigated and the results of previous Chinese studies are not easily applicable to Western populations. Therefore, we evaluated the relationship between onion and garlic intake and endometrial cancer, using data from an Italian case–control study.SettingWe analysed data from a multi-centre case–control study of 454 endometrial cancer cases and 908 controls, admitted to the same hospitals for a wide spectrum of acute, non-neoplastic conditions. Information was collected by trained interviewers using a validated and reproducible FFQ. Multivariate odds ratios and 95 % confidence intervals were obtained after allowance for recognized confounding factors.ResultsCompared with non-users, the OR of endometrial cancer for successive categories of onion intake were 0·94 (95 % CI 0·72, 1·21) for <2 portions/week and 0·40 (95 % CI 0·22, 0·72) for ≥2 portions/week, with a significant inverse trend in risk (P = 0·01). The OR for an increment of one portion (i.e. 80 g) of onions per week was 0·81 (95 % CI 0·70, 0·95). For garlic, the OR for successive categories of intake were 0·89 (95 % CI 0·68, 1·15) for intermediate use and 0·62 (95 % CI 0·42, 0·92) for high use, with a significant inverse trend in risk (P = 0·02).ConclusionsOur study found a moderate protective role of allium vegetables on the risk of endometrial cancer.

Establishing Urinary Leukotriene E4 as a Diagnostic Biomarker for Chronic Rhinosinusitis with Comorbid Asthma and Atopy

2019 ◽  
Vol 161 (5) ◽  
pp. 764-769 ◽  
Author(s):  
Griffin D. Santarelli ◽  
Kent K. Lam ◽  
Joseph K. Han
Keyword(s):  
Chronic Rhinosinusitis ◽  
Case Control Study ◽  
Medical Center ◽  
Case Control ◽  
Healthy Controls ◽  
Diagnostic Biomarker ◽  
Tertiary Referral ◽  
Cysteinyl Leukotriene ◽  
Inflammatory State ◽  
Control Study

Objective While urinary leukotriene E4 (uLTE4) is a validated biomarker for the cysteinyl leukotriene pathway, which is central to the pathophysiology of asthma, atopy, and chronic rhinosinusitis (CRS), the contributions of comorbid asthma and atopy to uLTE4 levels in various CRS subtypes have not been previously characterized. We sought to (1) identify reference values for uLTE4 in subjects with and without CRS and (2) determine how the presence of comorbid atopy and asthma affects uLTE4 levels in CRS. Setting Tertiary referral medical center. Subjects and Methods A prospective case-control study was conducted to compare uLTE4 levels between patients with CRS and healthy controls. Urinary LTE4 levels were measured by enzyme immunoassay and were adjusted for urinary creatinine concentrations (pg/mg Cr). Patients with CRS were stratified by the clinical comorbidities to determine normative uLTE4 values for patients with CRS with and without comorbid asthma or atopy. Results A total of 153 patients (mean age, 47.3; 47.1% female) were included in the study. Patients with CRS demonstrated significantly higher concentrations of uLTE4 than healthy controls (1652 vs 1065 pg/mg Cr, P = .032). Within the group of patients with CRS, comorbid asthma also individually correlated with elevated uLTE4 levels (1597 pg/mg Cr, P = .0098). Patients with CRS who did not have comorbid allergy and asthma, in contrast, did not have statistically higher uLTE4 levels than healthy controls (1142 pg/mg Cr, P = .61). Conclusion Urinary LTE4 serves as a noninvasive measure of the inflammatory state in CRS. Comorbid asthma and atopy contribute to elevated uLTE4 levels in CRS.

The effect of migraine and motion sickness on symptoms evoked by the caloric vestibular test

2021 ◽  
pp. 1-10
Author(s):  
Ozlem Gedik Soyuyuce ◽  
Pinar Yalinay Dikmen ◽  
Nazim Korkut
Keyword(s):  
Data Analysis ◽  
Motion Sickness ◽  
Retrospective Data ◽  
Tertiary Referral ◽  
Sensory Stimuli ◽  
Tertiary Referral Center ◽  
Retrospective Data Analysis ◽  
Increased Risk ◽  
Vestibular Symptoms ◽  
The Mean

BACKGROUND: The caloric vestibular test (CVT) may evoke headache and vestibular symptoms in susceptible people. Patients with migraines have higher susceptibility to motion sickness. In migraines, impaired habituation to repetitive stimuli is a well-known interictal abnormality. OBJECTIVE: This study is aimed at evaluating CVT-evoked headache, nausea, vomiting, and imbalance in patients with and without migraine and/or motion sickness. METHODS: A retrospective data analysis was performed on 554 patients with a complaint of dizziness who underwent bithermal CVT at a tertiary referral center. The occurrences of CVT-evoked headache, nausea, vomiting, and imbalance were observed in four groups: patients with only migraine (MG; n = 94), those with only motion sickness (MSG; n = 89), those with migraine and motion sickness (MMSG; n = 122), and those without migraine and motion sickness (non-MMSG; n = 146). The differences between the groups were assessed. RESULTS: The mean ages of groups were similar (p = 0.534). The proportions of females were higher in the MG, MSG, and MMSG (p = 0.001). The severity of nausea and headache for each gender was higher in the MG, MSG, and MMSG (p <  0.001). Vomiting was more common in MMSG among males (p = 0.003), while there was no difference between groups among females (p = 0.099). Imbalance was more common in MMSG among females (p <  0.001). A relationship was detected between age and imbalance (p <  0.001), where an increased risk for imbalance was evident with greater age. Three patients in the MMSG needed hospitalization after CVT. CONCLUSIONS: Special caution is needed when performing caloric testing for patients with migraines or MS since CVT-evoked symptoms may occur with higher incidence and intensity, which might be related to a lack of habituation in neuronal information processing after robust sensory stimuli like CVT.

scholarly journals Dietary inflammatory index and endometrial cancer risk in an Italian case–control study

2015 ◽  
Vol 115 (1) ◽  
pp. 138-146 ◽  
Author(s):  
Nitin Shivappa ◽  
James R. Hébert ◽  
Antonella Zucchetto ◽  
Maurizio Montella ◽  
Diego Serraino ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Wide Spectrum ◽  
Case Control ◽  
Dietary Inflammatory Index ◽  
Endometrial Cancer Risk ◽  
Inflammatory Index ◽  
Italian Case ◽  
Control Study

AbstractThe relation between inflammation deriving from diet and endometrial cancer risk has not yet been investigated. In this study, we explored the association between the dietary inflammatory index (DII) and endometrial cancer risk in an Italian case–control study. Cases comprised 454 patients with incident, histologically confirmed carcinoma of the endometrium, and controls comprised 908 subjects admitted to the same network of hospitals as cases for a wide spectrum of acute, non-neoplastic conditions. DII scores were computed on the basis of dietary intake assessed using a reproducible and valid seventy-eight-item FFQ. OR were calculated through logistic regression models conditioned on age and study centre and adjusted for recognised confounding factors, including total energy intake. Women with the most pro-inflammatory diet had a higher risk for endometrial cancer compared with women with the most anti-inflammatory diet (ORQuartile 4 v. 1 1·46; 95 % CI 1·02, 2·11; Ptrend=0·04). A pro-inflammatory diet may increase the risk for endometrial cancer.

Wall stress of the cervical carotid artery in patients with carotid dissection: a case-control study

2011 ◽  
Vol 300 (4) ◽  
pp. H1451-H1458 ◽  
Author(s):  
Fraser M. Callaghan ◽  
Roger Luechinger ◽  
Vartan Kurtcuoglu ◽  
Hakan Sarikaya ◽  
Dimos Poulikakos ◽  
...  
Keyword(s):  
Carotid Arteries ◽  
Case Control Study ◽  
Carotid Sinus ◽  
Wall Stress ◽  
Head Rotation ◽  
Case Control ◽  
Head Movements ◽  
Carotid Dissection ◽  
Artery Wall ◽  
Control Study

Spontaneous internal carotid artery (ICA) dissection (sICAD) results from an intimal tear located around the distal carotid sinus. The mechanisms causing the tear are unknown. This case-control study tested the hypotheses that head movements increase the wall stress in the cervical ICA and that the stress increase is greater in patients with sICAD than in controls. Five patients with unilateral, recanalized, left sICAD and five matched controls were investigated before and after maximal head rotation to the left and neck hyperextension after 45° head rotation to the left. The anatomy of the extracranial carotid arteries was assessed by magnetic resonance imaging and used to create finite element models of the right ICA. Wall stress increased after head movements. Increases above the 80th and 90th percentile were located at the intimal side of the artery wall from 7.4 mm below to 10 mm above the cranial edge of the carotid sinus, i.e., at the same location as histologically confirmed tears in patients with sICAD. Wall stress increase did not differ between patients and controls. The present findings suggest that wall stress increases at the intimal side of the artery wall surrounding the distal edge of the carotid bulb after head movements may be important for the development of carotid dissection. The lack of wall stress difference between the two groups indicates that the carotid arteries of patients with carotid dissection have either distinct functional or anatomical properties or endured unusually heavy wall stresses to initiate dissection.

scholarly journals Clinical Subtypes and vHIT Parameters in a Population With Bilateral Vestibulopathy

2021 ◽  
Vol 12 ◽  
Author(s):  
Fiorella Mancino-Moreira ◽  
Almudena Rueda ◽  
Jonathan Esteban-Sanchez ◽  
Eduardo Martin-Sanz
Keyword(s):  
Medical History ◽  
Family Background ◽  
Diagnostic Process ◽  
Case Review ◽  
Clinical Tool ◽  
Bilateral Vestibulopathy ◽  
Retrospective Case ◽  
Tertiary Referral Center ◽  
History Of ◽  
Unilateral Vestibulopathy

Objective: To evaluate the different peripheral, neurological, genetic, and systemic etiologies of bilateral vestibulopathy (BVP) and the value of vHIT in the diagnostic process.Materials and methods: A retrospective case review was performed on 176 patients diagnosed with BVP in a tertiary referral center, between 2010 and 2020. Inclusion criteria comprised imbalance and/or oscillopsia during locomotion and horizontal angular VOR gain on both sides &lt;0.8. We classified patients into different groups according to (1) their fulfillment of the Barany guideline for bilateral vestibulopathy (2) the definite etiology of BVP and (3) the four clinical subtypes distributed in our population (recurrent vertigo with BVP, rapidly progressive BVP, slowly progressive BVP, and slowly progressive BVP with ataxia). Medical history of vertigo, hypoacusis or migraine, and family background of imbalance and/or oscillopsia were assessed. Horizontal, posterior, and superior semicircular canal angular VOR gain was registered along with saccadic parameters such as velocity, and dispersion of the saccades' latency values.Results: Barany's Society diagnostic criteria for BVP was accomplished in 89 patients. Among our patients, 13.6% had migraines in their medical history and the idiopathic group accounted for 50% of the population. All four clinical subtypes were found in our population, slowly progressive bilateral vestibulopathy without vertigo was the most frequent one. A percentage of our population could not be categorized into any of the former subtypes, many of these patients were diagnosed with BVP after suffering a single vertigo episode. Lower vHIT gains were found in those patients with Barany's criteria for BVP and oscillopsia was significantly more prevalent in this group.Conclusions: Bilateral vestibulopathy manifests with very different patterns representing a very heterogeneous condition. The distribution of the clinical subtypes and Barany's criteria are a useful clinical tool to differentiate groups of patients. The vHIT can serve as an initial tool for identifying patients with BVP. The finding of bilateral vestibular involvement in a clinically suspected unilateral vestibulopathy should be considered in some patients.

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