Long-Term Effects of Intracerebroventricular Streptozotocin Treatment on Adult Neurogenesis in the Rat Hippocampus

2015 ◽  
Vol 12 (8) ◽  
pp. 772-784 ◽  
Author(s):  
Ping Sun ◽  
Ana Knezovic ◽  
Milena Parlak ◽  
Jacqueline Cuber ◽  
Margherita Karabeg ◽  
...  
Keyword(s):  
Adult Neurogenesis ◽  
Rat Hippocampus ◽  
Long Term Effects

scholarly journals Long-term effects of an acute and systemic administration of LPS on adult neurogenesis and spatial memory

2014 ◽  
Vol 8 ◽  
Author(s):  
Jorge Valero ◽  
Giorgia Mastrella ◽  
Ismael Neiva ◽  
Silvia Sánchez ◽  
João O. Malva
Keyword(s):  
Spatial Memory ◽  
Adult Neurogenesis ◽  
Systemic Administration ◽  
Long Term Effects

Long-term effects of neonatal exposure to MK-801 on recognition memory and excitatory–inhibitory balance in rat hippocampus

Neuroscience ◽  
2015 ◽  
Vol 308 ◽  
pp. 134-143 ◽  
Author(s):  
J.-T. Li ◽  
Y.-Y. Zhao ◽  
H.-L. Wang ◽  
X.-D. Wang ◽  
Y.-A. Su ◽  
...  
Keyword(s):  
Recognition Memory ◽  
Rat Hippocampus ◽  
Neonatal Exposure ◽  
Long Term Effects ◽  
Mk 801

Long-term effects of environmental stimulation following hypoxia–ischemia on the oxidative state and BDNF levels in rat hippocampus and frontal cortex

2009 ◽  
Vol 1247 ◽  
pp. 188-195 ◽  
Author(s):  
Lenir Orlandi Pereira ◽  
Patrícia Machado Nabinger ◽  
Atahualpa Cauê Paim Strapasson ◽  
Patrícia Nardin ◽  
Carlos Alberto Saraiva Gonçalves ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Rat Hippocampus ◽  
Long Term Effects ◽  
Hypoxia Ischemia ◽  
Environmental Stimulation ◽  
Oxidative State

scholarly journals Early Stroke Induces Long-Term Impairment of Adult Neurogenesis Accompanied by Hippocampal-Mediated Cognitive Decline

Cells ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 1654 ◽  
Author(s):  
Carolin Kathner-Schaffert ◽  
Lina Karapetow ◽  
Madlen Günther ◽  
Max Rudolph ◽  
Mahmoud Dahab ◽  
...  
Keyword(s):  
Adult Neurogenesis ◽  
Fluorescent Protein ◽  
Search Strategies ◽  
Neuronal Morphology ◽  
Aging Brain ◽  
Long Term Effects ◽  
Stroke Lesion ◽  
The Impact ◽  
Early Stroke

Stroke increases neurogenesis in the adult dentate gyrus in the short term, however, long-term effects at the cellular and functional level are poorly understood. Here we evaluated the impact of an early stroke lesion on neurogenesis and cognitive function of the aging brain. We hypothesized that a stroke disturbs dentate neurogenesis during aging correlate with impaired flexible learning. To address this issue a stroke was induced in 3-month-old C57Bl/6 mice by a middle cerebral artery occlusion (MCAO). To verify long-term changes of adult neurogenesis the thymidine analogue BrdU (5-Bromo-2′-deoxyuridine) was administrated at different time points during aging. One and half months after BrdU injections learning and memory performance were assessed with a modified version of the Morris water maze (MWM) that includes the re-learning paradigm, as well as hippocampus-dependent and -independent search strategies. After MWM performance mice were transcardially perfused. To further evaluate in detail the stroke-mediated changes on stem- and progenitor cells as well as endogenous proliferation nestin-green-fluorescent protein (GFP) mice were used. Adult nestin-GFP mice received a retroviral vector injection in the hippocampus to evaluate changes in the neuronal morphology. At an age of 20 month the nestin-GFP mice were transcardially perfused after MWM performance and BrdU application 1.5 months later. The early stroke lesion significantly decreased neurogenesis in 7.5- and 9-month-old animals and also endogenous proliferation in the latter group. Furthermore, immature doublecortin (DCX)-positive neurons were reduced in 20-month-old nestin-GFP mice after lesion. All MCAO groups showed an impaired performance in the MWM and mostly relied on hippocampal-independent search strategies. These findings indicate that an early ischemic insult leads to a dramatical decline of neurogenesis during aging that correlates with a premature development of hippocampal-dependent deficits. Our study supports the notion that an early stroke might lead to long-term cognitive deficits as observed in human patients after lesion.

scholarly journals Olanzapine Increases Neural Chemorepulsant—Draxin Expression in the Adult Rat Hippocampus

2021 ◽  
Vol 14 (4) ◽  
pp. 298
Author(s):  
Artur Pałasz ◽  
Aleksandra Suszka-Świtek ◽  
Jacek Francikowski ◽  
Marek Krzystanek ◽  
Katarzyna Bogus ◽  
...  
Keyword(s):  
Adult Neurogenesis ◽  
Neuronal Migration ◽  
Neurite Growth ◽  
Rat Hippocampus ◽  
The Novel ◽  
Adult Rat ◽  
Second Generation Antipsychotics ◽  
The Family ◽  
First Time

Draxin belongs to the family of inhibitory axon-guiding factors that regulate neuronal migration and axonal spreading in the developing brain. This glycoprotein has recently been considered to play an important role both in hippocampal differentiation and adult neurogenesis in the dentate gyrus. Given that it has been reported that antipsychotic drugs may affect neurite growth and neurogenesis, we have therefore investigated whether chronic treatment with olanzapine modulates draxin immunoreactivity in the adult rat hippocampus. After analysis of local fluorescence intensity, we found a significant increase of draxin immunoexpression both in the subgranular zone (SGZ) and granular zone of the rat hippocampus following long-term olanzapine administration. This study reveals, for the first time, the modulatory effect of the atypical antipsychotic medication olanzapine on expression of the novel chemorepulsive protein draxin in the context of adult neurogenesis regulation. Moreover, this is the first report dealing with pharmacological aspects of draxin signaling. An elevated draxin expression may indirectly support a recently formulated hypothesis that olanzapine may drive adult neurogenesis via paracrine draxin-related signaling. This action of draxin is a new element in the neurogenesis mechanism that may be part of the action of second-generation antipsychotics in the treatment of schizophrenia, indicating more detailed molecular studies are urgently required to fully investigate these potential novel mechanisms of neurogenesis.

Ovarian Dysfunction in Fetally Irradiated Beagles

1977 ◽  
Vol 35 ◽  
pp. 658-659
Author(s):  
T. M. Seed ◽  
M. H. Sanderson ◽  
D. L. Gutzeit ◽  
T. E. Fritz ◽  
D. V. Tolle ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Low Dose ◽  
Long Term Effects ◽  
Ovarian Dysfunction ◽  
Dose Rates ◽  
Highly Sensitive ◽  
Microscopic Evaluation ◽  
Ovarian Pathology ◽  
Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

Ultrastructural investigations of MDL 19,660-induced effects on the canine platelet and megakaryocyte

1990 ◽  
Vol 48 (3) ◽  
pp. 374-375
Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson
Keyword(s):  
Antidepressant Drug ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Short Term ◽  
Platelet Counts ◽  
Toxicological Studies ◽  
Induced Aggregation ◽  
Internal Architecture

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.

Sign in / Sign up

Export Citation Format

Share Document