scholarly journals Molecular and Clinical Significance of Fibroblast Growth Factor 2 in Development and Regeneration of the Auditory System

2021 ◽  
Vol 14 ◽  
Author(s):  
Minjin Jeong ◽  
Katarina Bojkovic ◽  
Varun Sagi ◽  
Konstantina M. Stankovic
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Auditory System ◽  
Therapeutic Agent ◽  
Cellular Proliferation ◽  
Fibroblast Growth Factor 2 ◽  
Biological Processes ◽  
Fibroblast Growth ◽  
Inner Ear Development

The fibroblast growth factor 2 (FGF2) is a member of the FGF family which is involved in key biological processes including development, cellular proliferation, wound healing, and angiogenesis. Although the utility of the FGF family as therapeutic agents has attracted attention, and FGF2 has been studied in several clinical contexts, there remains an incomplete understanding of the molecular and clinical function of FGF2 in the auditory system. In this review, we highlight the role of FGF2 in inner ear development and hearing protection and present relevant clinical studies for tympanic membrane (TM) repair. We conclude by discussing the future implications of FGF2 as a potential therapeutic agent.

scholarly journals Glypican-1 drives unconventional secretion of Fibroblast Growth Factor 2

2021 ◽  
Author(s):  
Carola Sparn ◽  
Eleni Dimou ◽  
Annalena Meyer ◽  
Roberto Saleppico ◽  
Sabine Wegehingel ◽  
...  
Keyword(s):  
Growth Factor ◽  
Heparan Sulfate ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 2 ◽  
Structural Basis ◽  
Limiting Factor ◽  
Fibroblast Growth ◽  
Unconventional Secretion ◽  
Rate Limiting

Fibroblast Growth Factor 2 (FGF2) is a tumor cell survival factor that is transported into the extracellular space by an unconventional secretory mechanism. Cell surface heparan sulfate proteoglycans are known to play an essential role in this process. Unexpectedly, we found that among the diverse sub-classes consisting of syndecans, perlecans, glypicans and others, Glypican-1 (GPC1) is both the principle and rate-limiting factor that drives unconventional secretion of FGF2. By contrast, we demonstrate GPC1 to be dispensable for FGF2 signaling into cells. We provide first insights into the structural basis for GPC1-dependent FGF2 secretion, identifying disaccharides with N-linked sulfate groups to be enriched in the heparan sulfate chains of GPC1 to which FGF2 binds with high affinity. Our findings have broad implications for the role of GPC1 as a key molecule in tumor progression.

Immunotherapy‐refractory vacuolar myopathy with mucin deposition in scleromyxedema: A possible role of fibroblast growth factor 2

2020 ◽  
Vol 40 (5) ◽  
pp. 492-495 ◽  
Author(s):  
Yuki Yanagihara ◽  
Shintaro Hayashi ◽  
Junpei Koge ◽  
Hiroyuki Honda ◽  
Ryo Yamasaki ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Vacuolar Myopathy

Ethanol induced increase of fibroblast growth factor 2 mRNA content in emotiogenic brain structures of rats

2020 ◽  
Vol 66 (5) ◽  
pp. 419-422
Author(s):  
M.I. Airapetov ◽  
S.O. Eresco ◽  
A.A. Lebedev ◽  
E.R. Bychkov ◽  
P.D. Shabanov
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Dopaminergic Neurons ◽  
Mrna Level ◽  
Brain Structures ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Mrna Content ◽  
The Brain

We studied the effects of acute, subacute, and chronic alcohol treatment of rats on the content of fibroblast growth factor 2 (FGF2) mRNA in various brain structures. Results suggest a possible role of FGF2 in the functioning of dopaminergic neurons in the midbrain. In our experiment, ethanol treatment of rats was accompanied by an increase in the FGF2 mRNA level in the emotiogenic structures of the brain. This effect was blocked by pretreatment of animals with chlorpromazine. This suggests FGF2 involvement in the mechanisms of alcohol dependence and can be considered as a possible diagnostic and therapeutic target in alcoholism.

scholarly journals Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation

2002 ◽  
Vol 61 (5) ◽  
pp. 1714-1728 ◽  
Author(s):  
Frank Strutz ◽  
Michael Zeisberg ◽  
Fuad N. Ziyadeh ◽  
Chang-Qing Yang ◽  
Raghu Kalluri ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Mesenchymal Transformation
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