Solanaceous Vegetables and Colorectal Cancer Risk: A Hospital-Based Matched Case-Control Study in Northeast China

Background: Dietary factors are regarded as an essential influence in changing colorectal cancer (CRC) risk. However, there is no clear conclusion of the relationship between solanaceous vegetables and colorectal cancer at present. The study aimed to evaluate the intake of solanaceous vegetables in relation to colorectal cancer risk among the Northeast Chinese population.Methods: We carried out a hospital-based case-control study in three hospitals in Northeast China from 2009 to 2011. The study finally included 833 patients with CRC and 833 controls matched separately according to age, gender, and city of residence. We applied a structural questionnaire to collect demographic characteristics and dietary information by face-to-face interview and adopted conditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Stratified analyses were conducted by sex and subsites.Results: There was no obvious correlation between total intake of solanaceous plants and CRC risk. The adjusted OR for the highest quartile and the lowest quartile was 1 (95% CI: 0.68–1.5). Certain types of solanaceous vegetables were negatively associated with the risk of CRC, such as eggplant (OR = 0.42; 95% CI:0.29–0.62) and sweet pepper (OR = 0.48; 95%CI: 0.33–0.7). Potato was found to have a positive correlation with CRC (OR = 1.76; 95% CI: 1.26–2.47). In the stratified analyses by gender, total solanaceous vegetables intake was inversely associated with CRC risk only in men. In the stratified analyses of cancer subsites, no significant association between total solanaceous vegetables intake and CRC risk was found.Conclusion: No findings showed that the intake of total solanaceous vegetables was related to the reduction of CRC risk. However, specific types of solanaceous vegetables indicated an inverse association with CRC risk.

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The effect of raw vegetable and fruit intake on thyroid cancer risk among women: a case–control study in South Korea

British Journal Of Nutrition ◽

10.1017/s0007114512000591 ◽

2012 ◽

Vol 109 (1) ◽

pp. 118-128 ◽

Cited By ~ 20

Author(s):

Su Kyoung Jung ◽

Kirang Kim ◽

Kyung Tae ◽

Gu Kong ◽

Mi Kyung Kim

Keyword(s):

Thyroid Cancer ◽

Cancer Risk ◽

Case Control Study ◽

Early Stage ◽

Conditional Logistic Regression ◽

Case Control ◽

Dietary Factors ◽

Inverse Association ◽

Thyroid Cancer Risk ◽

Control Study

Thyroid cancer is the most common cancer among Korean women. However, there are few data on dietary factors related to thyroid cancer risk. The objective of the present study was to evaluate the association between raw vegetables and fruits intake and thyroid cancer in a case–control study. We included 111 histologically confirmed malignant thyroid cancer cases and 115 benign cases. Controls who did not have nodules in thyroid ultrasonography were matched to cases by age ( ± 2 years). Food and nutrient intakes were estimated using a quantitative FFQ with 121 items. Conditional logistic regression analysis was used to obtain OR and corresponding 95 % CI. The intake of total vegetables was not associated with malignant thyroid cancer, but inversely associated with benign cases. High raw vegetable intake was inversely associated with thyroid cancer risk both in malignant and benign cases (P for trend = 0·01 in both malignant and benign cases). Among fruits, persimmon intake had an inverse association with thyroid cancer risk in both malignant and benign cases (P for trend = 0·06 in malignant cases; P for trend = 0·01 in benign cases) and tangerine intake had an inverse association in malignant cases (P for trend = 0·03). The frequency of consumption of raw vegetables and persimmon also had a consistent inverse association in both malignant and benign cases. These results suggest that high consumption of raw vegetables, persimmons and tangerines may decrease thyroid cancer risk and help prevent early-stage thyroid cancer.

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Use of antibiotics and colorectal cancer risk: a primary care nested case–control study in Belgium

BMJ Open ◽

10.1136/bmjopen-2021-053511 ◽

2021 ◽

Vol 11 (12) ◽

pp. e053511

Author(s):

Johannes Van der Meer ◽

Pavlos Mamouris ◽

Vahid Nassiri ◽

Bert Vaes ◽

Marjan van den Akker

Keyword(s):

Colorectal Cancer ◽

General Practice ◽

Cancer Risk ◽

Case Control Study ◽

Conditional Logistic Regression ◽

Case Control ◽

Colorectal Cancer Risk ◽

Oral Antibiotics ◽

Increased Risk ◽

Control Study

ObjectivesTo examine the association between the use of oral antibiotics and subsequent colorectal cancer risk.DesignMatched case–control study.SettingGeneral practice centres participating in the Integrated Computerised Network database in Flanders, Belgium.ParticipantsIn total, 1705 cases of colorectal cancer diagnosed between 01 January 2010 and 31 December 2015 were matched to 6749 controls by age, sex, comorbidity and general practice centre.Primary outcome measureThe association between the number of prescriptions for oral antibiotics and the incidence of colorectal cancer over a period of 1–10 years, estimated by a conditional logistic regression model.ResultsA significantly increased risk of colorectal cancer (OR 1.25, 95% CI 1.10 to 1.44) was found in subjects with one or more prescriptions compared with those with none after correction for diabetes mellitus. No dose-response relationship was found.ConclusionsThis study resulted in a modestly higher risk of having colorectal cancer diagnosed after antibiotic exposure. The main limitation was missing data on known risk factors, in particular smoking behaviour. This study did not allow us to examine the causality of the relationship, indicating the need of further investigation.

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Cruciferous vegetables and colorectal cancer risk: a hospital-based matched case–control study in Northeast China

European Journal of Clinical Nutrition ◽

10.1038/s41430-018-0341-5 ◽

2018 ◽

Vol 73 (3) ◽

pp. 450-457

Author(s):

Wanxia Fang ◽

Xiujuan Qu ◽

Jing Shi ◽

Heming Li ◽

Xiaoyu Guo ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Risk ◽

Northeast China ◽

Case Control Study ◽

Case Control ◽

Colorectal Cancer Risk ◽

Cruciferous Vegetables ◽

Matched Case ◽

Matched Case Control Study ◽

Control Study

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Association between phytosterol intake and colorectal cancer risk: a case–control study

British Journal Of Nutrition ◽

10.1017/s0007114517000617 ◽

2017 ◽

Vol 117 (6) ◽

pp. 839-850 ◽

Cited By ~ 17

Author(s):

Jing Huang ◽

Ming Xu ◽

Yu-Jing Fang ◽

Min-Shan Lu ◽

Zhi-Zhong Pan ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Risk ◽

Chinese Population ◽

Case Control Study ◽

Positive Association ◽

Case Control ◽

Colorectal Cancer Risk ◽

Inverse Association ◽

Increased Risk ◽

Control Study

AbstractA study in rodent models showed that phytosterols protected against colon carcinogenesis, probably by inhibiting dysregulated cell cycle progression and inducing cellular apoptosis. However, epidemiological studies on the relationship between phytosterols and colorectal cancer risk are quite limited. The aim of this study was to investigate dietary phytosterol intake in relation to colorectal cancer risk in the Chinese population. A case–control study was conducted from July 2010 to June 2016, recruiting 1802 eligible colorectal cancer cases plus 1813 age (5-year interval) and sex frequency-matched controls. Dietary information was collected by using a validated FFQ. The OR and 95 % CI of colorectal cancer risk were assessed by multivariable logistic regression models. A higher total intake of phytosterols was found to be associated with a 50 % reduction in colorectal cancer risk. After adjusting for various confounders, the OR of the highest quartile intake compared with the lowest quartile intake was 0·50 (95 % CI 0·41, 0·61, Ptrend<0·01) for total phytosterols. An inverse association was also found between the consumption of β-sitosterol, campesterol, campestanol and colorectal cancer risk. However, stigmasterol intake was related to an increased risk of colorectal cancer. No statistically significant association was found between β-sitostanol and colorectal cancer risk. Stratified analysis by sex showed that the positive association of stigmasterol intake with colorectal cancer risk was found only in women. These data indicated that the consumption of total phytosterols, β-sitosterol, campesterol and campestanol is inversely associated with colorectal cancer risk in a Chinese population.

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