scholarly journals Influence of the Type of Breastfeeding and Human Milk Polyamines on Infant Anthropometric Parameters

2022 ◽  
Vol 8 ◽  
Author(s):  
Nelly C. Muñoz-Esparza ◽  
Edgar M. Vásquez-Garibay ◽  
Elizabeth Guzmán-Mercado ◽  
Alfredo Larrosa-Haro ◽  
Oriol Comas-Basté ◽  
...  
Keyword(s):  
Body Composition ◽  
Human Milk ◽  
Infant Growth ◽  
Polyamine Metabolism ◽  
Inverse Association ◽  
Anthropometric Parameters ◽  
Anthropometric Indicators ◽  
Breastfed Infants ◽  
Cell Proliferation And Differentiation ◽  
Polyamine Content

Feeding choices in the early months of life are key determinants of growth during infancy. Polyamines participate in cell proliferation and differentiation, and it has also been suggested that polyamine metabolism plays a role in adipogenesis. As the main exogenous source of polyamines in the infant is human milk, the aim of this work was to study if the type of breastfeeding received and the polyamine intake from human milk has an influence on infant anthropometric parameters. A cohort of 78 full-term healthy newborns was followed up until 4 months of age; 55 were fully and 23 partially breastfed. Anthropometric measurements were taken at 2 and 4 months, when human milk samples were also collected for analysis of polyamine content by UHPLC-FL. Fully breastfed infants had a better anthropometric profile than those partially breastfed (p < 0.05). Furthermore, polyamine intake in partially breastfed infants was significantly lower compared to those fully breastfed. However, only two of the 15 anthropometric indicators evaluated (triceps skinfold and mean upper arm circumference) showed a significant inverse association with polyamine content in human milk and intake (p < 0.05). Infant growth and body composition differ according to the type of breastfeeding received. Based on the weak associations between polyamines and anthropometric indicators, it is not possible to conclude the influence of polyamines in infant growth and body composition.

Appetite-Regulating Hormones in Human Milk: A Plausible Biological Factor for Obesity Risk Reduction?

2020 ◽  
pp. 089033442095416
Author(s):  
D. Enette Larson-Meyer ◽  
Jessica Schueler ◽  
Erin Kyle ◽  
Kathleen J. Austin ◽  
Ann Marie Hart ◽  
...  
Keyword(s):  
Human Milk ◽  
Infant Growth ◽  
Maternal Serum ◽  
Biological Factor ◽  
Obesity Risk ◽  
Maternal Factors ◽  
Breastfed Infants ◽  
Z Scores ◽  
Glucagon Like Peptide 1 ◽  
Weight For Age

Background Human milk contains appetite-regulating hormones that may influence infant growth and obesity risk. Research aims We evaluated whether leptin, peptide tyrosine-tyrosine (PYY), glucagon-like peptide-1 (GLP-1), and ghrelin concentrations in human milk (1) changed during feeding (from foremilk to hindmilk) and during the first 6 months of infancy; (2) were explained by maternal factors; and (3) were associated with infant anthropometrics and growth. Methods Mother–infant dyads ( N = 22) participated. Samples of foremilk and hindmilk at 1 month postpartum were collected and analyzed for leptin, PYY, GLP-1, and ghrelin via radioimmunoassay and milkfat percentage estimated via creamatocrit. Samples were also collected in mothers ( n = 15) who breastfed through 6 months. Anthropometrics were obtained on all mother–infant dyads at 1 month and all infants at 6 months and 12 months. Results At 1 month, milk GLP-1 and milkfat concentration increased from foremilk to hindmilk ( p ≤ .05) while leptin and PYY concentrations remained stable during feeding. Milk hormone concentrations and milkfat tended to decline overtime, with lower leptin, PYY, and ghrelin at 6 months versus 1 month ( p < .05). At 1 month, milk leptin and milkfat content were associated with maternal markers of adiposity ( r = 0.49–0.78, p < .001); whereas, milk PYY was correlated with maternal serum PYY concentration ( r = 0.672, p = .001). Average 1-month milk concentrations of GLP-1 and leptin were negatively associated with weight-for-age z-scores at 6 months ( r = −0.46, p < .05) and 12 months ( r = −0.49, p < .05), respectively. Conclusion The content of certain appetite-regulating hormones in human milk may be influenced by maternal factors and play a role in infant growth; much needs to be learned about their role in the obesity protection of breastfed infants.

scholarly journals Reduction in Maternal Energy Intake during Lactation Decreased Maternal Body Weight and Concentrations of Leptin, Insulin and Adiponectin in Human Milk without Affecting Milk Production, Milk Macronutrient Composition or Infant Growth

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1892
Author(s):  
Gabriela E. Leghi ◽  
Merryn J. Netting ◽  
Ching T. Lai ◽  
Ardra Narayanan ◽  
Michael Dymock ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Human Milk ◽  
Milk Production ◽  
Fat Mass ◽  
Dietary Intervention ◽  
Infant Growth ◽  
Maternal Body ◽  
Sugar Intake ◽  
The Impact

Maternal diet has the potential to affect human milk (HM) composition, but very few studies have directly assessed the effect of maternal diets on HM composition. The primary aim of this study was to assess the effect of improving dietary quality in lactating women over 2 weeks on the concentrations of macronutrients and metabolic hormones in HM. The secondary aims were to assess the impact of the dietary intervention on 24 h milk production, maternal body composition and infant growth. Fifteen women completed a 1-week baseline period followed by a 2-week dietary intervention phase targeted towards reducing fat and sugar intake. Maternal anthropometric and body composition and infant growth measurements were performed weekly. Total 24 h milk production was measured before and after the dietary intervention, and HM samples were collected daily. Maternal intakes of energy (−33%), carbohydrate (−22%), sugar (−29%), fat (−54%) and saturated fat (−63%) were significantly reduced during the dietary intervention. HM insulin, leptin and adiponectin concentrations were 10–25% lower at the end of the dietary intervention, but HM concentrations of macronutrients were unaffected. Maternal body weight (−1.8%) and fat mass (−6.3%) were significantly reduced at the end of the dietary intervention, but there were no effects on 24 h milk production or infant growth. These results suggest that reducing maternal energy, carbohydrate, fat and sugar intake over a 2-week period is associated with significant reductions in HM insulin, leptin and adiponectin concentrations. These changes may be secondary to decreases in maternal weight and fat mass. The limited studies to date that have investigated the association between metabolic hormone concentrations in HM and infant growth raise the possibility that the changes in HM composition observed in the current study could impact infant growth and adiposity, but further studies are required to confirm this hypothesis.

scholarly journals Human Milk Composition Differs by Maternal BMI in the First 9 Months Postpartum

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1080-1080
Author(s):  
Clark Sims ◽  
Melissa Lipsmeyer ◽  
Donald Turner ◽  
Aline Andres
Keyword(s):  
Body Composition ◽  
Human Milk ◽  
Weight Status ◽  
Daily Intake ◽  
Milk Composition ◽  
Infant Growth ◽  
Effect Sizes ◽  
Time Points ◽  
Daily Intakes ◽  
Maternal Bmi

Abstract Objectives Recent studies indicate that human milk composition is modulated by maternal weight status; however, results are conflicting. The objective of this study was to examine the relationship between maternal body composition and human milk macronutrients and bioactive components, as well as the association between infant daily intakes and infant body composition. Methods Human milk samples (N = 990) were obtained from a longitudinal study (NCT#0,113,1117) in normal weight (NW: 18.5–24.9 kg/m,2 N = 88) and overweight/obese (OW: 25–35 kg/m,2 N = 86) women between 0.5 and 9 months postpartum. Macronutrient content was estimated using mid-infrared spectroscopy (MIRIS AB). Leptin, insulin, C-reactive protein (CRP), IL-6, IL-8 and TNF-α were measured using electrochemiluminescence immunoassays (Meso Scale Diagnostics). Infant body composition was obtained using quantitative magnetic resonance (Echo-MRI-AH). Linear mixed models adjusted for postpartum age and infant sex. Results Human milk was higher in fat and protein, and lower in carbohydrate content at only a few time points in OW compared to NW mothers. Human milk leptin and insulin concentrations were higher in OW mothers throughout lactation and CRP content differed at most time points compared to NW mothers. Similar results were observed when concentrations were normalized to infant daily intake and body weight. The effect sizes of infant daily intakes associated with infant growth parameters were small for macronutrients (0.005 to 0.05 Z-score units and 0.02 to 0.45 fat mass index (FMI)/fat free mass index (FFMI) units per unit of change in composition). Larger effect sizes were seen with human milk insulin and leptin, with infants of OW mothers exposed to 1.5 to 2.5 times higher concentrations compared to infants of NW mothers. Conclusions This study allows for a more comprehensive understanding of maternal BMI effects on human milk composition and its association with infant growth. Of note, the concentrations of leptin and insulin in human milk from OW mothers were higher than those in milk from NW mothers, resulting in higher daily intakes by their infants and modulation of FMI from 0.5 to 9 months postpartum. This study demonstrates the value of considering both human milk composition and infant daily intake when assessing infant growth. Funding Sources USDA/ARS Project # 6026–51,000-012–06S, NIH R01 DK107516.

Ramadan fasting affects body composition and anthropometric parameters in type 2 diabetic patients.

2020 ◽  
Author(s):  
Fatma Boukhayatia ◽  
Ibtissem Oueslati ◽  
Meriem Cheikh ◽  
Asma Kardi ◽  
Fatma Chaker ◽  
...  
Keyword(s):  
Body Composition ◽  
Diabetic Patients ◽  
Anthropometric Parameters ◽  
Type 2 Diabetic Patients ◽  
Ramadan Fasting ◽  
Type 2 Diabetic

scholarly journals Longitudinal Changes in the Concentration of Major Human Milk Proteins in the First Six Months of Lactation and Their Effects on Infant Growth

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1476
Author(s):  
Jian Zhang ◽  
Ai Zhao ◽  
Shiyun Lai ◽  
Qingbin Yuan ◽  
Xiaojiang Jia ◽  
...  
Keyword(s):  
Human Milk ◽  
Maternal Education ◽  
Mode Of Delivery ◽  
Milk Proteins ◽  
Protein Composition ◽  
Infant Growth ◽  
Term Infants ◽  
Longitudinal Changes ◽  
Milk Samples ◽  
The Impact

Our knowledge related to human milk proteins is still limited. The present study determined the changes in multiple human milk proteins during the first six months of lactation, investigated the influencing factors of milk proteins, and explored the impact of milk proteins on infant growth. A total of 105 lactating women and their full-term infants from China were prospectively surveyed in this research. Milk samples were collected at 1–5 days, 8–14 days, 1 month, and 6 months postpartum. Concentrations of total protein and α-lactalbumin were measured in all milk samples, and concentrations of lactoferrin, osteopontin, total casein, β-casein, αs−1 casein, and κ-casein were measured in milk from 51 individuals using ultra performance liquid chromatography coupled with mass spectrometry. The concentration of measured proteins in the milk decreased during the first six months of postpartum (p-trend < 0.001). Maternal age, mode of delivery, maternal education, and income impacted the longitudinal changes in milk proteins (p-interaction < 0.05). Concentrations of αs−1 casein in milk were inversely associated with the weight-for-age Z-scores of the infants (1 m: r −0.29, p 0.038; 6 m: r −0.33, p 0.020). In conclusion, the concentration of proteins in milk decreased over the first six months postpartum, potentially influenced by maternal demographic and delivery factors. Milk protein composition may influence infant weights.

Human milk oligosaccharides, infant growth, and adiposity over the first 4 months of lactation

2021 ◽  
Author(s):  
Aristea Binia ◽  
Luca Lavalle ◽  
Cheng Chen ◽  
Sean Austin ◽  
Massimo Agosti ◽  
...  
Keyword(s):  
Human Milk ◽  
Infant Growth ◽  
Human Milk Oligosaccharides ◽  
Milk Oligosaccharides

Polyamine Metabolism inAcanthamoeba: Polyamine Content and Synthesis of Ornithine, Putrescine, and Diaminopropane1

1987 ◽  
Vol 34 (3) ◽  
pp. 278-284 ◽  
Author(s):  
BYEONG G. KIM ◽  
ANDREZJ SOBOTA ◽  
ALAN J. BITONTI ◽  
PETER P. McCANN ◽  
THOMAS J. BYERS
Keyword(s):  
Polyamine Metabolism ◽  
Polyamine Content

Diversification of a fucosyllactose transporter within the genus Bifidobacterium

2021 ◽  
Author(s):  
Miriam N. Ojima ◽  
Yuya Asao ◽  
Aruto Nakajima ◽  
Toshihiko Katoh ◽  
Motomitsu Kitaoka ◽  
...  
Keyword(s):  
Human Milk ◽  
Binding Proteins ◽  
Heterologous Gene Expression ◽  
Metagenomic Data ◽  
Dependent Manner ◽  
Human Milk Oligosaccharides ◽  
Milk Oligosaccharides ◽  
Formula Milk ◽  
Breastfed Infants ◽  
Strain Dependent

Human milk oligosaccharides (HMOs), which are natural bifidogenic prebiotics, were recently commercialized to fortify formula milk. However, HMO-assimilation phenotypes of bifidobacteria vary by species and strain, which has not been fully linked to strain genotype. We have recently shown that specialized uptake systems, particularly for the internalization of major HMOs (fucosyllactose (FL)), are associated with the formation of a bifidobacteria-rich gut microbial community. Phylogenetic analysis has revealed that FL transporters have diversified into two clades harboring four clusters within the Bifidobacterium genus, but the underpinning functional diversity associated with this divergence remains underexplored. In this study, we examined the HMO-consumption phenotypes of two bifidobacterial species, Bifidobacterium catenulatum subspecies kashiwanohense and Bifidobacterium pseudocatenulatum , which both possess FL binding proteins that belong to phylogenetic clusters with unknown specificities. Growth assays, heterologous gene expression experiments, and HMO-consumption analysis showed that the FL transporter type from B. catenulatum subspecies kashiwanohense JCM 15439 T conferred a novel HMO-uptake pattern that includes the complex fucosylated HMOs (lacto- N- fucopentaose II and lacto- N- difucohexaose I/II). Further genomic landscape analyses of FL transporter-positive bifidobacterial strains revealed that H-antigen or Lewis antigen-specific fucosidase gene(s) and FL transporter specificities were largely aligned. These results suggest that bifidobacteria have acquired FL transporters along with the corresponding gene sets necessary to utilize the imported HMOs. Our results provide insight into the species- and strain-dependent adaptation strategies of bifidobacteria to HMO-rich environments. Importance The gut of breastfed infants is generally dominated by health-promoting bifidobacteria. Human milk oligosaccharides (HMOs) from breastmilk selectively promote the growth of specific taxa such as bifidobacteria, thus forming an HMO-mediated, host-microbe symbiosis. While the co-evolution of humans and bifidobacteria has been proposed, the underpinning adaptive strategies employed by bifidobacteria require further research. Here, we analyzed the divergence of the critical fucosyllactose (FL) HMO transporter within Bifidobacterium . We have shown that the diversification of the solute-binding proteins of the FL-transporter led to uptake specificities of fucosylated sugars ranging from simple trisaccharides to complex hexasaccharides. This transporter and the congruent acquisition of the necessary intracellular enzymes allows for bifidobacteria to import different types of HMOs in a predictable and strain-dependent manner. These findings explain the adaptation and proliferation of bifidobacteria in the competitive and HMO-rich infant gut environment and enable accurate specificity annotation of transporters from metagenomic data.

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