scholarly journals Assessment and management of undifferentiated carcinoma with osteoclastic like giant cells of the pancreas: a case report and revision of literature

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Elisabetta Cavalcanti ◽  
Nicolo’ Schena ◽  
Grazia Serino ◽  
Giulio Lantone ◽  
Raffaele Armentano
Keyword(s):  
Weight Loss ◽  
Abdominal Pain ◽  
Pancreatic Carcinoma ◽  
Gold Standard ◽  
Genetic Basis ◽  
Performance Status ◽  
Giant Cells ◽  
Undifferentiated Carcinoma ◽  
Case Presentation ◽  
Disease Free

Abstract Background Undifferentiated carcinoma with osteoclast-like giant cells (UCOGCs) is a rare and aggressive non endocrine pancreatic carcinoma characterized by the presence of osteoclastic giant cells mixed with mononuclear cell. Very few cases have been reported in the literature and the histogenesis is controversial as, at the time of diagnosis, the tumor is often of advanced size and stage and it is difficult to pathologically observe its relationship with the pancreatic duct. Case presentation We present a case of 65-year-old male patient presenting with abdominal pain, nausea, and weight loss, which was treated with surgical resection. Histological examination revealed an undifferentiated pancreatic carcinoma with osteoclast-like giant cells. The patient underwent to a routine pylorus preserving pancreatoduodenectomy. Actually, the patient was in good performance status and disease-free five months. Conclusions Based on the present case and limited previous data, further researches preferably with large cohorts are necessary to clarify the pathogenesis of the neoplasm. However, as show in this case, histopathological and immunohistochemically studies are the gold standard for the diagnosis of UCPOGC. Investigation of the genomic alterations in UPOGCs could help to explain the histologic diversity of variant tumor and could provide a genetic basis for prognosis and treatment.

Surgical adjuvant therapy for stage II and stage III adenocarcinoma and large-cell undifferentiated carcinoma.

1986 ◽  
Vol 4 (5) ◽  
pp. 710-715 ◽  
Author(s):  
E C Holmes ◽  
M Gail
Keyword(s):  
Weight Loss ◽  
Disease Free Survival ◽  
Large Cell ◽  
Undifferentiated Carcinoma ◽  
Stage Ii ◽  
Free Survival ◽  
Lung Cancer Study Group ◽  
Resected Stage ◽  
To Receive ◽  
Disease Free

The Lung Cancer Study Group randomized 141 patients with resected stage II and III adenocarcinoma and large-cell undifferentiated carcinoma to receive postoperative Cytoxan (Bristol-Meyers, Syracuse, NY), Adriamycin (Adria Laboratories, Columbus, Ohio), and cisplatin (CAP) chemotherapy or bacillus Calmette-Guerin (BCG) and levamisole immunotherapy. Careful intraoperative staging was performed on all patients. Before randomization, patients were stratified by stage, weight loss, cardiac arrhythmia, and institution. Prognostic variables such as stage, age, weight loss, and nodal involvement were equally distributed between the two groups. Disease-free survival was significantly prolonged in the group receiving chemotherapy. There was no evidence of a deleterious effect of the immunotherapy. This study indicates that postoperative CAP chemotherapy is effective in prolonging disease-free survival in these patients.

scholarly journals Undifferentiated Pancreatic Carcinoma With Osteoclast-Like Giant Cells: What Do We Know So Far?

2021 ◽  
Vol 11 ◽  
Author(s):  
Pieter Demetter ◽  
Raphaël Maréchal ◽  
Francesco Puleo ◽  
Myriam Delhaye ◽  
Sébastien Debroux ◽  
...  
Keyword(s):  
Pancreatic Carcinoma ◽  
Who Classification ◽  
Current Knowledge ◽  
Giant Cells ◽  
Undifferentiated Carcinoma ◽  
Rare Tumor ◽  
Carcinoma Of The Pancreas ◽  
Ductal Pancreatic Adenocarcinoma ◽  
Histological Appearance ◽  
Worse Prognosis

Undifferentiated carcinoma of the pancreas is an aggressive but rare tumor for which several other terms have been used to describe its histological appearance. In addition, as osteoclast-like giant cells may accompany undifferentiated carcinoma of the pancreas, the WHO Classification distinguishes undifferentiated carcinoma with osteoclast-like giant cells (UC-OGC) from plain undifferentiated carcinoma since there are a few histopathological and clinical differences. UC-OGC was initially thought to be associated with worse prognosis compared to invasive ductal pancreatic adenocarcinoma, since it is often unresectable at diagnosis and tends to recur rapidly even if completely resected. When true UC-OGGs are carefully dissected out from other anaplastic carcinomas, it becomes, however, clear that UC-OGCs do have more indolent behavior, especially the pure UC-OGCs. This mini-review summarizes the current knowledge on UC-OGC.

Unusual presentation of metastatic pancreatic carcinoma

2021 ◽  
pp. 1-6
Author(s):  
Muhammad Khurram Salahuddin ◽  
Zeeshan Waheed ◽  
Asif Jan Muhammad
Keyword(s):  
Weight Loss ◽  
Abdominal Pain ◽  
Case Report ◽  
Pancreatic Carcinoma ◽  
Respiratory Symptoms ◽  
Oral Intake ◽  
Unusual Presentation ◽  
The World ◽  
Abdominal Sign

Abstract Pancreatic carcinoma is one of the most common and deadly cancer in the world. It typically presents with abdominal pain, vomiting and weight loss. In this case report we reported a case who presented with respiratory symptoms of cough, fever and decrease oral intake without any typical abdominal sign and symptoms. Later on her workup revealed that she had advanced/metastatic pancreatic carcinoma. Keywords: Pancreatic Carcinoma, Continuous....

scholarly journals Undifferentiated carcinoma of The mesentery in a 51 year old male : A case report

2019 ◽  
Vol 20 (1) ◽  
pp. 29-31
Author(s):  
Din Mohammad ◽  
Sharmin Islam
Keyword(s):  
Weight Loss ◽  
Abdominal Pain ◽  
Case Report ◽  
Malignant Mesothelioma ◽  
Undifferentiated Carcinoma ◽  
Heterogeneous Group ◽  
Rare Entity ◽  
Retroperitoneal Mass ◽  
Mesenteric Tumors

Mesenteric tumors are rare and consist of a heterogeneous group of lesions. Among them undifferentiatedcarcinoma of the mesentery is very rare entity. Here we present a case of undifferentiatedcarcinoma of the mesentery in a 51 year old male presented with rapidly increasing hugeabdominal lump,central abdominal pain and weight loss. Ultrasound of the whole abdomen andCT scan of whole abdomen reports were suggestive of retroperitoneal mass. The tumor wasresected and histopathology report was suggestive of malignant mesothelioma whereas immunohistochemistryreport revealed undifferentiated carcinoma of the mesentery. Journal of Surgical Sciences (2016) Vol. 20 (1) : 29-31

scholarly journals Case of Six-Year Disease-Free Survival with Undifferentiated Carcinoma of the Pancreas

2016 ◽  
Vol 10 (2) ◽  
pp. 472-478 ◽  
Author(s):  
Hiroyuki Saito ◽  
Hiroshi Kashiyama ◽  
Takashi Murohashi ◽  
Kazunari Sasaki ◽  
Ryosuke Misawa ◽  
...  
Keyword(s):  
Mixed Type ◽  
Disease Free Survival ◽  
Giant Cells ◽  
Undifferentiated Carcinoma ◽  
Maintenance Chemotherapy ◽  
Free Survival ◽  
Carcinoma Of The Pancreas ◽  
Dismal Prognosis ◽  
Diaphragmatic Invasion ◽  
Disease Free

Undifferentiated carcinoma of the pancreas (UDC) is rare and has a dismal prognosis. Here, we report a case of 6-year disease-free survival with a mixed type of UDC and UDC with osteoclast-like giant cells, with a high mitotic index as well as perineural, lymphatic, vessel, and diaphragmatic invasion. The patient underwent radical distal pancreatectomy and was subsequently treated with adjuvant chemotherapy using gemcitabine plus S-1 followed by maintenance chemotherapy with oral tegafur-uracil. The patient has been doing well with no evidence of recurrence for more than 6 years after surgery.

Long-Term Disease-Free Survivors in Metastatic Undifferentiated Carcinoma of Nasopharyngeal Type

2000 ◽  
Vol 18 (6) ◽  
pp. 1324-1330 ◽  
Author(s):  
Abderrahim Fandi ◽  
Mounir Bachouchi ◽  
Nacer Azli ◽  
Abdelkrim Taamma ◽  
Hammouda Boussen ◽  
...  
Keyword(s):  
Performance Status ◽  
Disease Free Survival ◽  
Patient Characteristics ◽  
Complete Response ◽  
Undifferentiated Carcinoma ◽  
World Health ◽  
Term Survival ◽  
Tumor Node Metastasis Stage ◽  
Disease Free

PURPOSE: To review incidence and analyze profile of long-term complete responders among patients with undifferentiated carcinoma of nasopharyngeal type (UCNT) treated at a single institution.PATIENTS AND METHODS: We present a cohort of 20 long-term unmaintained complete responders to chemotherapy for metastatic UCNT treated at the Institut Gustave Roussy between April 1978 and November 1996. A patient was considered a long-term survivor if he or she was disease-free for more than 36 months without treatment after obtaining a complete response by chemotherapy. Patient characteristics were as follows: sex, 17 men and three women; median age, 28 years (range, 9 to 62 years); median World Health Organization performance status, 1; and initial tumor-node-metastasis stage (International Union Against Cancer–American Joint Committee on Cancer, 1987) of T3 to T4, 60%, and of N2b to N3, 75%. Epstein-Barr virus serology was characteristic in 19 patients. Of 16 pretreated patients, 11 were pretreated by radiotherapy alone and five by chemotherapy and radiotherapy. Thirteen patients had metastatic relapses of locally controlled UCNT. Tumor sites were bone in 15 patients, lung in four, and liver (biopsy-proven) in two. Chemotherapy included the following: cisplatin, bleomycin, and fluorouracil in five patients; bleomycin, epirubicin, and cisplatin in seven patients; fluorouracil, mitomycin, epirubicin, and cisplatin in four patients; and fluorouracil, bleomycin, epirubicin, and cisplatin in one patient. Three patients were treated with platinum-based regimens before 1985. Patients received a median of six cycles (range, three to 13). Thirteen patients with bone metastases received consolidating radiotherapy.RESULTS: As of June 1999, 14 of 20 patients were still alive with no evidence of disease after treatment (disease-free survival time, 82+ to 190+ months), three patients died of other causes while in complete response at 61, 109, and 208 months after treatment, and three patients died of disease at 42, 89, and 115 months after treatment. Long-term complete responses were obtained in both bone and visceral disease.CONCLUSION: Our data support a curative role for chemotherapy in metastatic UCNT and are a major incentive to continue research for better combinations to increase the percentage of patients with metastatic UCNT who attain complete responses and long-term survival.

scholarly journals A case of sigmoid volvulus in an unexpected demographic

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Mohammad Saba ◽  
Joshua Rosenberg ◽  
Gregory Wu ◽  
Gudata Hinika
Keyword(s):  
Abdominal Pain ◽  
Severe Pain ◽  
Rare Case ◽  
Young Female ◽  
Sigmoid Volvulus ◽  
Case Presentation ◽  
Operative Complications ◽  
History Of ◽  
Male Sex ◽  
Emergent Laparotomy

Abstract Background A sigmoid volvulus occurs when a segment of the colon twists upon its mesentery. This infliction is associated with old age, multiple co-morbidities, and the male sex. We present a rare case of sigmoid volvulus that occurred in a healthy young female. Case presentation A 28-year-old female presented with a one week history of constipation and abdominal pain. Her symptoms suddenly worsened and became associated with vomiting and severe pain. A focused history taking and physical examination showed peritoneal signs that led to timely diagnostic imaging to be implemented. Computed tomography (CT) of the abdomen was consistent with sigmoid volvulus. Our patient underwent emergent laparotomy with a sigmoidectomy and recovered with no post-operative complications. Conclusion This case report emphasizes the importance of clinicians maintaining a sigmoid volvulus as a rare, yet important differential when approaching abdominal pain in young healthy patients.

Efficacy and safety of denosumab treatment in a prepubertal patient with cherubism

2020 ◽  
Vol 33 (7) ◽  
pp. 963-966
Author(s):  
Haruka Kawamura ◽  
Satoshi Watanabe ◽  
Takashi I ◽  
Izumi Asahina ◽  
Hiroyuki Moriuchi ◽  
...  
Keyword(s):  
Autosomal Dominant ◽  
Therapeutic Potential ◽  
Giant Cells ◽  
Efficacy And Safety ◽  
Autosomal Dominant Disorder ◽  
Osteolytic Lesions ◽  
Case Presentation ◽  
Childhood Growth ◽  
Receptor Activator ◽  
Denosumab Treatment

AbstractBackgroundDenosumab is an inhibitor of receptor activator of nuclear factor kappa-B ligand, which strongly suppresses osteoclasts. Cherubism is a rare autosomal dominant disorder characterized by symmetrical swelling of the jaws, in which the bone is replaced by a fibrous granuloma containing osteoclast-like giant cells.Case presentationWe report the efficacy and safety of denosumab treatment in a prepubertal boy with progressive cherubism. The treatment consisting of eight subcutaneous denosumab injections (120 mg/dose) in 6 months not only suppressed the expansion of the osteolytic lesions but also dramatically ossified them. However, a transiently decreased growth rate and rebounded asymptomatic hypercalcemia were associated with the treatment.ConclusionsThe present case demonstrated the therapeutic potential of denosumab for treatment of cherubism, although adverse effects, especially those on childhood growth, remain obscure. Further studies are needed to establish a safe and effective protocol for denosumab treatment of children.

scholarly journals Seronegative Arthritis as a Complication of Whipple’s Disease

2021 ◽  
Vol 14 ◽  
pp. 117954762110177
Author(s):  
Rebecca DeBoer ◽  
Sahani Jayatilaka ◽  
Anthony Donato
Keyword(s):  
Rheumatoid Arthritis ◽  
Weight Loss ◽  
Abdominal Pain ◽  
Gastrointestinal Symptoms ◽  
Whipple’S Disease ◽  
Seronegative Arthritis ◽  
Whipple's Disease ◽  
Caucasian Male

Whipple’s disease (WD) is an uncommon cause of seronegative arthritis. WD is known for its gastrointestinal symptoms of diarrhea, weight loss, and abdominal pain. However, arthritis may precede gastrointestinal symptoms by 6 to 7 years. We describe a case of an 85-year-old Caucasian male with multiple joint complaints, not responsive to traditional treatments for conditions such as rheumatoid arthritis and osteoarthritis. We suggest that WD be considered for seronegative arthritis especially affecting large joints.

Sign in / Sign up

Export Citation Format

Share Document