scholarly journals Current Surgical Therapy of Locally Advanced cSCC: From Patient Selection to Microsurgical Tissue Transplant. Review

2021 ◽  
Vol 11 ◽  
Author(s):  
Tito Brambullo ◽  
Gian Paolo Azzena ◽  
Paolo Toninello ◽  
Giuseppe Masciopinto ◽  
Alberto De Lazzari ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Multidisciplinary Approach ◽  
Locally Advanced ◽  
Pedicled Flap ◽  
Node Dissection ◽  
Regional Lymph Nodes ◽  
Skin Cancers ◽  
Ablative Procedures ◽  
Tissue Transplant ◽  
Melanoma Skin

Among the non-melanoma skin cancers (NMSC) the squamous cell carcinoma (SCC) is one of the most challenging for the surgeon. Local aggressiveness and a tendency to metastasize to regional lymph nodes characterize the biologic behavior. The variants locally advanced and metastatic require wide excision and node dissection. Such procedures can be extremely detrimental for patients. The limit of the surgery can be safely pushed forward with a multidisciplinary approach. The concept of skin oncoplastic surgery, the ablative procedures and the reconstructive options (skin graft, pedicled flap, microsurgical free flap) are discussed together with a literature review.

scholarly journals Attitudes among dermatologists regarding non-melanoma skin cancer treatment options

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Luca Fania ◽  
Tonia Samela ◽  
Gaia Moretta ◽  
Francesco Ricci ◽  
Elena Dellambra ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Treatment Options ◽  
Locally Advanced ◽  
Central Italy ◽  
Therapeutic Approaches ◽  
Antibody Treatment ◽  
Skin Cancers ◽  
Melanoma Skin

AbstractNon-melanoma skin cancers include basal and squamous cell carcinoma. These tumors have become an important health issue for their high incidence and for the morbidity, especially if untreated for a long period. Over the last 20 years, therapeutic approaches for these tumours have been improved and tailored. In this survey we provided data from one hundred and ten Italian dermatologists regarding knowledge and attitude towards different therapeutic approaches on non-melanoma skin cancers. In our study, we observed that surgery and imiquimod 5% cream were the most used treatment by dermatologists for basal cell carcinoma, while, surgery was the most common treatment for cutaneous squamous cell carcinoma. Furthermore, we observed some differences regarding the prescribed therapies in the different Italian geographical areas (i.e., Mohs’ surgery and electrochemotherapy were more frequently used in Northern compared to Central and Southern Italy whereas immunotherapy was more used in Southern compared to Northern and Central Italy) and even considering the year of specialization of the dermatologists (i.e., immunotherapy with cemiplimab was prescribed mainly by dermatologists with 10–19 years of specialization). However, for locally advanced and metastatic forms of basal and squamous cell carcinoma, Hedgehog Pathway Inhibitors and anti- Programmed cell death protein antibody treatment, respectively, were used in line with the newest evolution of therapies regarding this topic. Considering the importance of skin cancers and its progressive increase in incidence, it is crucial to improve the knowledge of different therapeutic approaches among dermatologists.

scholarly journals A Case of Squamous Cell Carcinoma of Skin Subsequent to Subcutaneous Foreign Body

2016 ◽  
Vol 12 (1) ◽  
pp. 53-55
Author(s):  
P Anwar ◽  
S Mubashir ◽  
I Hassa ◽  
T Arif
Keyword(s):  
Squamous Cell Carcinoma ◽  
Foreign Body ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Foreign Bodies ◽  
Transposition Flap ◽  
Skin Cancers ◽  
Flap Closure ◽  
Melanoma Skin

Squamous cell carcinoma (SCC) of the skin is one of the most common non melanoma skin cancers (NMSC), along with basal cell carcinoma (BCC). Besides ultraviolet radiation, the role of exposure to industrial agents, ionizing radiation and areas of chronic inflammation is associated with the development of SCC. SCC may also be associated with foreign bodies. We report a rare case of cutaneous SCC in an elderly Kashmiri female, developing subsequent to subcutaneous non metallic foreign body, which was successfully excised with negative margins, and transposition flap closure. DOI: http://dx.doi.org/10.3126/njdvl.v12i1.10604 Nepal Journal of Dermatology, Venereology & Leprology Vol.12(1) 2014 pp.53-55

Mohs Surgery versus Standard Local Excision for Basal Cell Carcinoma, Squamous Cell Carcinoma, and Melanoma Skin Cancer

2020 ◽  
Vol 36 (02) ◽  
pp. 133-140
Author(s):  
Timothy M. Johnson ◽  
Noah R. Smith
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Local Excision ◽  
Mohs Surgery ◽  
Skin Cancers ◽  
The Face ◽  
Carcinoma Squamous Cell ◽  
Melanoma Skin

AbstractBasal cell carcinoma, squamous cell carcinoma, and melanoma represent the three most common skin cancers that occur on the face. The most common surgical treatments for facial skin cancers are Mohs surgery and standard local excision. The effective utilization of either of these techniques is based on tumor and patient risk stratification incorporating known risk factors for occult invasion and local recurrence, combined with patient comorbidities, expectations, and desires. Best available evidence highlights multiple and consistent risk factors for each specific skin cancer type, and dictate local control rates reported in the literature. Recognizing gaps in the literature, we compare and review surgical treatment guidelines and data for standard local excision versus Mohs surgery for cutaneous nonmelanoma and melanoma skin cancer. This article serves as a resource for optimal therapeutic decision making for surgical management of skin cancer on the face.

Non-melanoma skin cancer and premalignant conditions

2021 ◽  
pp. 69-78
Author(s):  
Barbara Jemec ◽  
Gregor B.E. Jemec
Keyword(s):  
Squamous Cell Carcinoma ◽  
Surgical Treatment ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Merkel Cell ◽  
Non Melanoma Skin Cancer ◽  
Skin Cancers ◽  
Carcinoma Squamous Cell ◽  
Non Surgical Treatment ◽  
Melanoma Skin

This chapter describes the diagnosis, non-surgical treatment, and surgical treatment of non-melanoma skin cancers, such as basal cell carcinoma, squamous cell carcinoma, Merkel cell carcinoma, and others.

scholarly journals Tactics of chemoradiotherapy in patients with locally advanced squamous cell carcinoma of the pharynx with index of metastatic regional lymph nodes stage N3

2021 ◽  
Vol 11 (2) ◽  
pp. 25-30
Author(s):  
S. B. Alieva ◽  
I. A. Zaderenko ◽  
T. N. Borisova ◽  
R. R. Kaledin ◽  
A. O. Sekretnaya ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Concurrent Chemoradiotherapy ◽  
Locally Advanced ◽  
Treatment Method ◽  
Advanced Squamous Cell Carcinoma ◽  
Regional Lymph Nodes ◽  
Free Survival

During 1996–2015 years, 53 patients with stage locally-advanced squamous cell carcinoma of the pharynx with stage N3 were treated in N. N. Blokhin National Research Center of Oncology. Depending on the treatment method, patients were divided into 2 groups: concurrent (n = 26) and induction (n = 27) chemoradiotherapy. Concurrent chemoradiotherapy (option 1) was given using: cisplatin 100 mg/m2 – every 3 weeks, or carboplatin 1.5 AUC weekly, or cisplatin 100 mg/m2 with 5-fluorouracil 1000 mg/m2 every 24 hours, in continuous infusion for 96 hours (PF). Induction chemotherapy (option 2) was performed in 2 modes: TPF (docetaxel, cisplatin, 5-fluorouracil) or PF (cisplatin, 5-fluorouracil). Radiation therapy was performed on a linear accelerator for 2 Gy daily up to SD 68–70 Gy for the primary tumor and 66 Gy for the affected lymph nodes. According to the results of our retrospective study, the 3 year overall and relapse-free survival rate depending on the chemoradiotherapy option was 37 and 32 % (option 1), 62 and 56 % (option 2). A promising option for chemoradiotherapy of locally advanced squamous cell carcinoma of the pharynx is induction chemoradiotherapy.

scholarly journals Neoadjuvant Therapy for Non-melanoma Skin Cancer: Updated Therapeutic Approaches for Basal, Squamous, and Merkel Cell Carcinoma

2021 ◽  
Vol 22 (4) ◽  
Author(s):  
Enrico Zelin ◽  
Iris Zalaudek ◽  
Marina Agozzino ◽  
Caterina Dianzani ◽  
Arianna Dri ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Checkpoint Inhibitors ◽  
Locally Advanced ◽  
Merkel Cell ◽  
Non Melanoma Skin Cancer ◽  
Skin Cancers ◽  
Multiple Basal Cell Carcinomas ◽  
Melanoma Skin

Opinion statementRecently introduced systemic therapies for locally advanced and metastatic non-melanoma skin cancers (NMSCs) are paving the way for neoadjuvant approach. Although none of the therapeutic options has currently gained indication in this setting, neoadjuvant approach for NMSCs is an open field and we are likely to see huge developments in the near future. Targeted therapy with sonic hedgehog pathway inhibitors is very effective in locally advanced or multiple basal cell carcinomas while immunotherapy with immune checkpoint inhibitors appears to be promising for advanced cutaneous squamous cell carcinoma and Merkel cell carcinoma. To date, targeted therapy and immunotherapy represent the frontiers in NMSC therapeutic management and, according to recent studies, good results can be achieved.

scholarly journals Climate change and its relationship with non-melanoma skin cancers

2018 ◽  
Vol 17 (12) ◽  
pp. 1913-1917 ◽  
Author(s):  
Rubén D. Piacentini ◽  
Lara Sofía Della Ceca ◽  
Adriana Ipiña
Keyword(s):  
Climate Change ◽  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Ambient Temperature ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Skin Cancers ◽  
Melanoma Skin

The increase in ambient temperature due to climate change is expected to affect the carcinogenicity of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC).

scholarly journals PD-1 and beyond to Activate T Cells in Cutaneous Squamous Cell Cancers: The Case for 4-1BB and VISTA Antibodies in Combination Therapy

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3310
Author(s):  
Quentin Wright ◽  
Jazmina L. Gonzalez Cruz ◽  
James W. Wells ◽  
Graham R. Leggatt
Keyword(s):  
Squamous Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Treatment Modalities ◽  
Immune Memory ◽  
Skin Cancers ◽  
Promising Therapeutic Approach ◽  
Localized Disease ◽  
Skin Surgery ◽  
Melanoma Skin

Non-melanoma skin cancers (NMSC) have a higher incidence than all other cancers combined with cutaneous squamous cell carcinoma (cSCC), capable of metastasis, representing approximately 20% of NMSCs. Given the accessibility of the skin, surgery is frequently employed to treat localized disease, although certain localities, the delineation of clear margins, frequency and recurrence of tumors can make these cancers inoperable in a subset of patients. Other treatment modalities, including cryotherapy, are commonly used for individual lesions, with varying success. Immunotherapy, particularly with checkpoint antibodies, is increasingly a promising therapeutic approach in many cancers, offering the potential advantage of immune memory for protection against lesion recurrence. This review addresses a role for PD-1, 4-1BB and VISTA checkpoint antibodies as monotherapies, or in combination as a therapeutic treatment for both early and late-stage cSCC.

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