Ventricular Cerebrospinal Fluid Sampling in Pediatric Diffuse Midline Glioma Patients: Institutional Experience and Review of the Literature

Two cases of linear nevus sebaceous syndrome are described and a review of the eleven cases now reported in the literature is undertaken. The first patient has retardation, seizures, and classic ectodermal lesions while the second patient manifests typical cutaneous lesions and only an elevated cerebrospinal fluid protein as evidence of neurologic disease. The rationale for defining the syndrome as an entity distinct from other neurocutaneous syndromes is discussed and a pleomorphic presentation of the syndrome is suggested.

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Beta-hemolytic group a streptococcal orthopaedic infections: Our institutional experience and review of the literature

Journal of Orthopaedics ◽

10.1016/j.jor.2020.03.015 ◽

2020 ◽

Vol 21 ◽

pp. 150-154

Author(s):

Priya Nori ◽

Naiha Nadeem ◽

Nidhi Saraiya ◽

Wendy Szymczak ◽

Carmel Boland-Reardon ◽

...

Keyword(s):

Review Of The Literature ◽

Orthopaedic Infections ◽

Institutional Experience ◽

Group A

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A minimally-invasive serial cerebrospinal fluid sampling model in conscious Göttingen minipigs

Journal of Biological Methods ◽

10.14440/jbm.2019.265 ◽

2019 ◽

Vol 6 (1) ◽

pp. 107 ◽

Cited By ~ 1

Author(s):

Alessandra Bergadano ◽

Eva Maria Amen ◽

Björn Jacobsen ◽

Sara Belli ◽

Anthony Vandjour ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Minimally Invasive ◽

Fluid Sampling

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Emergence of Refractory Otomastoiditis Due to Nontuberculous Mycobacteria: Institutional Experience and Review of the Literature

Clinical Infectious Diseases ◽

10.1093/cid/civ1033 ◽

2015 ◽

Vol 62 (6) ◽

pp. 739-745 ◽

Cited By ~ 3

Author(s):

Chien-Fu Yeh ◽

Tzong-Yang Tu ◽

Mao-Che Wang ◽

Chia-Huei Chu ◽

Chii-Yuan Huang ◽

...

Keyword(s):

Nontuberculous Mycobacteria ◽

Review Of The Literature ◽

Institutional Experience

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Bacterial Meningitis in the Absence of Cerebrospinal Fluid Pleocytosis: A Case Report and Review of the Literature

Canadian Journal of Infectious Diseases and Medical Microbiology ◽

10.1155/2014/568169 ◽

2014 ◽

Vol 25 (5) ◽

pp. 249-251 ◽

Cited By ~ 24

Author(s):

Ryota Hase ◽

Naoto Hosokawa ◽

Makito Yaegashi ◽

Kiyoharu Muranaka

Keyword(s):

Cerebrospinal Fluid ◽

Bacterial Meningitis ◽

Lumbar Puncture ◽

Early Stage ◽

Review Of The Literature ◽

Csf Analysis ◽

Cell Counts ◽

Csf Pleocytosis ◽

Cerebrospinal Fluid Pleocytosis ◽

Rule Out

Elevation of cerebrospinal fluid (CSF) cell count is a key sign in the diagnosis of bacterial meningitis. However, there have been reports of bacterial meningitis with no abnormalities in initial CSF testing. This type of presentation is extremely rare in adult patients. Here, a case involving an 83-year-old woman who was later diagnosed with bacterial meningitis caused byNeisseria meningitidisis described, in whom CSF at initial and second lumbar puncture did not show elevation of cell counts. Twenty-six non-neutropenic adult cases of bacterial meningitis in the absence of CSF pleocytosis were reviewed. The frequent causative organisms wereStreptococcus pneumoniaeandN meningitidis. Nineteen cases had bacteremia and seven died. The authors conclude that normal CSF at lumbar puncture at an early stage cannot rule out bacterial meningitis. Therefore, repeat CSF analysis should be considered, and antimicrobial therapy must be started immediately if there are any signs of sepsis or meningitis.

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Cerebrospinal Fluid Access Devices in Pediatric Diffuse Midline Glioma Patients: Literature Review and Evaluation of Institutional Practices

Neurosurgery ◽

10.1093/neuros/nyz310_650 ◽

2019 ◽

Vol 66 (Supplement_1) ◽

Author(s):

Daphne Li ◽

Wendy Stellpflug ◽

Amanda Muhs Saratsis

Keyword(s):

Cerebrospinal Fluid ◽

Liquid Biopsy ◽

Tumor Biology ◽

Significant Proportion ◽

Circulating Tumor Dna ◽

Response To Treatment ◽

Institutional Practices ◽

Medline Search ◽

Tumor Dna ◽

Diffuse Midline Glioma

Abstract INTRODUCTION Diffuse midline gliomas (DMG) are the number one cause of cancer death in children. H3K27M mutations occur in 80% of DMG, with distinct tumor biology and poorer response to treatment. H3K27M is detectable in cerebrospinal fluid (CSF) circulating tumor DNA (ctDNA), depending on CSF tumor proximity, and correlates with tumor volume and treatment response. Ventricular access devices (VAD) for serial CSF sampling (liquid biopsy) could therefore play a significant role in DMG management. Here, we set to characterize VAD placement practices in pediatric DMG. METHODS A retrospective review of patients <21 yr treated for DMG at our institution was performed (1984-2019). A MEDLINE search was conducted to identify reports of VAD placement in DMG. Full-text English reports of patients = 21 yr with VAD outcomes were analyzed. RESULTS A total of 106 DMG patients at our institution were identified. In total 49% had brainstem disease (n = 52). A total of 46.23% (n = 49) had VADs: 32.65% transient (ETV n = 5, EVD n = 11), 67.35% permanent (reservoir n = 7, shunt n = 26). A total of 17 had ETV at biopsy, 7 with concurrent reservoir placement. Of 10 ETV patients without initial reservoir, 5 ultimately underwent permanent VAD placement (reservoir n = 1, shunt n = 4). A total of 9 patients received EVDs at tumor surgery, 8 required EVD for acute hydrocephalus (HCP), with 6 converted to shunts. A total of 15 shunts were placed at tumor diagnosis: 4 required revision (27%). A total of 14 articles describing 240 DMG patients cited HCP in 22%-100%, with VAD placement in 22%-63%, and shunt-induced extraneural metastases in 7. Ventricular chemotherapy via indwelling reservoirs (481 patients) was associated with 29 infectious and 50 noninfectious complications. Standardized reservoir access procedures decreased infection rates. CONCLUSION VAD placement is clinically indicated in a significant proportion of pediatric DMG patients, with low morbidity. Ventricular CSF is superior to lumbar for ctDNA sequencing and quantification. VAD placement should therefore be considered to facilitate liquid biopsy in DMG.

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Thyroid carcinoma presenting in childhood or after treatment of childhood malignancies: an institutional experience and review of the literature

Journal of Pediatric Surgery ◽

10.1016/s0022-3468(03)00563-3 ◽

2003 ◽

Vol 38 (11) ◽

pp. 1574-1580 ◽

Cited By ~ 51

Author(s):

Kenneth W Gow ◽

Shelly Lensing ◽

D.Ashley Hill ◽

Matthew J Krasin ◽

M.Beth McCarville ◽

...

Keyword(s):

Thyroid Carcinoma ◽

Review Of The Literature ◽

Childhood Malignancies ◽

Institutional Experience

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Cerebrospinal Fluid Shunts in Pregnancy Report of Two Cases and a Review of the Literature

Obstetric Anesthesia Digest ◽

10.1097/00132582-198810000-00048 ◽

1988 ◽

Vol 8 (3) ◽

pp. 146

Author(s):

P. Samuels ◽

D. A. Driscoll ◽

M. B. Landon ◽

J. Ludmir ◽

P J. McKrisky ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Cerebrospinal Fluid Shunts ◽

Review Of The Literature ◽

In Pregnancy

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Amplitude and phase of cerebrospinal fluid pulsations: experimental studies and review of the literature

Journal of Neurosurgery ◽

10.3171/jns.2006.104.5.810 ◽

2006 ◽

Vol 104 (5) ◽

pp. 810-819 ◽

Cited By ~ 102

Author(s):

Mark E. Wagshul ◽

John J. Chen ◽

Michael R. Egnor ◽

Erin J. McCormack ◽

Patricia E. Roche

Keyword(s):

Cerebrospinal Fluid ◽

Stroke Volume ◽

Experimental Studies ◽

Volume Ratio ◽

Communicating Hydrocephalus ◽

Phase Lag ◽

Review Of The Literature ◽

Csf Flow ◽

Prepontine Cistern ◽

The Brain

Object A recently developed model of communicating hydrocephalus suggests that ventricular dilation may be related to the redistribution of pulsations in the cranium from the subarachnoid spaces (SASs) into the ventricles. Based on this model, the authors have developed a method for analyzing flow pulsatility in the brain by using the ratio of aqueductal to cervical subarachnoid stroke volume and the phase of cerebrospinal fluid (CSF) flow, which is obtained at multiple locations throughout the cranium, relative to the phase of arterial flow. Methods Flow data were collected in a group of 15 healthy volunteers by using a series of images acquired with cardiac-gated, phase-contrast magnetic resonance imaging. The stroke volume ratio was 5.1 ± 1.8% (mean ± standard deviation). The phase lag in the aqueduct was −52.5 ± 16.5° and the phase lag in the prepontine cistern was −22.1 ± 8.2°. The flow phase at the level of C-2 was +5.1 ± 10.5°, which was consistent with flow synchronous with the arterial pulse. The subarachnoid phase lag ventral to the pons was shown to decrease progressively to zero at the craniocervical junction. Flow in the posterior cervical SAS preceded the anterior space flow. Conclusions Under normal conditions, pulsatile ventricular CSF flow is a small fraction of the net pulsatile CSF flow in the cranium. A thorough review of the literature supports the view that modified intracranial compliance can lead to redistribution of pulsations and increased intraventricular pulsations. The phase of CSF flow may also reflect the local and global compliance of the brain.

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