scholarly journals Gene and drug delivery system and potential treatment into inner ear for protection and regeneration

2014 ◽  
Vol 5 ◽  
Author(s):  
Sho Kanzaki
Keyword(s):  
Drug Delivery ◽  
Inner Ear ◽  
Drug Delivery System ◽  
Delivery System ◽  
Potential Treatment

scholarly journals Promising Applications of Nanoparticles in the Treatment of Hearing Loss

2021 ◽  
Vol 9 ◽  
Author(s):  
Zilin Huang ◽  
Qiang Xie ◽  
Shuang Li ◽  
Yuhao Zhou ◽  
Zuhong He ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hearing Loss ◽  
Inner Ear ◽  
Drug Delivery System ◽  
Clinical Application ◽  
Delivery System ◽  
Diagnosis And Treatment ◽  
Biological Research ◽  
Medical Applications ◽  
Traditional Treatment

Hearing loss is one of the most common disabilities affecting both children and adults worldwide. However, traditional treatment of hearing loss has some limitations, particularly in terms of drug delivery system as well as diagnosis of ear imaging. The blood–labyrinth barrier (BLB), the barrier between the vasculature and fluids of the inner ear, restricts entry of most blood-borne compounds into inner ear tissues. Nanoparticles (NPs) have been demonstrated to have high biocompatibility, good degradation, and simple synthesis in the process of diagnosis and treatment, which are promising for medical applications in hearing loss. Although previous studies have shown that NPs have promising applications in the field of inner ear diseases, there is still a gap between biological research and clinical application. In this paper, we aim to summarize developments and challenges of NPs in diagnostics and treatment of hearing loss in recent years. This review may be useful to raise otology researchers’ awareness of effect of NPs on hearing diagnosis and treatment.

scholarly journals A Totally Implantable Drug Delivery System for Local Therapy of the Middle and Inner Ear

1997 ◽  
Vol 76 (8) ◽  
pp. 567-570 ◽  
Author(s):  
Rolf Lehner ◽  
Heribert Brugger ◽  
Marcus M. Maassen ◽  
Hans-Peter Zenner
Keyword(s):  
Drug Delivery ◽  
Inner Ear ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Application ◽  
Local Therapy ◽  
Trophic Factors ◽  
Mastoid Cavity ◽  
Round Window Membrane ◽  
Wide Range

Local therapy of middle and inner ear diseases is being used, but is restricted to cases of ear drum perforation or to repeated invasive intratympanic drug application by the physician. In accordance with the Medical Device Directive (class III), a bone-anchored, totally implantable drug delivery system (TI-DDS) has been developed. It includes a micropump for subcutaneous, patient-controlled activation, a drug reservoir and a septum port. A thin guide-wired catheter leads from the pump outlet to the point of application in the mastoid or middle ear cavities. Local inner ear therapy with suitable drugs is possible by positioning the catheter's end near the round window membrane. The system requires no battery and will offer a wide range of patient-controlled bolus applications (25 μl per activation). We first analyzed the three-dimensional implantation geometry of the mastoid cavity. Basic micromechanical problems have been solved in order to create several prototypes. The TI-DDS has already undergone extensive in vitro testing. Recent results of pump rate precision and digital pressure force testing are promising. Local drug treatment for conditions such as lidocaine-sensitive tinnitus, secretory otitis media, Meniere's disease, localized pain and intralesional cancer is under discussion. Furthermore, local application of future biotechnological trophic factors for inner ear treatment is anticipated. The basic engineering is completed and initial animal tests are in preparation.

A Novel Controlled Local Drug Delivery System for Inner Ear Disease

2008 ◽  
Vol 118 (4) ◽  
pp. 706-711 ◽  
Author(s):  
David P. Paulson ◽  
Waleed Abuzeid ◽  
Hao Jiang ◽  
Tomoyuki Oe ◽  
Bert W. O'Malley ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Inner Ear ◽  
Drug Delivery System ◽  
Delivery System ◽  
Local Drug Delivery ◽  
Inner Ear Disease ◽  
Local Drug Delivery System

Development of a drug delivery system for the inner ear using poly(amino acid)-based nanoparticles

Drug Delivery ◽  
2014 ◽  
Vol 22 (3) ◽  
pp. 367-374 ◽  
Author(s):  
Dong-Kee Kim ◽  
Shi-Nae Park ◽  
Kyoung-Ho Park ◽  
Chan Woo Park ◽  
Keum-Jin Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Amino Acid ◽  
Inner Ear ◽  
Drug Delivery System ◽  
Delivery System

A Novel Drug Delivery System: A Biodegradable Gel for the Treatment of Inner Ear Diseases

2004 ◽  
Vol 131 (2) ◽  
pp. P260-P260 ◽  
Author(s):  
Tsuyoshi Endo ◽  
Takayuki Nakagawa ◽  
Tomoko Kita ◽  
Tae Soo Kim ◽  
Fukuichiro Iguchi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Inner Ear ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ear Diseases ◽  
System A ◽  
Novel Drug Delivery System ◽  
Novel Drug

Implantable Drug Reservoir Devices for Inner Ear Delivery of Pharmacotherapeutics

2020 ◽  
Vol 163 (4) ◽  
pp. 791-798
Author(s):  
Ashley Kita ◽  
Johnny Saldate ◽  
Courtney Chang ◽  
Nitika Chellappa ◽  
Jeremy Jong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Inner Ear ◽  
Polylactic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Protective Efficacy ◽  
Topical Therapy ◽  
Human Neuroblastoma ◽  
Drug Reservoir

Objective Cisplatin is a platinum-based chemotherapeutic drug that secondarily induces toxicity in inner ear sensory epithelia, contributing to auditory and vestibular dysfunction. We describe the creation of a drug reservoir device (DRD) to combat this ototoxicity for the duration of chemotherapy. As ototoxic side effects of chemotherapy may limit an oncologist’s ability to prescribe first-line agents such as cisplatin, mitigating such devastating effects through prolonged topical therapy would be tremendously valuable. Study Design We investigated (1) the ability of an electrospun polylactic acid DRD to provide prolonged delivery of the posited otoprotectant metformin and (2) the development of an in vitro model utilizing Sh-Sy5y human neuroblastoma cells to assess the efficacy of metformin in reducing cisplatin-induced toxicity. Setting Neurophysiology laboratory. Methods Basic science experiments were performed to assess DRD properties and metformin’s effects on cisplatin toxicity in culture. Results We found that DRDs with increasing polylactic acid concentrations exhibited metformin release for up to 8 weeks. In modeling elution across the round window in vitro, continued elution of metformin was observed for at least 6 weeks, as quantified by spectrophotometry. Unfortunately, metformin did not exhibit protective efficacy in this model using Sh-Sy5y cells. Conclusion While metformin was not found to be protective in Sh-Sy5y cells, these results suggest that an electrospun DRD can provide a tailorable drug delivery system providing medication for the duration of chemotherapy treatment. This represents a novel drug delivery system and efficacy screening assay with broad clinical applications in personalized delivery of inner ear therapies.

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