scholarly journals Therapeutic Potential of Hydroxysafflor Yellow A on Cardio-Cerebrovascular Diseases

2020 ◽  
Vol 11 ◽  
Author(s):  
Xue Bai ◽  
Wen-Xiao Wang ◽  
Rui-Jia Fu ◽  
Shi-Jun Yue ◽  
Huan Gao ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Cerebrovascular Diseases ◽  
Hydroxysafflor Yellow A

Phytochemistry and Pharmacology of Carthamus tinctorius L.

2016 ◽  
Vol 44 (02) ◽  
pp. 197-226 ◽  
Author(s):  
Le-Le Zhang ◽  
Ke Tian ◽  
Zheng-Hai Tang ◽  
Xiao-Jia Chen ◽  
Zhao-Xiang Bian ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Therapeutic Potential ◽  
Blood Stasis ◽  
Carthamus Tinctorius ◽  
Cerebrovascular Diseases ◽  
Future Research ◽  
Asian Countries ◽  
Hydroxysafflor Yellow A ◽  
Traditional Herbal Medicine ◽  
Pharmacological Activities

Carthamus tinctorius L. is a multifunctional cash crop. Its flowers and seeds are extensively used in traditional herbal medicine in China, Korea, Japan, and other Asian countries, for treating various ailments such as gynecological, cardiovascular, and cerebrovascular diseases as well as blood stasis and osteoporosis. More than 100 compounds have been isolated and identified from C. tinctorius. Flavonoids and alkaloids, especially the quinochalcone c-glycoside hydroxysafflor yellow A, N-(p-Coumaroyl)serotonin, and N-feruloylserotonin, are responsible for most of the pharmacological activities of C. tinctorius. In this paper, comprehensive and up-to-date information on the phytochemistry and pharmacology of C. tinctorius is presented. This information will be helpful for further explorations of the therapeutic potential of C. tinctorius and may provide future research opportunities.

scholarly journals Circulating MicroRNAs: Potential and Emerging Biomarkers for Diagnosis of Cardiovascular and Cerebrovascular Diseases

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Meng Li ◽  
Junping Zhang
Keyword(s):  
Therapeutic Potential ◽  
Cerebrovascular Diseases ◽  
Mirna Regulation ◽  
Circulating Mirnas ◽  
Circulating Micrornas ◽  
Bodily Fluids ◽  
Regulatory Processes ◽  
Clinical Biomarkers ◽  
Extracellular Mirnas ◽  
Artery Disease

MicroRNAs (miRNAs) are composed of a group of endogenous and noncoding small RNAs which control expression of complementary target mRNAs. The extended functions of miRNAs enhance the complexity of gene-regulatory processes in cardiovascular and cerebrovascular diseases. Indeed, recent studies have shown that miRNAs are closely related to myocardial infarction, heart failure, atrial fibrillation, cardiomyopathy, hypertension, angiogenesis, coronary artery disease, dyslipidaemia, stroke, and so forth. These findings suggest a new therapeutic pointcut for cardiovascular and cerebrovascular diseases and show the extensive therapeutic potential of miRNA regulation. Moreover, it has been shown that circulating extracellular miRNAs are stable in bodily fluids, which indicates circulating miRNAs as potential and emerging biomarkers for noninvasive diagnosis. This review highlights the most recent findings indicative of circulating miRNAs as potential clinical biomarkers for diagnosis of cardiovascular and cerebrovascular diseases.

scholarly journals Therapeutic Potential of Remote Ischemic Conditioning in Vascular Cognitive Impairment

2021 ◽  
Vol 15 ◽  
Author(s):  
Rui Xu ◽  
Qianyan He ◽  
Yan Wang ◽  
Yi Yang ◽  
Zhen-Ni Guo
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Processing ◽  
Therapeutic Potential ◽  
Recurrent Stroke ◽  
Neurovascular Unit ◽  
Vascular Cognitive Impairment ◽  
Cerebrovascular Diseases ◽  
Remote Ischemic Conditioning ◽  
Ischemic Conditioning ◽  
Social Burden

Vascular cognitive impairment (VCI) is a heterogeneous disease caused by a variety of cerebrovascular diseases. Patients with VCI often present with slower cognitive processing speed and poor executive function, which affects their independence in daily life, thus increasing social burden. Remote ischemic conditioning (RIC) is a non-invasive and efficient intervention that triggers endogenous protective mechanisms to generate neuroprotection. Over the past decades, evidence from basic and clinical research has shown that RIC is promising for the treatment of VCI. To further our understanding of RIC and improve the management of VCI, we summarize the evidence on the therapeutic potential of RIC in relation to the risk factors and pathobiologies of VCI, including reducing the risk of recurrent stroke, decreasing high blood pressure, improving cerebral blood flow, restoring white matter integrity, protecting the neurovascular unit, attenuating oxidative stress, and inhibiting the inflammatory response.

scholarly journals Biological Activities, Health Benefits, and Therapeutic Properties of Avenanthramides: From Skin Protection to Prevention and Treatment of Cerebrovascular Diseases

2018 ◽  
Vol 2018 ◽  
pp. 1-17 ◽  
Author(s):  
Andrea Perrelli ◽  
Luca Goitre ◽  
Anna Maria Salzano ◽  
Andrea Moglia ◽  
Andrea Scaloni ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Biological Activities ◽  
Health Benefits ◽  
Cerebrovascular Diseases ◽  
Antiproliferative Effects ◽  
High Antioxidant Activity ◽  
Therapeutic Properties ◽  
Unique Source ◽  
Phenolic Amides ◽  
Molecular Components

Oat (Avena sativa) is a cereal known since antiquity as a useful grain with abundant nutritional and health benefits. It contains distinct molecular components with high antioxidant activity, such as tocopherols, tocotrienols, and flavanoids. In addition, it is a unique source of avenanthramides, phenolic amides containing anthranilic acid and hydroxycinnamic acid moieties, and endowed with major beneficial health properties because of their antioxidant, anti-inflammatory, and antiproliferative effects. In this review, we report on the biological activities of avenanthramides and their derivatives, including analogs produced in recombinant yeast, with a major focus on the therapeutic potential of these secondary metabolites in the treatment of aging-related human diseases. Moreover, we also present recent advances pointing to avenanthramides as interesting therapeutic candidates for the treatment of cerebral cavernous malformation (CCM) disease, a major cerebrovascular disorder affecting up to 0.5% of the human population. Finally, we highlight the potential of foodomics and redox proteomics approaches in outlining distinctive molecular pathways and redox protein modifications associated with avenanthramide bioactivities in promoting human health and contrasting the onset and progression of various pathologies.

scholarly journals Therapeutic potential of intranasal photobiomodulation therapy for neurological and neuropsychiatric disorders: a narrative review

2020 ◽  
Vol 31 (3) ◽  
pp. 269-286 ◽  
Author(s):  
Farzad Salehpour ◽  
Sevda Gholipour-Khalili ◽  
Fereshteh Farajdokht ◽  
Farzin Kamari ◽  
Tomasz Walski ◽  
...  
Keyword(s):  
Blood Flow ◽  
Therapeutic Potential ◽  
Blood Rheology ◽  
Potential Method ◽  
Cerebrovascular Diseases ◽  
Photobiomodulation Therapy ◽  
Light Sources ◽  
Novel Approach ◽  
Home Based ◽  
Wide Range

AbstractThe application of photobiomodulation therapy (PBMT) for neuronal stimulation is studied in different animal models and in humans, and has shown to improve cerebral metabolic activity and blood flow, and provide neuroprotection via anti-inflammatory and antioxidant pathways. Recently, intranasal PBMT (i-PBMT) has become an attractive and potential method for the treatment of brain conditions. Herein, we provide a summary of different intranasal light delivery approaches including a nostril-based portable method and implanted deep-nasal methods for the effective systemic or direct irradiation of the brain. Nostril-based i-PBMT devices are available, using either lasers or light emitting diodes (LEDs), and can be applied either alone or in combination to transcranial devices (the latter applied directly to the scalp) to treat a wide range of brain conditions such as mild cognitive impairment, Alzheimer’s disease, Parkinson’s disease, cerebrovascular diseases, depression and anxiety as well as insomnia. Evidence shows that nostril-based i-PBMT improves blood rheology and cerebral blood flow, so that, without needing to puncture blood vessels, i-PBMT may have equivalent results to a peripheral intravenous laser irradiation procedure. Up to now, no studies were conducted to implant PBMT light sources deep within the nose in a clinical setting, but simulation studies suggest that deep-nasal PBMT via cribriform plate and sphenoid sinus might be an effective method to deliver light to the ventromedial part of the prefrontal and orbitofrontal cortex. Home-based i-PBMT, using inexpensive LED applicators, has potential as a novel approach for neurorehabilitation; comparative studies also testing sham, and transcranial PBMT are warranted.

scholarly journals The Diagnostic and Therapeutic Potential of Galectin-3 in Cardiovascular Diseases

Biomolecules ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 46
Author(s):  
Grażyna Sygitowicz ◽  
Agata Maciejak-Jastrzębska ◽  
Dariusz Sitkiewicz
Keyword(s):  
Heart Failure ◽  
Therapeutic Potential ◽  
Regulatory Protein ◽  
Cerebrovascular Diseases ◽  
Myocardial Tissue ◽  
Arrhythmogenic Cardiomyopathy ◽  
Tissue Remodelling ◽  
Galectin 3 ◽  
Coronary Syndromes

Galectin-3 plays a prominent role in chronic inflammation and has been implicated in the development of many disease conditions, including heart disease. Galectin-3, a regulatory protein, is elevated in both acute and chronic heart failure and is involved in the inflammatory pathway after injury leading to myocardial tissue remodelling. We discussed the potential utility of galectin-3 as a diagnostic and disease severity/prognostic biomarker in different cardio/cerebrovascular diseases, such as acute ischemic stroke, acute coronary syndromes, heart failure and arrhythmogenic cardiomyopathy. Over the last decade there has been a marked increase in the understanding the role of galectin-3 in myocardial fibrosis and inflammation and as a therapeutic target for the treatment of heart failure and myocardial infarction.

Autologous Cell Therapy for Vascular Regeneration: The Role of Proangiogenic Cells

2018 ◽  
Vol 25 (35) ◽  
pp. 4518-4534 ◽  
Author(s):  
Vanessa Bianconi ◽  
Francesca Fallarino ◽  
Massimo Raffaele Mannarino ◽  
Francesco Bagaglia ◽  
Meisam Naeimi Kararoudi ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Therapeutic Potential ◽  
Cerebrovascular Diseases ◽  
Inflammatory Rheumatic Diseases ◽  
Peripheral Artery ◽  
Vascular Regeneration ◽  
Autologous Cell ◽  
Autologous Cell Therapy ◽  
Artery Disease

Background: Autologous cell therapy represents a novel treatment option for vascular regeneration in different disease conditions, with experimental and clinical studies indicating a therapeutic potential for proangiogenic cells (PCs), including endothelial progenitor cells, in the treatment of coronary and peripheral artery disease. <p> Objective: To provide a summary of the therapeutic potential of PCs administration or mobilization in peripheral artery disease, ischemic heart and cerebrovascular diseases, diabetic microvascular complications and inflammatory rheumatic diseases. <p> Methods: We undertook a search of bibliographic databases for peer-reviewed research literature on the role of PCs in vascular regeneration in preclinical and clinical models. <p> Results: Improvement of ischemic symptoms has been reported in different trials evaluating PCs for the treatment of critical limb ischemia. However, in this setting, contrasting results from meta-analyses question the long-term clinical efficacy of PC-based approaches. Preclinical studies and clinical trials support the safety and feasibility of PC therapy in the treatment of ischemic heart and cerebrovascular diseases, while evidence indicating a benefit on hard clinical outcomes is uncertain. Despite accumulating experimental results support a therapeutic role for PCs in diabetic retinopathy, results from randomized clinical trials are lacking. Whether PC therapy may limit premature atherosclerosis and reduce cardiovascular risk in inflammatory rheumatic diseases needs to be investigated. <p> Conclusion: Although the potential clinical applications of PCs are accumulating, there is also evidence of multiple limitations for autologous PC therapy. Thus, novel strategies aimed at improving PC viability and angiogenic function are warranted in order to improve the efficacy of cell therapy applications.

scholarly journals BuyangHuanwu Decoction (BYHWD) inhibits LPS-induced inflammation in BV2 microglial cells by NF-κB/NLRP3 pathway

2020 ◽  
Author(s):  
Zhuang Peng ◽  
Sha Peng ◽  
Zhe Shi ◽  
Lin Luo
Keyword(s):  
Mechanism Of Action ◽  
Therapeutic Potential ◽  
Morphological Changes ◽  
Cerebrovascular Disorders ◽  
Cerebrovascular Diseases ◽  
No Production ◽  
Therapeutic Effects ◽  
Potential Candidate ◽  
Local Synthesis ◽  
Tnf Α

Abstract Background: Neuroinflammation has been implicated in the pathogenesis of various neurological and cerebrovascular diseases. Recently, microglia has became a promising target to treat neuroinflammation-related diseases. BuyangHuanwu Decoction (BYHWD), a traditional Chinese medicine recipe, is a representative prescription for the treatment of neuroinflammation, showed great therapeutic potential in neuroinflammation-related cerebrovascular disorders including cerebral ischemia. However, it’s possible mechanism of action remains unclear.Methods: In the present research, we studied the therapeutic effects of BYHWD on LPS-induced inflammatory response in BV2 microglia cells. The inflammatory cytokines include interleukin (IL-6), tumor necrosis factor (TNF-α) and nitric oxide (NO) were detected by commercial kit. The inflammatory-related protein was measured by western blot and immunofluorescence.Results: Our findings showed that BYHWD could significantly reverse LPS-induced morphological changes in BV2 microglial and inhibit the local synthesis of proinflammatory cytokines and free radical via directly regulating NF-κB activity and inflammasome assembly. Our data showed that BYHWT inhibit LPS-induced TNF-α, IL-6, and NO production, Also can inhibit iNOS protein expression and the activation of NF-κB taccording to inhibit NLRP3 activation.Conclusions: In conclusion, our results demonstrated that BYHWD is a potential candidate for treating neuroinflammation-related diseases. Certainly, more comprehensive researches on the precise mechanism of action of BYHWD in cerebrovascular disease is required in future vivo studies.

Sign in / Sign up

Export Citation Format

Share Document