Phytochemistry and Pharmacology of Carthamus tinctorius L.

2016 ◽  
Vol 44 (02) ◽  
pp. 197-226 ◽  
Author(s):  
Le-Le Zhang ◽  
Ke Tian ◽  
Zheng-Hai Tang ◽  
Xiao-Jia Chen ◽  
Zhao-Xiang Bian ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Therapeutic Potential ◽  
Blood Stasis ◽  
Carthamus Tinctorius ◽  
Cerebrovascular Diseases ◽  
Future Research ◽  
Asian Countries ◽  
Hydroxysafflor Yellow A ◽  
Traditional Herbal Medicine ◽  
Pharmacological Activities

Carthamus tinctorius L. is a multifunctional cash crop. Its flowers and seeds are extensively used in traditional herbal medicine in China, Korea, Japan, and other Asian countries, for treating various ailments such as gynecological, cardiovascular, and cerebrovascular diseases as well as blood stasis and osteoporosis. More than 100 compounds have been isolated and identified from C. tinctorius. Flavonoids and alkaloids, especially the quinochalcone c-glycoside hydroxysafflor yellow A, N-(p-Coumaroyl)serotonin, and N-feruloylserotonin, are responsible for most of the pharmacological activities of C. tinctorius. In this paper, comprehensive and up-to-date information on the phytochemistry and pharmacology of C. tinctorius is presented. This information will be helpful for further explorations of the therapeutic potential of C. tinctorius and may provide future research opportunities.

Phytochemical, Pharmacological Activities and Ayurvedic Significances of Magical Plant Mimosa pudica Linn

2020 ◽  
Vol 17 ◽  
Author(s):  
Vijay Kumar
Keyword(s):  
Therapeutic Potential ◽  
Wide Spectrum ◽  
Chemical Constituents ◽  
Future Research ◽  
Mimosa Pudica ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Traditional Medicines ◽  
Crude Extracts ◽  
Anti Cancer

: Mimosa pudica Linn is an integrated part of Traditional Medicines Systems of India, China, Africa, Korea and America. It has been used from centuries in traditional medicines to cure different diseases like fever, diabetes, constipation, jaundice, ulcers, biliousness, and dyspepsia. It is an important ingredient of wide class of herbal formulations. To assess the scientific evidence for therapeutic potential of Mimosa pudica Linn and to identify the gaps for future research. The available information on the ethno-medicinal uses, phytochemistry, pharmacology and toxicology of Mimosa pudica Linn was collected via a library and electronic searches in Sci-Finder, Pub-Med, Science Direct, Google Scholar for the period, 1990 to 2020. In traditional medicinal systems, variety of ethno-medicinal applications of Mimosa pudica Linn has been noticed. Phytochemical investigation has resulted in identification of 40 well known chemical constituents, among which alkaloids, phenols and flavionoids are the predominant groups. The crude extracts and isolates have exhibited a wide spectrum of in vitro and in vivo pharmacological activities including anti-cancer, anti-inflammation, osteoporosis, neurological disorders, hypertension etc.. To quantify the Mimosa pudica Linn and its formulations, analytical techniques like HPLC and HPTLC has shown dominancy with good range of recovery and detection limit. Mimosa pudica Linn is the well-known herb since an ancient time. The pharmacological results supported some of the applications of Mimosa pudica Linn in traditional medicine systems. Perhaps, the predominance of alkaloids, phenols and flavionoids are responsible for the pharmacological activities the crude extracts and isolates of Mimosa pudica Linn. Further, there is need to isolate and evaluate the active chemical constituents of Mimosa pudica Linn having significant medicinal values. In future, it is important to study the exact mechanism associated with the phytochemicals of Mimosa pudica Linn especially on anti-cancer activities. Notably, toxicity studies on Mimosa pudica Linn are limited which are to be explored in future for the safe application of Mimosa pudica Linn and its formulations.

scholarly journals Phytochemistry, Traditional Use and Pharmacological Activity of Picrasma quassioides: A Critical Reviews

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2584
Author(s):  
Muhammad Daniel Hakim Mohd Jamil ◽  
Muhammad Taher ◽  
Deny Susanti ◽  
Md Atiar Rahman ◽  
Zainul Amiruddin Zakaria
Keyword(s):  
Herbal Medicine ◽  
Traditional Herbal Medicine ◽  
Pharmacological Activities ◽  
Traditional Use ◽  
Safety And Efficacy ◽  
Picrasma Quassioides ◽  
Anti Cancer ◽  
Real Value ◽  
High Doses ◽  
Toxicity Effects

Picrasma quassioides is a member of the Simaroubaceae family commonly grown in the regions of Asia, the Himalayas, and India and has been used as a traditional herbal medicine to treat various illnesses such as fever, gastric discomfort, and pediculosis. This study aims to critically review the presence of phytochemicals in P. quassioides and correlate their pharmacological activities with the significance of its use as traditional medicine. Data were collected by reviewing numerous scientific articles from several journal databases on the pharmacological activities of P. quassioides using certain keywords. As a result, approximately 94 phytochemicals extracted from P. quassioides were found to be associated with quassinoids, β-carbolines and canthinones. These molecules exhibited various pharmacological benefits such as anti-inflammatory, antioxidant, anti-cancer, anti-microbial, and anti-parasitic activities which help to treat different diseases. However, P. quassioides were also found to have several toxicity effects in high doses, although the evidence regarding these effects is limited in proving its safe use and efficacy as herbal medicine. Accordingly, while it can be concluded that P. quassioides may have many potential pharmacological benefits with more phytochemistry discoveries, further research is required to determine its real value in terms of quality, safety, and efficacy of use.

scholarly journals Hydroxysafflor Yellow A: A Systematical Review on Botanical Resources, Physicochemical Properties, Drug Delivery System, Pharmacokinetics, and Pharmacological Effects

2020 ◽  
Vol 11 ◽  
Author(s):  
Feng Zhao ◽  
Ping Wang ◽  
Yuanyuan Jiao ◽  
Xiaoxiao Zhang ◽  
Daquan Chen ◽  
...  
Keyword(s):  
Carthamus Tinctorius ◽  
Clinical Applications ◽  
Detection Methods ◽  
Pharmacological Effects ◽  
Hydroxysafflor Yellow A ◽  
Pharmacological Activities ◽  
Related Research ◽  
Chemical Instability ◽  
Anticancer Effects ◽  
Systematical Review

Hydroxysafflower yellow A (HSYA), as a principal natural ingredient extracted from safflower (Carthamus tinctorius L.), has significant pharmacological activities, such as antioxidant, anti-inflammatory, anticoagulant, and anticancer effects. However, chemical instability and low bioavailability have been severely hampering the clinical applications of HSYA during the treatment of cardiovascular and cerebrovascular disease. Therefore, this present review systematically summarized the materials about HSYA, including acquisition methods, extraction and detection methods, pharmacokinetics, pharmacological effects and molecular mechanism, especially focus on the possible causes and resolutions about the chemical instability and low bioavailability of HSYA, in order to provide relatively comprehensive basic data for the related research of HSYA.

scholarly journals Therapeutic Potential of Hydroxysafflor Yellow A on Cardio-Cerebrovascular Diseases

2020 ◽  
Vol 11 ◽  
Author(s):  
Xue Bai ◽  
Wen-Xiao Wang ◽  
Rui-Jia Fu ◽  
Shi-Jun Yue ◽  
Huan Gao ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Cerebrovascular Diseases ◽  
Hydroxysafflor Yellow A

Ethnomedicinal Uses, Phytochemistry and Pharmacology of Carica papaya Plant: A Compendious Review

2019 ◽  
Vol 16 (5) ◽  
pp. 463-480 ◽  
Author(s):  
Manpreet Kaur ◽  
Naveen Chandra Talniya ◽  
Seema Sahrawat ◽  
Arvind Kumar ◽  
Elena E. Stashenko
Keyword(s):  
Carica Papaya ◽  
Therapeutic Potential ◽  
Industrial Applications ◽  
Present Review ◽  
Future Research ◽  
Pharmacological Activities ◽  
Traditional System ◽  
Wide Range ◽  
Microbial Infections ◽  
Ethnomedicinal Uses

Medicinal properties of papaya (Carica papaya Linn.) fruit and other parts are wellknown in the traditional system of medicine. Papaya plant originated in Central America and now grown in tropical areas of worldwide, most particularly in Africa and Asia. Studies validate that, papaya has several pharmacological activities, such as antioxidant, antiulcer, antibacterial, woundhealing, anti-inflammatory and anti-sickling, just to name a few. The present review article provides the explicit and updated information on botanical aspects, ethnomedicinal uses, phytochemistry and pharmacological activities of C. papaya plant in order to explore their therapeutic potential. This review conducted a systematic search on C. papaya through electronic database search (Google Scholar, PubMed, SciFinder, Scopus, Science Direct, and Web of Science) and a library search for articles published in peer-reviewed journals, until January of 2018. Constituents of papaya plant belongs to different chemical classes that include alkaloids, flavonoids, terpenoids, saponins, steroids, tannin, vitamins, quinones, minerals and others. Experimental evidence confirmed that these classes of compounds cure the microbial infections, diabetes, inflammatory, cytotoxic and liver disorders. Conclusively, the present review aimed to summarize the information of ethnomedicinal uses, phytochemistry and pharmacological activities to prevent and treat the wide range of diseases and disorders. The future research draws the attention of the researcher for intensive investigations relating to phytochemicals, pharmacological activities and industrial applications.

THE GENUS ONOSMA L.: A COMPREHENSIVE REVIEW

2021 ◽  
pp. 219-227
Author(s):  
Aruna M. Rajapara ◽  
Mamta B. Shah
Keyword(s):  
Scientific Literature ◽  
Species Selection ◽  
Future Research ◽  
Asian Countries ◽  
Pharmacological Activities ◽  
Scientific Databases ◽  
Traditional Uses ◽  
Future Drug ◽  
Pharmacology And Toxicology ◽  
Selection For

In medicinal plant field ethnopharmacological knowledge aggrandizes legibility for prioritizing species selection for future research opportunities. Many plant species representing the genus Onosma have been documented to be important in communities world-wide as evidenced by the numerous records on traditional medicinal and ethno-botanical information. Various species of the genus are used in the traditional medicinal systems in Europe and Asian countries especially in India, China, Turky and Pakistan. The literature on the species distribution and their characterization was compiled from different regional floras, regional revisions and databases. The information related to traditional uses, pharmacological activities and phytochemistry was systematically collected from the scientific databases including reference books, SciFinder, Scopus, PubMed and Google Scholar. Absence of comprehensive literature review on genus Onosma species led to design present study and dig the recorded documents to comparatively gauge magnitude of studies on each of the Onosma species through an exhaustive bibliographic evaluation of scientifically studied species of genus Onosma that are also taxonomically identified and are valued as traditional medicinal remedy for diseases in their countries of origin. The study hinted about lack of scientific literature on most of the species. A comprehensive bibliographic review on the geographical distribution, identification, traditional uses, phytochemistry, pharmacology and toxicology of the genus Onosma is attempted here to give insights into promising future drug discovery strategies. KEYWORDS: Onosma, Distribution, Traditional uses, Phyto-Pharmacology

scholarly journals Liver Disease in Sri Lanka

2017 ◽  
Vol 7 (1) ◽  
pp. 78-81 ◽  
Author(s):  
Hasitha S Wijewantha
Keyword(s):  
Liver Disease ◽  
Sri Lanka ◽  
Herbal Medicine ◽  
South Asian ◽  
Dengue Infection ◽  
Published Data ◽  
Biliary Cirrhosis ◽  
Asian Countries ◽  
Traditional Herbal Medicine ◽  
Drug Induced

ABSTRACT Liver disease in Sri Lanka is mainly due to alcoholic liver disease and nonalcoholic fatty liver disease. In contrast to other South Asian countries, the prevalence of hepatitis B and C is low in Sri Lanka and prevalence of hepatitis A is intermediate. The few reported cases of hepatitis E in Sri Lanka are mainly in people who have traveled to neighboring South Asian countries. Wilson's disease, autoimmune hepatitis, hemochromatosis, drug-induced liver disease, and primary biliary cirrhosis are recognized causes of liver disease in Sri Lanka. Pyogenic and amebic liver abscesses and dengue infection are the other causes of liver disease. Some of the commonly used plants as traditional herbal medicine in Sri Lanka have been shown to have deleterious effects on the liver in animal studies. Considering the high popularity of traditional herbal medicine in the country, it is likely that herbal medicine is an etiological factor for liver disease in Sri Lanka, but no published data are available. Address reprint requests to: Wijewantha HS. Liver Disease in Sri Lanka. Euroasian J Hepato-Gastroenterol 2017;7(1):78-81.

scholarly journals DURANTA REPENS LINN. (VERBENACEAE): A COMPREHENSIVE REVIEW OF PHARMACOGNOSTIC, ETHNOMEDICINAL, PHARMACOLOGICAL, AND PHYTOCHEMICAL ASPECTS

2018 ◽  
Vol 11 (11) ◽  
pp. 91 ◽  
Author(s):  
Abhijeet V Puri
Keyword(s):  
Therapeutic Potential ◽  
Safety Data ◽  
Future Research ◽  
Pharmacological Activities ◽  
Scientific Publications ◽  
Comprehensive Review ◽  
Published Report ◽  
The Family ◽  
Therapeutic Properties ◽  
Source Of Information

Objective: This review is intended to investigate the published report regarding phytochemical, ethnomedicinal, and pharmacological activities and put forth the therapeutic potential of Duranta repens Linn. (D. repens). It belongs to the family Verbenaceae, one of the therapeutically important plants, broadly distributed all throughout the world. It is commonly referred as golden dewdrop, angel whisper, pigeon berry, or skyflower.Methods: I utilized logical writing and scientific literature regarding D. repens by referring search engine such as Springerlink, ScienceDirect, SciFinder, PubMed, Scopus, Google Scholar, and BioMed Central as well as relevant books, websites, scientific publications, and dissertations as a source of information that provided an up-to-date review. My work on morphology and extraction of various phytochemicals and their evaluation has helped to provide an insightful account of D. repens.Results: Phytochemical profiling of these species revealed the presence of some imperative phytochemicals such as alkaloids, flavonoids, glycosides, phenolics, saponins, steroids, tannins and terpenoids as the basis of its valuable therapeutic properties. The other imperative phytoconstituents which contribute to the therapeutic properties are durantol, repennoside, repenins, and scutellarein. The pharmacological activities exhibited by D. repens as antimicrobial, antioxidant, and insecticide properties are attributed to the presence of valuable bioactive phytoconstituents.Conclusion: Considering these facts, I endeavored to present a comprehensive review enlightening the phytochemistry and pharmacological activities of plant D. repens. Future research can be directed to an extensive investigation about phytochemistry, clinical trials, pharmacokinetics, and acquiring safety data so as to add new dimensions to the therapeutic utilization of D. repens and other Duranta species.

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