scholarly journals Effect of Chinese Herbal Medicine Therapy on Overall and Cancer Related Mortality in Patients With Advanced Nasopharyngeal Carcinoma in Taiwan

2021 ◽  
Vol 11 ◽  
Author(s):  
Chen-Yu Wang ◽  
Tang-Chuan Wang ◽  
Wen-Miin Liang ◽  
Chien-Hui Hung ◽  
Jian-Shiun Chiou ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Mortality Risk ◽  
Complementary Therapy ◽  
Chinese Herbal ◽  
Kaplan Meier ◽  
East And Southeast Asia ◽  
Trichosanthes Kirilowii ◽  
Related Mortality

Nasopharyngeal carcinoma (NPC) is a head and neck cancer involving epithelial squamous-cell carcinoma of the nasopharynx that mainly occurs in individuals from East and Southeast Asia. We investigated whether Chinese herbal medicine (CHM) as a complementary therapy offers benefits to these patients. We retrospectively evaluated the Taiwan Cancer Registry (Long Form) database for patients with advanced NPC, using or not using CHM, between 2007–2013. Cox proportional-hazard model and Kaplan‒Meier survival analyses were applied for patient survival. CHM-users showed a lower overall and cancer-related mortality risk than non-users. For advanced NPC patients, the overall mortality risk was 0.799-fold for CHM-users, after controlling for age, gender, and Charlson comorbidity index (CCI) score (Cancer stages 3 + 4: adjusted hazard ratio [aHR]: 0.799, 95% confidence interval [CI]: 0.676–0.943, p = 0.008). CHM-users also showed a lower cancer-related mortality risk than non-users (aHR: 0.71, 95% CI: 0.53–0.96, p = 0.0273). Association rule analysis showed that CHM pairs were Ban-Zhi-Lian (BZL; Scutellaria barbata D.Don) and For single herbs, Bai-Hua-She-She-Cao (Herba Hedyotis Diffusae; Scleromitrion diffusum (Willd.) R.J.Wang (syn. Hedyotis diffusa Willd.) and Mai-Men-Dong (MMD; Ophiopogon japonicus (Thunb.) Ker Gawl.), and Gan-Lu-Yin (GLY) and BHSSC. Network analysis revealed that BHSSC was the core CHM, and BZL, GLY, and Xin-Yi-Qing-Fei-Tang (XYQFT) were important CHMs in cluster 1. In cluster 2, ShengDH, MMD, Xuan-Shen (XS; Scrophularia ningpoensis Hensl.), and Gua-Lou-Gen (GLG; Trichosanthes kirilowii Maxim.) were important CHMs. Thus, as a complementary therapy, CHM, and particularly the 8 CHMs identified, are important for the treatment of advanced NPC patients.

scholarly journals Chinese Herbal Medicine Therapy Reduces the Risks of Overall and Anemia-Related Mortalities in Patients With Aplastic Anemia: A Nationwide Retrospective Study in Taiwan

2021 ◽  
Vol 12 ◽  
Author(s):  
Mu-Lin Chiu ◽  
Yu-Lung Hsu ◽  
Chao-Jung Chen ◽  
Te-Mao Li ◽  
Jian-Shiun Chiou ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Aplastic Anemia ◽  
Chinese Herbal Medicine ◽  
Large Scale ◽  
Salvia Miltiorrhiza ◽  
Bone Marrow Failure ◽  
Complementary Therapy ◽  
Population Based ◽  
Chinese Herbal ◽  
Kaplan Meier

Aplastic Anemia (AA) is a rare but fatal hematologic disease that may occur at any age and especially higher in Asia. We investigated whether Chinese herbal medicine (CHM) is beneficial to AA patients as a complementary therapy using a nationwide population-based database in Taiwan between 2000–2016. Patient survival was estimated by Kaplan‒Meier survival analyses and Cox proportional-hazard model. CHM-users presented lower risks of overall and anemia-related mortalities when compared to non-users. The risk of overall mortality for CHM-users in AA patients was 0.70-fold [adjusted hazard ratio (aHR): 0.70, 95% confidence interval (CI): 0.66-0.74, p < 0.001). The risk of anemia-related mortality was lower in CHM-users when compared to non-users (aHR: 0.46, 95% CI: 0.32-0.67, p < 0.001). The association rule analysis revealed that CHM pairs were Ban-Zhi-Lian (BZL; Scutellaria barbata D. Don)→Bai-Hua-She-She-Cao (BHSSC; Oldenlandia diffusa (Willd.) Roxb.), followed by Dang-Gui (DG; Angelica sinensis (Oliv.) Diels)→Huang-Qi (HQi; Astragalus membranaceus (Fisch.) Bunge), and Xian-He-Cao (XHC; Agrimonia pilosa f. borealis (Kitag.) Chu)→Gui-Pi-Tang (GPT). Network analysis showed that BZL, BHSSC, DG, HQi, XHC, GPT, and Dan-Shen (DanS; Salvia miltiorrhiza var. charbonnelii (H.Lév.) C.Y.Wu) were commonly used CHMs for AA patients. Therefore, further studies for these commonly prescribed herbs are needed in functional investigations in hematopoiesis-stimulating effect and large-scale randomized controlled trials (RCT) in bone marrow failure related diseases.

Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic acid loaded to fluorescence mesoporous silica nanoparticles for the location and therapy of nasopharyngeal carcinoma

The Analyst ◽  
2021 ◽  
Author(s):  
Yuke Liu ◽  
Le Zhou ◽  
Jing Tan ◽  
Weiqiang Xu ◽  
Guoliang Huang ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Herbal Medicine ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Chinese Herbal Medicine ◽  
Antitumour Activity ◽  
Mesoporous Silica Nanoparticles ◽  
Chinese Herbal

Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic acid (5F), isolated and purified from Chinese herbal medicine Pteris semipinnata L., is a diterpenoid, and has been known to exert antitumour activity in several kinds of malignant cancer...

scholarly journals Complementary Chinese Herbal Medicine Therapy Improves Survival of Patients With Pancreatic Cancer in Taiwan: A Nationwide Population-Based Cohort Study

2017 ◽  
Vol 17 (2) ◽  
pp. 411-422 ◽  
Author(s):  
Yi-Ting Kuo ◽  
Hou-Hsun Liao ◽  
Jen-Huai Chiang ◽  
Mei-Yao Wu ◽  
Bor-Chyuan Chen ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Mortality Risk ◽  
Cox Regression ◽  
Population Based ◽  
Hazard Ratio ◽  
Chinese Herbal ◽  
Hazard Ratios ◽  
Lower Hazard

Background: Pancreatic cancer is a difficult-to-treat cancer with a late presentation and poor prognosis. Some patients seek traditional Chinese medicine (TCM) consultation. We aimed to investigate the benefits of complementary Chinese herbal medicine (CHM) among patients with pancreatic cancer in Taiwan. Methods: We included all patients with pancreatic cancer who were registered in the Taiwanese Registry for Catastrophic Illness Patients Database between 1997 and 2010. We used 1:1 frequency matching by age, sex, the initial diagnostic year of pancreatic cancer, and index year to enroll 386 CHM users and 386 non-CHM users. A Cox regression model was used to compare the hazard ratios (HRs) of the risk of mortality. The Kaplan-Meier curve was used to compare the difference in survival time. Results: According to the Cox hazard ratio model mutually adjusted for CHM use, age, sex, urbanization level, comorbidity, and treatments, we found that CHM users had a lower hazard ratio of mortality risk (adjusted HR = 0.67, 95% CI = 0.56-0.79). Those who received CHM therapy for more than 90 days had significantly lower hazard ratios of mortality risk than non-CHM users (90- to 180-day group: adjusted HR = 0.56, 95% CI = 0.42-0.75; >180-day group: HR = 0.33, 95% CI = 0.24-0.45). The survival probability was higher for patients in the CHM group. Bai-hua-she-she-cao (Herba Oldenlandiae; Hedyotis diffusa Spreng) and Xiang-sha-liu-jun-zi-tang (Costus and Chinese Amomum Combination) were the most commonly used single herb and Chinese herbal formula, respectively. Conclusions: Complementary Chinese herbal therapy might be associated with reduced mortality among patients with pancreatic cancer. Further prospective clinical trial is warranted.

Adjunctive Chinese herbal medicine therapy for nasopharyngeal carcinoma: Clinical evidence and experimental validation

Head & Neck ◽  
2019 ◽  
Vol 41 (9) ◽  
pp. 2860-2872 ◽  
Author(s):  
Ying‐Chyi Song ◽  
Kuo‐Feng Hung ◽  
Kai‐Li Liang ◽  
Jen‐Huai Chiang ◽  
Hui‐Chi Huang ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Experimental Validation ◽  
Clinical Evidence ◽  
Chinese Herbal

scholarly journals Conventional Western Treatment Associated With Chinese Herbal Medicine Ameliorates the Incidence of Head and Neck Cancer Among Patients With Esophageal Cancer

2019 ◽  
Vol 18 ◽  
pp. 153473541983435
Author(s):  
Chia-Chen Chang ◽  
Kuo-Wei Bi ◽  
Hung-Jen Lin ◽  
Yuan-Chih Su ◽  
Wen-Ling Wang ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Herbal Medicine ◽  
Head And Neck ◽  
Chinese Herbal Medicine ◽  
Cumulative Incidence ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer ◽  
Chinese Herbal ◽  
Kaplan Meier

Background: Because of advances in medical treatment, the survival of cancer patients is prolonged. In line with the prolonged survival time of cancer the incidence of second primary cancer has increased. There is currently no effective way to prevent the occurrence of secondary primary cancer (SPC). Objectives: The aim of this study is to evaluate whether Chinese Herbal Medicine (CHM) is correlated with reduced occurrence of second primary cancer (SPC) of head and neck (H&N) in patients with esophageal cancer (EC). Method: We identified 15,546 patients who were diagnosed with esophageal cancer between Jan 1, 2000, and Dec 31, 2010. The patients with H&N cancer before receiving CHM were excluded. After the selection and matching process, both CHM and non-CHM cohorts each contained 850 individuals. We compared the cumulative incidence of SPC of H&N with or without CHM treatment in patients with EC by the Kaplan-Meier method. NodeXL is used to run a network analysis of CHM to examine the association between herbs and formulas. Results: Compared with non-CHM users, CHM-users showed a reduced incidence rate of SPC of H&N among the patients with EC. Reduced cumulative incidence of SPC of H&N among patients with EC was noted in the CHM cohort compared to the non-CHM cohort. The most commonly used single herbs and formulas were associated with reducing SPC occurrence. Conclusion: We propose that CHM as an adjuvant therapy may prevent the occurrence of SPC of H&N in patients with EC.

scholarly journals Integrated Chinese Herbal Medicine and Western Medicine on the Survival in Patients with Colorectal Cancer: A Retrospective Study of Medical Records

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Ming-Hsien Yeh ◽  
Hung-Pin Chiu ◽  
Mei-Chun Wu ◽  
Malcolm Koo ◽  
Nai-Wei Lin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cohort Study ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Retrospective Cohort Study ◽  
Western Medicine ◽  
Medical Records ◽  
Retrospective Cohort ◽  
Chinese Herbal ◽  
Kaplan Meier

Recent studies suggested that Traditional Chinese Medicine could play a beneficial role in conventional cancer treatment. The aim of this retrospective cohort study was to investigate the effect of Chinese herbal medicine (CHM) combined with Western medicine on the survival of patients with colorectal cancer. A retrospective cohort study was conducted on patients with newly diagnosed colorectal cancer identified from the Dalin Tzu Chi Hospital Cancer Registry Database in 2004–2014. Combining with the medical records of the study hospital, patients were classified into CHM users and CHM nonusers. Kaplan–Meier analyses and Cox proportional hazards regression analyses were used to investigate the survival between CHM users and CHM nonusers. A total of 535 patients with colorectal cancer were included in the study with 147 of them were CHM users. The log-rank test for Kaplan–Meier survival curve revealed a statistically significant difference between the survival of CHM users and CHM nonusers (P=0.006). Results from multivariate Cox regression analysis showed that CHM use was significantly associated with better survival (adjusted hazard ratio = 0.54, 95% CI = 0.38 to 0.77). In addition, the CHM formulae Jia Wei Xiao Yao San, Zhi Bah Di Huang Wan, Ping Wei San, and Qui Pi Tang were significantly associated with better survival. In conclusion, findings from this retrospective cohort study indicated that integrated CHM and Western medicine could improve survival in patients with colorectal cancer. Additional research on integrating TCM with Western medicine to improve cancer survival is warranted.

scholarly journals Radioprotective Effect of Flavonoids on Ionizing Radiation-Induced Brain Damage

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5719
Author(s):  
Qinqi Wang ◽  
Chenghao Xie ◽  
Shijun Xi ◽  
Feng Qian ◽  
Xiaochun Peng ◽  
...  
Keyword(s):  
Side Effects ◽  
Herbal Medicine ◽  
Ionizing Radiation ◽  
Brain Damage ◽  
Chinese Herbal Medicine ◽  
Genomic Stability ◽  
Complementary Therapy ◽  
Chinese Herbal ◽  
Brain Radiotherapy ◽  
Radiation Induced

Patients receiving brain radiotherapy may suffer acute or chronic side effects. Ionizing radiation induces the production of intracellular reactive oxygen species and pro-inflammatory cytokines in the central nervous system, leading to brain damage. Complementary Chinese herbal medicine therapy may reduce radiotherapy-induced side effects. Flavonoids are a class of natural products which can be extracted from Chinese herbal medicine and have been shown to have neuroprotective and radioprotective properties. Flavonoids are effective antioxidants and can also inhibit regulatory enzymes or transcription factors important for controlling inflammatory mediators, affect oxidative stress through interaction with DNA and enhance genomic stability. In this paper, radiation-induced brain damage and the relevant molecular mechanism were summarized. The radio-neuro-protective effect of flavonoids, i.e., antioxidant, anti-inflammatory and maintaining genomic stability, were then reviewed. We concluded that flavonoids treatment may be a promising complementary therapy to prevent radiotherapy-induced brain pathophysiological changes and cognitive impairment.

Long-term use of combined conventional medicine and Chinese herbal medicine decreases the mortality risk of patients with lung cancer

2020 ◽  
Vol 52 ◽  
pp. 102427
Author(s):  
Ming-Hsien Yeh ◽  
Hsien-Chang Wu ◽  
Nai-Wei Lin ◽  
Jin-Jian Hsieh ◽  
Jin-Wen Yeh ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Mortality Risk ◽  
Conventional Medicine ◽  
Chinese Herbal
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