scholarly journals Curcumin Derivative Cur20 Attenuated Cerebral Ischemic Injury by Antioxidant Effect and HIF-1α/VEGF/TFEB-Activated Angiogenesis

2021 ◽  
Vol 12 ◽  
Author(s):  
Runfang Zhang ◽  
Tingkui Zhao ◽  
Beibei Zheng ◽  
Yun Zhang ◽  
Xiaohui Li ◽  
...  
Keyword(s):  
Hydrolytic Stability ◽  
Ischemic Injury ◽  
Glucose Deprivation ◽  
Artery Occlusion ◽  
Carotid Artery Occlusion ◽  
Zebrafish Model ◽  
Cerebral Ischemic ◽  
Brain Microvessel ◽  
Common Carotid Artery Occlusion ◽  
Curcumin Derivative

In this paper, a curcumin derivative Cur20 was synthesized for better hydrolytic stability, which showed a higher angiogenic effect on zebrafish model than curcumin. In order to reveal the potential effects on neuroprotection, a mouse model of vascular dementia (VaD) induced by permanent right common carotid artery occlusion (rUCCAO) was established. After two weeks of curcumin administration, the cognitive function of mice was detected by Morris water maze and Y maze. The alteration on oxidative injuries and morphological damage were also analyzed by reactive oxygen species, superoxide dismutase, GSH, malondialdehyde tests, and Nissl stain on cortex/hippocampus. The angiogenesis and related signal factors were evaluated as well. The results showed that Cur20 significantly attenuated the cognitive dysfunction and histopathological changes of the VaD mice with enhanced antioxidant system and angiogenesis. In addition, primary rat brain microvessel endothelial cells (rBMECs) with oxygen glucose deprivation (OGD) were applied to further verify the possible mechanisms of Cur20-induced angiogenesis. The results demonstrated that the proliferation effect and the activation of pro-angiogenesis factors such as HIF-1α, VEGF, and TFEB might contribute to the protection of ischemic injury. Based on the above, our conclusion is that Cur20 can be considered as a promising therapeutic strategy for VaD.

Dietary Supplementation of Fenugreek Seed Extract and Choline-Docosahexaenoic acid on Oxidative Stress and Neurodegeneration in Ovariectomized Rats with Bilateral Common Carotid Artery Occlusion

2021 ◽  
pp. 2153-2161
Author(s):  
Anjaneyulu Konuri ◽  
Kumar M R Bhat ◽  
Kiranmai S Rai ◽  
Nagamma T ◽  
Rajesh Thangarajan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Learning And Memory ◽  
Artery Occlusion ◽  
Carotid Artery Occlusion ◽  
Seed Extract ◽  
Fenugreek Seed ◽  
Bilateral Common Carotid Artery ◽  
Brain Oxidative Stress ◽  
Cerebral Ischemic ◽  
Common Carotid Artery Occlusion

As impairment of memory and ischemic brain injury is more common in female of menopausal age, the current study aims to evaluate the protective role of fenugreek seed extract and choline-Docosahexaenoic acid (DHA) on cognitive behavior, oxidative stress and neurodegeneration in ovariectomized-cerebral ischemic rats. Cerebral ischemia was induced by bilateral common carotid artery occlusion (BCCAO) surgery to ovariectomized adult female wistar rats. Fenugreek, choline-DHA and combination of fenugreek with choline-DHA was supplemented for 30days after ovariectomy and continued for 14 more days after BCCAO surgery. Effect of this supplementation on learning and memory, brain oxidative stress and neurodegeneration in the CA1, CA3 hippocampal sub-regions were analyzed. Ovariectomized-cerebral ischemic rats demonstrated learning and memory impairment when subjected to passive avoidance task. Further, these rats also had increased brain oxidative stress, and neurodegeneration in CA1, CA3 sub-regions of hippocampus. Conversely, combined supplementation of fenugreek with choline-DHA to ovariectomized-cerebral ischemic rats exhibited a significant improvement in their learning and memory abilities, with reduced oxidative stress and neurodegeneration in CA1 and CA3 sub-regions of hippocampus.

scholarly journals Common Carotid Artery Occlusion Treatment: Revealing a Gap in the Current Guidelines

2013 ◽  
Vol 58 (3) ◽  
pp. 846 ◽  
Author(s):  
C. Klonaris ◽  
G.N. Kouvelos ◽  
M. Kafeza ◽  
A. Koutsoumpelis ◽  
A. Katsargyris ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Common Carotid Artery ◽  
Artery Occlusion ◽  
Carotid Artery Occlusion ◽  
Common Carotid Artery Occlusion ◽  
Current Guidelines

scholarly journals Endovascular Revascularization of a Symptomatic Common Carotid Artery Occlusion

2016 ◽  
Vol 44 (1) ◽  
pp. 120-123 ◽  
Author(s):  
Julie Kromm ◽  
Tim E. Darsaut ◽  
Khurshid Khan ◽  
Robert Ashforth ◽  
Esseddeeg Ghrooda
Keyword(s):  
Carotid Artery ◽  
Common Carotid Artery ◽  
Clinical Presentation ◽  
Artery Occlusion ◽  
Carotid Artery Occlusion ◽  
Common Site ◽  
Extracranial Carotid Artery ◽  
The Common ◽  
Common Carotid Artery Occlusion ◽  
Diagnostic Investigations

AbstractAlthough the common carotid artery is the second most common site for extracranial carotid artery stenosis, complete symptomatic occlusion in the absence of devastating stroke is rare. We present a case of complete common carotid artery occlusion failing medical management and requiring endovascular intervention. The clinical presentation, diagnostic investigations, and management of complete carotid artery occlusions are discussed.

scholarly journals Inhibition of Vascular Nitric Oxide after Rat Chronic Brain Hypoperfusion: Spatial Memory and Immunocytochemical Changes

2005 ◽  
Vol 25 (6) ◽  
pp. 663-672 ◽  
Author(s):  
Jack C. de la Torre ◽  
Gjumrakch Aliev
Keyword(s):  
Nitric Oxide ◽  
Spatial Memory ◽  
Memory Function ◽  
Critical Role ◽  
Artery Occlusion ◽  
Carotid Artery Occlusion ◽  
Significant Loss ◽  
Electron Microscopic ◽  
Vessel Occlusion ◽  
Common Carotid Artery Occlusion

An aging rat model of chronic brain hypoperfusion (CBH) that mimics human mild cognitive impairment (MCI) was used to examine the role of nitric oxide synthase (NOS) isoforms on spatial memory function. Rats with CBH underwent bilateral common carotid artery occlusion (2-vessel occlusion (2-VO)) for either 26 or 8 weeks and were compared with nonoccluded sham controls (S-VO). The neuronal and endothelial (nNOS/eNOS) constitutive inhibitor nitro-L-arginine methyl ester (L-NAME) 20 mg/kg was administered after 26 weeks for 3 days to 2-VO and S-VO groups and spatial memory was assessed with a modified Morris watermaze test. Only 2-VO rats worsened their spatial memory ability after L-NAME. Electron microscopic immunocytochemical examination using an antibody against eNOS showed 2-VO rats had significant loss or absence of eNOS-containing positive gold particles in hippocampal endothelium and these changes were associated with endothelial cell compression, mitochondrial damage and heavy amyloid deposition in hippocampal capillaries and perivascular region. In the 8-week study, three groups of 2-VO rats were administered an acute dose of 7-NI, aminoguanidine or L-NIO, the relatively selective inhibitors of nNOS, inducible NOS and eNOS. Only rats administered the eNOS inhibitor L-NIO worsened markedly their watermaze performance ( P=0.009) when compared with S-VO nonoccluded controls. We conclude from these findings that vascular nitric oxide derived from eNOS may play a critical role in spatial memory function during CBH possibly by keeping cerebral perfusion optimal through its regulation of microvessel tone and cerebral blood flow and that disruption of this mechanism can result in spatial memory impairment. These findings may identify therapeutic targets for preventing MCI and treating Alzheimer's disease.

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