scholarly journals Update on Novel Non-Operative Treatment for Osteoarthritis: Current Status and Future Trends

2021 ◽  
Vol 12 ◽  
Author(s):  
Tao Chen ◽  
Weidong Weng ◽  
Yang Liu ◽  
Romina H. Aspera-Werz ◽  
Andreas K Nüssler ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Operative Treatment ◽  
Therapeutic Option ◽  
Cartilage Damage ◽  
Cartilage Regeneration ◽  
Pharmacological Therapy ◽  
Current Status ◽  
Future Directions ◽  
Joint Arthroplasties

Osteoarthritis (OA) is a leading cause of pain and disability which results in a reduced quality of life. Due to the avascular nature of cartilage, damaged cartilage has a finite capacity for healing or regeneration. To date, conservative management, including physical measures and pharmacological therapy are still the principal choices offered for OA patients. Joint arthroplasties or total replacement surgeries are served as the ultimate therapeutic option to rehabilitate the joint function of patients who withstand severe OA. However, these approaches are mainly to relieve the symptoms of OA, instead of decelerating or reversing the progress of cartilage damage. Disease-modifying osteoarthritis drugs (DMOADs) aiming to modify key structures within the OA joints are in development. Tissue engineering is a promising strategy for repairing cartilage, in which cells, genes, and biomaterials are encompassed. Here, we review the current status of preclinical investigations and clinical translations of tissue engineering in the non-operative treatment of OA. Furthermore, this review provides our perspective on the challenges and future directions of tissue engineering in cartilage regeneration.

scholarly journals Convalescent Plasma Therapy for COVID-19: Current Status and Future Directions

2020 ◽  
Vol 7 (03) ◽  
pp. 140-147
Author(s):  
Jayanth Seshan ◽  
Surya K. Dube ◽  
Vanitha Rajagopalan ◽  
Pragyan S. Panda ◽  
Girija P. Rath
Keyword(s):  
Rescue Therapy ◽  
Therapeutic Option ◽  
Current Status ◽  
Past Century ◽  
Short Term ◽  
Plasma Therapy ◽  
Future Directions ◽  
Health Crisis ◽  
Influenza Outbreak ◽  
Initial Results

AbstractThe ongoing pandemic of coronavirus disease 2019 (COVID-19) has triggered a global health crisis probably due to a lack of a reliable cure till date. Several clinical trials are ongoing, but initial results have not been overly promising. Convalescent plasma (CP), which refers to plasma collected from individuals recovered from an illness and developed antibodies against the pathogen, is also being proposed as a therapeutic option for COVID-19 treatment in severe cases to achieve short-term immunity against the virus. Use of CP is not new, and it has been used in various outbreaks over the past century, ranging from the Spanish influenza outbreak in 1918 to the recent Middle East respiratory syndrome (MERS). However, data available on its use in COVID-19 patients is limited. Use of CP so far is restricted to a “rescue therapy” and needs further trials to assess its possible use in other situations (prevention, postexposure prophylaxis) and patient populations (considering age and comorbid illnesses). In this review, we will try to summarize the current status of use of CP for COVID-19 and ongoing trials in India and elsewhere and will discuss the possible avenues for its use in future.

scholarly journals Percutaneous Management of Malignant Biliary Strictures: Current Status and Future Directions

2017 ◽  
Vol 01 (01) ◽  
pp. 036-046
Author(s):  
Mohammed Attaya ◽  
Hosam Attaya ◽  
Ashraf Thabet
Keyword(s):  
New Technologies ◽  
Current Status ◽  
Biliary Strictures ◽  
Biliary Stents ◽  
Future Directions ◽  
Improve Patient Survival ◽  
Percutaneous Interventions ◽  
Improve Patient ◽  
Transhepatic Biliary Drainage

AbstractVarious minimally invasive percutaneous interventions may be performed for the treatment and management of malignant biliary obstruction. The types of percutaneous interventions include percutaneous transhepatic biliary drainage, percutaneous cholecystostomy, and biliary stent placement. Biliary stents have undergone continued evolution in design to prolong patency, increase cost-effectiveness, improve patient survival, and quality of life. Furthermore, investigational techniques, such as radiofrequency ablation, intraluminal brachytherapy, and photodynamic therapy promise new technologies in the field of biliary intervention. This review focuses on the current status of percutaneous therapies for malignant biliary strictures and obstruction.

Quality-of-Life Research in Acne Vulgaris: Current Status and Future Directions

2019 ◽  
Vol 20 (4) ◽  
pp. 527-538 ◽  
Author(s):  
Servando E. Marron ◽  
Pavel V. Chernyshov ◽  
Lucia Tomas-Aragones
Keyword(s):  
Quality Of Life ◽  
Acne Vulgaris ◽  
Current Status ◽  
Future Directions ◽  
Quality Of Life Research

Quality of life evaluation in sarcoidosis: current status and future directions

2008 ◽  
Vol 14 (5) ◽  
pp. 470-477 ◽  
Author(s):  
David E Victorson ◽  
David Cella ◽  
Marc A Judson
Keyword(s):  
Quality Of Life ◽  
Current Status ◽  
Future Directions ◽  
Life Evaluation

scholarly journals Medical Devices for Tremor Suppression: Current Status and Future Directions

Biosensors ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 99
Author(s):  
Jiancheng Mo ◽  
Ronny Priefer
Keyword(s):  
Medical Devices ◽  
Daily Living ◽  
Physical Activities ◽  
Current Status ◽  
Future Directions ◽  
Surgical Interventions ◽  
Tremor Suppression ◽  
Surgical Treatments ◽  
Deep Brain

Tremors are the most prevalent movement disorder that interferes with the patient’s daily living, and physical activities, ultimately leading to a reduced quality of life. Due to the pathophysiology of tremor, developing effective pharmacotherapies, which are only suboptimal in the management of tremor, has many challenges. Thus, a range of therapies are necessary in managing this progressive, aging-associated disorder. Surgical interventions such as deep brain stimulation are able to provide durable tremor control. However, due to high costs, patient and practitioner preference, and perceived high risks, their utilization is minimized. Medical devices are placed in a unique position to bridge this gap between lifestyle interventions, pharmacotherapies, and surgical treatments to provide safe and effective tremor suppression. Herein, we review the mechanisms of action, safety and efficacy profiles, and clinical applications of different medical devices that are currently available or have been previously investigated for tremor suppression. These devices are primarily noninvasive, which can be a beneficial addition to the patient’s existing pharmacotherapy and/or lifestyle intervention.

scholarly journals Translational Application of 3D Bioprinting for Cartilage Tissue Engineering

2021 ◽  
Vol 8 (10) ◽  
pp. 144
Author(s):  
Sophie McGivern ◽  
Halima Boutouil ◽  
Ghayadah Al-Kharusi ◽  
Suzanne Little ◽  
Nicholas J. Dunne ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cartilage Repair ◽  
Treatment Options ◽  
Cartilage Damage ◽  
Cartilage Tissue Engineering ◽  
Cartilage Regeneration ◽  
Bioactive Molecules ◽  
Cartilage Tissue ◽  
Layer By Layer ◽  
3D Bioprinting

Cartilage is an avascular tissue with extremely limited self-regeneration capabilities. At present, there are no existing treatments that effectively stop the deterioration of cartilage or reverse its effects; current treatments merely relieve its symptoms and surgical intervention is required when the condition aggravates. Thus, cartilage damage remains an ongoing challenge in orthopaedics with an urgent need for improved treatment options. In recent years, major advances have been made in the development of three-dimensional (3D) bioprinted constructs for cartilage repair applications. 3D bioprinting is an evolutionary additive manufacturing technique that enables the precisely controlled deposition of a combination of biomaterials, cells, and bioactive molecules, collectively known as bioink, layer-by-layer to produce constructs that simulate the structure and function of native cartilage tissue. This review provides an insight into the current developments in 3D bioprinting for cartilage tissue engineering. The bioink and construct properties required for successful application in cartilage repair applications are highlighted. Furthermore, the potential for translation of 3D bioprinted constructs to the clinic is discussed. Overall, 3D bioprinting demonstrates great potential as a novel technique for the fabrication of tissue engineered constructs for cartilage regeneration, with distinct advantages over conventional techniques.

scholarly journals Application of Cord Blood and Cord Blood-Derived Induced Pluripotent Stem Cells for Cartilage Regeneration

2018 ◽  
Vol 28 (5) ◽  
pp. 529-537 ◽  
Author(s):  
Yeri Alice Rim ◽  
Yoojun Nam ◽  
Ji Hyeon Ju
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Articular Cartilage ◽  
Cord Blood ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Cartilage Regeneration ◽  
Cartilage Tissue ◽  
Current Status ◽  
Induced Pluripotent

Regeneration of articular cartilage is of great interest in cartilage tissue engineering since articular cartilage has a low regenerative capacity. Due to the difficulty in obtaining healthy cartilage for transplantation, there is a need to develop an alternative and effective regeneration therapy to treat degenerative or damaged joint diseases. Stem cells including various adult stem cells and pluripotent stem cells are now actively used in tissue engineering. Here, we provide an overview of the current status of cord blood cells and induced pluripotent stem cells derived from these cells in cartilage regeneration. The abilities of these cells to undergo chondrogenic differentiation are also described. Finally, the technical challenges of articular cartilage regeneration and future directions are discussed.

scholarly journals Quality of Reporting in Preclinical Urethral Tissue Engineering Studies: A Systematic Review to Assess Adherence to the ARRIVE Guidelines

Animals ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2456
Author(s):  
Tariq O. Abbas ◽  
Abubakr Elawad ◽  
Abdul Kareem Pullattayil S. ◽  
Cristian Pablo Pennisi
Keyword(s):  
Systematic Review ◽  
Tissue Engineering ◽  
Animal Studies ◽  
Therapeutic Option ◽  
Laboratory Animals ◽  
Size Estimation ◽  
Ethical Guidelines ◽  
Preclinical Research ◽  
Quality Of Reporting

Preclinical research within the area of urethral tissue engineering has not yet been successfully translated into an efficient therapeutic option for patients. This gap could be attributed, in part, to inadequate design and reporting of the studies employing laboratory animals. In this study, a systematic review was conducted to investigate the quality of reporting in preclinical studies utilizing tissue engineering approaches for urethral repair. The scope was on studies performed in rabbits, published between January 2014 and March 2020. Quality assessment of the data was conducted according to the Animal Research: Reporting of in Vivo Experiments (ARRIVE) guidelines by the scoring of a 38-item checklist in different categories. A total of 28 articles that fulfilled the eligibility criteria were included in the study. The range of ARRIVE score was from 0 to 100, taking into consideration having reported the item in question or not. The mean checklist score was 53%. The items that attained the highest scores included the number of animals utilized, the size of control and experimental groups, and the definition of experimental outcomes. The least frequently reported items included the data regarding the experimental procedure, housing and husbandry, determination and justification of the number of animals, and reporting of adverse events. Surprisingly, full disclosure about ethical guidelines and animal protocol approval was missing in 54% of the studies. No paper stated the sample size estimation. Overall, our study found that a large number of studies display inadequate reporting of fundamental information and that the quality of reporting improved marginally over the study period. We encourage a comprehensive implementation of the ARRIVE guidelines in animal studies exploring tissue engineering for urethral repair, not only to facilitate effective translation of preclinical research findings into clinical therapies, but also to ensure compliance with ethical principles and to minimize unnecessary animal studies.

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