scholarly journals A Mouse Intra-Intestinal Infusion Model and its Application to the Study of Nanoparticle Distribution

2016 ◽  
Vol 7 ◽  
Author(s):  
Ana Sadio ◽  
Ana L. Amaral ◽  
Rute Nunes ◽  
Sara Ricardo ◽  
Bruno Sarmento ◽  
...  
Keyword(s):  
Nanoparticle Distribution ◽  
Intestinal Infusion

Monocytes as Carriers of Magnetic Nanoparticles for Tracking Inflammation in the Epileptic Rat Brain

2019 ◽  
Vol 16 (7) ◽  
pp. 637-644 ◽  
Author(s):  
Hadas Han ◽  
Sara Eyal ◽  
Emma Portnoy ◽  
Aniv Mann ◽  
Miriam Shmuel ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Ex Vivo ◽  
In Vivo Studies ◽  
Nanoparticle Distribution ◽  
Spontaneous Seizures ◽  
Systemic Distribution ◽  
Hippocampal Ca1 ◽  
Pilocarpine Model

Background: Inflammation is a hallmark of epileptogenic brain tissue. Previously, we have shown that inflammation in epilepsy can be delineated using systemically-injected fluorescent and magnetite- laden nanoparticles. Suggested mechanisms included distribution of free nanoparticles across a compromised blood-brain barrier or their transfer by monocytes that infiltrate the epileptic brain. Objective: In the current study, we evaluated monocytes as vehicles that deliver nanoparticles into the epileptic brain. We also assessed the effect of epilepsy on the systemic distribution of nanoparticleloaded monocytes. Methods: The in vitro uptake of 300-nm nanoparticles labeled with magnetite and BODIPY (for optical imaging) was evaluated using rat monocytes and fluorescence detection. For in vivo studies we used the rat lithium-pilocarpine model of temporal lobe epilepsy. In vivo nanoparticle distribution was evaluated using immunohistochemistry. Results: 89% of nanoparticle loading into rat monocytes was accomplished within 8 hours, enabling overnight nanoparticle loading ex vivo. The dose-normalized distribution of nanoparticle-loaded monocytes into the hippocampal CA1 and dentate gyrus of rats with spontaneous seizures was 176-fold and 380-fold higher compared to the free nanoparticles (p<0.05). Seizures were associated with greater nanoparticle accumulation within the liver and the spleen (p<0.05). Conclusion: Nanoparticle-loaded monocytes are attracted to epileptogenic brain tissue and may be used for labeling or targeting it, while significantly reducing the systemic dose of potentially toxic compounds. The effect of seizures on monocyte biodistribution should be further explored to better understand the systemic effects of epilepsy.

High-resolution scanning transmission soft X-ray microscopy for rapid probing of nanoparticle distribution and sufferance features in exposed cells

2015 ◽  
Vol 44 (3) ◽  
pp. 163-168 ◽  
Author(s):  
G. Kourousias ◽  
L. Pascolo ◽  
P. Marmorato ◽  
J. Ponti ◽  
G. Ceccone ◽  
...  
Keyword(s):  
High Resolution ◽  
X Ray ◽  
Nanoparticle Distribution ◽  
Scanning Transmission

scholarly journals Surface Texturing of Polyethylene Terephthalate Induced by Excimer Laser in Silver Nanoparticle Colloids

Materials ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3263
Author(s):  
Jakub Siegel ◽  
Tatiana Savenkova ◽  
Jana Pryjmaková ◽  
Petr Slepička ◽  
Miroslav Šlouf ◽  
...  
Keyword(s):  
Surface Morphology ◽  
Polyethylene Terephthalate ◽  
Excimer Laser ◽  
Silver Nanoparticle ◽  
Polymer Surface ◽  
Surface Texturing ◽  
Nanoparticle Distribution ◽  
Pulse Excimer Laser ◽  
Variable Surface ◽  
Variable Morphology

We report on a novel technique of surface texturing of polyethylene terephthalate (PET) foil in the presence of silver nanoparticles (AgNPs). This approach provides a variable surface morphology of PET evenly decorated with AgNPs. Surface texturing occurred in silver nanoparticle colloids of different concentrations under the action of pulse excimer laser. Surface morphology of PET immobilized with AgNPs was observed by AFM and FEGSEM. Atomic concentration of silver was determined by XPS. A presented concentration-controlled procedure of surface texturing of PET in the presence of silver colloids leads to a highly nanoparticle-enriched polymer surface with a variable morphology and uniform nanoparticle distribution.

scholarly journals Incorporation of ZnO Nanoparticles into Soy Protein-Based Bioplastics to Improve Their Functional Properties

Polymers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 486
Author(s):  
Mercedes Jiménez-Rosado ◽  
Víctor Perez-Puyana ◽  
Pablo Sánchez-Cid ◽  
Antonio Guerrero ◽  
Alberto Romero
Keyword(s):  
Controlled Release ◽  
Environmental Impact ◽  
Soy Protein ◽  
Zno Nanoparticles ◽  
Injection Moulding ◽  
Mould Temperature ◽  
Uptake Capacity ◽  
Nanoparticle Distribution ◽  
Water Uptake Capacity ◽  
Key Factor

The union of nanoscience (nanofertilization) with controlled release bioplastic systems could be a key factor for the improvement of fertilization in horticulture, avoiding excessive contamination and reducing the price of the products found in the current market. In this context, the objective of this work was to incorporate ZnO nanoparticles in soy protein-based bioplastic processed using injection moulding. Thus, the concentration of ZnO nanoparticles (0 wt%, 1.0 wt%, 2.0 wt%, 4.5 wt%) and mould temperature (70 °C, 90 °C and 110 °C) were evaluated through a mechanical (flexural and tensile properties), morphological (microstructure and nanoparticle distribution) and functional (water uptake capacity, micronutrient release and biodegradability) characterization. The results indicate that these parameters play an important role in the final characteristics of the bioplastics, being able to modify them. Ultimately, this study increases the versatility and functionality of the use of bioplastics and nanofertilization in horticulture, helping to prevent the greatest environmental impact caused.

Three-Dimensional Nanoparticle Distribution and Local Curvature of Heterogeneous Catalysts Revealed by Electron Tomography

2007 ◽  
Vol 111 (31) ◽  
pp. 11501-11505 ◽  
Author(s):  
Edmund P. W. Ward ◽  
Timothy J. V. Yates ◽  
José-Jesús Fernández ◽  
David E. W. Vaughan ◽  
Paul A. Midgley
Keyword(s):  
Heterogeneous Catalysts ◽  
Electron Tomography ◽  
Three Dimensional ◽  
Local Curvature ◽  
Nanoparticle Distribution

scholarly journals Different distributions of gold nanoparticles on the tumor and calculation of dose enhancement factor by Monte Carlo simulation

2019 ◽  
Vol 5 (4) ◽  
pp. 361-371 ◽  
Author(s):  
Sajad Keshavarz ◽  
Dariush Sardari
Keyword(s):  
Gold Nanoparticles ◽  
Uniform Distribution ◽  
Enhancement Factor ◽  
Radiation Energy ◽  
Distribution Model ◽  
Distribution Models ◽  
Dose Enhancement ◽  
X Ray ◽  
Nanoparticle Distribution ◽  
Nanoparticle Sizes

Gold nanoparticles can be used to increase the dose of the tumor due to its high atomic number as well as being free from apparent toxicity. The aim of this study is to evaluate the effect of distribution of gold nanoparticles models, as well as changes in nanoparticle sizes and spectrum of radiation energy along with the effects of nanoparticle penetration into surrounding tissues in dose enhancement factor DEF. Three mathematical models were considered for distribution of gold nanoparticles in the tumor, such as 1-uniform, 2- non-uniform distribution with no penetration margin and 3- non-uniform distribution with penetration margin of 2.7 mm of gold nanoparticles. For this purpose, a cube-shaped water phantom of 50 cm size in each side and a cube with 1 cm side placed at depth of 2 cm below the upper surface of the cubic phantom as the tumor was defined, and then 3 models of nanoparticle distribution were modeled. MCNPX code was used to simulate 3 distribution models. DEF was evaluated for sizes of 20, 25, 30, 50, 70, 90 and 100 nm of gold nanoparticles, and 50, 95, 250 keV and 4 MeV photon energies. In uniform distribution model the maximum DEF was observed at 100 nm and 50 keV being equal to 2.90, in non-uniform distribution with no penetration margin, the maximum DEF was measured at 100 nm and 50 keV being 1.69, and in non-uniform distribution with penetration margin of 2.7 mm, the maximum DEF was measured at 100 nm and 50 keV as 1.38, and the results have been showed that the dose was increased by injecting nanoparticles into the tumor. It is concluded that the highest DEF could be achieved in low energy photons and larger sizes of nanoparticles. Non-uniform distribution of gold nanoparticles can increase the dose and also decrease the DEF in comparison with the uniform distribution. The non-uniform distribution of nanoparticles with penetration margin showed a lower DEF than the non-uniform distribution without any margin and uniform distribution. Meanwhile, utilization of the real X-ray spectrum brought about a smaller DEF in comparison to mono-energetic X-ray photons.

Dielectric response and breakdown behavior of polymer-ceramic nanocomposites: The effect of nanoparticle distribution

2017 ◽  
Vol 145 ◽  
pp. 105-113 ◽  
Author(s):  
Ziming Cai ◽  
Xiaohui Wang ◽  
Bingcheng Luo ◽  
Wei Hong ◽  
Longwen Wu ◽  
...  
Keyword(s):  
Dielectric Response ◽  
Nanoparticle Distribution ◽  
Ceramic Nanocomposites

Intestinal infusion of a liquid diet alters CCK and NPY concentrations in specific brain areas of rats

1990 ◽  
Vol 48 (3) ◽  
pp. 423-428 ◽  
Author(s):  
Mary Anne Della-Fera ◽  
James Koch ◽  
Ronald L. Gingerich ◽  
Clifton A. Baile
Keyword(s):  
Liquid Diet ◽  
Brain Areas ◽  
Intestinal Infusion

scholarly journals Modeling of macroscopic quantum states in functional properties of the laser-induced 4D-topological nanoclusters in thin films on solid surface

2019 ◽  
Vol 220 ◽  
pp. 01002
Author(s):  
S.M. Arakelian ◽  
A.O. Kucherik ◽  
T.A. Khudaberganov ◽  
D.N. Bukharov
Keyword(s):  
Thin Films ◽  
Lattice Structure ◽  
Wave Length ◽  
Spatial Period ◽  
Nanoparticle Distribution ◽  
De Broglie Wave ◽  
Different Types ◽  
Quantum Behavior ◽  
New Type ◽  
Coherent Tunneling

Nanocluster structures can be easily modified in necessary direction and by controlled way in femtonanophotonics experiments. The variation of the key topology parameters can result in new type of the quantum correlation states/size effect for charged particles. In our earlier experiments we studied laser-induced topological nanoclusters structures of different types in thin films with unique phenomena in electrophysics and optics (see [1-3]). A simple 2-steps mechanism for enhancement of quantum behavior (e.g. in electroconductivity) exists for different conditions. First, when inelastic length linelastic > acluster we have no incoherent electron-phonon (e-ph) scattering, i.e. the coherent process takes place. Second, when de Broglie wave length λdB ≡ ℓcoh < Λ, (acluster – cluster size , Λ – spatial period of nanoparticle distribution) the coherent tunneling without loss occurs, and a long-range order with interference of the states takes place in the medium due to lattice structure.

scholarly journals Importance of the pyrolysis for microstructure and superconducting properties of CSD-grown GdBa2Cu3O7−x-HfO2 nanocomposite films by the ex-situ approach

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Pablo Cayado ◽  
Hannes Rijckaert ◽  
Els Bruneel ◽  
Manuela Erbe ◽  
Jens Hänisch ◽  
...  
Keyword(s):  
Processing Parameters ◽  
Nanocomposite Films ◽  
Ex Situ ◽  
Superconducting Properties ◽  
Critical Temperatures ◽  
Solution Deposition ◽  
Nanoparticle Distribution ◽  
Current Densities ◽  
First Time ◽  
Lower Heating

Abstract For the first time, GdBa2Cu3O7−x nanocomposites were prepared by chemical solution deposition following the ex-situ approach. In particular, ~ 220 nm GdBa2Cu3O7−x-HfO2 (GdBCO-HfO2) nanocomposite films were fabricated starting from a colloidal solution of 5 mol% HfO2 nanoparticles. Hereby, one of the main challenges is to avoid the accumulation of the nanoparticles at the substrate interface during the pyrolysis, which would later prevent the epitaxial nucleation of the GdBCO grains. Therefore, the effect of pyrolysis processing parameters such as heating ramp and temperature on the homogeneity of the nanoparticle distribution has been investigated. By increasing the heating ramp to 300 °C/h and decreasing the final temperature to 300 °C, a more homogenous nanoparticle distribution was achieved. This translates into improved superconducting properties of the grown films reaching critical temperatures (Tc) of 94.5 K and self-field critical current densities ($${J}_{\mathrm{c}}^{\mathrm{sf}}$$ J c sf ) at 77 K of 2.1 MA/cm2 with respect to films pyrolyzed at higher temperatures or lower heating ramps.

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