scholarly journals Dysbiosis, Host Metabolism, and Non-communicable Diseases: Trialogue in the Inborn Errors of Metabolism

2021 ◽  
Vol 12 ◽  
Author(s):  
Chiara Montanari ◽  
Sara Parolisi ◽  
Elisa Borghi ◽  
Lorenza Putignani ◽  
Giulia Bassanini ◽  
...  

Inborn errors of metabolism (IEMs) represent a complex system model, in need of a shift of approach exploring the main factors mediating the regulation of the system, internal or external and overcoming the traditional concept of biochemical and genetic defects. In this context, among the established factors influencing the metabolic flux, i.e., diet, lifestyle, antibiotics, xenobiotics, infectious agents, also the individual gut microbiota should be considered. A healthy gut microbiota contributes in maintaining human health by providing unique metabolic functions to the human host. Many patients with IEMs are on special diets, the main treatment for these diseases. Hence, IEMs represent a good model to evaluate how specific dietary patterns, in terms of macronutrients composition and quality of nutrients, can be related to a characteristic microbiota associated with a specific clinical phenotype (“enterophenotype”). In the present review, we aim at reporting the possible links existing between dysbiosis, a condition reported in IEMs patients, and a pro-inflammatory status, through an altered “gut-liver” cross-talk network and a major oxidative stress, with a repercussion on the health status of the patient, increasing the risk of non-communicable diseases (NCDs). On this basis, more attention should be paid to the nutritional status assessment and the clinical and biochemical signs of possible onset of comorbidities, with the goal of improving the long-term wellbeing in IEMs. A balanced intestinal ecosystem has been shown to positively contribute to patient health and its perturbation may influence the clinical spectrum of individuals with IEMs. For this, reaching eubiosis through the improvement of the quality of dietary products and mixtures, the use of pre-, pro- and postbiotics, could represent both a preventive and therapeutic strategy in these complex diseases.

2020 ◽  
Vol 9 (1) ◽  
pp. 3
Author(s):  
Giuseppe Novelli ◽  
Michela Biancolella ◽  
Andrea Latini ◽  
Aldo Spallone ◽  
Paola Borgiani ◽  
...  

The increase in life expectancy during the 20th century ranks as one of society’s greatest achievements, with massive growth in the numbers and proportion of the elderly, virtually occurring in every country of the world. The burden of chronic diseases is one of the main consequences of this phenomenon, severely hampering the quality of life of elderly people and challenging the efficiency and sustainability of healthcare systems. Non-communicable diseases (NCDs) are considered a global emergency responsible for over 70% of deaths worldwide. NCDs are also the basis for complex and multifactorial diseases such as hypertension, diabetes, and obesity. The epidemics of NCDs are a consequence of a complex interaction between health, economic growth, and development. This interaction includes the individual genome, the microbiome, the metabolome, the immune status, and environmental factors such as nutritional and chemical exposure. To counteract NCDs, it is therefore essential to develop an innovative, personalized, preventative, early care model through the integration of different molecular profiles of individuals to identify both the critical biomarkers of NCD susceptibility and to discover novel therapeutic targets.


2020 ◽  
Vol 17 (2) ◽  
pp. 11
Author(s):  
Oliver Hoon Leh Ling ◽  
Siti Nur Afiqah Mohamed Musthafa ◽  
Muhammad Solahuddin Hamzah ◽  
Marlyana Azyyati Marzukhi ◽  
Nurul Ashikin Mabahwi

Environmental health is referring to the health of people in relation to environmental quality. Due to rapid urbanisation, more people are living in urban neighbourhoods. Urban planning and design aspects including the neighbourhood environment are potentially affecting the human healthy lifestyle and health condition. Thus, the relationship between Malaysian neighbourhood environmental aspects and human health has become the concern of this research. One of the neighbourhood units in Shah Alam city had been chosen as the study area for this purpose. Questionnaire survey had been carried out to examine the health condition and physical activeness of residents. Besides, the perception of residents on the quality of neighbourhood environmental aspects also had been collected in the questionnaire survey. The health condition of residents was measured by non-communicable diseases (NCD) and the physical activeness was measured in duration as well as the frequency of physical exercise activities. The study found that the quality of neighbourhood environmental aspects significantly increased the physical activeness of respondents. The physical activeness was positively associated with human health as measured in NCD (heart diseases and high blood pressure, HBP). It shows that neighbourhood environmental (physical and social) aspects are potentially affecting the healthy life of people living in the neighbourhood.Keywords: Healthy life, Neighbourhood environment, Non-communicable diseases (NCD), Physical activeness, Quality.


2017 ◽  
Vol 5 ◽  
pp. 943-947
Author(s):  
Teodora Dimcheva ◽  
Boryana Levterova ◽  
Desislava Bakova ◽  
Nonka Mateva

Introduction: The prevalence of chronic non-communicable diseases (NCDs) worldwide acquires epidemic dimensions. In Europe, five nosological groups (diabetes mellitus, cardiovascular disease, cancer, chronic respiratory diseases and mental disabilities) constitute 77% of NCDs and cause about 86% of deaths in the region.Objectives: This study aimed to assess the quality of life in patients with chronic non-communicable diseases under dispensary observation.Methods: The pilot cross-sectional study was performed among adult with chronic diseases in primary care practices in the Plovdiv district (the second largest in Bulgaria) from May to June 2013.Results: A total of 200 adults with chronic diseases participated in the study. The mean age was 55.6 years (range 25–95, standard deviation (SD) 16.9). The most common chronic diseases in our study were cardiovascular 51% (ischemic heart disease, hypertension, etc.), followed by endocrinology diseases (23%). There was statistically significant differences in the assessments of "general health" in different groups of participants by gender (χ2 = 16.65, P <0.002), age (χ2 = 12.57, P <0.05) and social status (χ2 = 28.54, P <0.0001).Conclusion: The subjective assessment of health is a factor that has a strong impact on the quality of life of patients and is an important component in evaluating the effectiveness of provided health care for patients with chronic non-communicable diseases.


2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Mingmin Xu ◽  
Lu Wang ◽  
Yu Guo ◽  
Wei Zhang ◽  
Ying Chen ◽  
...  

Functional constipation (FC) is a common and often recurrent functional bowel disorder that seriously affects the quality of life of affected individuals and incurs a significant economic burden on both the individual and society. There is accumulating evidence that intestinal dysbiosis contributes to constipation and that rebalancing the gut microbiota may be a novel therapeutic modality for FC. Electroacupuncture (EA) has been shown to restore the gut microbiota to normal levels in a variety of diseases. Additionally, several high-quality clinical studies have confirmed that EA is an effective, sustained, and safe treatment for FC. However, whether the effects of EA are secondary to changes in the gut microbiota and how EA modulates intestinal dysbiosis induced by constipation are unknown. Therefore, here, we focused on the potential regulatory mechanisms of EA on diphenoxylate-induced constipation in mice by analyzing structural changes in the gut microbiota. Our results showed that EA treatment effectively rebalanced the gut microbiota of constipated mice, mainly by decreasing the Firmicutes/Bacteroidetes ratio, which may represent one way in which EA promotes gastrointestinal motility and alleviates constipation. Our findings lay the foundation for further mechanistic and clinical research into the application of EA in patients with FC.


2021 ◽  
Vol 14 (2) ◽  
pp. e240147
Author(s):  
Geminiganesan Sangeetha ◽  
Senthil Chandran ◽  
Swathi Ganesan ◽  
Jaippreetha Jayaraj

Alkaptonuria is a rare genetic disorder resulting in abnormality of tyrosine metabolism. It is one of the Garrod’s tetrad of ‘inborn errors of metabolism’ proposed to have Mendelian recessive inheritance. The disorder is characterised by deposition of homogentisic acid leading to ochronosis and ochronotic osteoarthropathy; however, blackish discoloration of urine is the only childhood manifestation. Other manifestations present only after third decade. A 13-year-old boy presented to paediatric nephrology clinic with blackish discolouration of urine since infancy. Examination revealed bluish black discolouration of bilateral sclera and ear cartilage; however, he had no symptoms of ochronotic osteoarthropathy. Genetic test pointed towards alkaptonuria. Currently, he is on regular follow-up and is being treated with vitamin C to delay the progression of the disease. Early diagnosis with appropriate intervention delays the onset of complications and preserves the quality of life of the patient.


2020 ◽  
Vol 10 (3) ◽  
pp. 339-349
Author(s):  
Ike Wuri Winahyu Sari ◽  
Novita Nirmalasari

Background: Family caregivers spend 24 hours a day looking after and assisting patients. However, they are not always adequately prepared for all the problems they face. There is a lack of evidence exploring caregivers’ preparedness among family caregivers of patients with non-communicable diseases in Indonesia.Purpose: This study aimed to identify caregivers’ preparedness among family caregivers of patients with non-communicable diseases.Methods: This was a cross-sectional study conducted on 120 Indonesian family caregivers for patients with non-communicable diseases, who were selected using a purposive sampling technique. Data were collected using the Indonesian version of the Preparedness for Caregiving Scale (PCS) which had been validated before its use. The possible scores of this tool ranged from 0.00 to 4.00. The higher the score, the more prepared the family caregivers were. Data were analyzed using one way ANOVA .Results: Family caregivers reported feeling of moderately prepared for caregiving. The score of family caregiver preparedness for patients with diabetes, cancer, and chronic kidney disease were 2.97±0.42; 2.83±0.40; 2.89±0.49, respectively with possible range from 0.00 to 4.00. There were no differences on the caregivers’ preparedness among family caregivers of patients with non-communicable diseases (p=0.387).Conclusion: Caregivers’ preparedness is an essential element of patient care. Nurses have to be proactive in assessing each family caregiver’s preparedness to enhance the quality of life of both the family caregivers and the patients themselves, so that they can be empowered as a source of nursing care.


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