scholarly journals Small Airway Dysfunction in Cough Variant Asthma: Prevalence, Clinical, and Pathophysiological Features

2022 ◽  
Vol 12 ◽  
Author(s):  
Fang Yi ◽  
Ziyu Jiang ◽  
Hu Li ◽  
Chunxing Guo ◽  
Hankun Lu ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Small Airway ◽  
Asthma Prevalence ◽  
Cough Variant Asthma ◽  
Forced Expiratory Flow ◽  
Sputum Eosinophils ◽  
Expiratory Flow

Introduction: Small airway dysfunction (SAD) commonly presents in patients with classic asthma, which is associated with airway inflammation, disease severity, and asthma control. However, the prevalence of SAD, its relationship with cough severity and airway inflammation, and its development after antiasthmatic treatment in patients with cough variant asthma (CVA) need to be clarified. This study aimed to investigate the prevalence of SAD and its relationship with clinical and pathophysiological characteristics in patients with CVA and the change in small airway function after antiasthmatic treatment.Methods: We retrospectively analyzed 120 corticosteroid-naïve patients with CVA who had finished a standard questionnaire and relevant tests in a specialist cough clinic, such as cough visual analog scale (VAS), differential cells in induced sputum, fractional exhaled nitric oxide (FeNO) measurement, spirometry, and airway hyper-responsiveness. Information of 1-year follow-up was recorded in a part of patients who received complete cough relief after 2 months of treatment. SAD was defined as any two parameters of maximal mid-expiratory flow (MMEF)% pred, forced expiratory flow at 50% of forced vital capacity (FEF50%) pred, and forced expiratory flow at 75% of forced vital capacity (FEF75%) pred measuring <65%.Results: SAD occurred in 73 (60.8%) patients with CVA before treatment. The patients with SAD showed a significantly longer cough duration (24.0 vs. 6.0, p = 0.031), a higher proportion of women (78.1 vs. 59.6%, p = 0.029), older mean age (41.9 vs. 35.4, p = 0.005), and significantly lower forced expiratory volume in 1 s (FEV1%) pred, FEV1/FVC, MMEF% pred, FEF50% pred, FEF75% pred, PEF% pred, and PD20 (all p < 0.01) as compared with patients without SAD. There were no significant differences in cough VAS, sputum eosinophils count, FeNO, and TIgE level between patients with SAD and those without SAD. Among 105 patients who completed 2 months of antiasthmatic treatment and repeatedly experienced spirometry measurement, 57 (54.3%) patients still had SAD, despite a significant improvement in cough VAS, sputum eosinophils, FeNO, FEF50% pred, and PEF% pred (all p < 0.01). As compared with patients without SAD, patients with SAD showed no significant differences in the relapse rate (50.0 vs. 41.9%, p = 0.483) and wheeze development rate (10.4 vs. 0%, p = 0.063) during the follow-up.Conclusions: Small airway dysfunction occurred in over half of patients with CVA and persisted after short-term antiasthmatic treatment, which showed distinctive clinical and pathophysiological features.

An assessment of forced expiratory volumes and flow rates in the detection of early ventilatory impairment in RN submariners

1985 ◽  
Vol 71 (3) ◽  
pp. 167-170
Author(s):  
R. Herrmann ◽  
G. M. Clifford ◽  
D. J. Smith ◽  
Caroline S. M. Searing
Keyword(s):  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Linear Regression Analysis ◽  
Smoking Habit ◽  
Multiple Linear Regression Analysis ◽  
Forced Expiratory Volume ◽  
Single Breath ◽  
Forced Expiratory Flow ◽  
Expiratory Flow ◽  
Highly Correlated

AbstractA prospective study of an early diagnostic test of small airway dysfunction, the forced expiratory flow between 75 and 85% of the forced vital capacity, was carried out in 230 RN submariners. All the subjects were male caucasians, of whom 105 were smokers and 125 non-smokers. Measurements were performed using a single breath wedge spirometer (Vitalograph®) and forced vital capacity (FVC), forced expiratory volume in one second (FEV1), ratio of the FEV1 to the FVC (FEV1/FVC%) and the forced expiratory flow between 75 and 85% of the forced vital capacity (FEF75–85) obtained from the tracings in accordance with the recommendations of the American Thoracic Society. Multiple linear regression analysis of these four measurements together with height, age and smoking habit showed age to be the most significant factor for FEF75–85, followed by height Height was the most significant factor for FVC and FEV1 followed by age. Age was the only significant factor for FEV1/FVC%. FEF75-85 was highly correlated with FEV1/FVC% (r = 0.72) and to a lesser extent with FEV1 and FVC (r = 0.70 and 0.37 respectively). In the presence of age and height no significant effect of smoking habit on FEF75–85 could be demonstrated. However when the FEV1/FYC%, age and smoking habit were examined, there was found to be a significantly greater decrease in FEV1/FYC% with age in the smokers. It would appear that in this study FEV1/FVC% is a more sensitive index of early obstructive changes induced by smoking than measurement of flow at low lung volumes.

scholarly journals Effects of PM2.5 on Cardio-Pulmonary Function Injury in Open Manganese Mine Workers

2019 ◽  
Vol 16 (11) ◽  
pp. 2017 ◽  
Author(s):  
Yuanni Huang ◽  
Mian Bao ◽  
Jiefeng Xiao ◽  
Zhaolong Qiu ◽  
Kusheng Wu
Keyword(s):  
Pulmonary Function ◽  
Forced Vital Capacity ◽  
Prevalence Rate ◽  
Vital Capacity ◽  
Open Pit ◽  
Control Group ◽  
Significant Difference ◽  
Forced Expiratory Flow ◽  
Pm2.5 Exposure ◽  
Expiratory Flow

Exposure to fine particulate matter 2.5 (PM2.5) is associated with adverse health effects, varying by its components. The health-related effects of PM2.5 exposure from ore mining may be different from those of environment pollution. The aim of this study was to investigate the effects of different concentrations of PM2.5 exposure on the cardio-pulmonary function of manganese mining workers. A total of 280 dust-exposed workers who were involved in different types of work in an open-pit manganese mine were randomly selected. According to the different concentrations of PM2.5 in the working environment, the workers were divided into an exposed group and a control group. The electrocardiogram, blood pressure, and multiple lung function parameters of the two groups were measured and analyzed. The PM2.5 exposed group had significantly lower values in the pulmonary function indexes of forced expiratory volume in one second (FEV1.0), maximum mid expiratory flow (MMEF), peak expiratory flow rate (PEFR), percentage of peak expiratory flow out of the overall expiratory flow volume (PEFR%), forced expiratory flow at 25% and 75% of forced vital capacity (FEF 25, FEF75), forced expiratory flow when 25%, 50%, and 75% of forced vital capacity has been exhaled (FEF25%,FEF50%, FEF75%), and FEV1.0/FVC% (the percentage of the predicted value of forced vital capacity) than the control group (all p < 0.05). Both groups had mild or moderate lung injury, most of which was restrictive ventilatory disorder, and there was significant difference in the prevalence rate of restrictive respiratory dysfunction between the two groups (41.4% vs. 23.6%, p = 0.016). Electrocardiogram (ECG) abnormalities, especially sinus bradycardia, were shown in both groups, but there was no statistical difference of the prevalence rate between the two groups (p > 0.05). Also, no significant difference of the prevalence rate of hypertension was observed between the PM2.5 exposure and control groups (p > 0.05). PM2.5 exposure was associated with pulmonary function damage of the workers in the open-pit manganese mine, and the major injury was restrictive ventilatory disorder. The early effect of PM2.5 exposure on the cardiovascular system was uncertain at current exposure levels and exposure time.

The effect of brace treatment on pulmonary functions in adolescent idiopathic scoliosis: An 8-month follow-up study

2021 ◽  
pp. 1-7
Author(s):  
Yasin Yurt ◽  
İlker Yatar ◽  
Mehtap Malkoç ◽  
Yavuz Yakut ◽  
Serpil Mıhçıoğlu ◽  
...  
Keyword(s):  
Adolescent Idiopathic Scoliosis ◽  
Idiopathic Scoliosis ◽  
Vital Capacity ◽  
Forced Expiratory Volume ◽  
Pulmonary Functions ◽  
Measurement Results ◽  
Forced Expiratory Flow ◽  
Permanent Effect ◽  
Expiratory Flow

BACKGROUND: The instant effect of a brace on pulmonary functions of patients with adolescent idiopathic scoliosis (AIS) is known. However, the permanent effects of its regular use are still unclear. OBJECTIVE: This study aimed to determine whether a brace in patients with AIS had a permanent effect on respiratory functions. METHODS: Fifteen patients with a mean age of 13.2 ± 1.6 years, and a major Cobb angle of 25.8∘± 7.7∘ participated in this study. Lung volumes and respiratory muscle strength were measured with and without thoracolumbosacral brace, at the end of first month and follow-up period after the patients started using the brace for 23 hours daily. RESULTS: When the brace was on, the forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), ratio of FEV1/FVC, peak expiratory flow, and forced expiratory flow between 25% and 75% of vital capacity values were found to be lower at both first month and follow-up. After the follow-up, the measurement results did not differ from the results of the first month. CONCLUSIONS: The brace had a momentary restrictive effect on patients with AIS. However, it did not cause a permanent change in pulmonary functions after the 8-month follow-up.

Pulmonary Function Testing Reference Values and Interpretations in Pediatric Training Programs

PEDIATRICS ◽  
1990 ◽  
Vol 85 (5) ◽  
pp. 768-773
Author(s):  
Edward N. Pattishall
Keyword(s):  
Pulmonary Function ◽  
Statistical Methods ◽  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Training Programs ◽  
Pulmonary Function Tests ◽  
Forced Expiratory Volume ◽  
Reference Standards ◽  
Forced Expiratory Flow ◽  
Expiratory Flow

A questionnaire was sent to all pediatric training programs to evaluate the use of pulmonary function reference standards and the interpretation of pulmonary function test results. Responses were obtained from 107 of 130 institutions, and 94 of these had pulmonary function laboratories available. Of the 94, 60 used one of three reference standards. The primary reason the reference standards were chosen was either unknown or because they came with the spirometer (24), were recommended by another person or were those used in that person's training (34), or were thought to be the best standards available or most applicable to the population to be tested (31). To define abnormality, most used an 80% predicted cutoff for forced vital capacity, forced expiratory volume in 1 second, and forced expiratory flow at 25% to 75% vital capacity. For a change in an individual through time, most used a 10% change for forced vital capacity, forced expiratory volume in 1 second, and forced expiratory flow at 25% to 75% vital capacity. Thirteen used statistical methods to define abnormal individuals and none used statistical methods to define a significant change over time. Although there are a few guidelines for reference standards and interpretations of pulmonary function tests, it appears that most laboratories are not using those guidelines and that further guidelines and education are needed.

scholarly journals Lung Function Monitoring; A Randomized Agreement Study

2016 ◽  
Vol 10 (1) ◽  
pp. 51-57 ◽  
Author(s):  
Sveinung Berntsen ◽  
Solvor B. Stølevik ◽  
Petter Mowinckel ◽  
Wenche Nystad ◽  
Trine Stensrud
Keyword(s):  
Lung Function ◽  
Confidence Interval ◽  
Peak Expiratory Flow ◽  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Forced Expiratory Volume ◽  
Mean Difference ◽  
Forced Expiratory Flow ◽  
Expiratory Flow ◽  
Agreement Study

Objective: To determine the agreement between devices and repeatability within devices of the forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), peak expiratory flow (PEF) and forced expiratory flow at 50% of FVC (FEF50) values measured using the four spirometers included in the study. Methods: 50 (24 women) participants (20-64 years of age) completed maximum forced expiratory flow manoeuvres and measurements were performed using the following devices: MasterScreen, SensorMedics, Oxycon Pro and SpiroUSB. The order of the instruments tested was randomized and blinded for both the participants and the technicians. Re-testing was conducted on a following day within 72 hours at the same time of the day. Results: The devices which obtained the most comparable values for all lung function variables were SensorMedics and Oxycon Pro, and MasterScreen and SpiroUSB. For FEV1, mean difference was 0.04 L (95% confidence interval; -0.05, 0.14) and 0.00 L (-0.06, 0.06), respectively. When using the criterion of FVC and FEV1 ≤ 0.150 L for acceptable repeatability, 67% of the comparisons of the measured lung function values obtained by the four devices were acceptable. Overall, Oxycon Pro obtained most frequently values of the lung function variables with highest precision as indicated by the coefficients of repeatability (CR), followed by MasterScreen, SensorMedics and SpiroUSB (e.g. min-max CR for FEV1; 0.27-0.46). Conclusion: The present study confirms that measurements obtained by the same device at different times can be compared; however, measured lung function values may differ depending on spirometers used.

scholarly journals Sexual features of spirometric indices within the juvenile period of ontogenesis

2019 ◽  
pp. 41-46
Author(s):  
Yu. V. Kyrychenko ◽  
L. A. Sarafyniuk ◽  
P. V. Sarafyniuk ◽  
O. I. Romanenko ◽  
G. B. Lischyshyn
Keyword(s):  
Sex Differences ◽  
Young Women ◽  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Young Men ◽  
Sex Characteristics ◽  
Juvenile Period ◽  
General Group ◽  
Forced Expiratory Flow ◽  
Expiratory Flow

The factor of sexual dimorphism is dominant in the ontogenetic formation of various organs and systems, in particular the respiratory organs, whose morpho-functional indicators have significant sex differences. The aim of this work is to establish the sex characteristics of spirographic normative indices in practically healthy young men and young women within the juvenile ontogeny period. Spirographic examination of 109 young women of the ontogeny adolescence was performed, including: 17-year-olds – 29; 18-year-olds – 27; 19-year-olds – 25; 20-year-olds – 28 people and 124 young men, including: 17-year-olds – 28; 18-year-olds – 37; 19-year-olds – 27; 20-year-olds – 32 people. Spirographic examination was performed according to the method of the American Association of Pulmonologists (1995) on the device Medgraphics Pulmonary Function System 1070 series. The analysis of the obtained results was carried out with the help of the licensing program “Statistica 5.5” using non-parametric methods of estimation of indicators. It is established that the indicators of vital capacity of lungs, forced vital capacity, forced capacity of lungs on inhalation, maximal voluntary ventilation, forced expiratory flow rate respectively of 25 % of forced vital capacity, maximum peak expiratory flow, inspiratory capacity, expiratory reserve volume and one-second forced exhalation volume in young men each calendar year and the general group is significantly higher compared to the corresponding years of ontogeny in young women. The only spirometric indicator that is significantly higher for young women than for young men is the Tiffno Index. The revealed sex differences in the magnitude of spirometric parameters can be explained by the significant somatometric differences between the male and female body. Based on the results obtained, we can conclude that the vast majority of spirometric parameters in young men in all calendar periods of adolescence have higher rates than in young women. The most significant gender differences in the majority of spirometric parameters were identified in 18-year-olds.

scholarly journals Evaluation of spirometry in asthmatic children

2017 ◽  
Vol 4 (3) ◽  
pp. 729
Author(s):  
Kriti Hegde ◽  
Amit S. Saxena ◽  
Rajesh Kumar Rai
Keyword(s):  
Peak Expiratory Flow ◽  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Pulmonary Function Tests ◽  
Forced Expiratory Volume ◽  
Cold Weather ◽  
Asthmatic Children ◽  
Modifiable Factors ◽  
Forced Expiratory Flow ◽  
Expiratory Flow

Background:The use of spirometry in the assessment of children with asthma is taking on new importance with the realization that considerable airway obstruction may exist in the absence of clinically detectable abnormalities. Hence this study was planned to evaluate, forced expired volume in 1 second (FEV1), forced vital capacity (FVC), the forced expiratory flow between 25% and 75% of vital capacity (FEF25-75) and Peak Expiratory Flow rates (PEFR) in asthmatic children aged 6-12 years. The objective of the study was to determine prevalence of asthma according to clinical classification and identify common trigger factors and to determine which is more sensitive between FEV1, FVC, FEV1/FVC, FEF 25-75 and PEFR in different age groups.Methods: The present study was conducted among 60 patients of age group 6 to 12 years with asthma. Forced vital capacity (FVC), Forced expiratory volume in 1 second (FEV1), Ratio of forced expiratory volume in 1 second and forced vital capacity (FEV1/FVC), PEFR and Forced expiratory flow between 25-75% were recorded. Data was analyzed using chi-square test, Karl Pearson’s correlation coefficient. Level of significance was set at 5%. All p values less than 0.05 were treated as significant.Results:In Age and Sex wise correlation with classification of asthma, a male preponderance was seen in all the age groups i.e. between 6-8 years, 9-10 years and 11-12 years. Mosquito coils were the most common indoor agents to trigger an asthmatic accounting for nearly 80%. Amongst the outdoor triggers, exacerbation of symptoms during the cold weather accounted for 90 % followed by variation during festivals like Diwali, dust, pollution, exercise and insects. Comparison of Pre and Post bronchodilator FEF 25-75 values have shown a high statistical significance.Conclusions:Parents need to be educated regarding certain modifiable factors that can improve the prognosis. Pulmonary Function tests should be performed as a routine office procedure. Peak expiratory flow meter is a handy instrument. In all children above 6 years of age suspected to have asthma, this test should be performed before beginning therapy.

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