Evidence for an Interaction Between NEDD4 and Childhood Trauma on Clinical Characters of Schizophrenia With Family History of Psychosis

Background: Neural precursor cell-expressed developmentally downregulated 4 (NEDD4) polymorphisms and childhood trauma (CT) are associated with schizophrenia. However, whether NEDD4 interacts with CT on symptoms of schizophrenia remains unknown. This study aimed to investigate the gene–environment interaction effect.Methods: We recruited 289 schizophrenia patients and 487 controls and genotyped rs2303579, rs3088077, rs7162435, rs11550869, and rs62043855 in their NEDD4 gene.Results: We found significant differences in the rs2303579 and rs3088077 between the two groups. Patients with the rs2303579 CC genotype had higher scores compared with other genotype (P = 0.026) in the test of positive schizophrenia syndrome scores, whereas patients with the rs3088077 TT (P = 0.037) and rs7162435 CC genotypes (P = 0.009) had higher scores compared with the other genotypes in the test of excitement factor. Patients with a family history of psychosis (FH+) reported higher negative scores (P = 0.012) than those without. Patients exposed to physical abuse (PA) reported a lower language learning and memory score (P = 0.017) and working memory score (P = 0.047) than those not. Patients exposed to sexual abuse (SA) reported a lower reasoning and problem-solving skills score (P = 0.025); those exposed to emotional neglect (EN) reported a lower social cognition score (P = 0.044); and those exposed to physical neglect reported a lower social cognition score (P = 0.036) but higher visual learning and memory score (P = 0.032). Rs3088077 could interact with EN to increase risk for schizophrenia. Optimal model rs62043855 × EA, rs3088077 × rs7162435 × rs11550869 × SA × EN and rs2303579 × rs7162435 × rs11550869 × rs62043855 × EA × PA could explain positive symptom, excitement symptom and working memory, respectively, in FH+ group.Conclusion: The study highlighted that the combined interaction of NEDD4 and CT may be associated with symptoms of schizophrenia especially for those with FH+.

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Association between plasma homocysteine levels and cognitive deficits in Han Chinese patients with schizophrenia across age groups

Scientific Reports ◽

10.1038/s41598-021-99239-3 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Sumiao Zhou ◽

Yuanyuan Huang ◽

Yangdong Feng ◽

Hehua Li ◽

Kai Wu ◽

...

Keyword(s):

Working Memory ◽

Cognitive Function ◽

Learning And Memory ◽

Cognitive Deficits ◽

Visual Learning ◽

Verbal Learning ◽

Age Groups ◽

Speed Of Processing ◽

Function Score ◽

Cognitive Function Score

AbstractIt was still unclear how homocysteine (Hcy) levels and cognitive deficits change in patients with schizophrenia of various ages. The present article attempts to assess the relationship between Hcy levels and cognitive deficits in patients with schizophrenia across age groups, especially in young people. Totals of 103 patients and 122 healthy controls were included. All participants were stratified into four groups according to their age: 18–29 years, 30–39 years, 40–49 years, and 50–59 years. Clinical data, plasma Hcy levels, and cognitive function score were collected. Cognitive function was evaluated using the MATRICS Consensus Cognitive Battery of tests assessing speed of processing, verbal learning and memory, visual learning and memory, working memory, and attention/vigilance. Compared with the healthy group, Hcy levels increased significantly, and all the measured cognitive function score were significantly lower in all age groups of patients with schizophrenia (p < 0.001). Hcy levels were negatively associated with speed of processing (SoP), working memory (WM), and visual learning and memory (Vis Lrng) score in 18–29 years. Further multiple regression analysis showed that SoP were independently associated with Hcy levels in patients with schizophrenia aged 18–29 years (B = 0.74, t = 3.12, p = 0.008). Based on our results, patients with schizophrenia performed worse on cognitive assessments and Hcy levels were more closely related to cognition in young patients.

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The Role of Phonological Working Memory and Environmental Factors in Lexical Development in Italian-Speaking Late Talkers: A One-Year Follow-Up Study

Journal of Speech Language and Hearing Research ◽

10.1044/2017_jslhr-l-15-0415 ◽

2017 ◽

Vol 60 (12) ◽

pp. 3462-3473 ◽

Cited By ~ 6

Author(s):

Andrea Marini ◽

Milena Ruffino ◽

Maria Enrica Sali ◽

Massimo Molteni

Keyword(s):

Working Memory ◽

Family History ◽

Home Literacy Environment ◽

Home Literacy ◽

Semantic Fluency ◽

Literacy Environment ◽

Follow Up Study ◽

Late Talkers ◽

History Of

Purpose This follow-up study assessed (a) the influence of phonological working memory (pWM), home literacy environment, and a family history of linguistic impairments in late talkers (LTs); (b) the diagnostic accuracy of a task of nonword repetition (NWR) in identifying LTs; and (c) the persistence of lexical weaknesses after 10 months. Method Two hundred ninety-three children were assessed at approximately 32 (t1) and 41 (t2) months. At t1, they were administered the Italian adaptation of the Language Development Survey, an NWR task (used to assess pWM), and questionnaires assessing home literacy environment and family history of language impairments. Thirty-three LTs were identified. The linguistic skills of the participants were evaluated at t2 by administering tasks assessing Articulation, Naming, Semantic Fluency, and Lexical Comprehension. Results At t2, LTs performed more poorly as compared with age-matched typically developing peers in articulatory and naming skills, had reduced lexical comprehension abilities, and had limited lexical knowledge. Their performance on the NWR task at t1 correlated with the extension of their vocabularies at t2 (as estimated with a Semantic Fluency task). Conclusions The Language Development Survey recently adapted to Italian is sensitive to LTs. Former LTs still have a mild lexical delay at approximately 40 months. As an indirect measure of pWM, the task of NWR is an early indicator of future lexical deficits.

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S80. CHILDHOOD TRAUMA AND SOCIAL COGNITION IN DELUSIONAL PSYCHOSES

Schizophrenia Bulletin ◽

10.1093/schbul/sbaa031.146 ◽

2020 ◽

Vol 46 (Supplement_1) ◽

pp. S64-S65

Author(s):

Covadonga Díaz-Caneja ◽

Marcos González-Iglesias ◽

Victoria Del Amo ◽

Ignacio García-Cabeza ◽

Celso Arango ◽

...

Keyword(s):

Working Memory ◽

Executive Function ◽

Social Cognition ◽

Childhood Trauma ◽

Neuropsychological Functioning ◽

Attributional Bias ◽

Cohen’S D ◽

Dsm Iv ◽

The Difference ◽

Cohen's D

Abstract Background Deficits in social cognition could be involved in the pathogenesis of delusions in psychotic disorders (Bentall et al., 2009). Childhood trauma (CT) has been associated with an increased risk for psychosis (Varese et al., 2012). Neurocognitive and social cognition deficits could mediate in the association between CT and psychosis (Mansueto et al., 2019). Social cognition and childhood trauma have been understudied so far in delusional disorder (DD). We aimed to assess social cognition in a sample of patients with delusional psychoses (i.e., DD and schizophrenia) and healthy controls (HC) and to explore the potential effect of childhood trauma on social cognition and delusion. Methods This cross-sectional, transdiagnostic study included 69 patients with a DSM-IV-TR-confirmed diagnosis of DD (mean age 44.06 ± 11.39 years, 53.6% female), 77 with DSM-IV-TR-confirmed schizophrenia (mean age 38.12 ± 9.27 years, 27.3% female), and 63 HC (mean age 43.6 ± 13.0 years, 68.3% female). Attributional bias was assessed with the “Internal, Personal, and Situational Attributions Questionnaire.” Theory of Mind (ToM) performance was assessed with the “Reading the Mind in the Eyes Test” and the “Faux Pas Recognition Test.” Childhood trauma was measured with the “Childhood Trauma Questionnaire.” Neuropsychological functioning was measured with a comprehensive battery assessing attention, verbal learning, working memory, and executive function. We used ANCOVAs and linear regression analyses to assess the association between the three measures of social cognition and i) diagnosis, ii) dimensional measures of delusion proneness (Peters Delusion Inventory, PDI) and intensity (Maudsley Assessment of Delusion Schedule, MADS), and iii) childhood trauma; after controlling for potential confounders (age, sex, socioeconomic status, and estimated premorbid intelligence quotient). Results Patients with DD showed significantly poorer performance on the “Eyes Test” than HC (Cohen’s d=-0.44, p=0.037), after controlling for potential confounding variables. The difference was no longer significant after controlling for verbal memory. Patients with schizophrenia (d=-1.54, p<0.001) and DD (Cohen’s d=-0.60, p=0.002) showed significantly poorer performance than HC on the “Faux Pas Test,” after controlling for potential confounders. The difference between patients with schizophrenia and HC remained significant after controlling for neuropsychological functioning (Cohen’s d=-1.09, p<0.001), while differences between patients with DD and HC were no longer significant after controlling for executive function and working memory performance (Cohen’s d=-0.23, p=0.596). No significant differences were found between diagnostic groups in externalizing or personalizing attributional bias. In the fully adjusted models, intensity of the delusional idea was significantly associated with performance in the “Faux Pas Test” in DD, and with externalizing and personalizing attributional bias in schizophrenia. A positive history of CT was significantly associated with lower performance on the “Faux Pas Test” (Cohen’s d=-0.40, p=.022) and higher delusional proneness scores in the delusional psychosis samples (Cohen’s d=-0.49, p=.006), but not in HC. Discussion Social cognition deficits are associated with delusional intensity in delusional psychoses. Childhood trauma could increase the risk of psychosis through its effect on social cognition.

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Atypical Spatial Working Memory and Task-General Brain Activity in Adolescents with a Family History of Alcoholism

Alcoholism Clinical and Experimental Research ◽

10.1111/j.1530-0277.2012.01948.x ◽

2012 ◽

Vol 37 (3) ◽

pp. 390-398 ◽

Cited By ~ 18

Author(s):

Kristen L. Mackiewicz Seghete ◽

Anita Cservenka ◽

Megan M. Herting ◽

Bonnie J. Nagel

Keyword(s):

Working Memory ◽

Family History ◽

Spatial Working Memory ◽

Brain Activity ◽

History Of ◽

And Task

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Associations Between Family History of Substance Use, Childhood Trauma, and Age of First Drug Use in Persons With Methamphetamine Dependence

Journal of Addiction Medicine ◽

10.1097/adm.0000000000000233 ◽

2016 ◽

Vol 10 (4) ◽

pp. 269-273 ◽

Cited By ~ 10

Author(s):

Leah Svingen ◽

Rita E. Dykstra ◽

Jamie L. Simpson ◽

Anna E. Jaffe ◽

Rick A. Bevins ◽

...

Keyword(s):

Substance Use ◽

Family History ◽

Drug Use ◽

Childhood Trauma ◽

Methamphetamine Dependence ◽

History Of

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The association between childhood trauma and empathy in patients with stable schizophrenia

European Psychiatry ◽

10.1016/j.eurpsy.2016.01.606 ◽

2016 ◽

Vol 33 (S1) ◽

pp. s241-s241

Author(s):

A. Arous ◽

R. Trabelsi ◽

J. Mrizak ◽

A. Aissa ◽

H. Ben Ammar ◽

...

Keyword(s):

Sexual Abuse ◽

Childhood Trauma ◽

Perspective Taking ◽

Point Of View ◽

Affective Empathy ◽

Affective States ◽

Childhood Trauma Questionnaire ◽

History Of ◽

Physical Neglect ◽

Affective Components

IntroductionEmpathy, which refers to the ability to understand and share the thoughts and feelings of others, has emerged as an important topic in the field of social neuroscience. It is one of the most understudied dimensions of social cognition in schizophrenia (SCZ).ObjectivesTo investigate the relationship between cognitive and affective empathy and CT in SCZ.MethodsFifty-eight outpatients with stable SCZ completed the Childhood Trauma Questionnaire retrospectively assessing five types of childhood trauma (emotional, physical and sexual abuse, and emotional and physical neglect). They also completed the Questionnaire of Cognitive and Affective Empathy (QCAE) comprising five subscales intended to assess cognitive and affective components of empathy.ResultsPatients with a history of sexual abuse better emotion contagion scores (P = 0.048) which means that develop more easily self-oriented emotional state matching the affective states of others. Patients with a history of emotional neglect or/and in denial of CT had higher scores in perspective taking score (P = 0.017). Perspective taking assesses the extent to which respondents can take another's perspective or see things from another's point-of-view.ConclusionsInvestigating psychosocial mechanisms, specifically the role of CT, underlying the development of empathic capacities is important since empathy can represent a treatment-target.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Association Between Plasma Homocysteine Levels and Cognitive Deficits in Han Chinese Patients with Schizophrenia across Age Groups

10.21203/rs.3.rs-226210/v1 ◽

2021 ◽

Author(s):

Sumiao Zhou ◽

Yuanyuan Huang ◽

Yangdong Feng ◽

Hehua Li ◽

Kai Wu ◽

...

Keyword(s):

Working Memory ◽

Cognitive Function ◽

Learning And Memory ◽

Cognitive Deficits ◽

Visual Learning ◽

Verbal Learning ◽

Age Groups ◽

Speed Of Processing ◽

Function Score ◽

Cognitive Function Score

Abstract Background: It was still unclear how homocysteine (Hcy) levels and cognitive deficits change in patients with schizophrenia of various ages. The present article attempts to assess the relationship between Hcy levels and cognitive deficits in patients with schizophrenia across age groups, especially in young people.Methods: Totals of 103 patients and 122 healthy controls were included. All participants were stratified into four groups according to their age: 18-29 years, 30-39 years, 40-49 years, and 50-59 years. Clinical data, plasma Hcy levels, and cognitive function score were collected. Cognitive function was evaluated using the MATRICS Consensus Cognitive Battery of tests assessing speed of processing, verbal learning and memory, visual learning and memory, working memory, and attention/vigilance.Results: Compared with the healthy group, Hcy levels increased significantly, and all the measured cognitive function score were significantly lower in all age groups of patients with schizophrenia (p < 0.001). Hcy levels were negatively associated with speed of processing (SoP), working memory (WM), and visual learning and memory (Vis Lrng) score in 18-29 years. Further multiple regression analysis showed that SoP were independently associated with Hcy levels in patients with schizophrenia aged 18-29 years (B = 0.61, t = 3.17, p = 0.013).Conclusions: Based on our results, patients with schizophrenia performed worse on cognitive assessments and Hcy levels were more closely related to cognition in young patients.

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Genetic contribution to variation in atherothrombotic phenotypes in the Asian Indian population

Thrombosis and Haemostasis ◽

10.1160/th08-01-0018 ◽

2009 ◽

Vol 102 (08) ◽

pp. 379-388 ◽

Cited By ~ 5

Author(s):

Natesha Khadrinarasimhaih ◽

Saikat Kanjilal ◽

Manjari Mukerjee ◽

Vijay Kakkar ◽

Veena Rao

Keyword(s):

Risk Factors ◽

Family History ◽

Interleukin 6 ◽

Indian Population ◽

Environment Interaction ◽

Parental History ◽

Pair Correlations ◽

Lipoprotein A ◽

History Of ◽

Family Based

SummaryCoronary artery disease (CAD) is a multifactorial disease, and family history is the best available tool to assess gene-environment interaction. This study addressed the heritability of quantitative traits, namely lipid, coagulation/fibrinolysis and pro-inflammatory markers in the ongoing family-based Indian Atherosclerosis Research Study and assessed the effect of the type/lineage of CAD family history on inheritance patterns in the highrisk Indian population. A total of 518 families comprising 2,305 individuals were recruited in phase I of the IARS; of these, 1,195 individuals from 220 families were included in the heritability analysis. With the exception of leptin, all phenotypes exhibited significant age- and sex-adjusted heritability (p<0.0001). Amongst all the phenotypes analysed after adjustment for confounding factors, the significantly higher heritability estimates of triglycerides (0.53, p<0.0001), lipoprotein (a) (0.83, p<0.0001) and interleukin-6 (0.46, p<0.0001) with low spouse pair correlations identifies them as possible CAD risk factors. Families with parental history of CAD had onset of CAD symptoms at much younger ages with significantly higher heritability of proinflammatory markers, whereas in families with sibling history of CAD, more risk factors were present at significantly higher levels. Triglycerides, lipoprotein (a) and interleukin-6 appear to be promising atherothrombotic candidate phenotypes in this population. Genes controlling these phenotypes are possible candidate genes linked with CAD. An informed understanding and incorporation of ‘family history’ as a screening tool may help in the prevention and pre-emption of CAD.

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Family History of Alcohol and Drug Abuse, Childhood Trauma, and Age of First Drug Injection

Substance Use & Misuse ◽

10.3109/10826084.2014.901383 ◽

2014 ◽

Vol 49 (10) ◽

pp. 1311-1316 ◽

Cited By ~ 34

Author(s):

Chris Taplin ◽

Sahoo Saddichha ◽

Kathy Li ◽

Michael R. Krausz

Keyword(s):

Drug Abuse ◽

Family History ◽

Childhood Trauma ◽

Drug Injection ◽

History Of ◽

Alcohol And Drug Abuse

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Intergeneration Transmission of Violence in Forensic Patients With a Diagnosis of Schizophrenia and Psychosis: Was Parental Alcoholic Abuse a Significant Factor?

Frontiers in Psychiatry ◽

10.3389/fpsyt.2021.765279 ◽

2021 ◽

Vol 12 ◽

Author(s):

Milena Petrovic ◽

Lidija Injac Stevovic

Keyword(s):

Mental Illness ◽

Family History ◽

Alcohol Abuse ◽

Childhood Trauma ◽

Psychotic Disorders ◽

Violent Behavior ◽

Traumatic Events ◽

History Of ◽

The Impact ◽

Parental Alcohol

Background: Child abuse during childhood and the presence of parental alcohol abuse increase the risk of developing mental illness in children, as well as the risk of violent behavior in adulthood. The association of these factors has not been sufficiently investigated when it comes to forensic mental patients. In this study, we examined the impact of traumatic events in childhood and the presence of mental illness and alcohol abuse of parents in subjects with psychosis and schizophrenia who committed serious crimes.Methods: One-hundred and forty-three respondents were included in the current study. Information on childhood abuse was collected by Childhood Trauma Questionnaire (CTQ). The sample included participants diagnosed with psychotic disorders and schizophrenia with a history of violent behavior (PSCH-V, n = 20), patients diagnosed with psychotic disorders and schizophrenia without a history of violent behavior (Non-V-PSCH, n = 51), and healthy control patients (HC, n = 72). Participants were diagnosed according to the ICD 10 classification system. MINI and CAINS scales were used to confirm the diagnosis. Data on sociodemographic and clinical characteristics were collected. Differences between groups in terms of traumatic events in childhood as well as parental alcohol abuse are presented and analyzed, using descriptive statistical values and nonparametric techniques of inferential statistics.Results: Statistically significant differences were obtained for total scores (χ2 = 28.522, p < 0.001) as well as for (1) major upheaval between the parents (χ2 = 20.739, p < 0.001), (2) being victim of violence—other than sexual (χ2 = 12.701, p < 0.01), and (3) other major upheaval that may have shaped life or personality significantly (χ2 = 30.920, p < 0.001). PSCH-V, compared to HC, had greater exposure to all of the three domains of childhood trauma (U = 396.500, 436.500, and 376.000, respectively; p < 0.001). Similar results were obtained when Non V-PSCH were compared with HC (U = 1,223.000, 1,535.000, and 999.000, respectively; p < 0.001). The results indicated statistically insignificant differences between PSCH-V and Non-V-PSCH in having a family history of mental illness. On the other hand, family history of mental illness was less present in HC compared to PSCH-V (χ2 = 24.238, p < 0.001) and Non V-PSCH (χ2 = 14.456, p < 0.001). The presence of parental alcohol abuse was predominantly present in the PSCH-V group (60%) while a significantly lower presence was found in the Non-V PSCH group (35%) and HC (5.5%).Conclusion: Both PSCH-V and Non-V-PSCH groups had a high degree of exposure to traumatic events in childhood compared to the HC. In PSCH-V, the presence of parental alcohol abuse compared to Non-V-PSCH was dominant. Mental illness coupled with a history of violent behavior represents a factor of polyvictimization, which may increase the likelihood of violent behavior of offspring.

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