LRRK2 Gene Variants Associated With a Higher Risk for Alcohol Dependence in Multiethnic Populations

Background: Genetics influence the vulnerability to alcohol use disorders, and among the implicated genes, three previous studies have provided evidences for the involvement of LRRK2 in alcohol dependence (AD). LRRK2 expression is broadly dysregulated in postmortem brain from AD humans, as well as in the brain of mice with alcohol dependent-like behaviors and in a zebrafish model of alcohol preference. The aim of the present study was to evaluate the association of variants in the LRRK2 gene with AD in multiethnic populations from South and North America.Methods: Alcohol-screening questionnaires [such as CAGE and Alcohol Use Disorders Identification Test (AUDIT)] were used to determine individual risk of AD. Multivariate logistic regression analyses were done in three independent populations (898 individuals from Bambuí, Brazil; 3,015 individuals from Pelotas, Brazil; and 1,316 from the United States). Linkage disequilibrium and conditional analyses, as well as in silico functional analyses, were also conducted.Results: Four LRRK2 variants were significantly associated with AD in our discovery cohort (Bambuí): rs4768231, rs4767971, rs7307310, and rs1465527. Two of these variants (rs4768231 and rs4767971) were replicated in both Pelotas and US cohorts. The consistent association signal (at the LRRK2 locus) found in populations with different genetic backgrounds reinforces the relevance of our findings.Conclusion: Taken together, these results support the notion that genetic variants in the LRRK2 locus are risk factors for AD in humans.

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Approval of Baclofen for Alcohol Use Disorders in France: A Perspective From the United States

Alcohol and Alcoholism ◽

10.1093/alcalc/agz084 ◽

2019 ◽

Vol 55 (1) ◽

pp. 48-48

Author(s):

James C Garbutt

Keyword(s):

United States ◽

Alcohol Use ◽

Alcohol Use Disorders ◽

The United States

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Gender-specific risk relationship between heavy alcohol use/alcohol use disorders and suicidal thoughts and behavior among adults in the United States over time

Social Psychiatry and Psychiatric Epidemiology ◽

10.1007/s00127-022-02225-x ◽

2022 ◽

Author(s):

Shannon Lange ◽

Huan Jiang ◽

Courtney Bagge ◽

Charlotte Probst ◽

Alexander Tran ◽

...

Keyword(s):

United States ◽

Alcohol Use ◽

Alcohol Use Disorders ◽

The United States ◽

Suicidal Thoughts ◽

Heavy Alcohol ◽

Heavy Alcohol Use ◽

And Behavior ◽

Gender Specific ◽

Over Time

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A Cross-Sectional Comparison of Drinking Patterns, Alcohol Use and Related Medical Morbidities in a Secondary Versus Tertiary Setting

Kathmandu University Medical Journal ◽

10.3126/kumj.v11i2.12492 ◽

2015 ◽

Vol 11 (2) ◽

pp. 152-157

Author(s):

A Risal ◽

H Tharoor

Keyword(s):

Alcohol Use ◽

Alcohol Dependence ◽

Tertiary Care ◽

Alcohol Use Disorders ◽

Care Utilization ◽

Drinking Patterns ◽

Tertiary Care Centre ◽

Cross Sectional ◽

Patterns Of Drinking ◽

Level Hospital

Background Alcohol Dependence exists in different spectrums at different settings and associated with various medical morbidities, disability and health care utilization costs. Objectives To study the drinking patterns, alcohol use disorders and alcohol related medical morbidities in patients diagnosed with Alcohol Dependence Syndrome (ADS) and attending out / in-patient psychiatry services at secondary and tertiary care centre. Methods A cross-sectional comparative study was done among the patients diagnosed with ADS attending psychiatry services at District hospital, Udupi and Kasturba Hospital, Manipal. Serial sampling was done. Patients having any other psychiatric illnesses were excluded. The two groups were compared in relation to socio-demographic variables, drinking related variables, patterns of drinking and alcohol related medical morbidities identified. Results Significant differences in some socio-demographic parameters among the patients from the two different treatment centers were found with secondary level hospital (N=50) having more illiterate, laborers and below the poverty line population in comparison to the tertiary level hospital (N=75). Maximum frequency of gastro-intestinal morbidities was seen in both the hospital population, irrespective of the patterns of drinking. Conclusion Alcohol use disorders and alcohol related medical morbidities show some variations in their presentations in the different treatment centers. DOI: http://dx.doi.org/10.3126/kumj.v11i2.12492 Kathmandu University Medical Journal Vol.11(2) 2013: 152-157

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Toward the prevention of alcohol use disorders: Overdrinking (unintentional binge drinking) in a community sample

Health Psychology Open ◽

10.1177/2055102918792705 ◽

2018 ◽

Vol 5 (2) ◽

pp. 205510291879270 ◽

Cited By ~ 1

Author(s):

F Michler Bishop ◽

Jose Luis Rodriquez Orjuela

Keyword(s):

United States ◽

Pilot Study ◽

Alcohol Use ◽

Binge Drinking ◽

Alcohol Use Disorder ◽

Problem Drinking ◽

Community Sample ◽

Alcohol Use Disorders ◽

The United States ◽

The Past

Approximately 64,000,000 people in the United States report binge drinking at least once in the past month. Unlike overeating and oversleeping, “overdrinking”—defined as drinking more than a person intends to drink—does not exist in the literature. Terms such as binge and problem drinking do not consider the intent of the drinker. The results of this pilot study suggest that most people drink more than they intend to drink. Moreover, they also report often being surprised that they overdrank. Smartphones may help overdrinkers be less often surprised by overdrinking and may prevent drinkers from developing an alcohol use disorder.

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Evaluation of childhood traumatic experience as a risk factor for alcohol use disorder in adulthood

BMC Psychiatry ◽

10.1186/s12888-020-2428-5 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Lan Wang ◽

Cui-Xia An ◽

Mei Song ◽

Na Li ◽

Yuan-Yuan Gao ◽

...

Keyword(s):

Risk Factors ◽

Alcohol Use ◽

Alcohol Abuse ◽

Alcohol Dependence ◽

Physical Abuse ◽

Emotional Abuse ◽

Alcohol Use Disorder ◽

Alcohol Use Disorders ◽

Traumatic Experience ◽

Frequent Drinking

Abstract Background We aimed to investigate the effect of early-age (prenatal, infant, and childhood) trauma on adulthood alcohol use disorder. Methods A total number of 1534 subjects who were born and live in the city of Tangshan were selected. The subjects were divided into three age groups. General demographic data, conditions of the mothers during pregnancy, and condition of the babies at birth, were collected. The diagnosis of alcohol use disorder was based on Structured Clinical Interviews for DSM-IV Axis Disorders (patient version) (SCID). The childhood trauma questionnaire short form (CTQ-SF) [1] and the Lifetime of Experience Questionnaire (LTE-Q) [2] were used to evaluate stress in childhood and adulthood, respectively. Results Only male subjects were diagnosed with lifelong alcohol abuse and alcohol dependence. There was no statistically significant difference in the prevalence of lifetime alcohol use disorder (X2 = 4.480, P = 0.345), current alcohol abuse, and current alcohol dependence among the three groups (X2abuse = 2.177, X2depedence = 2.198, P > 0.05). However, higher prevalence of lifetime alcohol use disorders was found in group with higher scores of CTQ (X2 = 9.315, P = 0.009), emotional abuse (X2 = 8.025, P = 0.018), physical abuse (X2 = 20.4080, P < 0.001), but not in the group with higher scores of emotional neglect (X2 = 1.226, P = 0.542), sexual abuse (X2 = 2.779, P = 0.249), physical neglect (X2 = 3.978, P = 0.137), LTE-Q (X2 = 5.415, P = 0.067), and PSQI (X2 = 5.238, P = 0.073). Protective factor for alcohol abuse for men was identified to be heavy drinking (OR = 0.085, 95%CI: 0.011–0.661), and the risk factors for alcohol abuse were identified to be frequent drinking (OR = 2.736, 95%CI: 1.500, 4.988), and consumption of low liquor (OR = 2.563, 95%CI: 1.387, 4.734). Risk factors for alcohol dependence in males were identified to be consumption of low liquor (OR = 5.501, 95%CI: 2.004, 15.103), frequent drinking (OR = 2.680, 95%CI: 1.164, 6.170), and childhood physical abuse (OR = 2.310, 95% CI: 1.026, 5.201). Conclusion Traumatic experience during infant and prenatal periods does not have a strong statistical correlation with alcohol use disorders for male adults. However, subjects with high CTQ scores, experience of emotional abuse and physical abuse show a statistically higher prevalence of lifetime alcohol use disorders. Several risk factors including consumption of low liquor, frequent drinking, and childhood physical abuse contribute to alcohol dependence in male adults.

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