scholarly journals Behavioral Economic Assessment of Alcohol and Cigarette Demand in Smokers With Alcohol Use Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
Yong Cui ◽  
Paulina Linares Abrego ◽  
Jin Ho Yoon ◽  
Maher Karam-Hage ◽  
Paul M. Cinciripini ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Principal Component ◽  
Economic Assessment ◽  
Behavioral Economic ◽  
Substance Exposure ◽  
Cigarette Demand ◽  
Alcohol Demand ◽  
Quitting Smoking ◽  
Response Output

Background and Objectives: Behavioral economic purchase tasks are widely used to assess drug demand in substance use disorder research. Comorbid alcohol use is common among cigarette smokers and associated with greater difficulty in quitting smoking. However, demand for alcohol and cigarettes in this population has not been fully characterized. The present study addressed this gap by examining alcohol and cigarette demand among treatment-seeking smokers with alcohol use disorder (AUD).Methods: Alcohol and cigarette demand was assessed among 99 smokers with AUD. We conducted Principal Component Analysis (PCA) and correlational analyses on the demand indices.Results: Participants showed higher demand for alcohol than for cigarettes, as evidenced lower elasticity (resistance to increasing price) and higher Omax (maximum response output for drug). PCA revealed a two-factor structure (Persistence and Amplitude) for both alcohol and cigarette demand indices. Cigarette-related demand indices were positively correlated with nicotine dependence, but alcohol-related demand indices were not associated with alcohol dependence, suggesting dissociation between alcohol demand and use behaviors.Discussion and Conclusions: Our results suggest that smokers with AUD were more resistant to price elevations in relation to reducing alcohol consumption as compared to cigarette consumption, suggesting preferential demand for alcohol over cigarettes. However, it is unclear how acute substance exposure/withdrawal impacts the demand indices.Scientific Significance: Potentially differential alcohol and cigarette demands among smokers with AUD should be considered in the concurrent treatment of smoking and alcohol.

scholarly journals Polygenic risk prediction based on singular value decomposition with applications to alcohol use disorder

2022 ◽  
Vol 23 (1) ◽  
Author(s):  
James J. Yang ◽  
Xi Luo ◽  
Elisa M. Trucco ◽  
Anne Buu
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Large Scale ◽  
Methodological Issue ◽  
Secondary Data ◽  
Principal Component ◽  
Polygenic Risk Score ◽  
Adult Health ◽  
Polygenic Risk ◽  
Target Data

Abstract Background/aim The polygenic risk score (PRS) shows promise as a potentially effective approach to summarize genetic risk for complex diseases such as alcohol use disorder that is influenced by a combination of multiple variants, each of which has a very small effect. Yet, conventional PRS methods tend to over-adjust confounding factors in the discovery sample and thus have low power to predict the phenotype in the target sample. This study aims to address this important methodological issue. Methods This study proposed a new method to construct PRS by (1) approximating the polygenic model using a few principal components selected based on eigen-correlation in the discovery data; and (2) conducting principal component projection on the target data. Secondary data analysis was conducted on two large scale databases: the Study of Addiction: Genetics and Environment (SAGE; discovery data) and the National Longitudinal Study of Adolescent to Adult Health (Add Health; target data) to compare performance of the conventional and proposed methods. Result and conclusion The results show that the proposed method has higher prediction power and can handle participants from different ancestry backgrounds. We also provide practical recommendations for setting the linkage disequilibrium (LD) and p value thresholds.

scholarly journals Pilot trial investigating a brief behavioral economic intervention as an adjunctive treatment for alcohol use disorder

2020 ◽  
Vol 113 ◽  
pp. 108002 ◽  
Author(s):  
Lidia Z. Meshesha ◽  
Kathryn E. Soltis ◽  
Edward A. Wise ◽  
Damaris J. Rohsenow ◽  
Katie Witkiewitz ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Pilot Trial ◽  
Adjunctive Treatment ◽  
Behavioral Economic

scholarly journals Validation of the AUDIT scale and factors associated with alcohol use disorder in adolescents: results of a national Lebanese study

2020 ◽  
Author(s):  
Jennyfer Hallit ◽  
Pascale Salameh ◽  
Chadia Haddad ◽  
Hala Sacre ◽  
Michel Soufia ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Alcohol Use ◽  
Alcohol Dependence ◽  
Internet Addiction ◽  
Alcohol Use Disorder ◽  
Principal Component ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Study Objective ◽  
Audit Score

Abstract Background This study objective was to evaluate the prevalence as well as factors (smoking, internet addiction, social phobia, depression, child abuse and bullying) associated with alcohol use disorder among a representative sample of Lebanese young people, in addition to validating and confirming psychometric properties of the AUDIT scale. Methods A cross-sectional study, conducted between January and May 2019, enrolled 1810 adolescents aged between 14 and 17. Alcohol dependence was defined as a high AUDIT score. A principal component analysis technique to confirm the validity of the construct of the AUDIT scale score was done and a confirmatory analysis to assess the structure of the instrument was conducted. Results The mean AUDIT score was 6.46 ± 8.44 and high risk of hazardous alcohol drinking was found in 28% of adolescents. One factor solution of the AUDIT scale had been found after running the factor analysis and the confirmatory factor analysis demonstrated that the χ2/df=2.4, the Steiger-Lind RMSEA was 0.10 [0.084-0.155] and the Joreskog GFI equaled 0.91 and AGFI equaled 0.92. Higher cigarette (Beta=0.372) and waterpipe (Beta=0.319) dependence, higher child sexual (Beta=0.581) and neglect (Beta=0.106) abuse, higher internet addiction (Beta=0.088), separated parents compared to living together (Beta=3.202) and higher bullying victimization (Beta=0.143) were significantly associated with higher AUDIT scores. Conclusion Alcohol dependence seems to be influenced by several risk factors among the Lebanese adolescents such as cigarette and waterpipe dependence, higher internet addiction, bullying, and child sexual and neglect abuse. Parents and healthcare professionals could use this data to influence intervention efforts.

scholarly journals Behavioral Economic Demand for Alcohol and Cigarettes in Heavy Drinking Smokers: Evidence of Asymmetric Cross-commodity Reinforcing Value

2020 ◽  
Author(s):  
ReJoyce Green ◽  
James MacKillop ◽  
Emily E Hartwell ◽  
Aaron C Lim ◽  
Wave-Ananda Baskerville ◽  
...  
Keyword(s):  
Clinical Sample ◽  
Community Sample ◽  
Heavy Drinking ◽  
The Other ◽  
Cigarette Use ◽  
Latent Factors ◽  
Behavioral Economic ◽  
Cigarette Demand ◽  
Alcohol Demand ◽  
Alcohol Purchase Task

Abstract Introduction Previous studies have highlighted a strong bidirectional relationship between cigarette and alcohol consumption. To advance our understanding of this relationship the present study uses a behavioral economic approach in a community sample (N = 383) of nontreatment seeking heavy drinking smokers. Aims and Methods The aims were to examine same-substance and cross-substance relationships between alcohol and cigarette use, and latent factors of demand. A community sample of nontreatment seeking heavy drinking smokers completed an in-person assessment battery including measures of alcohol and tobacco use as well as the Cigarette Purchase Task and the Alcohol Purchase Task. Latent factors of demand were derived from these hypothetical purchase tasks. Results Results revealed a positive correlation between paired alcohol and cigarette demand indices (eg, correlation between alcohol intensity and cigarette intensity) (rs = 0.18–0.46, p ≤ .003). Over and above alcohol factors, cigarette use variables (eg, Fagerström Test for Nicotine Dependence and cigarettes per smoking day) significantly predicted an additional 4.5% (p < .01) of the variance in Persistence values but not Amplitude values for alcohol. Over and above cigarette factors, alcohol use variables predicted cigarette Persistence values (ΔR2 = .013, p = .05), however, did not predict Amplitude values. Conclusions These results advance our understanding of the overlap between cigarette and alcohol by demonstrating that involvement with one substance was associated with demand for the other substance. This asymmetric profile—from smoking to alcohol demand, but not vice versa—suggests that it is not simply tapping into a generally higher reward sensitivity and warrants further investigation. Implications To our knowledge, no study to date has examined alcohol and cigarette demand, via hypothetical purchase tasks, in a clinical sample of heavy drinking smokers. This study demonstrates that behavioral economic indices may be sensitive to cross-substance relationships and specifically that such relationships are asymmetrically stronger for smoking variables affecting alcohol demand, not the other way around.

scholarly journals Associations between the Brief Assessment of Alcohol Demand (BAAD) questionnaire and alcohol use disorder severity in UK samples of student and community drinkers

2021 ◽  
Vol 113 ◽  
pp. 106724
Author(s):  
Lorna Hardy ◽  
Alexandra E. Bakou ◽  
Ruichong Shuai ◽  
Samuel F. Acuff ◽  
James MacKillop ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Brief Assessment ◽  
Alcohol Demand

DSM-5 alcohol use disorder features among treatment-seeking older adults

2018 ◽  
Vol 64 (4) ◽  
pp. 185-196 ◽  
Author(s):  
Silke Behrendt ◽  
Barbara Braun ◽  
Randi Bilberg ◽  
Gerhard Bühringer ◽  
Michael Bogenschutz ◽  
...  
Keyword(s):  
Older Adults ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
The Elderly ◽  
Treatment Seeking ◽  
Controlled Clinical Trial ◽  
Dsm 5 ◽  
Wide Range ◽  
And Gender ◽  
International Multicenter

Abstract. Background: The number of older adults with alcohol use disorder (AUD) is expected to rise. Adapted treatments for this group are lacking and information on AUD features in treatment seeking older adults is scarce. The international multicenter randomized-controlled clinical trial “ELDERLY-Study” with few exclusion criteria was conducted to investigate two outpatient AUD-treatments for adults aged 60+ with DSM-5 AUD. Aims: To add to 1) basic methodological information on the ELDERLY-Study by providing information on AUD features in ELDERLY-participants taking into account country and gender, and 2) knowledge on AUD features in older adults seeking outpatient treatment. Methods: baseline data from the German and Danish ELDERLY-sites (n=544) were used. AUD diagnoses were obtained with the Mini International Neuropsychiatric Interview, alcohol use information with Form 90. Results: Lost control, desired control, mental/physical problem, and craving were the most prevalent (> 70 %) AUD-symptoms. 54.9 % reported severe DSM-5 AUD (moderate: 28.2 %, mild: 16.9 %). Mean daily alcohol use was 6.3 drinks at 12 grams ethanol each. 93.9 % reported binging. More intense alcohol use was associated with greater AUD-severity and male gender. Country effects showed for alcohol use and AUD-severity. Conclusion: European ELDERLY-participants presented typical dependence symptoms, a wide range of severity, and intense alcohol use. This may underline the clinical significance of AUD in treatment-seeking seniors.

Persönliche vs. computerbasierte Alkoholintervention für Krankenhauspatienten: Studiendesign

2015 ◽  
Vol 61 (6) ◽  
pp. 347-355 ◽  
Author(s):  
Jennis Freyer-Adam ◽  
Sophie Baumann ◽  
Inga Schnuerer ◽  
Katja Haberecht ◽  
Ulrich John ◽  
...  
Keyword(s):  
Public Health ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Identification Test ◽  
Disorder Identification

Zusammenfassung. Ziel: Persönliche Beratungen können bei stationären Krankenhauspatienten Alkoholkonsum und Mortalität reduzieren. Sie sind jedoch mit hohen Kosten verbunden, wenn aus Public-Health-Erfordernis viele Menschen einer Bevölkerung erreicht werden müssen. Computerbasierte Interventionen stellen eine Alternative dar. Jedoch ist ihre Wirksamkeit im Vergleich zu persönlichen Beratungen und im Allgemeinkrankenhaus noch unklar. Eine quasi-randomisierte Kontrollgruppenstudie „Die Bedeutung der Vermittlungsform für Alkoholinterventionen bei Allgemeinkrankenhauspatienten: Persönlich vs. Computerisiert“ soll dies untersuchen. Design und Methoden werden beschrieben. Methode: Über 18 Monate sind alle 18- bis 64-jährigen Patienten auf Stationen der Universitätsmedizin Greifswald mittels Alcohol Use Disorder Identification Test (AUDIT) zu screenen. Frauen/Männer mit AUDIT-Consumption ≥ 4/5 und AUDIT < 20 werden einer von drei Gruppen zugeordnet: persönliche Intervention (Beratungen zur Konsumreduktion), computerbasierte Intervention (individualisierte Rückmeldebriefe und Broschüren) und Kontrollgruppe. Beide Interventionen erfolgen im Krankenhaus sowie telefonisch bzw. postalisch nach 1 und 3 Monaten. In computergestützten Telefoninterviews nach 6, 12, 18 und 24 Monaten wird Alkoholkonsum erfragt. Schlussfolgerung: Das Studienvorhaben, sofern erfolgreich umgesetzt, ist geeignet die längerfristige Wirksamkeit einer persönlichen und computerbasierten Intervention im Vergleich zu untersuchen.

Sign in / Sign up

Export Citation Format

Share Document