Prediction of Clinical Outcomes With EEG Microstate in Patients With Major Depressive Disorder

Background: The difficulty in timely evaluating patient response to antidepressants has brought great challenge to the treatment of major depressive disorder (MDD). Some studies found that the electroencephalogram (EEG) microstates might be a reliable marker to evaluate patient response to treatment. The present study aims to evaluate the relationship between EEG microstate parameters and MDD symptoms before and after treatment to identify predictive biological markers for patient response.Methods: Thirty drug-naïve MDD patients (20 females and 10 males) were enrolled in this study. All the patients received effective dosages of selective serotonin reuptake inhibitors, and EEG recordings were collected at baseline and 2 weeks of treatment. Brain activities during the eyes-closed state were recorded using 64-channel electroencephalography, and the patients' microstates were clustered into four maps according to their topography (labeled A, B, C, and D). The differences of EEG microstates before and after treatment were compared using paired t-test. Spearman correlation coefficients were calculated to identify the relationships between the improvement of depression and anxiety symptoms and microstate parameters.Results: The mean duration (69.67 ± 10.33 vs. 64.00 ± 7.70, p < 0.001) and occurrence (4.06 ± 0.69, vs. 3.69 ± 0.70, p = 0.002) of microstate B decreased significantly after treatment. The proportion of microstate B also decreased (27.53 ± 5.81, vs. 23.23 ± 4.61, p < 0.001), while the occurrence of microstate A increased after treatment. A significant negative correlation was found between the change of score of Hamilton Rating Scale for Anxiety and the increase of the occurrence of microstate A (r = −0.431, p < 0.05) after 2 weeks of treatment. The reduction of the duration of microstate B was found to be predictive of patient response to antidepressants after 3 months.Conclusion: This study explored the relationship between changes of EEG microstates and patient response to antidepressants. Depression symptoms might be associated with the duration of microstate B and anxiety symptoms related to the occurrence of microstate A. Therefore, the duration of microstate B and the occurrence of microstate A are potential biological markers for MDD patients' early response and further clinical outcomes.

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The Relationship Between Depression Symptoms and Anxiety Symptoms During Acute ECT for Patients With Major Depressive Disorder

The International Journal of Neuropsychopharmacology ◽

10.1093/ijnp/pyz038 ◽

2019 ◽

Author(s):

Chun-Jen Huang ◽

Ching-Hua Lin ◽

Jyh-I Wu ◽

Wei-Cheng Yang

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Electroconvulsive Therapy ◽

Goodness Of Fit ◽

Rating Scale ◽

Anxiety Symptoms ◽

Depression Symptoms ◽

Major Depressive ◽

Chi Square ◽

Hamilton Depression Rating Scale

AbstractBackgroundWe investigated the efficacy of electroconvulsive therapy in patients with major depressive disorder and concomitant anxiety symptoms and explored the relationships between depression symptoms and anxiety symptoms during acute electroconvulsive therapy.MethodsMajor depressive disorder inpatients (N = 130) requiring electroconvulsive therapy were recruited for a maximum of 12 treatments each. Depression symptoms, using the core factor subscale derived from the 17-item Hamilton Depression Rating Scale, and anxiety symptoms, using the anxiety/somatization subscale from the Hamilton Depression Rating Scale-17, were assessed before electroconvulsive therapy, after every 3 electroconvulsive therapy treatments, and after the final electroconvulsive therapy. Both core factor subscale and anxiety/somatization subscale scores were converted to T-score units to compare the degrees of changes between depression symptoms and anxiety symptoms after electroconvulsive therapy. The relationships between core factor subscale and anxiety/somatization subscale were analyzed using the cross-lagged longitudinal model during acute electroconvulsive therapy.ResultsA total 116 patients who completed at least the first 3 electroconvulsive therapy treatments were included in the analysis. Reduction of core factor scale T-scores was significantly greater than that of anxiety/somatization subscale T-scores. The model satisfied all indices of goodness-of-fit (chi-square = 30.204, df = 24, P = 0.178, Tucker-Lewis Index = 0.976, Comparative Fit Index = 0.989, Root Mean Square Error of Approximation = 0.047). Core factor subscale changes did not definitely predict subsequent anxiety/somatization subscale changes.ConclusionsElectroconvulsive therapy is effective in the acute treatment of major depressive disorder patients associated with anxiety symptoms. Anxiety symptoms improved less than depression symptoms during acute electroconvulsive therapy. However, earlier reduction in depression symptoms does not definitely drive subsequent relief in anxiety symptoms.

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The role of leptin mediating the relationship between ‘Somatic Anxiety’ symptoms and major depressive disorder

10.21203/rs.2.17147/v1 ◽

2019 ◽

Author(s):

Fei Wang ◽

Yue Zhu ◽

Yange Wei ◽

Jia Duan ◽

Ran Zhang ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Emotional Processing ◽

Clinical Symptoms ◽

Anxiety Symptoms ◽

Clinical State ◽

Major Depressive ◽

Somatic Anxiety ◽

Drug Naïve ◽

The Relationship

Abstract Background：Leptin is a multifunctional hormone with influences on neural circuitry in emotional processing, and it may play a role in the pathophysiology of major depressive disorder (MDD). In this study, we aimed to investigate whether leptin levels were differentiated in patients with MDD and those at genetic high risk of MDD (GHR-MDD) and the relationship between leptin and clinical symptoms. Methods: Participants (18 drug-naïve MDD, 15 GHR-MDD and 40 healthy controls) completed clinical assessments and provided blood samples for measurement of leptin levels. Leptin levels were compared across all groups and associations between leptin and clinical symptoms were explored and mediation models tested. Results: We found that leptin was increased in MDD. We also found a correlation between leptin and ‘Somatic Anxiety’ symptoms in MDD and that leptin was a significant and independent mediator of clinical state and ‘Somatic Anxiety’ symptoms. Conclusions: MDD patients occured with dysregulation of leptin. Additionally, there was a correlation between leptin and ‘Somatic Anxiety’ symptoms in MDD. The finding of leptin as a significant and independent mediator of clinical state and ‘Somatic Anxiety’ symptoms suggested leptin plays an indirect effect in somatic depressive symptoms in MDD.

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Study of the relationship between episodic memory performance and hippocampal subfield volumes in major depressive disorder

PsycEXTRA Dataset ◽

10.1037/e534982014-059 ◽

2013 ◽

Author(s):

N. V. Malykhin ◽

S. Travis ◽

Y. Huang ◽

N. J. Coupland ◽

P. Silverstone ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Episodic Memory ◽

Memory Performance ◽

Major Depressive ◽

The Relationship

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Quetiapine - adjunctive treatment of Major depressive disorder with anxiety symptoms

10.26226/morressier.5971be83d462b80290b53094 ◽

2017 ◽

Author(s):

Srebrenka Bise

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Anxiety Symptoms ◽

Adjunctive Treatment ◽

Major Depressive

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Comparison of clinical outcomes with two Transcranial Magnetic Stimulation treatment protocols for major depressive disorder

Brain Stimulation ◽

10.1016/j.brs.2020.12.003 ◽

2021 ◽

Vol 14 (1) ◽

pp. 173-180

Author(s):

LindaL. Carpenter ◽

ScottT. Aaronson ◽

Todd M. Hutton ◽

Miriam Mina ◽

Kenneth Pages ◽

...

Keyword(s):

Major Depressive Disorder ◽

Transcranial Magnetic Stimulation ◽

Depressive Disorder ◽

Clinical Outcomes ◽

Magnetic Stimulation ◽

Major Depressive ◽

Treatment Protocols

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The Symptom Structure of Postdisaster Major Depression: Convergence of Evidence from 11 Disaster Studies Using Consistent Methods

Behavioral Sciences ◽

10.3390/bs11010008 ◽

2021 ◽

Vol 11 (1) ◽

pp. 8

Author(s):

Carol S. North ◽

David Baron

Keyword(s):

Major Depressive Disorder ◽

Major Depression ◽

Depressive Disorder ◽

Diagnostic Assessment ◽

Self Report ◽

Depression Symptoms ◽

Symptom Scale ◽

Major Depressive ◽

Report Symptom ◽

Symptom Patterns

Agreement has not been achieved across symptom factor studies of major depressive disorder, and no studies have identified characteristic postdisaster depressive symptom structures. This study examined the symptom structure of major depression across two databases of 1181 survivors of 11 disasters studied using consistent research methods and full diagnostic assessment, addressing limitations of prior self-report symptom-scale studies. The sample included 808 directly-exposed survivors of 10 disasters assessed 1–6 months post disaster and 373 employees of 8 organizations affected by the September 11, 2001 terrorist attacks assessed nearly 3 years after the attacks. Consistent symptom patterns identifying postdisaster major depression were not found across the 2 databases, and database factor analyses suggested a cohesive grouping of depression symptoms. In conclusion, this study did not find symptom clusters identifying postdisaster major depression to guide the construction and validation of screeners for this disorder. A full diagnostic assessment for identification of postdisaster major depressive disorder remains necessary.

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The relationship of olfactory function and clinical traits in major depressive disorder

Behavioural Brain Research ◽

10.1016/j.bbr.2020.112594 ◽

2020 ◽

Vol 386 ◽

pp. 112594

Author(s):

Fang Wang ◽

Xiaohui Wu ◽

Jerry Gao ◽

Yongchao Li ◽

Yuncheng Zhu ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Olfactory Function ◽

Major Depressive ◽

Relationship Of ◽

The Relationship

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The relationship between loneliness and working-memory-related frontoparietal network connectivity in people with major depressive disorder

Behavioural Brain Research ◽

10.1016/j.bbr.2020.112776 ◽

2020 ◽

Vol 393 ◽

pp. 112776

Author(s):

Mengxia Gao ◽

Robin Shao ◽

Chih-Mao Huang ◽

Ho-Ling Liu ◽

Yao-Liang Chen ◽

...

Keyword(s):

Working Memory ◽

Major Depressive Disorder ◽

Depressive Disorder ◽

Network Connectivity ◽

Major Depressive ◽

Frontoparietal Network ◽

The Relationship

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Reduced latency to first antidepressant treatment in Italian patients with a more recent onset of major depressive disorder

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.715 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S529-S529

Author(s):

B. Grancini ◽

B. Dell’Osso ◽

L. Cremaschi ◽

F. De Cagna ◽

B. Benatti ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Antidepressant Treatment ◽

Stressful Events ◽

Major Depressive ◽

Recent Onset ◽

Valid Predictor ◽

Before And After ◽

Competing Interest ◽

Year 2000

IntroductionMajor depressive disorder (MDD) is a prevalent burdensome disease, which frequently remains untreated. The duration of untreated illness (DUI) is modifiable parameter and a valid predictor of outcome. Previous investigation in patients with MDD revealed a DUI of different years, while recent reports have documented a reduction of DUI across time, in patients with different psychiatric disorders.Objectives/aimsThe present study was aimed to investigate potential differences in terms of DUI and related variables in patients with MDD across time.MethodsAn overall sample of 188 patients with MDD was divided in two subgroups on the basis of their epoch of onset (onset before and after year 2000). DUI and other onset-related variables were assessed through a specific questionnaire and compared between the two subgroups.ResultsThe whole sample showed a mean DUI of approximately 4.5 years, with a lower value in patients with more recent onset compared to the other subgroup (27.1 ± 42.6 vs. 75.8 ± 105.2 months, P < .05). Moreover, patients with onset after 2000 reported higher rates of onset-related stressful events and lower ones for benzodiazepines prescription (65% vs. 81%; P = 0.02; 47% vs. 30%; P = 0.02).ConclusionsThe comparison of groups with different epochs of onset showed a significant reduction in terms of DUI and benzodiazepines prescription, and a higher rate of onset-related stressful events in patients with a more recent onset. Reported findings are of epidemiologic and clinical relevance in order to evaluate progress and developments in the diagnostic and therapeutic pathways of MDD in Italian and other countries.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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