scholarly journals Randomized Controlled Trial Comparing Autologous Protein Solution to Hyaluronic Acid Plus Triamcinolone for Treating Hip Osteoarthritis in Dogs

2021 ◽  
Vol 8 ◽  
Author(s):  
Samuel P. Franklin ◽  
Ashley L. Franklin
Keyword(s):  
Hyaluronic Acid ◽  
Treatment Time ◽  
Controlled Trial ◽  
Weight Bearing ◽  
Relative Weight ◽  
Hip Osteoarthritis ◽  
Statistical Error ◽  
Protein Solution ◽  
Significant Difference ◽  
Time Point

Twenty-three dogs with bilateral hip osteoarthritis were used to compare the efficacy of intra-articular injections of autologous protein solution (APS) to hyaluronic acid plus triamcinolone (HAT). Prior to treatment, owner assessments of pain and mobility were obtained using the canine brief pain inventory (CBPI) and Liverpool Osteoarthritis for Dogs (LOAD) questionnaires. Owners were also asked to list all medications used to control signs of pain associated with hip osteoarthritis (OA). In addition, objective kinetic data using a pressure sensitive walkway was used to quantify the relative weight bearing of each of the limbs (total pressure index; TPI). One hip was then selected using a random number generator for injection with HAT and the contralateral hip was injected with APS under the same sedation event. At 1-, 3-, and 6 months following injection, medication usage was recorded and dogs were re-assessed using the CBPI and LOAD questionnaires and using objective gait analysis to determine the TPI. Twenty dogs completed all aspects of the study and statistically significant (p < 0.05) improvements were noted by dog owners at every post-treatment time point in every category of pain and mobility as assessed by the CBPI and LOAD questionnaires. Only 5 dogs, compared to 14 pre-treatment, received any oral NSAID or other analgesic for the duration of the 6-month study period. The TPI, and change in TPI from baseline, were not statistically significantly different between the two treatments at any time point. These data suggest clinical efficacy of both APS and HAT, but fail to show superiority of one treatment vs. the other. The inability to detect a statistically significant difference between the two treatments could be attributable to a true lack of a difference, or a type II statistical error.

scholarly journals The Effect of TRX vs. Aquatic Exercises on Self-Reported Knee Instability and Affected Factors in Women with Knee Osteoarthritis: A Randomized Controlled Trial

2019 ◽  
Author(s):  
Shirin Asar ◽  
Farzaneh Gandomi ◽  
Mahsa Mozafari ◽  
Freshteh Sohaili
Keyword(s):  
Knee Osteoarthritis ◽  
Knee Flexion ◽  
Controlled Trial ◽  
Weight Bearing ◽  
Quadriceps Strength ◽  
Knee Instability ◽  
Control Groups ◽  
Significant Difference ◽  
And Control ◽  
Over Time

Abstract Background: Knee Instability (KI) is described as a sense of knee buckling, shifting, or giving way during the weight bearing activities. High prevalence (60-80%) has been reported for KI amongst the patients with knee osteoarthritis (KOA). In this line, the present study targeted the effect of two interventions on self-reported KI and affected factors. Methods: In this single blind, randomized, and controlled trial, 36 patients with radiographic grading (Kellgren–Lawrence > II) of KOA were selected. Patients were divided into three groups namely, aquatic (n=12), Total Resistance exercises (TRX) (n=12) and control (n=12) by random. Then both 8-week TRX and aquatic exercises were carried out by experimental groups. The following measure were taken before and after interventions: Pain by visual analog scale (VAS), balance by Berg Balance Scale (BBS), quadriceps strength by dynamometer, knee flexion range of motion (ROM) by inclinometer, knee stiffness with Western Ontario and McMaster Universities Osteoarthritis (WOMAC), and self-reported KI with Felson's questionnaire. Results: The results demonstrated that KI, VAS, BBS improved over time both in TRX and aquatic groups significantly (p<0.05), but WOMAC(stiffness), knee flexion ROM, and quadriceps strength were significantly improved over time only for TRX (p<0.05). Post hoc test, also, showed that there were significant differences between interventions and control groups (p<0.05) for the VAS, KI, BBS, but for WOMAC(stiffness), a significant difference was observed only between TRX and control groups (p=0.05). Conclusions: Although TRX and aquatic interventions had a similar effect on the patients’ balance, pain and KI, TRX had more effect on WOMAC(stiffness), quadriceps strength, and knee flexion ROM than aquatic exercises.

Efficacy and Safety of a Hyaluronic Acid-Containing Gauze Pad in the Treatment of Chronic Venous or Mixed-Origin Leg Ulcers: A Prospective, Multicenter, Randomized Controlled Trial

2021 ◽  
Vol 66 (6) ◽  
pp. 147-157
Author(s):  
Jacek Mikosinski ◽  
Anna Di Landro ◽  
Krzysztofa Łuczak-Szymerska ◽  
Emilie Soriano ◽  
Carol Caverzasio ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Chronic Wounds ◽  
Treatment Time ◽  
Complete Healing ◽  
Leg Ulcers ◽  
Efficacy And Safety ◽  
Significant Difference ◽  
Multicenter Randomized Controlled Trial ◽  
Mixed Origin ◽  
Chronic Leg Ulcers

Introduction. Hyaluronic acid (HA)-containing formulations routinely are utilized along with standard therapy to promote faster healing of chronic wounds; evidence to guide clinical decisions on the use of topical HA in the healing of vascular leg ulcers is limited. Objective. This study compared the efficacy and safety of an HA-impregnated gauze pad with an identical gauze pad without HA in the treatment of chronic leg ulcers of vascular origin. Materials and Methods. A prospective, multicenter, multinational, parallel-group, randomized, double-blind, clinical study was conducted between June 13, 2017, and December 31, 2018. Adults with 1 or more chronic leg ulcers of venous or mixed origin between 2 months and 4 years’ duration were eligible to participate. Participants were randomized to treatment consisting of standard care (ie, ulcer cleansing, debridement/anesthesia as necessary, and optimized compression) and either application of a gauze pad containing 0.05% HA or a neutral comparator once daily for a maximum of 20 weeks. The primary efficacy endpoint was complete ulcer healing (100% reepithelialization of the wound area centrally assessed by 1 independent and experienced assessor blinded with respect to the treatment applied, as shown on digital photographs taken under standardized conditions at or before 20 weeks and confirmed 3 weeks later). Secondary efficacy endpoints included the percentage of completely healed target ulcers, residual area of target ulcer relative to baseline, the condition of the periulcerous skin, the total amount of analgesics used, the incidence of infection at the ulcer site of the target ulcer, patient adherence to treatment, time to achieve complete healing as centrally assessed, and pain intensity as measured by a visual analog scale. Results. Among the 168 participants (82 in the HA gauze pad group and 86 in the neutral gauze pad group), 33 (39.8%) in the HA group experienced complete healing of the target ulcer, which was significantly higher than the neutral comparator group (15, 18.5%; P = .002). Results in the full analysis and per-protocol sets were consistent with the primary results; no significant difference was noted in outcomes when participants’ wounds were stratified according to baseline ulcer size. Conclusions. HA delivered in a gauze pad formulation could be a beneficial treatment for chronic leg ulcers of venous or mixed origin.

Inhibiting effect of etomidate or propofol combined with remifentanil hydrochloride on adrenal cortex function in severe burn patients : a randomized, double-blind and controlled trial

2020 ◽  
Author(s):  
xiulan Liu ◽  
guoyu Ji ◽  
haibo Liu ◽  
jingmin Zhang ◽  
ruhong Li ◽  
...  
Keyword(s):  
Adrenal Cortex ◽  
Statistical Difference ◽  
Controlled Trial ◽  
Statistical Significance ◽  
Patient Characteristics ◽  
Anesthesia Induction ◽  
Severe Burn ◽  
Significant Difference ◽  
Significant Change ◽  
Time Point

Abstract Background: Etomidate is widely used for anesthetic induction in clinical practice. Adrenal insufficiency induced by etomidate has been demonstrated. However, a variety of studies present that etomidate plays an important role in patients with severe burn injuries.Methods: Forty patients with severe burns were randomly divided into etomidate group (Group E) and propofol group (Group P). Etomidate, propofol and remifentanil hydrochloride were used for anesthesia induction and maintenance. General patient characteristics, mean arterial pressure (MAP), heart rate (HR) and bispectral index (BIS) value were measured and recorded at the baseline (t0), before the intubation (t1), 1, 3, 5, and 30 min following the intubation (t2–5), and the end of the surgery (t6). Before induction of anesthesia and at 30 min, 2h, 24h, and 48h after end of surgery (T0, T1, T2, T3 and T4), artery blood (2 ml) was collected and the concentrations of adrenocorticotropic hormone (ACTH), cortisol (Cor) and aldosterone (ALD) were measured.Results: There were no significant difference in general patient characteristics between the two groups (P>0.05). The MAP values decreased significantly, the HR values decreased at the t1 and there was a statistical difference between the two groups; There was no statistical difference between the two groups at each time point. The patient's ACTH levels in two groups decreased significantly compared with that at preanesthesia, and the levels at T4 were apparently higher than T3 in Group E. The patient's Cor levels in Group E significantly decreased at T2, while that in Group P have no significant change. The differences were not statistical significance between the two groups. The patient's ALD levels in Group E were significantly lower than before induction; while the levels in Group P have no significant change at each time point; the levels in Group P were apparently higher than group E at T2, T3 and T4.Conclusion: Propofol and etomidate for anesthesia induction and maintenance could cause hemodynamic changes, but the effect of etomidate was lighter. The propofol and etomidate both suppress adrenal cortex function, that inhibitory effect of etomidate was greater than propofol, therefore etomidate had a certain beneficial effect.

scholarly journals Functional and Radiological Comparison of Umbilical Cord Mesenchymal Stem Cells, Somatotropin, and Hyaluronic Acid Injection for Cartilage Repair in Early Osteoarthritis of the Knee: A Randomized Controlled Trial

2020 ◽  
Vol 8 (5_suppl5) ◽  
pp. 2325967120S0004
Author(s):  
J Fiolin ◽  
IH Dilogo ◽  
AMT Lubis ◽  
JA Pawitan ◽  
IK Liem ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Hyaluronic Acid ◽  
Knee Osteoarthritis ◽  
Umbilical Cord ◽  
Controlled Trial ◽  
Osteoarthritis Of The Knee ◽  
Significant Difference ◽  
Group A ◽  
Ikdc Score

The umbilical cord-mesenchymal stem cells (UC-MSC) has been shown to improve the viability of degenerated chondrocytes in knee osteoarthritis (KOA) in cellular level. Additional somatotropin injection also shown clinical improvement in patients. The present trial is conducted to assess the efficacy of umbilical cord mesenchymal stem cells (UC-MSC) in comparison to somatotropin and hyaluronic acid (HA) injection to treat and slow the progression of knee osteoarthritis. Methods: This study was conducted from January 2016 to April 2018 in Cipto Mangunkusumo General Hospital. A total of 28 knees from 15 patients with early KOA Kellgren Lawrence I-II were randomized into three groups. Group A was treated with 1x106 units of intra-articular UC-MSCs + 2 ml HA followed with 2 consecutive weeks of HA injection; group B was treated with the same dose of HA with additional 8 IU of Somatotropin; group C was treated as control. The International Knee Documentation Committee (IKDC) score, The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), visual analogue score (VAS), were assessed on the 1st and 3rd month, then every 3rd month until 12 months. Cartilage evaluation using MRI cartigram were performed at pre-implantation, and after the 6th and 12th month after implantation Results: General improvement were observed in all groups after 6 and 12 months. The IKDC score improved significantly among groups after 12 months (69.43 [48.3-89.66], 79.31 [51.72-90.08], and 75.9 [67.82-97.7] in group A, B, and C, respectively, p =0.005). We did not find a significant difference between groups in VAS and WOMAC results. However, we observed a medial T2 improvement in group A (39.55 [32.65-67.85] initially and 45.64 [38.12-70.65] 12 months after implantation). Conclusion: Injection of UC-MSC could improve knee function and cartilage profile in early KOA. However, further multicenter studies with larger samples are required to investigate the efficacy of such treatment for treating knee osteoarthritis.

scholarly journals A comparison between the Disposcope endoscope and fiberoptic bronchoscope for nasotracheal intubation-A randomized controlled trial

2019 ◽  
Author(s):  
Junma Yu ◽  
Rui Hu ◽  
Lining Wu ◽  
Peng Sun ◽  
Zhi Zhang
Keyword(s):  
Adverse Reactions ◽  
Controlled Trial ◽  
Nasotracheal Intubation ◽  
Fiberoptic Bronchoscopy ◽  
Randomized Controlled ◽  
Significant Difference ◽  
Severe Epistaxis ◽  
Nasal Bleeding ◽  
Severe Adverse Reactions ◽  
Time Point

Abstract Background Nasotracheal intubation (NTI) is frequently performed in oral and maxillofacial surgeries. This study evaluated whether NTI is easier when guided by Disposcope endoscopy or fiberoptic bronchoscopy. Methods Sixty patients (30 per group) requiring NTI were randomly assigned to undergo fiberoptic bronchoscopy-guided (fibreoptic group) or Disposcope endoscope-guided (Disposcope group) NTI. Then, the NTI time were recorded. Epistaxis was recorded using direct laryngoscopy five minutes after completing NTI. Results The time to complete NTI was significantly longer in the fiberoptic group than the Disposcope group (38.4 sec vs 24.1 sec; mean difference, 14.2 sec; 95% CI, 10.4 to 18.1). In addition, Mild epistaxis (nasal bleeding) was observed in 8 patients in the fiberoptic group and 7 patients in the Disposcope group (26.7% vs 23.3%, respectively; relative risk, 1.2; 95% CI, 0.4 to 3.9). No moderate or severe epistaxis occurred in either group. Furthermore, there was no obvious nasal pain at any time point after extubation in the Disposcope group, and there was no significant difference between the two groups. Conclusion NTI can be completed successfully using either fiberoptic bronchoscopy or a Disposcope endoscope as a guide without any severe adverse reactions. However, compared to fiberoptic bronchoscopy, the Disposcope endoscope requires less transaction time.

Quality of life evaluation of the effect of decapeptyl compared with zoladex preradiotherapy: Final results of randomised controlled trial.

2017 ◽  
Vol 35 (6_suppl) ◽  
pp. 62-62
Author(s):  
Amit Bahl ◽  
Amarnath Challapalli ◽  
Rosemary Greenwood ◽  
Katrina Hurley ◽  
Rajendra Persad
Keyword(s):  
Quality Of Life ◽  
Treatment Time ◽  
Controlled Trial ◽  
Block Design ◽  
Analysis Of Covariance ◽  
Radical Radiotherapy ◽  
Time Points ◽  
Significant Difference ◽  
Clinically Significant

62 Background: Hormone therapy in combination with radiotherapy is a curative treatment option for prostate cancer (CaP). There is paucity of data regarding quality of life (QoL) evaluation of neoadjuvant Decapeptyl. We reported on the equivalence of cytoreductive efficacy of neoadjuvant Decapeptyl and Zoladex previously. Here we present the final QoL evaluation of the effect of Decapeptyl compared with Zoladex preradiotherapy. Methods: Seventy-one patients with localised CaP who have chosen radical radiotherapy had been randomised by stratified block design, toreceive either Decapeptyl (D: n = 37) or Zoladex (Z: n = 34) with bicalutamide cover. All the patients had subsequent radical radiotherapy and followed up as per departmental protocol. The effect of Decapeptyl and Zoladex on QoL was assessed using EQ5D, QLQ-PR25, QLQ-C30 questionnaires, which were completed at baseline, 6, 10 & 14 weeks after start of therapy. QoL scores were analysed as mean scores over the 4 treatment time points for all domains, controlling for baseline scores using Analysis of Covariance. Results: There was no clinically significant difference or trend towards worsening QoL with either Z or D in the global (EQ5D) and cancer-specific (QLQ-C30) domains. The cancer-specific (QLQ-C30) symptom score also showed no trend towards worsening QoL with either Z or D. Symptom scores in the QLQ-PR25 questionnaire did not show a significant difference between Z and D arms with the exception of hormone symptoms. The hormone symptoms showed an increasing trend over the 4 treatment time points, with those in the Z arm significantly (p = 0.02) more affected (3 points higher on average) than patients in the D arm, despite equivalence in cytoreductive effect and achieving castrate levels of testosterone. Conclusions: There were no clinically significant differences in QoL domains between Zoladex and Decapeptyl, apart from hormones symptoms which were worse with Zoladex. Further validation is required with affect on hormone symptoms as the primary outcome measure. To our knowledge this is the first reported prospective randomised data demonstrating the effect of Zoladex and Decapeptyl, on QoL in the neoadjuvant setting. Clinical trial information: EduraCT: 2008-007028-25.

scholarly journals Comparative outcomes of foot cast and short leg cast in pseudo-Jones avulsion fracture: a single blinded randomized controlled trial

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Peerapong Piyapittayanun ◽  
Kanakij Mutthakalin ◽  
Alisara Arirachakaran ◽  
Jatupon Kongtharvonskul
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Weight Bearing ◽  
Randomized Controlled ◽  
Metatarsal Bones ◽  
Significant Difference ◽  
Metatarsal Fractures ◽  
The Mean ◽  
Foot Fractures ◽  
To Receive

Abstract Background Fractures of the metatarsal bones account for 35% of all foot fractures. Conservative management of fractures proximal to the metaphyseal-diaphyseal junction of the fifth metatarsal bone (pseudo-Jones) is by protected weight bearing. The methods of protected weight bearing include short-leg casting and splinting (boot cast, Jones’s bandage and elastic bandage). However, currently there is no consensus as to which method is the most suitable. Method We have conducted a randomized controlled trial to compare outcomes of foot casting (FC) and short leg casting (SLC) to assess pain, function and complication outcomes for the treatment of pseudo-jones metatarsal fractures. This single-center, single blind,randomized controlled trial was conducted between 1 June 2016–1 July 2018 at Police General Hospital, Bangkok, Thailand. Result A total of 72 pseudo-jones metatarsal fracture participants were randomly allocated to treatment by foot cast or short leg cast. The primary outcomes were pain VAS, AOFAS and complications measured at 2, 4, 6 and 8 weeks after receiving the treatment. Seventy-two patients (36 paticipants per group) were enrolled to receive either FC or SLC. The mean VAS measured at baseline, 2 weeks, 4 weeks, 6 weeks and 8 weeks were 7.36, 1.97, 0.58, 0.17 and 0.08 respectively in the FC group; and 6.09, 2.91, 1.23, 0.37 and 0.11 respectively in the SLC group. The mean AOFAS at baseline, 2, 4, 6 and 8 weeks were 33.60, 68.22, 82.72, 91.75 and 98.11 respectively in the FC group; and 32.60, 60.20, 70.20, 92.24 and 99.13 in the SLC group. The estimated mean difference of pain VAS and AOFAS at 2 weeks and 4 weeks were − 0.94 (95% CI: − 1.53, − 0.34), − 0.65 (95%CI: − 1.24, − 0.05), 8.02 (95%CI: 3.74, 12.10) and 12.52 (95%CI: 8.27, 16.78), which were statistically significantly better in the FC groups when compared to the SLC groups. However, there were no statistically significant difference between the two groups at 6 and 8 weeks. Conclusion This study demonstrated that the application of foot casting can improve pain VAS and AOFAS function at 2 and 4 weeks in the treatment of pseudo-jones metatarsal fractures when compared to short leg casting. However, at 6 and 8 weeks, there were no statistically significantly different between the two groups.

scholarly journals Treatment of Early Hip Osteoarthritis: Ultrasound-Guided Platelet Rich Plasma versus Hyaluronic Acid Injections in a Randomized Clinical Trial

Joints ◽  
2017 ◽  
Vol 05 (03) ◽  
pp. 152-155 ◽  
Author(s):  
Carlo Doria ◽  
Giulia Mosele ◽  
Gianfilippo Caggiari ◽  
Leonardo Puddu ◽  
Emanuele Ciurlia
Keyword(s):  
Hyaluronic Acid ◽  
Platelet Rich Plasma ◽  
Controlled Trial ◽  
Hip Osteoarthritis ◽  
Harris Hip Score ◽  
Ultrasound Guided ◽  
Level Of Evidence ◽  
Level Ii ◽  
Group 2 ◽  
Double Blinded

Purpose The aim of this study was to compare the clinical efficacy of ultrasound-guided intra-articular injections of autologous platelet rich plasma (PRP) versus hyaluronic acid (HA) for symptomatic early osteoarthritis (OA) of the hip. Methods A prospective controlled double-blinded randomized trial on 80 patients with hip OA was conducted. The patients were divided in two groups of 40 patients each: group 1 underwent three PRP intra-articular ultrasound-guided injections, whereas group 2 underwent three HA injections. WOMAC, VAS, and Harris Hip Score were evaluated for both groups before and at 6 and 12 months after treatment. Results The two groups were comparable in age, sex, body mass index, and severity of hip OA. Both groups showed a significant improvement from baseline at 6-month and 12-month follow-ups for all the outcome measures. No major complications were observed during the treatment and at follow-ups in both the groups. Conclusion PRP did not offer significantly better results compared with HA in patients with moderate signs of OA, and thus it should not be considered as first-line treatment. Level of Evidence Level II, randomized controlled trial.

scholarly journals The Effect of Using a Modified Dentoalveolar Distractor on Canine Angulation following Rapid Canine Retraction: A Split-mouth Design Randomized Controlled Trial

2016 ◽  
Vol 17 (1) ◽  
pp. 49-57 ◽  
Author(s):  
Mohammad Y Hajeer ◽  
Khaled I Al-Ainawi ◽  
Yaser Al-Mdalal
Keyword(s):  
Randomized Controlled Trial ◽  
Treatment Time ◽  
Controlled Trial ◽  
Latency Period ◽  
Canine Retraction ◽  
Randomized Controlled ◽  
Bodily Movement ◽  
Significant Difference ◽  
Term Basis ◽  
Time Required

ABSTRACT Background and Objectives New studies have been published and aimed to retract canines by means of distraction osteogenesis to reduce treatment time. Although a great care has been given to achieve a bodily movement of the canines, a significant amount of tipping of the canines has been observed. This trial aimed to assess the effect of applying a modified distractor on canine angulation. Materials and methods The sample of the study consisted of 14 canines in seven patients (16–25 years). After the osteotomy procedure, two distractors were applied (one distractor on each side). After 5 days of a latency period, the two distractors were activated at a rate of 1 mm/day. Results There was a significant difference between the two distractors regarding the time required to retract the canines (p = 0.008) and the observed change in canine angulation following retraction (p = 0.028). The change in the overjet and the mandibular plane angle was statistically insignificant. Eight out of 14 distracted canines reacted positively to the pulp vitality tester after 3 months of completion of distraction. There was no clinical sign of discoloration or pulpal pain in any canine. Conclusion Within the limits of this study, the modified distractor caused a bodily movement of the canine with a minimal tipping. Further research is required on a long-term basis on a larger group of patients to gain more insight on the observed changes. How to cite this article The Effect of Using a Modified Dentoalveolar Distractor on Canine Angulation following Rapid Canine Retraction: A Split-mouth Design Randomized Controlled Trial. J Contemp Dent Pract 2016;17(1):49-57.

scholarly journals The Effect of TRX vs. Aquatic Exercises on Self-Reported Knee Instability and Affected Factors in Women with Knee Osteoarthritis: A Randomized Controlled Trial

2019 ◽  
Author(s):  
Shirin Asar ◽  
Farzaneh Gandomi ◽  
Mahsa Mozafari ◽  
Freshteh Sohaili
Keyword(s):  
Knee Osteoarthritis ◽  
Controlled Trial ◽  
Weight Bearing ◽  
Berg Balance Scale ◽  
Quadriceps Strength ◽  
Knee Instability ◽  
Significant Difference ◽  
High Prevalence ◽  
Before And After ◽  
And Control

Abstract Background Knee Instability (KI) is described as a sense of the knee buckling, shifting, or giving way during the weight bearing activities. High prevalence (65%) has been reported for KI amongst the patients with knee osteoarthritis (KOA). So, we studied the effect of two interventions on self-reported KI and affected factors.Methods In this single blind, randomized, and controlled trial, 36 patients with radiographic grading (Kellgren–Lawrence 1–4) of knee osteoarthritis were selected for participating. patients were allocated in three groups aquatic exercises (n=12), Total Resistance eXercises (TRX) exercises (n=12) and control (n=12) by random. 8-week TRX and aquatic exercises were carried out by experimental groups. Pain severity was assessed by visual analog scale (VAS), Balance was also evaluated by Berg Balance Scale (BBS), quadriceps strength by dynamometer, and knee range of motion (ROM) by inclinometer, Western Ontario and McMaster Universities Osteoarthritis (WOMAC), self-reported KI were also measured before and after interventions.Results The results of One-way ANOVA showed that there was no significant difference between aquatic exercises and TRX (P>0.05) for KI, BBS, WOMAC, and pain. But there was significant difference between the aquatic exercises and the control for KI (P=0.0001), BBS (P=0.0001), WOMAC Stiffness (P=0.0001), and pain (P=0.006). Also, there was significant difference between the TRX and the control for KI (P=0.0001), BBS (P=0.0001), and pain (P=0.003) except WOMAC Stiffness (P=0.07).Conclusions TRX and aquatic interventions had a similar effect on the patients’ KI, pain, function, and also balance variables, but TRX exercises had more effect on the knee stiffness improvement.

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