scholarly journals The Genomic Variation in the Aosta Cattle Breeds Raised in an Extensive Alpine Farming System

Animals ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 2385
Author(s):  
Maria Giuseppina Strillacci ◽  
Mario Vevey ◽  
Veruska Blanchet ◽  
Roberto Mantovani ◽  
Cristina Sartori ◽  
...  
Keyword(s):  
Principal Component ◽  
Enrichment Analysis ◽  
Farming System ◽  
Genomic Variation ◽  
Dual Purpose ◽  
Cattle Breeds ◽  
Dual Purpose Cattle ◽  
Summer Pasture ◽  
The Mean ◽  
Genomic Inbreeding

The Aosta Red Pied (Valdostana Pezzata Rossa (VRP)), the Aosta Black Pied (Valdostana Pezzata Nera (VBP)) and the Aosta Chestnut (Valdostana Castana (CAS)) are dual-purpose cattle breeds (meat and milk), very well adapted to the harsh environmental conditions of alpine territories: their farming is in fact characterized by summer pasture at very high altitude. A total of 728 individuals were genotyped with the GeenSeek Genomic Profiler® (GGP) Bovine 150K Illumina SNP chip as a part of the DUALBREEDING-PSRN Italian-funded research project. The genetic diversity among populations showed that the three breeds are distinct populations based on the FST values, ADMIXTURE and Principal Component Analysis (PCA) results. Runs of Homozygosity (ROH) were obtained for the three populations to disclose recent autozygosity. The genomic inbreeding based on the ROH was calculated and coupled with information derived from the F (inbreeding coefficient) and FST parameters. The mean FROH values were low: CAS = 0.06, VBP = 0.05 and VRP = 0.07, while the average F values were −0.003, −0.01 and −0.003, respectively. The annotation and enrichment analysis, performed in the identified most frequent ROH (TOP_ROH), showed genes that can be linked to the resilience capacity of these populations to harsh environmental farming conditions, and to the peculiar characteristics searched for by farmers in each breed.

scholarly journals Colostrum composition and immunoglobulin G content in dairy and dual-purpose cattle breeds

2020 ◽  
Vol 98 (8) ◽  
Author(s):  
Evelyne C Kessler ◽  
Rupert M Bruckmaier ◽  
Josef J Gross
Keyword(s):  
Dairy Cows ◽  
Immunoglobulin G ◽  
Passive Immunization ◽  
Mature Milk ◽  
Dual Purpose ◽  
Cattle Breeds ◽  
Holstein Friesian ◽  
Essential Components ◽  
Dual Purpose Cattle ◽  
And Performance

Abstract Immunoglobulins (Ig) are essential components in the colostrum of bovine species that enable passive immunization of newborn calves. Concentrations of fat and protein are greater in colostrum compared with mature milk and represent a vital source of energy and nutrients. Colostral IgG was shown to vary between individual dairy cows, but comparative data on different breeds and performance levels are scarce. The objective of the present field study was to investigate the contents of total IgG, fat, protein, and lactose in colostrum in different Swiss and German dairy and dual-purpose breeds. We collected colostrum samples of 458 cows of 13 different breeds (dairy breeds: Brown Swiss, Swiss and German Holstein Friesian, and New Zealand Holstein; dual-purpose breeds: German Fleckvieh, Holstein Friesian × Montbéliarde, Montbéliarde, Murnau-Werdenfels, Original Braunvieh, Pinzgauer, Rhetic Gray, and Simmental; and beef-type crossbred: Charolais × Holstein Friesian). Colostrum samples were obtained between 5 and 900 min after calving and analyzed for total IgG, fat protein, and lactose contents. Immunoglobulin G concentrations varied between 12.7 and 204.0 mg/mL. No effect of breeding purpose (i.e., dairy or dual-purpose) nor of previous lactation yield on IgG content was observed. However, milking of cows for the first time later than 12 h after parturition resulted in lower colostrum IgG concentrations compared with colostrum harvest within 9 h after calving (P < 0.05). Multiparous cows had a higher colostral IgG concentration than primiparous cows (P < 0.0001). Overall, concentrations of IgG and other constituents in colostrum varied widely in the different cattle breeds. High-yielding dairy cows did not have poorer colostrum quality compared with lower-yielding animals or beef and dual-purpose breeds, which suggests an individually different transfer of circulating IgG into colostrum.

scholarly journals Investigation of the DGAT1 K232A and VNTR mutations in dairy and dual purpose cattle breeds

2007 ◽  
Vol 6 (sup1) ◽  
pp. 137-137 ◽  
Author(s):  
L. Fontanesi ◽  
E. Scotti ◽  
F. Schiavini ◽  
V. La Mattina ◽  
R. Davoli ◽  
...  
Keyword(s):  
Dual Purpose ◽  
Cattle Breeds ◽  
Dual Purpose Cattle

scholarly journals Investigation of allele frequencies of the growth hormone receptor(GHR) F279Ymutation in dairy and dual purpose cattle breeds

2007 ◽  
Vol 6 (4) ◽  
pp. 415-420 ◽  
Author(s):  
Luca Fontanesi ◽  
Emilio Scotti ◽  
Marco Tazzoli ◽  
Francesca Beretti ◽  
Stefania Dall’Olio ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Allele Frequencies ◽  
Dual Purpose ◽  
Cattle Breeds ◽  
Dual Purpose Cattle

scholarly journals m6A-Mediated Tumor Invasion and Methylation Modification in Breast Cancer Microenvironment

2021 ◽  
Vol 2021 ◽  
pp. 1-17
Author(s):  
Fei Liu ◽  
Xiaopeng Yu ◽  
Guijin He
Keyword(s):  
Breast Cancer ◽  
Tumor Microenvironment ◽  
Immune Cell ◽  
Principal Component ◽  
Enrichment Analysis ◽  
Genomic Variation ◽  
Gene Set Enrichment Analysis ◽  
Single Sample ◽  
Gene Set Enrichment ◽  
Gene Set

Background. We analyzed the n6-methyladenosine (m6A) modification patterns of immune cells infiltrating the tumor microenvironment of breast cancer (BC) to provide a new perspective for the early diagnosis and treatment of BC. Methods. Based on 23 m6A regulatory factors, we identified m6A-related gene characteristics and m6A modification patterns in BC through unsupervised cluster analysis. To examine the differences in biological processes among various m6A modification modes, we performed genomic variation analysis. We then quantified the relative infiltration levels of different immune cell subpopulations in the tumor microenvironment of BC using the CIBERSORT algorithm and single-sample gene set enrichment analysis. Univariate Cox analysis was used to screen for m6A characteristic genes related to prognosis. Finally, we evaluated the m6A modification pattern of patients with a single BC by constructing the m6Ascore based on principal component analysis. Results. We identified three different m6A modification patterns in 2128 BC samples. A higher abundance of the immune infiltration of the m6Acluster C was indicated by the results of CIBERSORT and the single-sample gene set enrichment analysis. Based on the m6A characteristic genes obtained through screening, the m6Ascore was determined. The BC patients were segregated into m6Ascore groups of low and high categories, which revealed significant survival benefits among patients with low m6Ascores. Additionally, the high-m6Ascore group had a higher mutation frequency and was associated with low PD-L1 expression, and the m6Ascore and tumor mutation burden showed a positive correlation. In addition, treatment effects were better in patients in the high-m6Ascore group. Conclusions. In case of a single patient with BC, the immune cell infiltration characteristics of the tumor microenvironment and the m6A methylation modification pattern could be evaluated using the m6Ascore. Our results provide a foundation for improving personalized immunotherapy of BC.

scholarly journals Prevalence of Neospora caninum bovine serum antibodies in the Central and Eastern regions of Mexico

2020 ◽  
Vol 26 (1) ◽  
pp. e1996
Author(s):  
Juan Prisciliano Zárate-Martínez ◽  
Jorge Víctor Rosete-Fernández ◽  
Guadalupe Asunción Socci-Escatell ◽  
Abraham Fragoso-Islas ◽  
Sara Olazarán-Jenkins ◽  
...  
Keyword(s):  
Logistic Regression Model ◽  
Neospora Caninum ◽  
San Jose ◽  
Dual Purpose ◽  
Blood Samples ◽  
Elisa Kit ◽  
Dual Purpose Cattle ◽  
Southern Gulf Of Mexico ◽  
The Mean ◽  
San Rafael

Objective. To determine the prevalence of antibodies against Neospora caninum (PSA) in beef and dual-purpose cattle from the Central and Southern Gulf of Mexico regions, as well as to evaluate its association with the reproductive status (RS) of the cow (pregnant, not pregnant). Materials and methods. Blood samples were taken from 422 cows. Antibodies were detected with a commercial ELISA kit. PSA was analyzed with a logistic regression model that included state, township nested within state, and ranch nested within township. Results. The states of Tabasco, Puebla and Veracruz had similar PSA (p>0.05). The mean PSA for the three states was 24.0%. The PSA varied from 7.8 to 43.3% across townships. In Puebla, the PSA in cattle from San José Acateno township was more than two-fold greater than that in cattle from Hueytamalco and Nauzontla townships (p<0.05). In Tabasco, Cunduacán, Huimanguillo and Ranchería El Puente townships showed similar (p>0.05) PSA. In Veracruz, cows from Cotaxtla and Medellín de Bravo townships presented higher (p<0.05) PSA than those from San Rafael township. The RS of seropositive females was similar (p>0.05) to that of seronegative females. Conclusions. The three states had similar PSA. All the herds had antibodies against N. caninum, suggesting that this parasite is amply distributed in the three states. In addition, great variation existed among herds and among townships; finally, the presence of N. caninum antibodies was not associated with the RS of the cow.

scholarly journals Genetic and phenotypic trends for weights of major beef and dual-purpose cattle breeds in Slovak Republic

2020 ◽  
Vol 23 (3) ◽  
pp. 174-191
Author(s):  
Ján Tomka ◽  
Ján Huba ◽  
Milan Kumičík
Keyword(s):  
Beef Cattle ◽  
Slovak Republic ◽  
Genetic Evaluation ◽  
The Other ◽  
Genetic Progress ◽  
Dual Purpose ◽  
Cattle Breeds ◽  
Other Hand ◽  
Dual Purpose Cattle ◽  
Further Development

Genetic evaluation of beef cattle in Slovakia started in first years of this century. After the first decade of running the routine evaluations it is important to review the progress made and to discuss the further development. The aim of this paper was to compile and deliver genetic and phenotypic trends in order to review importance of evaluated traits with respect to four major beef (Charolais, Limousine) and dual-purpose breeds (Slovak Pinzgau cattle, Slovak Spotted cattle). The study showed different progress made across the breeds. Higher genetic progress was observed in Charolais purebreds compared to Limousine counterparts. Moreover, almost similar progress to that in Charolais was observed in dual-purpose Slovak Pinzgau cattle. On the other hand no progress was observed in Slovak Spotted purebreds. Results also showed higher progress in bulls compared to cows. Phenotypic trends showed reserves for improvement in Charolais and closing to breed standards in Limousine. In dualpurpose breeds improvement was shown only in Slovak Pinzgau, while no improvement or decrease in actual weights was shown in Slovak Spotted purebreds.

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