scholarly journals Anti-Obesity Effects of Combined Cornus officinalis and Ribes fasciculatum Extract in High-Fat Diet-Induced Obese Male Mice

Animals ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 3187
Author(s):  
Eunkuk Park ◽  
Chang-Gun Lee ◽  
Hyoju Jeon ◽  
Hyesoo Jeong ◽  
Subin Yeo ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Insulin Action ◽  
Normal Diet ◽  
Male Mice ◽  
Impaired Glucose Metabolism ◽  
High Fat ◽  
Beneficial Effects ◽  
Cornus Officinalis ◽  
Treatment And Prevention ◽  
Obese Male

Medicinal plants are widely used as supplements for the treatment of various diseases because of their few side-effects. Here, we examined the anti-obesity effects of a mixture extract of Cornus officinalis and Ribes fasciculatum (CR) in high-fat diet (HFD)-induced obese male mice. Four week old male C57BL/6J mice were fed a normal diet (ND) or 60% high-fat diet (HFD) with different concentrations of CR extracts (75, 150, and 300 mg/kg/day) by oral administration for 12 weeks. CR extract administration prevented HFD-induced weight gain, hepatic steatosis, and adipocyte enlargement through the downregulation of adipogenesis-associated genes in obese male mice. In addition, CR administration improved the impaired glucose metabolism, insulin action, biochemical obesity parameters, and metabolic profiles in HFD-induced male mice. Consequently, the CR extract exhibited beneficial effects on HFD-induced systemic metabolic challenges. Taken together, our findings suggest that CR extract may be a potent therapeutic supplement for the treatment and prevention of obesity.

scholarly journals Soy isoflavones improve the oxidative stress induced hypothalamic inflammation and apoptosis in high fat diet-induced obese male mice through PGC1-alpha pathway

Aging ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 8710-8727 ◽  
Author(s):  
Dejiang Pang ◽  
Chengcheng Yang ◽  
Qihui Luo ◽  
Chao Li ◽  
Wentao Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Soy Isoflavones ◽  
Male Mice ◽  
High Fat ◽  
Hypothalamic Inflammation ◽  
Obese Male

scholarly journals Prebiotic prevents impaired kidney and renal Oat3 functions in obese rats

2018 ◽  
Vol 237 (1) ◽  
pp. 29-42 ◽  
Author(s):  
Keerati Wanchai ◽  
Sakawdaurn Yasom ◽  
Wannipa Tunapong ◽  
Titikorn Chunchai ◽  
Parameth Thiennimitr ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Renal Function ◽  
High Fat Diet ◽  
Organic Anion ◽  
Normal Diet ◽  
Organic Anion Transporter ◽  
High Fat ◽  
Insulin Resistant ◽  
Beneficial Effects ◽  
Anion Transporter

Obesity is health issue worldwide, which can lead to kidney dysfunction. Prebiotics are non-digestible foods that have beneficial effects on health. This study aimed to investigate the effects of xylooligosaccharide (XOS) on renal function, renal organic anion transporter 3 (Oat3) and the mechanisms involved. High-fat diet was provided for 12 weeks in male Wistar rats. After that, the rats were divided into normal diet (ND); normal diet treated with XOS (NDX); high-fat diet (HF) and high-fat diet treated with XOS (HFX). XOS was given daily at a dose of 1000 mg for 12 weeks. At week 24, HF rats showed a significant increase in obesity and insulin resistance associated with podocyte injury, increased microalbuminuria, decreased creatinine clearance and impaired Oat3 function. These alterations were improved by XOS supplementation. Renal MDA level and the expression of AT1R, NOX4, p67phox, 4-HNE, phosphorylated PKCα and ERK1/2 were significantly decreased after XOS treatment. In addition, Nrf2-Keap1 pathway, SOD2 and GCLC expression as well as renal apoptosis were also significantly reduced by XOS. These data suggest that XOS could indirectly restore renal function and Oat3 function via the reduction of oxidative stress and apoptosis through the modulating of AT1R-PKCα-NOXs activation in obese insulin-resistant rats. These attenuations were instigated by the improvement of obesity, hyperlipidemia and insulin resistance.

scholarly journals Chronic rhein treatment improves recognition memory in high-fat diet-induced obese male mice

2016 ◽  
Vol 36 ◽  
pp. 42-50 ◽  
Author(s):  
Sen Wang ◽  
Xu-Feng Huang ◽  
Peng Zhang ◽  
Hongqin Wang ◽  
Qingsheng Zhang ◽  
...  
Keyword(s):  
Recognition Memory ◽  
High Fat Diet ◽  
Male Mice ◽  
High Fat ◽  
Obese Male

Knockout of nephron ATP6AP2 impairs proximal tubule function and prevents high fat diet induced obesity in male mice

Endocrinology ◽  
2021 ◽  
Author(s):  
Silas A Culver ◽  
Safia Akhtar ◽  
Callie Rountree-Jablin ◽  
Susanna R Keller ◽  
Helen P Cathro ◽  
...  
Keyword(s):  
Body Weight ◽  
Proximal Tubule ◽  
Knockout Mice ◽  
High Fat Diet ◽  
Caloric Intake ◽  
Normal Diet ◽  
Male Mice ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Urinary Glucose

Abstract ATP6AP2 expression is increased in the nephron during high fat diet (HFD) and its knockout (ATP6AP2 KO) reduces body weight (WT) in mice. We evaluated the contribution of ATP6AP2 to urinary glucose (UG) and albumin (Ualb) handling during HFD. We hypothesized that nephron ATP6AP2 KO increases UG and Ualb and minimizes HFD-induced obesity. Eight-week old male C57BL/6J mice with inducible nephron specific ATP6AP2 KO and non-induced controls (C) were fed either normal diet (ND, 12% kcal fat) or HFD (45% kcal fat) for 6 months. ATP6AP2 KO mice on ND had 20% (p<0.01) lower WT compared to C. HFD fed mice had 41% (p<0.05) greater WT than ND fed C. In contrast, ATP6AP2 KO abrogated the increase in WT induced by HFD by 40% (p<0.05). Mice on HFD had less caloric intake compared to ND controls (p<0.01). There were no significant differences in metabolic rate between all groups. UG and Ualb was significantly increased in ATP6AP2 KO mice on both ND and HFD. ATP6AP2 KO showed greater levels of proximal tubule apoptosis and histologic evidence of proximal tubule injury. In conclusion, our results demonstrate that nephron specific ATP6AP2 KO is associated with glucosuria and albuminuria, most likely secondary to renal proximal tubule injury and/or dysfunction. Urinary loss of nutrients may have contributed to the reduced WT of knockout mice on ND and lack of WT gain in response to HFD. Future investigation should elucidate the mechanisms by which loss of renal ATP6AP2 causes proximal tubule injury and dysfunction.

scholarly journals Oleuropein Induces AMPK-Dependent Autophagy in NAFLD Mice, Regardless of the Gender

2018 ◽  
Vol 19 (12) ◽  
pp. 3948 ◽  
Author(s):  
Cristiana Porcu ◽  
Silvia Sideri ◽  
Maurizio Martini ◽  
Alessandra Cocomazzi ◽  
Andrea Galli ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Liver Steatosis ◽  
Normal Diet ◽  
Male Mice ◽  
High Fat ◽  
Unhealthy Diet ◽  
Autophagic Process ◽  
Related Proteins ◽  
Gender Specific ◽  
Novel Therapeutic

Oleuropein (Ole) is one of the most plentiful phenolic compounds with antioxidant, anti-inflammatory, anti-atherogenic, hypoglycemic and hypolipidemic effects. The aim of our study was to establish whether the positive Ole-related effects on liver steatosis could be associated with autophagy. Female and male C57BL/6J mice were fed normal diet (ND) or high-fat diet (HFD) for eight weeks, and Ole was added or not for the following eight weeks. The autophagy-related proteins Akt, mTOR, AMPK, ULK1, Beclin-1, LC3B and p62/Sqstm1 were analyzed. Interestingly, Ole induced a different regulation of the Akt/mTOR pathway in female compared to male mice, but was able to activate the autophagic process in ND and HFD mice through AMPK-dependent phosphorylation of ULK1 at Ser555, regardless of the gender. Our work reveals the ability of Ole to induce, in liver of ND and HFD mice, autophagy independently by gender-specific mTOR activation. We highlight Ole as a novel therapeutic approach to counteract unhealthy diet-related liver steatosis by targeting autophagy.

Ursolic acid induces white adipose tissue beiging in high-fat-diet obese male mice

2021 ◽  
Author(s):  
Ao Sun ◽  
Xiaoqin Hu ◽  
Huijian Chen ◽  
Yulan Ma ◽  
Xiyue Yan ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Ursolic Acid ◽  
White Adipose Tissue ◽  
High Fat Diet ◽  
Signal Pathway ◽  
Male Mice ◽  
High Fat ◽  
Obese Male

Ursolic acid increases the secretion of irisin by the PRDM16–PGC-1α–FNDC5 signal pathway to induce beiging of WAT and improve obese conditions.

scholarly journals The disassembly of the neuromuscular synapse in high-fat diet-induced obese male mice

2020 ◽  
Vol 36 ◽  
pp. 100979
Author(s):  
Isabel Martinez-Pena y Valenzuela ◽  
Mohammed Akaaboune
Keyword(s):  
High Fat Diet ◽  
Neuromuscular Synapse ◽  
Male Mice ◽  
High Fat ◽  
Obese Male

scholarly journals Influence of sex, high-fat diet, and exercise training on potassium currents of swine coronary smooth muscle

2007 ◽  
Vol 293 (3) ◽  
pp. H1553-H1563 ◽  
Author(s):  
Yan Yang ◽  
Allan W. Jones ◽  
Tom R. Thomas ◽  
Leona J. Rubin
Keyword(s):  
Smooth Muscle ◽  
Exercise Training ◽  
High Fat Diet ◽  
Normal Diet ◽  
High Fat ◽  
Coronary Smooth Muscle ◽  
Endothelin 1 ◽  
Beneficial Effects ◽  
Diet And Exercise ◽  
Males And Females

Potassium channels in vascular smooth muscle (VSM) control vasodilation and are potential regulatory targets. This study evaluated effects of sex differences, exercise training (EX), and high-fat diet (HF) on K+ currents ( IK) of coronary VSM cells. Yucatan male and female swine were assigned to either sedentary confinement (SED), 16 wk of EX, 20 wk of HF, or 20 wk of HF with 16 wk of EX (HF-EX). VSM cells of normal-diet SED animals exhibited three components of IK: 4-aminopyridine-sensitive IK(KV), TEA-sensitive IK(BK), and 4-aminopyridine + TEA-insensitive IK. Females exhibited significantly higher basal IK than males in the same group. EX increased basal IK in males and females. HF reduced IK in males and females and nullified effects of EX. Endothelin-1 increased IK significantly in males but not in females. In the presence of endothelin-1, 1) IK(KV) was similar in SED males and females and EX increased IK(KV) to a greater extent in males than in females and 2) IK(BK) was greater in SED females than in males and EX increased IK(BK) to a greater extent in males, resulting in IK(BK) similar to EX females. Importantly, HF nullified effects of EX on IK(KV) and IK(BK). These data indicate that basal IK of SED female swine is inherently greater than that shown in SED males and that males require EX to achieve comparable levels of IK. Importantly, HF reduced IK in males and females and nullified effects of EX, suggesting HF abrogates beneficial effects of EX on coronary smooth muscle.

scholarly journals Effect ofLactobacillus plantarumStrain K21 on High-Fat Diet-Fed Obese Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Chien-Chen Wu ◽  
Wei-Lien Weng ◽  
Wen-Lin Lai ◽  
Hui-Ping Tsai ◽  
Wei-Hsien Liu ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Body Weight Gain ◽  
Normal Diet ◽  
Peroxisome Proliferator ◽  
Bacterial Strains ◽  
High Fat ◽  
Peroxisome Proliferator Activated Receptor ◽  
Hepatic Expression ◽  
Beneficial Effects

Recent studies have demonstrated beneficial effects of specific probiotics on alleviating obesity-related disorders. Here we aimed to identify probiotics with potential antiobesity activity among 88 lactic acid bacterial strains viain vitroscreening assays, and aLactobacillus plantarumstrain K21 was found to harbor abilities required for hydrolyzing bile salt, reducing cholesterol, and inhibiting the accumulation of lipid in 3T3-L1 preadipocytes. Furthermore, effects of K21 on diet-induced obese (DIO) mice were examined. Male C57Bl/6J mice received a normal diet, high-fat diet (HFD), or HFD with K21 administration (109 CFU in 0.2 mL PBS/day) for eight weeks. Supplementation of K21, but not placebo, appeared to alleviate body weight gain and epididymal fat mass accumulation, reduce plasma leptin levels, decrease cholesterol and triglyceride levels, and mitigate liver damage in DIO mice. Moreover, the hepatic expression of peroxisome proliferator-activated receptor-γ(PPAR-γ) related to adipogenesis was significantly downregulated in DIO mice by K21 intervention. We also found that K21 supplementation strengthens intestinal permeability and modulates the amount ofLactobacillusspp.,Bifidobacteriumspp., andClostridium perfringensin the cecal contents of DIO mice. In conclusion, our results suggest that dietary intake of K21 protects against the onset of HFD-induced obesity through multiple mechanisms of action.

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