Age at First Gestation in Beef Heifers Affects Fetal and Postnatal Growth, Glucose Metabolism and IGF1 Concentration

This study aimed to determine the effects of age at first gestation on offspring growth performance, glucose metabolism, and IGF1 concentration. Heifers impregnated by AI from a single bull at 15 months of age (15 M, n = 20), or 27 months of age (27 M, n = 20), and multiparous cows (adult, n = 20) were used. Dams from all groups were managed in a single group during gestation and lactation. Gestational length was longer in the 15 M and 27 M than in adult dams (p = 0.009). Bodyweight at birth, at weaning and ADG during lactation were higher in calves from adult dams than in those from 27 M dams, and higher in calves from the latter than in 15 M calves (p < 0.001). Calves from 15 M dams had an increased head circumference/BW ratio compared to calves from 27 M dams, while calves from this latter group had an increased ratio compared to calves from adults (p = 0.005). Body mass index was greater in calves from adults than in those from 15 M and 27 M dams (p = 0.002). Milk production from 15 M and 27 M dams was similar but lower than that from adults (p = 0.03). Calves born from adult dams had greater blood glucose concentrations than those from 15 M and 27 M dams (p < 0.05). Serum IGF1 concentrations were higher in calves from adults than in calves from 15 M and 27 M dams (p = 0.01). This study showed that age at first gestation affects offspring postnatal growth performance, glucose metabolism and IGF1 concentration.

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Random blood glucose concentrations and their association with body mass index in Indian school children

Indian Journal of Endocrinology and Metabolism ◽

10.4103/ijem.ijem_536_19 ◽

2019 ◽

Vol 23 (5) ◽

pp. 529

Author(s):

AnuradhaV Khadilkar ◽

Nikhil Lohiya ◽

Sejal Mistry ◽

Shashi Chiplonkar ◽

Vaman Khadilkar ◽

...

Keyword(s):

Body Mass Index ◽

Blood Glucose ◽

Body Mass ◽

School Children ◽

Indian School ◽

Random Blood Glucose ◽

Blood Glucose Concentrations

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Chronic vagus nerve stimulation for drug-resistant epilepsy influences fasting blood glucose concentration

10.21203/rs.3.rs-18513/v1 ◽

2020 ◽

Author(s):

Hongyun Liu ◽

Ping Zhan ◽

Fangang Meng ◽

Weidong Wang

Keyword(s):

Body Mass Index ◽

Blood Glucose ◽

Vagus Nerve Stimulation ◽

Fasting Blood Glucose ◽

Drug Resistant ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Drug Resistant Epilepsy ◽

Blood Glucose Concentrations

Abstract Background Cervical vagus nerve stimulation (VNS) has been widely accepted as adjunctive therapy for drug-resistant epilepsy and major depression. Its effects on glycemic control in humans were however poorly understood. The aim of our study was to investigate the potential effects of VNS on fasting blood glucose in patients with drug-resistant epilepsy.Methods Patients with drug-resistant epilepsy who had received VNS implants at the same hospital in a randomized, controlled trial were retrospectively studied. Effects on fasting blood glucose, weight, body mass index and blood pressure were evaluated at 4, 8 and 12 months of follow-up.Results 32 subjects (11 females/21males, 19±9 years, body mass index 22.2±4.0 kg/m 2 ) completed 12-month follow-up. At the 4 months, there were no significant changes in fasting blood glucose concentrations from baseline to follow-up in both Sham-VNS (4.89±0.54 vs. 4.56±0.54 mmol/L, p=0.101) and VNS (4.80±0.54 vs. 4.50±0.56 mmol/L, p=0.117) groups. However, after 8 (4.90±0.42 mmol/L, p=0.001) and 12 (4.86±0.40 mmol/L, p=0.002) months of VNS, fasting blood glucose levels significantly increased compared to baseline values (4.52±0.54 mmol/L). Changes in fasting blood glucose concentrations at both 8 (R 2 =0.502, p<0.001) and 12 (R 2 =0.572, p<0.001) months were negatively correlated with baseline fasting blood glucose levels.Conclusions Our study suggests that chronic cervical VNS elevates fasting blood glucose levels with commonly used stimulation parameters in patients with epilepsy.Trial registration: VNSRE, NCT02378792. Registered 4 March 2015 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02378792

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Differential effects of prenatal stress and glucocorticoid administration on postnatal growth and glucose metabolism in rats

Journal of Endocrinology ◽

10.1677/joe-09-0390 ◽

2009 ◽

Vol 204 (3) ◽

pp. 319-329 ◽

Cited By ~ 29

Author(s):

K L Franko ◽

A J Forhead ◽

A L Fowden

Keyword(s):

Glucose Metabolism ◽

Glucose Tolerance ◽

Body Fat ◽

Glycogen Content ◽

Postnatal Growth ◽

Female Offspring ◽

Fat Content ◽

Body Fat Content ◽

Offspring Growth ◽

Gluconeogenic Enzyme

Glucocorticoid administration during pregnancy programmes cardiovascular and metabolic functions in the adult offspring. Often, the control procedures are stressful per se and raise maternal glucocorticoid concentrations. This study compared the effects of maternal injection with dexamethasone (dex, 200 μg/kg) or saline with no treatment from 15 to 20 days of rat pregnancy on offspring growth and glucose metabolism. Near term, maternal corticosterone concentrations were higher in the saline-treated dams and lower in the dex-treated dams relative to untreated animals. In both male and female offspring, growth rate was measured for 14 weeks, and glucose tolerance was assessed between 12 and 13 weeks together with body fat content and plasma concentrations of insulin, leptin, and corticosterone between 14 and 15 weeks. Offspring liver was collected at different ages and was analyzed for glycogen content and gluconeogenic enzyme activity. Compared with untreated animals, both dex and saline treatments altered postnatal growth although adult body weight was unaffected. The two treatments had different effects on adult insulin concentrations and on hepatic glycogen content and gluconeogenic enzyme activities both pre- and postnatally. Relative to untreated animals, adult glucose tolerance was improved by maternal saline injection in males but not in females, while it was impaired in female offspring but not in male offspring of the dex-treated dams. Adult glucose tolerance was related to male body fat content but not to female body fat content. Dex and saline treatments of pregnant rats have differential sex-linked effects on the growth and glucose metabolism of their offspring, which indicates that the programming actions of natural and synthetic glucocorticoids may differ.

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Pengaruh Terapi Akupunktur terhadap Metabolisme Glukosa pada Penderita Overweight dan Obesitas di Kelurahan Mojosongo Surakarta

Jurnal Keterapian Fisik ◽

10.37341/jkf.v5i1.204 ◽

2020 ◽

Vol 5 (1) ◽

pp. 13-30

Author(s):

Purwanto Purwanto

Keyword(s):

Body Mass Index ◽

Blood Glucose ◽

Glucose Metabolism ◽

Acupuncture Therapy ◽

Body Mass ◽

Bone Diseases ◽

Obese Patients ◽

Processing Application ◽

Glucose Levels ◽

Blood Glucose Levels

Obesity is a multifactorial disease, which occurs as a result of excessive fat tissue accumulation and if not treated properly in the long term will lead to risks and complications of dangerous diseases including diabetes mellitus, cardiovascular disease, reproductive system disorders, gallstones, and bone diseases and joints. The purpose of this study is to determine the effect of acupuncture on glucose metabolism in overweight and obese patients. This study uses a quasi-experimental one-group pretest-posttest design. This research was conducted at the Posyandu Elderly in Mojosongo, Jebres, Surakarta City. This study focuses on acupuncture therapy on blood glucose levels, body mass index (BMI) and serum Hb.A1c levels before and after acupuncture therapy. Data analysis with Paired T-Test using SPSS Series 23 data processing application. The results showed that there was a significant but not significant effect of acupuncture on overweight and obese patients, there was a significant effect of acupuncture on Body Mass Index (BMI) in overweight and obese patients, and there is a significant effect of acupuncture on Hb.A1c levels in overweight and obese patients. The conclusion of this study shows that acupuncture therapy can affect glucose metabolism and reduce body mass index so as to prevent the onset of dangerous chronic diseases in the future. Keywords: Overweight-obesity, Acupuncture, Body Mass Index (BMI), Blood glucose levels, Hb.A1c.

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