scholarly journals Chronic vagus nerve stimulation for drug-resistant epilepsy influences fasting blood glucose concentration

2020 ◽  
Author(s):  
Hongyun Liu ◽  
Ping Zhan ◽  
Fangang Meng ◽  
Weidong Wang
Keyword(s):  
Body Mass Index ◽  
Blood Glucose ◽  
Vagus Nerve Stimulation ◽  
Fasting Blood Glucose ◽  
Drug Resistant ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Drug Resistant Epilepsy ◽  
Blood Glucose Concentrations

Abstract Background Cervical vagus nerve stimulation (VNS) has been widely accepted as adjunctive therapy for drug-resistant epilepsy and major depression. Its effects on glycemic control in humans were however poorly understood. The aim of our study was to investigate the potential effects of VNS on fasting blood glucose in patients with drug-resistant epilepsy.Methods Patients with drug-resistant epilepsy who had received VNS implants at the same hospital in a randomized, controlled trial were retrospectively studied. Effects on fasting blood glucose, weight, body mass index and blood pressure were evaluated at 4, 8 and 12 months of follow-up.Results 32 subjects (11 females/21males, 19±9 years, body mass index 22.2±4.0 kg/m 2 ) completed 12-month follow-up. At the 4 months, there were no significant changes in fasting blood glucose concentrations from baseline to follow-up in both Sham-VNS (4.89±0.54 vs. 4.56±0.54 mmol/L, p=0.101) and VNS (4.80±0.54 vs. 4.50±0.56 mmol/L, p=0.117) groups. However, after 8 (4.90±0.42 mmol/L, p=0.001) and 12 (4.86±0.40 mmol/L, p=0.002) months of VNS, fasting blood glucose levels significantly increased compared to baseline values (4.52±0.54 mmol/L). Changes in fasting blood glucose concentrations at both 8 (R 2 =0.502, p<0.001) and 12 (R 2 =0.572, p<0.001) months were negatively correlated with baseline fasting blood glucose levels.Conclusions Our study suggests that chronic cervical VNS elevates fasting blood glucose levels with commonly used stimulation parameters in patients with epilepsy.Trial registration: VNSRE, NCT02378792. Registered 4 March 2015 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02378792

scholarly journals Chronic vagus nerve stimulation for drug-resistant epilepsy may influence fasting blood glucose concentration

2020 ◽  
Author(s):  
Hongyun Liu ◽  
Ping Zhan ◽  
Fangang Meng ◽  
Weidong Wang
Keyword(s):  
Body Mass Index ◽  
Blood Glucose ◽  
Vagus Nerve ◽  
Body Mass ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Fasting Blood Glucose ◽  
Drug Resistant ◽  
Drug Resistant Epilepsy

Abstract Background Cervical vagus nerve stimulation (VNS) has been widely accepted as adjunctive therapy for drug-resistant epilepsy and major depression. Its effects on glycemic control in humans were however poorly understood. The aim of our study was to investigate the potential effects of VNS on fasting blood glucose (FBG) in patients with drug-resistant epilepsy. Methods Patients with drug-resistant epilepsy who had received VNS implants at the same hospital were retrospectively studied. Effects on FBG, weight, body mass index and blood pressure were evaluated at 4, 8 and 12 months of follow-up. Results 32 subjects (11 females/21males, 19±9 years, body mass index 22.2±4.0 kg/m 2 ) completed 12-month follow-up. At the 4 months, there were no significant changes in FBG concentrations from baseline to follow-up in both Sham-VNS (4.89±0.54 vs. 4.56±0.54 mmol/L, N=13, p=0.101) and VNS (4.80±0.54 vs. 4.50±0.56 mmol/L, N=19, p=0.117) groups. However, after 8 (4.90±0.42 mmol/L, N=32, p=0.001) and 12 (4.86±0.40 mmol/L, N=32, p=0.002) months of VNS, FBG levels significantly increased compared to baseline values (4.52±0.54 mmol/L, N=32). Changes in FBG concentrations at both 8 (R 2 =0.502, N=32, p<0.001) and 12 (R 2 =0.572, N=32, p<0.001) months were negatively correlated with baseline FBG levels. Conclusions Our study suggests that chronic cervical VNS elevates FBG levels with commonly used stimulation parameters in patients with epilepsy.

Perioperative blood glucose concentrations in kittens following overnight fasting and gonadectomy

2017 ◽  
Vol 20 (4) ◽  
pp. 344-348
Author(s):  
Danielle N Semick ◽  
Stephanie L Shaver ◽  
Heather N Cornell ◽  
Nancy C Bradley ◽  
Rachael E Kreisler
Keyword(s):  
Blood Glucose ◽  
Body Condition Score ◽  
Fasting Blood Glucose ◽  
Clinical Signs ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Condition Score ◽  
Prolonged Fast ◽  
Overnight Fasting ◽  
Blood Glucose Concentrations

Objectives The objective of this study was to determine if hypoglycemia is an effect of overnight fasting and gonadectomy in kittens, as well as to determine predictors of baseline and postoperative blood glucose. Methods This was a prospective observational study. Seventy-five kittens between the age of 8 and 16 weeks undergoing routine castration or ovariohysterectomy at an animal shelter were included. Two blood glucose measurements were analyzed per kitten after an overnight fast: a baseline reading prior to preoperative examination, and a reading immediately postoperatively. Predictors of the baseline and postoperative blood glucose levels were determined using multi-level mixed-effects linear regression. Results Kittens, when fasted overnight, were not hypoglycemic (<60 mg/dl). No kittens exhibited clinical signs consistent with hypoglycemia. No kittens had a blood glucose <70 mg/dl postoperatively. Postoperative hyperglycemia (>150 mg/dl) was observed in 44% of kittens. The only predictor of fasted blood glucose levels was body condition score. The only predictor of postoperative blood glucose levels was the fasting blood glucose value. Conclusions and relevance Overnight fasting prior to elective sterilization in 8- to 16-week-old kittens did not result in hypoglycemia. Concern regarding hypoglycemia after a prolonged fast in kittens may be unwarranted for short procedures in healthy animals.

scholarly journals Fasting blood glucose level and its association with sex, body mass index and blood pressure: a cross sectional study on a Bangladeshi public university students

2017 ◽  
Vol 4 (8) ◽  
pp. 2663
Author(s):  
Md Imam Hossain ◽  
Md. Shariful Islam ◽  
Mirza Rokibul Hasan ◽  
Moriom Akter ◽  
Md. Sadek Hosen Khoka
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Blood Glucose ◽  
University Students ◽  
Blood Glucose Level ◽  
Body Mass ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels

Background: In resource-limited countries like Bangladesh, there is a scarcity of epidemiological researches examining the relationship of blood glucose level with hypertension and BMI among the graduate level students. This research was therefore undertaken to evaluate fasting blood glucose levels of Mawlana Bhashani Science and Technology University students and to check its associations with sex, body mass index (BMI) and hypertension. Methods: For the study the 240 students (120 male and 120 female) were randomly selected. The demographic data of the study subjects were collected by interviewing the subjects with standardized questionnaires. Their fasting blood glucose levels were measured using portable blood glucose meter. The BMI and blood pressure of the subjects were also recorded following standard protocol. Finally the data were analyzed with SPSS software. Results: The fasting blood glucose levels of the study subjects indicated that 0.4% of subjects were diabetic and, 5.4% of subjects were pre-diabetic. The blood glucose levels (mean±SE) of female subjects (4.88±0.07) were higher than that of the male (4.61±0.04) subjects. The mean blood glucose levels of hypertensive subjects (4.81±0.07 mmol/L) were higher than that of the normotensive counterpart (4.73±0.05 mmol/L). The fasting blood glucose levels shows significant positive associations with SBP (r=0.155, p<0.05) and DBP (r=0.149, p<0.05).The fasting blood glucose levels also showed a significant positive association with the BMI (r=0.193, p<0.01) of the subjects. Conclusions: This study reveals the diabetic and hypertension status of the Bangladeshi graduate level students. The result of the study is very important in the context of public concern health of Bangladesh.  

scholarly journals The Relation between Estradiol Levels and Body Mass Index with Fasting Blood Glucose Levels in Premenopausal Women in Padang in 2017

2021 ◽  
Vol 8 (9) ◽  
pp. 338-344
Author(s):  
Melani Razuli ◽  
Afriwardi . ◽  
Fika Tri Anggraini
Keyword(s):  
Body Mass Index ◽  
Blood Glucose ◽  
Body Mass ◽  
Pearson Correlation ◽  
Fasting Blood Glucose ◽  
Premenopausal Women ◽  
P Value ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Estradiol Levels

Premenopause is a transitional period that occurs due to decreased generative or endocrine function of the ovaries. In premenopausal women, there is a decrease in estrogen hormone levels and an increase in Body Mass Index (BMI) so that it will increase the risk of diabetes mellitus which is one of the four priority non-communicable diseases. The incidence of diabetes mellitus in women is much higher when compared to men. The research was conducted in the city of Padang, with an observational, cross-sectional design. The sampling technique used was multistage random sampling with a sample of 99 premenopausal women. The estradiol level was assessed by ELISA method, BMI was assessed by weight (kg) divided by height (m) squared, fasting blood glucose level was assessed by the enzymatic photometric method. The correlation between estradiol levels and fasting blood glucose levels was analyzed by using the Pearson Correlation test. The correlation between BMI and fasting blood glucose levels was analyzed by using the Pearson Correlation test. The mean of estradiol level was (148,689±49,417) pg/ml. Average Body Mass Index (BMI) was included in the Obese category I (26.5 kg/m2). The mean fasting blood glucose level was (98,766±6,549) mg/dL. There is a correlation between estradiol levels and fasting blood glucose levels (p value = 0.007 and r value = 0.270). In addition, there is a correlation between BMI and fasting blood glucose levels (p value = 0.023). The conclusion of this study is that there is a significant correlation between estradiol levels and fasting blood glucose. There is a significant correlation between BMI and fasting blood glucose Keywords: Estradiol Levels, Body Mass Index, Fasting Blood Glucose Levels, Premenopause.

scholarly journals Diabetes status affects long-term changes in coronal caries - The SHIP Study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Julia Schmolinsky ◽  
Thomas Kocher ◽  
Wolfgang Rathmann ◽  
Henry Völzke ◽  
Christiane Pink ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Population Based ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Term Change ◽  
Diabetes Status

Abstract We estimated effects of diabetes mellitus and metabolic control on long-term change in coronal caries and restorative status using 11-year-follow-up data from the population-based Study of Health in Pomerania. Data of 3731 participants with baseline and 5- and 11-year follow-up information were included. Diabetes was defined via self-reported physician´s diagnosis or intake of glucose-lowering drugs or hemoglobin A1c (HbA1c) ≥6.5% or fasting blood glucose levels ≥11.1 mmol/l. The diabetes status was defined as no diabetes (HbA1c < 6.5% or non-fasting blood glucose <11.1 mmol/l), subjects with known or undetected diabetes mellitus and HbA1c ≤ 7% (well-controlled diabetes), and subjects with known or undetected diabetes mellitus and HbA1c > 7% (poorly-controlled diabetes). The caries status was clinically assessed using the half-mouth method and the Decayed Missing Filled Surfaces (DMFS) index and its component scores were determined. Covariate-adjusted linear mixed models were evaluated. Rates in change in DMFS were significantly higher in subjects with poorly-controlled diabetes compared to subjects without diabetes. Subjects with poorly- and well-controlled diabetes had significantly higher rates in change in Missing Surfaces (MS) compared to subjects without diabetes. For the DFS, rates in change were significantly lower for subjects with well-controlled diabetes and higher for subjects with poorly-controlled diabetes as compared to subjects without diabetes. Concordantly, all rates in change increased proportional to HbA1c levels. Effects were even more pronounced in subjects with diabetes duration of ≥5 years. Subjects with poorly-controlled diabetes are at higher risk for caries progression compared to subjects without diabetes, especially in case of longer disease duration.

scholarly journals Association between chronic generalized periodontitis and hyperlipidemia – a case control study

2010 ◽  
Vol 9 (2) ◽  
pp. 95-100 ◽  
Author(s):  
Amirisetty Ramesh ◽  
Jacob P Shaju ◽  
RM Zade
Keyword(s):  
Body Mass Index ◽  
Blood Glucose ◽  
Periodontal Disease ◽  
Total Cholesterol ◽  
Chronic Periodontitis ◽  
Plasma Lipids ◽  
Fasting Blood Glucose ◽  
Low Density ◽  
Glucose Levels ◽  
Blood Glucose Levels

Introduction: Hyperlipidemia is a major risk factor for cardiovascular disease. Periodontal disease is caused by predominantly anaerobic gram negative bacteria. Microbial substances initiate and perpetuate the inflammation resulting in the production of high levels of proinflammatory cytokines and hyperactivity of white blood cells and of blood platelets, thus promoting the development of hyperlipidemia. Objective: To evaluate the plasma lipids (Total cholesterol, Low Density Lipoproteins and Triglycerides) as well as Fasting blood glucose levels in non diabetic, non-obese periodontal disease patients and controls. Materials and methods: 18 subjects with chronic periodontal disease (aged 38 to 50 years) were matched for age, sex and BMI (Body Mass Index) with 18 healthy subjects. Total cholesterol, low density lipoprotein, triglycerides and fasting blood glucose levels were measured using routine enzymatic biochemical methods. Results: Total cholesterol, LDL cholesterol and triglycerides was significantly higher in chronic periodontitis patients by 12% ( p<0.02), 14% ( p<0.03) and 22% ( p<0.03) respectively as compared to controls. Fasting blood glucose levels was higher by 7% (p<0.04) in chronic periodontitis patients than controls. Conclusion: Hyperlipidemia and prediabetic state may be associated with chronic periodontitis. Key words: chronic periodontitis; plasma lipids; body mass index; fasting blood glucose. DOI: 10.3329/bjms.v9i2.5657Bangladesh Journal of Medical Science Vol.09 No.2 Apr 2010 pp.95-100

scholarly journals Body Mass Index, Waist-Hip Ratio and Fasting Blood Glucose Levels amongst the University Students

2021 ◽  
Vol 57 (1) ◽  
pp. 53
Author(s):  
Rury Tiara Oktariza ◽  
Viskasari Pintoko Kalanjati ◽  
Ni Wajan Tirthaningsih
Keyword(s):  
Body Mass Index ◽  
Blood Glucose ◽  
University Students ◽  
Body Mass ◽  
Fasting Blood Glucose ◽  
Overweight And Obesity ◽  
Asia Pacific ◽  
Male And Female ◽  
Glucose Levels ◽  
Blood Glucose Levels

Overweight and obesity have been correlated to the higher risk for developing metabolic diseases in later life, i.e. DM type 2. We study the body mass index (BMI), the waist to hip ratio (WHR) and the fasting blood glucose levels (FBG) in the seemingly healthy male and female university students to comprehend these variables amongst the youth in Indonesia in 2019. The BMI and WHR of 150 male and female students aged 18-22 years old of the IIKBW, Kediri were measured by standardised anthropometry. The FBG was measured after 8 hours-minimum of fasting from the capillary blood drop using glucometer. Data was then analysed using SPSS 17 with level of significance of p<0.05. According to Asia-Pacific BMI classification, students were 30.7% obese with males significantly higher than females (p=0.016), 18% overweight (significantly higher in females, p=0.04), 36% normal and 15.3% underweight.When compared between genders, the WHR is significantly higher in males (p<0.001); whilst no significant differences in FBG (p=0.6). Four males and 5 females with FBG ≥ 100 mg/dl, whereas others were within normal limits. There are positive significant correlations between BMI and WHR in males and females (r=0.777, p<0.001; r=0.54, p<0.001, respectively). There is a significant positive correlation between the BMI and FBG with r=0.217, p=0.008; and between the WHR and FBG with r=0.21, p=0.01 amongst all students. In this study, male students have significantly higher BMI and WHR than females. Higher FBG was well observed in students with either higher BMI or WHR.

Effects of Fasting Blood Glucose on the Progression of Arterial Stiffness in Nondiabetic Population

2021 ◽  
Vol 34 (10) ◽  
pp. 1125-1125
Author(s):  
Xu Han ◽  
Qian Liu ◽  
Yi-han Ma ◽  
Xiao-ming Zheng ◽  
Chun-yu Ruan ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Linear Regression ◽  
Arterial Stiffness ◽  
Multiple Linear Regression ◽  
Linear Regression Analysis ◽  
Fasting Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
The Impact

Abstract Background To investigate the relationship between baseline fasting blood glucose levels and the progression of arterial stiffness in nondiabetic population. Methods In this research, the individuals participated in the Kailuan research cohort and completed 2 tests of brachial–ankle pulse wave velocity (baPWV) from 2010 to 2018 and were not diabetic at the first baPWV testing were included. A multiple linear regression was applied to analyze the impact of baseline fasting blood glucose levels on baPWV and its progress during the follow-up. Results A total of 16,875 with 10,453 male (61.94%) subjects met the inclusion criteria. The average age at baseline (the first baPWV measurement) was (45.9 ± 13.0) years old and the average baPWV was (1,439.0 ± 309.3) cm/s. During the follow-up (the second baPWV measurement), the average age was (49.6 ± 13.3) years old, and the average baPWV was (1,494.6 ± 334.3) cm/s. The baPWV progression in the observed subjects was (55.7 ± 233.4) cm/s. After adjusted for other confounding factors, multiple linear regression analysis found that there was a positive correlation between the baseline fasting blood glucose levels and the follow-up baPWV. With every 1 mmol/l baseline fasting blood glucose increase, the follow-up baPWV increased 16.89 cm/s. With every 1 mmol/l fasting blood glucose level increase, the progress of baPWV increased by 3.70 cm/s. Conclusions Fasting blood glucose levels in nondiabetics affect arterial stiffness during follow-up. Elevated fasting blood glucose levels during the follow-up period are a risk factor that may increase the progression of arterial stiffness.

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