scholarly journals Noise-Induced Vascular Dysfunction, Oxidative Stress, and Inflammation Are Improved by Pharmacological Modulation of the NRF2/HO-1 Axis

Antioxidants ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 625
Author(s):  
Maria Teresa Bayo Jimenez ◽  
Katie Frenis ◽  
Swenja Kröller-Schön ◽  
Marin Kuntic ◽  
Paul Stamm ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sound Pressure Level ◽  
Vascular Function ◽  
Sound Pressure ◽  
Molecular Mechanisms ◽  
Noise Exposure ◽  
Vascular Dysfunction ◽  
Pressure Level ◽  
Aircraft Noise ◽  
Heme Oxygenase 1

Vascular oxidative stress, inflammation, and subsequent endothelial dysfunction are consequences of traditional cardiovascular risk factors, all of which contribute to cardiovascular disease. Environmental stressors, such as traffic noise and air pollution, may also facilitate the development and progression of cardiovascular and metabolic diseases. In our previous studies, we investigated the influence of aircraft noise exposure on molecular mechanisms, identifying oxidative stress and inflammation as central players in mediating vascular function. The present study investigates the role of heme oxygenase-1 (HO-1) as an antioxidant response preventing vascular consequences following exposure to aircraft noise. C57BL/6J mice were treated with the HO-1 inducer hemin (25 mg/kg i.p.) or the NRF2 activator dimethyl fumarate (DMF, 20 mg/kg p.o.). During therapy, the animals were exposed to noise at a maximum sound pressure level of 85 dB(A) and a mean sound pressure level of 72 dB(A). Our data showed a marked protective effect of both treatments on animals exposed to noise for 4 days by normalization of arterial hypertension and vascular dysfunction in the noise-exposed groups. We observed a partial normalization of noise-triggered oxidative stress and inflammation by hemin and DMF therapy, which was associated with HO-1 induction. The present study identifies possible new targets for the mitigation of the adverse health effects caused by environmental noise exposure. Since natural dietary constituents can achieve HO-1 and NRF2 induction, these pathways represent promising targets for preventive measures.

P4478Noise pollution exacerbates the development of arterial hypertension via additive oxidative stress and impairment of NO signaling

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
S Steven ◽  
K Frenis ◽  
S Kroeller-Schoen ◽  
S Kalinovic ◽  
J Helmstaedter ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Endothelial Dysfunction ◽  
Sound Pressure ◽  
Cardiovascular Health ◽  
Noise Exposure ◽  
Pressure Level ◽  
Aircraft Noise ◽  
Pressure Measurements ◽  
Additive Increase

Abstract Background Environmental noise pollution has been identified as a cardiovascular risk and is characterized by moderate hypertension, endothelial dysfunction, increased oxidative stress, and inflammation. We have gained insights into the mechanism by which these consequences occur by exposing mice lacking the critical NADPH oxidase subunit gp91phox to aircraft noise. Mice were protected from the effects of aircraft noise exposure. NADPH oxidase is believed to be the mediator by which angiotensin II increases oxidative stress, making investigation into the additive effect of noise and hypertension an important subject in modern cardiovascular health research. Methods and results C57Bl/6J mice were implanted with subcutaneous osmotic mini-pumps, delivering a moderate dose of 0.5mg/kg/d of angiotensin II for 7 days. Immediately following the implantation, half the mice were exposed to aircraft noise for 7 days at a maximum sound pressure level of 85 dB(A) and a mean sound pressure level of 72 dB(A), a level at which hearing loss does not occur*. Non-invasive blood pressure measurements revealed an additive increase in blood pressure in noise-exposed hypertensive mice. Following sacrifice, endothelial dysfunction was evaluated through isometric tension recordings of 3mm aortic ring segments. These recordings support the blood pressure measurements and indicate a more serious impairment in acetylcholine-induced vasorelaxation in hypertensive mice exposed to noise than the hypertensive or noise only controls. Whole blood stimulated with phorbol 12,13-dibutyrate (PDBu) or zymosan A showed an additive increase in oxidative burst in in noise-exposed hypertensive mice. Dihydroethidium (DHE) staining was used to assess the presence of vascular and cerebral oxidative stress, showing similar additive effects in mice with hypertension plus noise exposure. High performance liquid chromatography (HPLC) measurement of 2-hydroxyethidium further confirmed additive increase of oxidative stress in the aorta and brain. Western blot analysis of aortic tissue revealed highest levels of gp91phox in mice with hypertension plus noise exposure and indicated a decrease in the ratio of P-eNOSSer1177:eNOS as well as a decrease in the ratio of eNOS dimer:monomer, exposing eNOS uncoupling as a potential pathomechanism for endothelial dysfunction and gp91phox as a source for the oxidative stress.Ongoing immunohistochemical and flow cytometric investigations will characterize the role of immune cells in these adverse effects. Conclusion Herein, we present novel data demonstrating additive noise-induced cardiovascular consequences on developing hypertension. Noise has previously been established as a cardiovascular risk factor, but the effects have not been determined in pre-existing or developing cardiovascular disease. Our results show a cumulative effect between noise exposure and hypertension and forge an important link between environmental stressors and cardiovascular health. Acknowledgement/Funding Boehringer Ingelheim Foundation

scholarly journals Individual Aircraft Noise Exposure Assessment for a Case-Crossover Study in Switzerland

2020 ◽  
Vol 17 (9) ◽  
pp. 3011 ◽  
Author(s):  
Apolline Saucy ◽  
Beat Schäffer ◽  
Louise Tangermann ◽  
Danielle Vienneau ◽  
Jean-Marc Wunderli ◽  
...  
Keyword(s):  
Crossover Study ◽  
Exposure Assessment ◽  
Sound Pressure Level ◽  
Sound Pressure ◽  
Noise Exposure ◽  
Pressure Level ◽  
Aircraft Noise ◽  
Spatial And Temporal Variation ◽  
Acute Effects ◽  
Case Crossover

Accurate exposure assessment is essential in environmental epidemiological studies. This is especially true for aircraft noise, which is characterized by a high spatial and temporal variation. We propose a method to assess individual aircraft noise exposure for a case-crossover study investigating the acute effects of aircraft noise on cardiovascular deaths. We identified all cases of cardiovascular death (24,886) occurring near Zürich airport, Switzerland, over fifteen years from the Swiss National Cohort. Outdoor noise exposure at the home address was calculated for the night preceding death and control nights using flight operations information from Zürich airport and noise footprints calculated for major aircraft types and air routes. We estimated three different noise metrics: mean sound pressure level (LAeq), maximum sound pressure level (LAmax), and number above threshold 55 dB (NAT55) for different nighttime windows. Average nighttime aircraft noise levels were 45.2 dB, 64.6 dB, and 18.5 for LAeq, LAmax, and NAT55 respectively. In this paper, we present a method to estimate individual aircraft noise exposure with high spatio-temporal resolution and a flexible choice of exposure events and metrics. This exposure assessment will be used in a case-crossover study investigating the acute effects of noise on health.

scholarly journals Vascular function and arginine and dimethylarginines in gentamicin-induced renal failure: a possible effect of heme oxygenase 1 inducer hemin

2017 ◽  
Vol 95 (12) ◽  
pp. 1406-1413 ◽  
Author(s):  
Esra Aycan-Ustyol ◽  
Merve Kabasakal ◽  
Seldag Bekpinar ◽  
F. Ilkay Alp-Yıldırım ◽  
Ozge Tepe ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heme Oxygenase ◽  
Vascular Function ◽  
Asymmetric Dimethylarginine ◽  
Vascular Dysfunction ◽  
Cardiovascular Complication ◽  
Heme Oxygenase 1 ◽  
Antioxidant Enzyme Activities ◽  
Symmetric Dimethylarginine ◽  
Inflammatory Changes

Increased oxidative stress and disturbance in nitric oxide bioavailability lead to endothelial dysfunction and cardiovascular complication in renal disease. Gentamicin (GM), a commonly used antibiotic, exhibits a toxic effect on renal proximal tubules. Prevention of its nephrotoxicity is important. Therefore, we investigated whether heme oxygenase 1 HO-1) induction influenced kidney and vascular function in GM-administered rats. GM (100 mg·kg–1·day–1; i.p.) was given to rats alone or together with hemin (20 mg·kg–1 on alternate days; i.p.) for 14 days. Plasma and kidney l-arginine, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) as well as kidney 4-hydroxynonenal (HNE) levels and myeloperoxidase (MPO) activity were measured. Histopathological examinations of kidney and relaxation and contraction responses of aorta were also examined. GM increased serum SDMA, urea nitrogen (BUN), and creatinine levels and caused histopathological alterations in the kidney. GM elevated HO-1 protein and mRNA expressions, 4-HNE level, and MPO activity and decreased antioxidant enzyme activities and l-arginine levels in the kidney. Decreased relaxation and contraction were detected in the aorta. Hemin restored renal oxidative stress and inflammatory changes together with vascular dysfunction, but did not affect SDMA, BUN, or creatinine levels. We conclude that HO-1 induction may be effective in improving renal oxidative stress, inflammation, and vascular dysfunction mediated by GM.

scholarly journals Landscape depressions can create silent zones in noise polluted parks

2021 ◽  
Vol 263 (4) ◽  
pp. 2550-2554
Author(s):  
Timothy Van Renterghem ◽  
Pieter Thomas ◽  
Dick Botteldooren
Keyword(s):  
Sound Pressure Level ◽  
Sound Pressure ◽  
Noise Exposure ◽  
Road Traffic ◽  
Traffic Noise ◽  
Pressure Level ◽  
Road Traffic Noise ◽  
Efficient Measure ◽  
Natural Means

Excessive road traffic noise exposure in (sub)urban parks hinders its restorative function and will negatively impact the number of visitors. Especially in such green environments, noise abatements by natural means, well integrated in the landscape, are the most desired solutions. Although dense vegetation bordering the park or raised berms could come first in mind, local landscape depressions are typically underused. In this work, a case-study of a small suburban park, squeezed in between two major arterial roads, is analyzed. The spatially dependent road traffic noise exposure in the park is assessed in detail by mobile sound pressure level measurements. Local reductions of up to 6-7 dBA are found at landscape depressions of only a few meters deep. It can therefore be concluded that this is an efficient measure and should be added to the environmental noise control toolbox for noise polluted parks.

Temporary Threshold Shift from a Toy Cap Gun

1974 ◽  
Vol 39 (2) ◽  
pp. 163-168 ◽  
Author(s):  
Lynne Marshall ◽  
John F. Brandt
Keyword(s):  
Hearing Loss ◽  
Sound Pressure Level ◽  
Sound Pressure ◽  
Noise Exposure ◽  
Pressure Level ◽  
Threshold Shift ◽  
Temporary Threshold Shift ◽  
Fixed Frequency ◽  
Before And After ◽  
The Subject

Temporary threshold shift resulting from exposure to one and five toy cap gun pistol shots was investigated using 11 normal-hearing adult subjects and one subject with a noise-induced hearing loss. The subjects fired the cap gun at arm’s length, and absolute thresholds at 4000 Hz were obtained before and after noise exposure by a fixed-frequency Bekesy technique. After exposure to one gunshot, five subjects showed a small TTS, five demonstrated no TTS, and two (including the subject with the hearing loss) exhibited negative TTS. No TTS occurred in any of the subjects after exposure to five shots. It was postulated that the small amount of TTS was due to the unexpectedly low sound pressure level produced by the cap gun and to the contraction of the middle ear muscles in some subjects prior to firing.

scholarly journals Validity of Reference Time Intervals in Noise Indicators for Aircraft Noise Policy in Vietnam

Urban Science ◽  
2020 ◽  
Vol 4 (2) ◽  
pp. 19
Author(s):  
Thu Lan Nguyen ◽  
Ichiro Yamada ◽  
Takashi Yano ◽  
Koichi Makino ◽  
Masaharu Ohya
Keyword(s):  
Sound Pressure Level ◽  
Traffic Congestion ◽  
Sound Pressure ◽  
Leisure Activities ◽  
Pressure Level ◽  
Aircraft Noise ◽  
Small Scale ◽  
Time Interval ◽  
Time Intervals ◽  
Reference Time

Many decibel-based noise indicators are used in noise policy to evaluate aircraft sound in the environment. Among those, day–evening–night-weighted sound pressure level ( L den ), day–night-weighted sound pressure level ( L dn ), and nighttime average sound pressure level ( L night ) are the most widely used. However, the designation of reference time intervals (e.g., day, evening, and night) differs depending on the country’s lifestyle and culture. A dataset—extracted from socio-acoustic surveys conducted in Vietnam (2005–2019)—was analyzed to investigate temporal patterns of the Vietnamese lifestyle and changes in L den , L dn , and L night when temporal interval segmentations in these indicators were adjusted. Traffic congestion hours, go-to-bed time, and wake-up time in southern Vietnam were approximately one hour later than those in northern and central Vietnam. Further, a small-scale and Internet-based questionnaire survey on Vietnamese life rhythms was conducted to examine Vietnamese people’s daily behaviors. These data were compared with the relevant data of Japanese individuals, extracted from the Survey on Time Use and Leisure Activities of Japan. Differences in sleeping times and mealtimes were found between Japanese and Vietnamese data. We suggest an appropriate reference time interval for aircraft noise policy in Vietnam, referring to the current national and international noise standards and regulations.

scholarly journals Noise Emissions in Milking Parlours with Various Construction Solutions

2016 ◽  
Vol 19 (2) ◽  
pp. 49-51
Author(s):  
Marie Šístková ◽  
Martin Pšenka ◽  
Ivo Celjak ◽  
Petr Bartoš ◽  
Štefan Mihina ◽  
...  
Keyword(s):  
Dairy Cows ◽  
Sound Pressure Level ◽  
Sound Pressure ◽  
Noise Exposure ◽  
Pressure Level ◽  
Different Types ◽  
Sound Pressure Levels ◽  
Mechanical Devices

Abstract Mechanical devices in parlours are a source of noise, and this noise has an effect not only on the operators of the parlour but also on dairy cows. They have more sensitive hearing than humans. The aim of this article was to analyse the sound pressure level and determine the noise exposure of dairy cows at different technological solutions of milking parlours, during their day routine. In the experiment, tandem, herringbone and rotary milking parlours were used. Noise exposure was measured during the milking process. After evaluation of noise pressure levels of different types of milking parlours, it can be concluded that in this experiment, the equivalent noise pressure level was lowest in the tandem milking parlour. Equivalent sound pressure levels in the rotary and herringbone milking parlour were almost about the same values. These values are higher than values in the tandem milking parlour, about 10 decibels. The differences within mean LAFeq values between the herringbone milking parlour and tandem milking parlour were highly statistically significant (P <0.001***).

Potentiation of Kanamycin Ototoxicity by a History of Noise Exposure

1978 ◽  
Vol 86 (1) ◽  
pp. ORL-125-ORL-128 ◽  
Author(s):  
Allen F. Ryan ◽  
Robert C. Bone
Keyword(s):  
Hearing Loss ◽  
Sound Pressure Level ◽  
Sound Pressure ◽  
Noise Exposure ◽  
Pressure Level ◽  
Threshold Shift ◽  
Noise Band ◽  
Pathologic Condition ◽  
History Of

Chinchillas were exposed to a noise band (1,414 to 5,656 Hz, 100-dB sound pressure level [SPL] for one hour) and treated with kanamycin (150 mg/kg a day until hearing loss was noted at 6.0 kHz) either separately, simultaneously, or sequentially. Simultaneous noise and kanamycin resulted in interactive potentiation of threshold shift and cochlear pathologic condition. Kanamycin treatment two months after noise exposure produced similar potentiation. No interaction was seen when noise exposure occurred one month after kanamycin treatment.

scholarly journals Mitigasi dampak kebisingan bandara terhadap kehidupan pemukiman sekitar bandara SSK II Pekanbaru

Jurnal Zona ◽  
2021 ◽  
Vol 4 (2) ◽  
pp. 91-106
Author(s):  
Eko Hendi Saputra ◽  
Yusni Ikhwan Siregar ◽  
Hafidawati Hafidawati
Keyword(s):  
Sound Pressure Level ◽  
Sound Pressure ◽  
Noise Exposure ◽  
Pressure Level ◽  
Noise Attenuation ◽  
Residential Areas ◽  
Noise Levels ◽  
Residential Communities ◽  
The People ◽  
The Impact

This study aims to determine the level of noise caused by flight activities at Sultan Syarif Kasim II Airport Pekanbaru, analyze noise levels that occur due to flight activities at Sultan Syarif Kasim II Airport Pekanbaru and analyze efforts to control the negative impact of airport noise on the living environment of community settlements. around Sultan Syarif Kasim II Airport Pekanbaru. This research uses field observation method, which is making direct observations at the research location by looking at the condition of the location and the suitability of the location which is the sampling point of the study (the noise level boundary at Sultan Syarif Kasim II Airport). Observations were made for 16 hours (Ls) at an interval of 06.00 - 22.00. Measurement of sound pressure level is carried out on holidays (Sunday) and weekdays (Monday), which starts on November 1, November 2, November 8, and November 9, 2020, which is carried out in residential areas around Sultan Syarif Kasim II Airport Pekanbaru, which are spread across 6 measurement points where the measurement of sound pressure level is done in duplicate, namely: Jl. Kaswari (point 1), Jl. Rawa Indah II (Point 2), Jl. Rawa Indah III (Point 3), Jl. Cinnamon (Point 4), Jl. Pahlawan Kerja gg.Pala 49 (Point 5) and Jl. Nur Asiyah (Point 6) The results of the processing of noise measurement data were made of a mapping model using surfer 11 software and to clarify the noise description at the sampling location, the map of the results of surfer 11 software processing was plotted on the airport area map.     Based on the results of measurements of noise levels around Sultan Syarif Kasim II airport, it is known that the location of point 1 (Jl. Rawa Indah II) experienced the highest noise exposure. These results indicate the location of point 1 should receive serious attention for the people who live around the airport, because the impact of airport noise has the potential to negatively affect the lives of residential communities. From the observations, it was also known that the level of noise attenuation was still low, both in terms of trees around the settlement and height, walls and fences were still not effective at reducing noise.         Based on the results of measurements of noise levels around Sultan Syarif Kasim II airport, it is known that the location of point 1 (Jl. Rawa Indah II) experienced the highest noise exposure. These results indicate that the location of point 1 should receive serious attention for the people who live around the airport, because the impact of airport noise has the potential to negatively affect the lives of residential communities. From the observations, it was also known that the level of noise attenuation was still low, both in terms of trees around the settlement and height, walls and fences were still not effective at reducing noise.         From the results of the research that has been done, several mitigation strategies can be formulated to reduce noise levels around Sultan Syarif Kasim II airport. Planting plants in accordance with the needs of controlling or reducing noise in human settlements. Tree categories suitable for planting in residential areas around the airport are: shady trees that can be planted tightly or with lots of leaves that can grow to a height of about 4 - 15 m (such as acacia, mahogany, flamboyant, ironwood or banyan trees, bamboo or cypress)

Assessment of Impulse Noise Hazard and the Use of Hearing Protection Devices in Workplaces Where Forging Hammers are Used

2015 ◽  
Vol 39 (1) ◽  
pp. 73-79 ◽  
Author(s):  
Rafał Młyński ◽  
Emil Kozłowski ◽  
Jan Adamczyk
Keyword(s):  
Sound Pressure Level ◽  
Impulse Noise ◽  
Sound Pressure ◽  
Noise Exposure ◽  
Pressure Level ◽  
Hearing Protection ◽  
Exposure Level ◽  
Limit Values ◽  
Noise Parameters ◽  
Protection Devices

Abstract The impulse noise is agent harmful to health not only in the case of shots from firearms and the explosions of explosive materials. This kind of noise is also present in many workplaces in the industry. The paper presents the results of noise parameters measurements in workplaces where four different die forging hammers were used. The measured values of the C-weighted peak sound pressure level, the A-weighted maximum sound pressure level and A-weighted noise exposure level normalized to an 8 h working day (daily noise exposure level) exceeded the exposure limit values. For example, the highest measured value of the C-weighted peak sound pressure level was 148.9 dB. In this study possibility of the protection of hearing with the use of earplugs or earmuffs was assessed. The measurement method for the measurements of noise parameters under hearing protection devices using an acoustical test fixture instead of testing with the participation of subjects was used. The results of these measurements allows for assessment which of two tested earplugs and two tested earmuffs sufficiently protect hearing of workers in workplaces where forging hammers are used.

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