scholarly journals Anticancer Effects of Lingonberry and Bilberry on Digestive Tract Cancers

Antioxidants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 850
Author(s):  
Tuulia Onali ◽  
Anne Kivimäki ◽  
Matti Mauramo ◽  
Tuula Salo ◽  
Riitta Korpela
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Digestive Tract ◽  
Cancer Cell ◽  
Tumor Formation ◽  
Cancer Cell Growth ◽  
Antitumor Effects ◽  
Anticancer Effects ◽  
Wild Berries

Wild berries are part of traditional Nordic diets and are a rich source of phytochemicals, such as polyphenols. Various berry treatments have shown to interfere with cancer progression in vitro and in vivo. Here, we systematically reviewed the anticancer effects of two Nordic wild berries of the Vaccinium genus, lingonberry (Vaccinium vitis-idaea) and bilberry (Vaccinium myrtillus), on digestive tract cancers. The review was conducted according to the PRISMA 2020 guidelines. Searches included four databases: PubMed, Scopus, Web of Science, and CAB abstracts. Publications not written in English, case-reports, reviews, and conference abstracts were excluded. Moreover, studies with only indirect markers of cancer risk or studies with single compounds not derived from lingonberry or bilberry were not included. Meta-analysis was not performed. The majority (21/26) of studies investigated bilberry and colorectal cancer. Experimental studies on colorectal cancer indicated that bilberry inhibited intestinal tumor formation and cancer cell growth. One uncontrolled pilot human study supported the inhibitory potential of bilberry on colorectal cancer cell proliferation. Data from all 10 lingonberry studies suggests potent inhibition of cancer cell growth and tumor formation. In conclusion, in vitro and animal models support the antiproliferative and antitumor effects of various bilberry and lingonberry preparations on digestive tract cancers.

scholarly journals HOXB4 inhibits the proliferation and tumorigenesis of cervical cancer cells by downregulating the activity of Wnt/β-catenin signaling pathway

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Dan Lei ◽  
Wen-Ting Yang ◽  
Peng-Sheng Zheng
Keyword(s):  
Cervical Cancer ◽  
Cell Growth ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Tumor Formation ◽  
Cervical Cancer Cell ◽  
Cancer Cell Growth ◽  
Bioinformatics Analyses

AbstractHomeobox B4 (HOXB4), which belongs to the homeobox (HOX) family, possesses transcription factor activity and has a crucial role in stem cell self-renewal and tumorigenesis. However, its biological function and exact mechanism in cervical cancer remain unknown. Here, we found that HOXB4 was markedly downregulated in cervical cancer. We demonstrated that HOXB4 obviously suppressed cervical cancer cell proliferation and tumorigenic potential in nude mice. Additionally, HOXB4-induced cell cycle arrest at the transition from the G0/G1 phase to the S phase. Conversely, loss of HOXB4 promoted cervical cancer cell growth both in vitro and in vivo. Bioinformatics analyses and mechanistic studies revealed that HOXB4 inhibited the activity of the Wnt/β-catenin signaling pathway by direct transcriptional repression of β-catenin. Furthermore, β-catenin re-expression rescued HOXB4-induced cervical cancer cell defects. Taken together, these findings suggested that HOXB4 directly transcriptional repressed β-catenin and subsequently inactivated the Wnt/β-catenin signaling pathway, leading to significant inhibition of cervical cancer cell growth and tumor formation.

scholarly journals microRNA-16 represses colorectal cancer cell growth in vitro by regulating the p53/survivin signaling pathway

2013 ◽  
Vol 29 (4) ◽  
pp. 1652-1658 ◽  
Author(s):  
QUNYING MA ◽  
XINYING WANG ◽  
ZHAO LI ◽  
BINGSHENG LI ◽  
FENGLI MA ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Colorectal Cancer Cell ◽  
Cancer Cell Growth

ECRG4 as a novel tumor suppressor gene inhibits colorectal cancer cell growth in vitro and in vivo

Tumor Biology ◽  
2016 ◽  
Vol 37 (7) ◽  
pp. 9111-9120 ◽  
Author(s):  
Zhengxu Cai ◽  
Pin Liang ◽  
Jize Xuan ◽  
Jiajia Wan ◽  
Huishu Guo
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Cancer Cell ◽  
Suppressor Gene ◽  
Colorectal Cancer Cell ◽  
Cancer Cell Growth

LYTAK1, a novel TAK1 inhibitor, suppresses KRAS mutant colorectal cancer cell growth in vitro and in vivo

Tumor Biology ◽  
2014 ◽  
Vol 36 (5) ◽  
pp. 3301-3308 ◽  
Author(s):  
Jundong Zhou ◽  
Bing Zheng ◽  
Jiansong Ji ◽  
Fei Shen ◽  
Han Min ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Colorectal Cancer Cell ◽  
Cancer Cell Growth

scholarly journals Adenovirus-mediated expression of SSAT inhibits colorectal cancer cell growth in vitro

2008 ◽  
Vol 29 (5) ◽  
pp. 606-613 ◽  
Author(s):  
Hui SUN ◽  
Bin LIU ◽  
Ya-pei YANG ◽  
Chun-xiao XU ◽  
Yun-fei YAN ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Colorectal Cancer Cell ◽  
Cancer Cell Growth

scholarly journals LKB1 and YAP phosphorylation play important roles in Celastrol-induced β-catenin degradation in colorectal cancer

2019 ◽  
Vol 11 ◽  
pp. 175883591984373 ◽  
Author(s):  
Shuren Wang ◽  
Kai Ma ◽  
Cuiqi Zhou ◽  
Yu Wang ◽  
Guanghui Hu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Transcriptional Activation ◽  
Molecular Mechanisms ◽  
Inhibitory Effect ◽  
Colorectal Cancer Cell ◽  
Cancer Cell Growth

Wnt/β-catenin and Hippo pathways play essential roles in the tumorigenesis and development of colorectal cancer. We found that Celastrol, isolated from Tripterygium wilfordii plant, exerted a significant inhibitory effect on colorectal cancer cell growth in vitro and in vivo, and further unraveled the molecular mechanisms. Celastrol induced β-catenin degradation through phosphorylation of Yes-associated protein (YAP), a major downstream effector of Hippo pathway, and also Celastrol-induced β-catenin degradation was dependent on liver kinase B1 (LKB1). Celastrol increased the transcriptional activation of LKB1, partially through the heat shock factor 1 (HSF1). Moreover, LKB1 activated AMP-activated protein kinase α (AMPKα) and further phosphorylated YAP, which eventually promoted the degradation of β-catenin. In addition, LKB1 deficiency promoted colorectal cancer cell growth and attenuated the inhibitory effect of Celastrol on colorectal cancer growth both in vitro and in vivo. Taken together, Celastrol inhibited colorectal cancer cell growth by promoting β-catenin degradation via the HSF1–LKB1–AMPKα–YAP pathway. These results suggested that Celastrol may potentially serve as a future drug for colorectal cancer treatment.

Molecular Size Fractions of Bay Leaf(Laurus nobilis)Exhibit Differentiated Regulation of Colorectal Cancer Cell Growth In Vitro

2013 ◽  
Vol 65 (5) ◽  
pp. 746-764 ◽  
Author(s):  
Louise Bennett ◽  
Mahinda Abeywardena ◽  
Sharon Burnard ◽  
Santina Forsyth ◽  
Richard Head ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Molecular Size ◽  
Colorectal Cancer Cell ◽  
Laurus Nobilis ◽  
Cancer Cell Growth ◽  
Size Fractions
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