scholarly journals A Single-Dose of a Polyphenol-Rich Fucus Vesiculosus Extract is Insufficient to Blunt the Elevated Postprandial Blood Glucose Responses Exhibited by Healthy Adults in the Evening: A Randomised Crossover Trial

Antioxidants ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 49 ◽  
Author(s):  
Margaret Murray ◽  
Aimee Dordevic ◽  
Lisa Ryan ◽  
Maxine Bonham
Keyword(s):  
Blood Glucose ◽  
Crossover Trial ◽  
Blood Glucose Concentration ◽  
Rice Flour ◽  
Fucus Vesiculosus ◽  
Healthy Adults ◽  
Postprandial Hyperglycaemia ◽  
Postprandial Blood Glucose ◽  
Double Blind ◽  
Postprandial Glycaemia

When healthy adults consume carbohydrates at night, postprandial blood glucose responses are elevated and prolonged compared to daytime.Extended postprandial hyperglycaemia is a risk factor for type 2 diabetes. Polyphenols are bioactive secondary metabolites of plants and algae with potential to moderate postprandial glycaemia. This study investigated whether a polyphenol-rich alga (Fucus vesiculosus) extract moderated postprandial glycaemia in the evening in healthy adults. In a double blind, placebo-controlled, randomised three-way crossover trial, 18 participants consumed a polyphenol-rich extract, a cellulose placebo and rice flour placebo (7:15 p.m.) prior to 50 g available carbohydrate from bread (7:45 p.m.), followed by three hours of blood sampling to assess glucose and insulin. A subset of participants (n = 8) completed the same protocol once in the morning with only the cellulose placebo (7:15 a.m.). No effect of the polyphenol-rich extract was observed on postprandial glycaemia in the evening, compared with placebos, in the group as a whole. However, in females only, peak blood glucose concentration was reduced following the polyphenol-rich extract. In the subset analysis, as expected, participants exhibited elevated postprandial blood glucose in the evening compared with the morning following the cellulose placebo. This was the first study to investigate whether a polyphenol intervention moderated evening postprandial hyperglycaemia. The lowering effect observed in females suggests that this warrants further investigation.

scholarly journals Effect of Acute Acai (Euterpe oleracea Mart.) Supplementation on Postprandial Glycaemia in Healthy Adults: A Pilot Randomised Controlled Study

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 853-853
Author(s):  
Kyriaki Myrissa ◽  
Paul Chappell ◽  
Eirini Kelaiditi
Keyword(s):  
Dietary Intervention ◽  
Disease Risk ◽  
Blood Glucose Concentration ◽  
Healthy Adults ◽  
Controlled Study ◽  
Euterpe Oleracea ◽  
Double Blind ◽  
Postprandial Glycaemia ◽  
Significant Difference ◽  
Acai Berry

Abstract Objectives Anthocyanin rich foods may ameliorate postprandial glycaemia. Postprandial glycaemia is associated with Type 2 Diabetes and a risk factor for cardiovascular disease. Acai berry is high in anthocyanins and has received attention for its health benefits. However, human trials are limited. The objective of the present study was to investigate the effect of acai berry extract on postprandial glycaemia responses in healthy adults. Methods Ten healthy participants, aged 18–65 years (mean 33 ± 16), with a body mass index (BMI) of 18.5–24.9 kg/m2 (mean 22.2 ± 1.5) completed a randomized, controlled, double-blind, crossover, acute dietary intervention trial. Participants consumed either an acai-based smoothie (AS) containing 150g acai pulp or a macronutrient-matched control placebo smoothie (PS). The primary endpoint was blood glucose concentration (BGC) which was determined by a capillary sampling method at baseline and at regular intervals up to 2 hours postprandially. Results Consumption of acai resulted in lower mean BGC compared to placebo (5.38 ± 0.46mmol/l vs. 5.40 ± 0.63mmol/l), but this was not significant (p = 0.888), even after controlling for age and BMI. There was no significant difference in BGC incremental area under the curve (iAUC) for acai relative to placebo. Conclusions In this acute study on heathy adults of a wide age range, acai consumption was not associated with improvements in postprandial glycaemia. Future long-term, adequately powered intervention studies, assessing additional biomarkers of disease risk are needed to fully elucidate the benefits of acai to health. Funding Sources None.

scholarly journals Postprandial glycaemic and appetite responses to cookies following in-corporation of Stevia and Moringa leaf powder

2017 ◽  
Vol 1 (1) ◽  
pp. 3
Author(s):  
Imran Khan
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Concentration ◽  
Area Under The Curve ◽  
Postprandial Blood Glucose ◽  
Caloric Test ◽  
Postprandial Glycaemia ◽  
Gastrointestinal Discomfort ◽  
Lower Blood ◽  
Leaf Powder ◽  
Design And Methods

Background/objective: Medicinal plants including Stevia and Moringa constitute an important source of health-beneficial bioactive components and hence, their intake may beneficially modulate biomarkers of chronic diseases. Therefore, the objective of the present study was to investigate the effect of cookies incorporating stevia and Moringa leaf powder on postprandial glycaemia, appetite, palatability and       gastrointestinal wellbeing in humans. Design and methods: In a randomized   crossover design, twenty healthy subjects consumed three iso-caloric test foods (each providing 50 g available carbohydrates) of control cookies (CC), stevia leaf-containing cookies (SC) and Moringa leaf-containing cookies (MC) as breakfast. Blood glucose and subjective appetite were measured at fasting and over 2 hours after consumption of the cookies. Palatability and gastrointestinal wellbeing were measured using standard questionnaires. Results: Compared to CC, MC resulted in a significant  decrease in postprandial blood glucose concentration at 30 and 45 min (P = 0.002 and P = 0.003, respectively) and showed a tendency (P = 0.077) for lower blood glucose incremental area under the curve (iAUC). Subjects were significantly less hungry  after SC and MC intake (P= 0.035 and P= 0.041, respectively) compared to CC. In addition, the SC resulted in significantly (P = 0.037) lower hunger incremental area over the curve (iAOC) compared to CC. All the cookies were liked by the subjects without any reported gastrointestinal discomfort. Conclusion: In conclusion, the  results showed that compared to CC, MC improved postprandial glycaemia and reduced hunger, while SC reduced hunger only. Future studies are now warranted to explore the mechanisms responsible for these observed effects.

scholarly journals The Comparative Effect on Satiety and Subsequent Energy Intake of Ingesting Sucrose or Isomaltulose Sweetened Trifle: A Randomized Crossover Trial

Nutrients ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1504 ◽  
Author(s):  
Fiona Kendall ◽  
Olivia Marchand ◽  
Jillian Haszard ◽  
Bernard Venn
Keyword(s):  
Blood Glucose ◽  
Energy Intake ◽  
Glucose Concentration ◽  
Crossover Trial ◽  
Blood Glucose Concentration ◽  
Area Under The Curve ◽  
Double Blind ◽  
Satiety Response ◽  
Diet Records ◽  
Significant Difference

The effect that blood glucose concentration has on feelings of satiety is unclear. Our aims were to assess satiety and subsequent energy intake following the ingestion of trifle sweetened with sucrose or isomaltulose whilst measuring plasma glucose concentration to confirm glycemic differences between trifles. Seventy-seven healthy adults participated in a double-blind crossover trial where trifle sweetened with sucrose or isomaltulose was consumed on separate days with a two-week washout. Blood was sampled at the baseline, 1 and 2 h postprandially, and satiety assessed using visual analogue scales (VAS). Weighed diet records were taken on test days. A statistically significant difference in blood glucose concentration between trifles was found at 60 min following consumption, with the isomaltulose trifle having a 0.69 mmol/L (95% confidence interval: −1.07, −0.31) lower concentration when compared with the sucrose trifle. Mean satiety response by area-under-the-curve (AUC) was not significantly different between trifles. Mean (SD) appetite scores for the sucrose and isomaltulose trifles were 4493 (2393) and 4527 (2590) mm·min, respectively, with a between trifle difference of −9 (95% CI: −589, 572) mm·min. Mean (SD) energy intake for the remainder of the day following trifle consumption was 3894 kJ (1950 kJ) and 3530 kJ (1926 kJ) after the sucrose and isomaltulose trifles, respectively, and was not significantly different (p = 0.133). The differing glycemic response to trifle was not related to satiety or to subsequent energy intake.

scholarly journals Single-Dose Pinitol Ingestion Suppresses Post-Prandial Glucose Levels: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial

2019 ◽  
Vol 14 (12) ◽  
pp. 1934578X1989081
Author(s):  
Yoshio Suzuki ◽  
Keishoku Sakuraba ◽  
Takuya Wada ◽  
Naoya Watabane ◽  
Seijiro Wada ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Single Dose ◽  
Blood Glucose ◽  
Crossover Trial ◽  
Postprandial Blood Glucose ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Glucose Levels ◽  
Blood Glucose Levels

Limited studies have demonstrated that chronic consumption of pinitol improved glucose tolerance, and single-dose ingestion (0.6 g) 60 minutes prior to meals suppressed postprandial glucose levels in patients with type 2 diabetes mellitus. However, higher doses (6 g) were required in healthy people who ingested pinitol with a meal. This randomized, double-blind, placebo-controlled, crossover trial was conducted to clarify the effect of 0.6 g of pinitol with a meal on postprandial blood glucose levels in healthy adults. Twenty volunteers aged 18 to 25 years participated in this study. Participants visited the laboratory after an overnight fast. After measuring fasting blood glucose levels (FBG), they consumed test food (0.6 g of pinitol or placebo) and then ate breakfast (577 kcal; protein 14.0 g; fat 5.6 g; and carbohydrate 117.7 g). Blood glucose levels were measured immediately after eating and at 30, 60, 90, and 120 minutes after breakfast. Participants’ mean FBG level was 102.6 ± 8.2 mg/dL. Participants were categorized by their FBG as normal ( n = 5; ≤99 mg/dL) or impaired glucose tolerance (IGT) ( n = 15; 100-125 mg/dL). The incremental area under the curve of blood glucose over 120 minutes after the meal was significantly suppressed by pinitol in the IGT group ( P < 0.05), but not in the normal group. Therefore, pinitol was considered to maintain postprandial blood glucose levels in healthy people with IGT, and may contribute to the prevention of type 2 diabetes.

scholarly journals The Timing of Activity after Eating Affects the Glycaemic Response of Healthy Adults: A Randomised Controlled Trial

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1743 ◽  
Author(s):  
Andrew Reynolds ◽  
Bernard Venn
Keyword(s):  
Blood Glucose ◽  
Controlled Trial ◽  
Time Lag ◽  
Healthy Adults ◽  
Postprandial Blood Glucose ◽  
Sedentary Control ◽  
Glycaemic Response ◽  
Glucose Response ◽  
Blood Glucose Response ◽  
Postprandial Glycaemia

There is scant information on how a time lag between the cessation of eating and commencement of physical activity affects postprandial glycaemia. Starting at baseline (t = 0), participants ingested white bread containing 50 g of available carbohydrates within 10 min. Using two crossover conditions, we tested the effect over 2 h on postprandial glycaemia of participants undertaking light activity at 15 or 45 min following baseline and compared it with a sedentary control condition. The activity involved cycling on a stationary ergometer for 10 min at 40 revolutions per min with zero resistance. Seventy-eight healthy adults were randomized to the 15 or 45 min activity arm and then randomised to the order in which they undertook the active and sedentary conditions. Cycling 45 min after baseline changed the course of the blood glucose response (likelihood ratio chi square = 31.47, p < 0.01) and reduced mean blood glucose by 0.44 mmol/L (95% confidence interval 0.14 to 0.74) at 60 min when compared with the sedentary control. No differences in postprandial blood glucose response were observed when cycling started 15 min after baseline compared with the sedentary control. Undertaking activity after waiting for 30 min following eating might be optimal in modifying the glycaemic response.

scholarly journals The Research of Improved Grey GM (1, 1) Model to Predict the Postprandial Glucose in Type 2 Diabetes

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Yannian Wang ◽  
Fenfen Wei ◽  
Changqing Sun ◽  
Quanzhong Li
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Prediction Model ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Original Data ◽  
Postprandial Glucose ◽  
Postprandial Blood Glucose ◽  
Glucose Prediction

Diabetes may result in some complications and increase the risk of many serious health problems. The purpose of clinical treatment is to carefully manage the blood glucose concentration. If the blood glucose concentration is predicted, treatments can be taken in advance to reduce the harm to patients. For this purpose, an improved grey GM (1, 1) model is applied to predict blood glucose with a small amount of data, and especially in terms of improved smoothness it can get higher prediction accuracy. The original data of blood glucose of type 2 diabetes is acquired by CGMS. Then the prediction model is established. Finally, 50 cases of blood glucose from the Henan Province People’s Hospital are predicted in 5, 10, 15, 20, 25, and 30 minutes, respectively, in advance to verify the prediction model. The prediction result of blood glucose is evaluated by the EGA, MSE, and MAE. Particularly, the prediction results of postprandial blood glucose are presented and analyzed. The result shows that the improved grey GM (1, 1) model has excellent performance in postprandial blood glucose prediction.

scholarly journals Efficacy and Safety of Zhenyuan Capsule for Coronary Heart Disease with Abnormal Glucose and Lipid Metabolism: Study Protocol for a Randomized, Double-Blind, Parallel-Controlled, Multicenter Clinical Trial

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Yu Qiao ◽  
Jingchun Zhang ◽  
Yue Liu ◽  
Zhiqi Liang ◽  
Yuhua Wang ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Lipid Metabolism ◽  
Blood Glucose ◽  
Glycosylated Hemoglobin ◽  
Postprandial Blood Glucose ◽  
Common Disease ◽  
Efficacy And Safety ◽  
Double Blind ◽  
Glucose And Lipid Metabolism

Background. Coronary heart disease (CHD) and abnormal glucose and lipid metabolism are closely associated and generally coexist. The Qi and Yin deficiency syndrome is a common disease pattern encountered in traditional Chinese medicine. We designed a protocol to determine the effectiveness and safety of Zhenyuan capsules for CHD with abnormal glucose and lipid metabolism. Methods. This multicenter, randomized, double-blind, parallel-controlled trial was designed in accordance with the CONSORT. We will recruit 200 eligible male patients aged 45–75 years from three participating centers and randomly assign them to treatment and control groups (1 : 1). The primary indicators are glycosylated hemoglobin, fasting blood glucose, 2-hour postprandial blood glucose, and triglyceride levels. The secondary indicators are the Seattle Angina Questionnaire, TCM symptom indicators, ultrasonic cardiography finding, coagulation indicator, and P-selectin level. Measurements will be performed at baseline (T0), the end of the run-in period (T1), and weeks 4 (T2), 8 (T3), and 12 (T4) of the treatment period. Adverse events will be monitored during the trial. Discussion. This study aims to evaluate the efficacy and safety of Zhenyuan capsules in patients with CHD and abnormal glucose and lipid metabolism. The results will provide critical evidence of the usefulness of the Chinese herbal medicine for CHD with abnormal glucose and lipid metabolism. Trial Registration. This trial is registered with the Chinese Clinical Trials Registry, with identifier number ChiCTR-TRC-14004639, May 4, 2014.

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