scholarly journals The Antioxidant Role of Soy and Soy Foods in Human Health

Antioxidants ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 635
Author(s):  
Gianluca Rizzo
Keyword(s):  
Clinical Trials ◽  
Scientific Evidence ◽  
Antioxidant Properties ◽  
Oxygen Species ◽  
Healthy Foods ◽  
Bioactive Substances ◽  
Soy Foods ◽  
Antioxidant Mechanisms ◽  
Final Synthesis

Oxidative stress seems to play a role in many chronic diseases, such as cardiovascular diseases, diabetes, and some cancers. Research is always looking for effective approaches in the prevention and treatment of these pathologies with safe strategies. Given the central role of nutrition, the identification of beneficial healthy foods can be the best key to having a safe and at the same time effective approach. Soy has always aroused great scientific interest but often this attention is galvanized by the interaction with estrogen receptors and related consequences on health. However, soy, soy foods, and soy bioactive substances seem to have antioxidant properties, suggesting their role in quenching reactive oxygen species, although it was frequently mentioned but not studied in depth. The purpose of this review is to summarize the scientific evidence of the antioxidant properties of soy by identifying the human clinical trials available in the literature. A total of 58 manuscripts were individuated through the literature search for the final synthesis. Soy bioactive substances involved in redox processes appear to be multiple and their use seems promising. Other larger clinical trials with adequate standardization and adequate choice of biomarkers will fill the gap currently existing on the suggestive role of soy in antioxidant mechanisms.

scholarly journals Effect of Blueberry Anthocyanins Malvidin and Glycosides on the Antioxidant Properties in Endothelial Cells

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Wuyang Huang ◽  
Yunming Zhu ◽  
Chunyang Li ◽  
Zhongquan Sui ◽  
Weihong Min
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Endothelial Cells ◽  
Functional Food ◽  
Functional Role ◽  
Antioxidant Properties ◽  
Heme Oxygenase 1 ◽  
Oxygen Species ◽  
Good Resource

The objective of this research was to survey the antioxidant functional role of the main anthocyanins of blueberries in endothelial cells. Changes on the reactive oxygen species (ROS), xanthine oxidase-1 (XO-1), superoxide dismutase (SOD), and heme oxygenase-1 (HO-1) in cells of malvidin and the two glycosides were investigated. The results showed that these anthocyanins decreased the levels of ROS and XO-1 but increased the levels of SOD and HO-1. Glycosides improved the antioxidant capacity of malvidin to a great extent. The changes in the antioxidant properties of malvidin-3-glucoside were more pronounced than malvidin-3-galactoside. Variation in levels of malvidin-3-glucoside and malvidin-3-galactoside had a significant impact on antioxidant properties to different extents. It indicates that blueberries are a good resource of anthocyanins, which can protect cells from oxidative deterioration and use blueberry as a potential functional food to prevent diseases related to oxidative stress.

scholarly journals Dysregulation of redox pathways in liver fibrosis

2016 ◽  
Vol 311 (4) ◽  
pp. G667-G674 ◽  
Author(s):  
Natalie J. Torok
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Fate ◽  
Liver Diseases ◽  
Oxygen Species ◽  
Chronic Liver Diseases ◽  
Cell Fate Decisions ◽  
Novel Treatment ◽  
Antioxidant Mechanisms ◽  
Precise Role

Reactive oxygen species are implicated in physiological signaling and cell fate decisions. In chronic liver diseases persistent and increased production of oxidative radicals drives a fibrogenic response that is a common feature of disease progression. Despite our understanding the biology of the main prooxidant enzymes, their targets, and antioxidant mechanisms in the liver, there is still lack of knowledge concerning their precise role in the pathogenesis of fibrosis. This review will examine the role of physiological redox signaling in the liver, provide an overview on recent advances in prooxidant and antioxidant pathways that are dysregulated during fibrosis, and highlight possible novel treatment targets.

scholarly journals Long-term macrolide antibiotics in asthma therapy

2011 ◽  
Vol 2 (4) ◽  
pp. 243-258
Author(s):  
Daisuke Takekoshi ◽  
Patrick Belvitch ◽  
Israel Rubinstein
Keyword(s):  
Clinical Trials ◽  
Antimicrobial Properties ◽  
Inflammatory Cells ◽  
Macrolide Antibiotics ◽  
Oxygen Species ◽  
Immunomodulatory Effects ◽  
Diffuse Panbronchiolitis ◽  
Heterogeneous Nature

Macrolide antibiotics drew worldwide attention when their use was dramatically successful in the treatment of diffuse panbronchiolitis in 1980s. The success was attributed to their immunomodulatory effects, rather than their antimicrobial properties. Since then, studies have shown that macrolides exert their immunomodulatory effects through several mechanisms, including suppression of proinflammatory cytokines, promoting apoptosis of inflammatory cells, improving phagocytic function, ameliorating airway hypersecretion, and inhibiting production of reactive oxygen species. Macrolides have also been studied in the treatment of asthma. This review highlights the role of macrolides in the treatment of asthma, presenting an overview of the main clinical trials. Despite favourable preclinical data and reports of anecdotal successes, the results of clinical trials are conflicting. This may be due to the heterogeneous nature of asthma. Further studies are needed to identify particular subgroup of asthma that will respond to macrolides.

scholarly journals From Neuroinflammation to Neuroprotection: Focus on Potential New Therapeutic Targets in Cognitive Impairment

2020 ◽  
pp. 1-4
Author(s):  
Pietro Gareri ◽  
Antonino Maria Cotroneo ◽  
Pietro Gareri ◽  
Valeria Graziella Laura Manfredi
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Cell Activation ◽  
Scientific Evidence ◽  
Neuronal Cell ◽  
Cholinergic Neuron ◽  
Oxygen Species ◽  
Cell Energy ◽  
Neuroprotective Action

Neurodegeneration is closely linked to neuroinflammation. It is often associated with oxidative stress and meaningful changes in cell energy metabolism. Neuroinflammation is due to non-neuronal cell activation (microglia, astrocytes, mast cells) activation and proliferation. Also, it is associated with pro-inflammatory substances release, able to modify synaptic plasticity. Microglia and astrocytes activation lead to toxic agent’s release (reactive oxygen species, inflammatory cytokines); however, the final target of this process is the cholinergic neuron. A number of substances can promote neuroprotection; recent scientific evidence focuses on the role of sirtuins. In particular, SIRT1 is activated by caloric restriction, NAD biosynthesis and different activators, called STACs (Sirtuin Activating Compounds). Citicoline is one of the most powerful STACs. It has been widely shown to possess neuroprotective action, and lots of studies strengthened its possible role.

scholarly journals Long-term macrolide antibiotics in asthma therapy

2011 ◽  
Vol 2 (4) ◽  
pp. 243
Author(s):  
Daisuke Takekoshi ◽  
Patrick Belvitch ◽  
Israel Rubinstein
Keyword(s):  
Clinical Trials ◽  
Antimicrobial Properties ◽  
Inflammatory Cells ◽  
Macrolide Antibiotics ◽  
Oxygen Species ◽  
Immunomodulatory Effects ◽  
Diffuse Panbronchiolitis ◽  
Heterogeneous Nature

Macrolide antibiotics drew worldwide attention when their use was dramatically successful in the treatment of diffuse panbronchiolitis in 1980s. The success was attributed to their immunomodulatory effects, rather than their antimicrobial properties. Since then, studies have shown that macrolides exert their immunomodulatory effects through several mechanisms, including suppression of proinflammatory cytokines, promoting apoptosis of inflammatory cells, improving phagocytic function, ameliorating airway hypersecretion, and inhibiting production of reactive oxygen species. Macrolides have also been studied in the treatment of asthma. This review highlights the role of macrolides in the treatment of asthma, presenting an overview of the main clinical trials. Despite favourable preclinical data and reports of anecdotal successes, the results of clinical trials are conflicting. This may be due to the heterogeneous nature of asthma. Further studies are needed to identify particular subgroup of asthma that will respond to macrolides.

scholarly journals Therapies with Antioxidant Potential in Psoriasis, Vitiligo, and Lichen Planus

Antioxidants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1087
Author(s):  
Fabrizio Guarneri ◽  
Lucrezia Bertino ◽  
Giovanni Pioggia ◽  
Marco Casciaro ◽  
Sebastiano Gangemi
Keyword(s):  
Lichen Planus ◽  
Inflammatory Diseases ◽  
Antioxidant Properties ◽  
Antioxidant Systems ◽  
Oxygen Species ◽  
Standard Drug ◽  
Drug Treatments ◽  
Endogenous Antioxidant ◽  
Clinical Changes

Oxidative stress plays an important pathogenetic role in many chronic inflammatory diseases, including those of dermatological interest. In particular, regarding psoriasis, vitiligo, and lichen planus, excess reactive oxygen species and a decline in endogenous antioxidant systems are observed. In this regard, treatments with antioxidant properties could be appropriate therapeutic options. To date, clinical trials in dermatology on these treatments are limited. We reviewed the available studies on the efficacy of antioxidant therapies in psoriasis, vitiligo, and lichen planus. The role of herbal derivatives, vitamins, and trace elements was analyzed. The antioxidant properties of conventional therapies were also evaluated. Data from the literature suggest that antioxidants might be useful, but available studies on this topic are limited, heterogeneous, not completely standardized, and on small populations. Furthermore, in most cases, antioxidants alone are unable to induce significant clinical changes, except perhaps in mild forms, and must be used in conjunction with standard drug treatments to achieve measurable results. Further studies need to be conducted, considering larger populations and using internationally validated scales, in order to compare the results and clinical efficacy.

scholarly journals Antioxidant Mechanisms and ROS-Related MicroRNAs in Cancer Stem Cells

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Ilaria Dando ◽  
Marco Cordani ◽  
Elisa Dalla Pozza ◽  
Giulia Biondani ◽  
Massimo Donadelli ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Biological Process ◽  
Oxygen Species ◽  
Poor Clinical Outcome ◽  
Differentiation Potential ◽  
Self Renewal ◽  
Induced Stress ◽  
Antioxidant Mechanisms

Increasing evidence indicates that most of the tumors are sustained by a distinct population of cancer stem cells (CSCs), which are responsible for growth, metastasis, invasion, and recurrence. CSCs are typically characterized by self-renewal, the key biological process allowing continuous tumor proliferation, as well as by differentiation potential, which leads to the formation of the bulk of the tumor mass. CSCs have several advantages over the differentiated cancer cell populations, including the resistance to radio- and chemotherapy, and their gene-expression programs have been shown to correlate with poor clinical outcome, further supporting the relevance of stemness properties in cancer. The observation that CSCs possess enhanced mechanisms of protection from reactive oxygen species (ROS) induced stress and a different metabolism from the differentiated part of the tumor has paved the way to develop drugs targeting CSC specific signaling. In this review, we describe the role of ROS and of ROS-related microRNAs in the establishment and maintenance of self-renewal and differentiation capacities of CSCs.

Anti-oxidant Features of Amla –A Review

2021 ◽  
Vol 2 (1) ◽  
pp. 92-102
Author(s):  
Dr Sahara Shrestha ◽  
Dr Rejina Shrestha ◽  
Dr Pratibha Tripathi
Keyword(s):  
Negative Impact ◽  
Antioxidant Properties ◽  
Antioxidant Property ◽  
Depth Information ◽  
Oxygen Species ◽  
General Introduction ◽  
Wide Range ◽  
Anti Oxidant ◽  
And Oxidative Stress

The role of reactive oxygen species and oxidative stress in bringing about a negative impact on health and providing an open invitation to a plethora of diseases is a well-known fact. This has led to the search of antioxidants. The number of conventional available antioxidants have certain limitations and researchers are constantly in search of herbs and medicinal plants. Amla possesses a wide range of medicinal values used ardently by our seers for the treatment of the diseased and to maintain the health of the healthy people as well. Researches have thrown light upon the fact that Amla possess anti-oxidative features and has a wide range of therapeutic utilities. The antioxidant property of Amla has been even experimented to offer a readily available alternative in certain cases as well. The scattered information pertaining to the antioxidant potential of Amla is reported. Present review embraces the general introduction, morphology, phytochemical and pharmacological attributes and an in-depth information of reported antioxidant properties of Amla in terms of available experimental and clinical studies.

scholarly journals Anthracycline-associated cardiotoxicity in adults: systematic review on the cardioprotective role of beta-blockers

2018 ◽  
Vol 64 (8) ◽  
pp. 745-754 ◽  
Author(s):  
Roberto Ramos Barbosa ◽  
Taissa Borges Bourguignon ◽  
Luíza Dias Torres ◽  
Lorenza Silveira Arruda ◽  
Tiago de Melo Jacques ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Selection Criteria ◽  
Beta Blockers ◽  
Scientific Evidence ◽  
Control Groups ◽  
Significant Difference ◽  
Oncologic Patients ◽  
Positive Results

SUMMARY OBJECTIVES This study aimed at assessing the role of beta-blockers on preventing anthracycline-induced cardiotoxicity in adults. METHODS A systematic review was performed on electronic databases, including relevant studies that analysed beta-blockers as cardioprotective agents before the use of anthracyclines by adult oncologic patients. RESULTS After application of eligibility and selection criteria, eight articles were considered as high quality, complying with the proposed theme; all eight clinical trials, four of them placebo-controlled, with a total number of 655 patients included. From this sample, 281 (42.9%) used beta-blocker as intervention, and carvedilol was the most frequent (167 patients – 25.5%). Six studies were considered positive regarding the cardioprotection role played by beta-blockers, although only four demonstrated significant difference on left ventricle ejection fraction after chemotherapy on groups that used beta-blockers compared to control groups. Carvedilol and nebivolol, but not metoprolol, had positive results regarding cardioprotection. Other beta-blockers were not analysed in the selected studies. CONCLUSIONS Despite the potential cardioprotective effect of beta-blockers, as demonstrated in small and unicentric clinical trials, its routine use on prevention of anthracycline-associated cardiotoxicity demands greater scientific evidence.

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