scholarly journals Bifunctional Aptamer Drug Carrier Enabling Selective and Efficient Incorporation of an Approved Anticancer Drug Irinotecan to Fibrin Gels

2020 ◽  
Vol 10 (23) ◽  
pp. 8755
Author(s):  
Hiroto Fujita ◽  
Yuka Kataoka ◽  
Masayasu Kuwahara
Keyword(s):  
Cell Proliferation ◽  
Drug Therapy ◽  
Anticancer Drug ◽  
Drug Carrier ◽  
Significant Inhibition ◽  
Tumor Cell Growth ◽  
Binding Properties ◽  
Fibrin Gels ◽  
Human Thrombin ◽  
Suppress Cell Proliferation

We have previously developed a bifunctional aptamer (bApt) binding to both human thrombin and camptothecin derivative (CPT1), and showed that bApt acts as a drug carrier under the phenomenon named selective oligonucleotide entrapment in fibrin polymers (SOEF), which enables efficient enrichment of CPT1 into fibrin gels, resulting in significant inhibition of tumor cell growth. However, although the derivative CPT1 exhibits anticancer activity, it is not an approved drug. In this study, we evaluated the binding properties of bApt to irinotecan, a camptothecin analog commonly used for anticancer drug therapy, in addition to unmodified camptothecin (CPT). Furthermore, we have revealed that irinotecan binds to bApt like CPT1 and is selectively concentrated on fibrin gels formed around the tumor cells under the SOEF phenomenon to suppress cell proliferation.

scholarly journals SETDB1 mediated FosB expression increases the cell proliferation rate during anticancer drug therapy

BMB Reports ◽  
2016 ◽  
Vol 49 (4) ◽  
pp. 238-243 ◽  
Author(s):  
Han-Heom Na ◽  
Hee-Jung Noh ◽  
Hyang-Min Cheong ◽  
Yoonsung Kang ◽  
Keun-Cheol Kim
Keyword(s):  
Cell Proliferation ◽  
Drug Therapy ◽  
Anticancer Drug ◽  
Proliferation Rate ◽  
Cell Proliferation Rate

scholarly journals MiR-188-3p and miR-133b Suppress Cell Proliferation in Human Hepatocellular Carcinoma via Post-Transcriptional Suppression of NDRG1

2021 ◽  
Vol 20 ◽  
pp. 153303382110330
Author(s):  
Zhenzhao Luo ◽  
Yue Fan ◽  
Xianchang Liu ◽  
Shuiyi Liu ◽  
Xiaoyu Kong ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Cell Migration ◽  
Cell Growth ◽  
Suppressive Effect ◽  
Luciferase Reporter ◽  
Invasion And Migration ◽  
And Migration ◽  
Cancer Tissues ◽  
Suppress Cell Proliferation

Background: Previous studies reported that N-myc downstream-regulated gene 1 (NDRG1) was upregulated in various cancer tissues and decreased expression of miR-188-3p and miR-133b could suppress cell proliferation, metastasis, and invasion and induce apoptosis of cancer cells. However, the molecular mechanism of NRDG1 involved in hepatocellular carcinoma (HCC) tumorigenesis is still unknown. Methods: The expressions of miR-188-3p, miR-133b, and NRDG1 in HCC tissues and cells were quantified by qRT-PCR and Western blot. MTT assay and transwell invasion assay were performed to evaluate cell growth and cell migration, respectively. Luciferase reporter assay were performed to determine whether miR-188-3p and miR-133b could directly bind to NRDG1 in HCC cells. Results: The results showed that NRDG1 was upregulated and these 2 microRNAs were downregulated in HCC tissues. NRDG1 was negatively correlated with miR-188-3p and miR-133b in HCC tissues. MiR-188-3p and miR-133b were demonstrated to directly bind to 3′UTR of NRDG1 and inhibit its expression. Upregulation of miR-188-3p and miR-133b reduced NRDG1 expression in hepatocellular carcinoma cell lines, which consequently inhibited cell growth and cell migration. Conclusions: Our finding suggested that miR-188-3p and miR-133b exert a suppressive effect on hepatocellular carcinoma proliferation, invasion, and migration through downregulation of NDRG1.

scholarly journals Correction to “Thermosensitive Chitosan-Based Injectable Hydrogel as an Efficient Anticancer Drug Carrier”

ACS Omega ◽  
2020 ◽  
Vol 5 (38) ◽  
pp. 24973-24973
Author(s):  
Anam Ahsan ◽  
Muhammad Asim Farooq ◽  
Wen-xia Tian ◽  
Amna Parveen
Keyword(s):  
Anticancer Drug ◽  
Drug Carrier ◽  
Injectable Hydrogel

Good's buffer derived highly emissive carbon quantum dots: excellent biocompatible anticancer drug carrier

2016 ◽  
Vol 4 (14) ◽  
pp. 2412-2420 ◽  
Author(s):  
Aneeya K. Samantara ◽  
Santanu Maji ◽  
Arnab Ghosh ◽  
Bamaprasad Bag ◽  
Rupesh Dash ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Anticancer Drug ◽  
Drug Carrier ◽  
Carbon Quantum Dots ◽  
One Step

A facile one-step approach has been developed for the synthesis of carbon quantum dots (CQDs) from Good’s buffer.

Design and synthesis of periodic mesoporous organosilica materials with a multi-compartment structure

RSC Advances ◽  
2015 ◽  
Vol 5 (109) ◽  
pp. 89397-89406 ◽  
Author(s):  
Chun Xiang Cynthia Lin ◽  
Siddharth Jambhrunkar ◽  
Pei Yuan ◽  
Chun Hui Clayton Zhou ◽  
George Xiu Song Zhao
Keyword(s):  
Anticancer Drug ◽  
Release Rate ◽  
Slow Release ◽  
Drug Carrier ◽  
High Loading ◽  
Loading Capacity ◽  
Periodic Mesoporous Organosilica ◽  
Design And Synthesis ◽  
Mesoporous Organosilica ◽  
Organosilica Materials

Multi-compartment periodic mesoporous organosilica materials show desirable properties as anticancer drug carrier with high loading capacity and slow release rate.

scholarly journals Blood flow boosts BMP signaling to keep vessels in shape

2016 ◽  
Vol 214 (7) ◽  
pp. 793-795 ◽  
Author(s):  
Claudio A. Franco ◽  
Holger Gerhardt
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cells ◽  
Blood Flow ◽  
Vascular Remodeling ◽  
Bmp Signaling ◽  
Mural Cells ◽  
Bone Morphogenic Proteins ◽  
Cell Biol ◽  
Suppress Cell Proliferation

Bone morphogenic proteins (BMPs) and blood flow regulate vascular remodeling and homeostasis. In this issue, Baeyens et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603106) show that blood flow sensitizes endothelial cells to BMP9 signaling by triggering Alk1/ENG complexing to suppress cell proliferation and to recruit mural cells, thereby establishing endothelial quiescence.

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