Metal complex interactions with DNA

2015 ◽  
Vol 44 (8) ◽  
pp. 3505-3526 ◽  
Author(s):  
Benjamin J. Pages ◽  
Dale L. Ang ◽  
Elisé P. Wright ◽  
Janice R. Aldrich-Wright
Keyword(s):  
Transition Metal ◽  
Metal Complex ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Spectroscopic Techniques ◽  
Binding Modes ◽  
Dna Interactions ◽  
Diverse Range ◽  
Dna Structures ◽  
Complex Interactions

Increasing numbers of DNA structures are being revealed using a diverse range of transition metal complexes and biophysical spectroscopic techniques. Here we present a review of metal complex-DNA interactions in which several binding modes and DNA structural forms are explored.

scholarly journals Ru(II)-Dppz Derivatives and Their Interactions with DNA: Thirty Years and Counting

2021 ◽  
Vol 11 (7) ◽  
pp. 3038
Author(s):  
Maria Letizia Di Pietro ◽  
Giuseppina La Ganga ◽  
Francesco Nastasi ◽  
Fausto Puntoriero
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Small Molecules ◽  
Transition Metal Complexes ◽  
Mechanism Of Action ◽  
Spectroscopic Techniques ◽  
Biological Applications ◽  
Ancillary Ligands ◽  
Structural Modifications ◽  
Over Time

Transition metal complexes with dppz-type ligands (dppz = dipyrido[3,2-a:2′,3′-c]phenazine) are extensively studied and attract a considerable amount of attention, becoming, from the very beginning and increasingly over time, a powerful tool for investigating the structure of the DNA helix. In particular, [Ru(bpy)2(dppz)]2+ and [Ru(phen)2(dppz)]2+ and their derivatives were extensively investigated as DNA light-switches. The purpose of this mini-review, which is not and could not be exhaustive, was to first introduce DNA and its importance at a biological level and research in the field of small molecules that are capable of interacting with it, in all its forms. A brief overview is given of the results obtained on the Ru-dppz complexes that bind to DNA. The mechanism of the light-switch active in this type of species is also briefly introduced along with its effects on structural modifications on both the dppz ligand and the ancillary ligands. Finally, a brief mention is made of biological applications and the developments obtained due to new spectroscopic techniques, both for understanding the mechanism of action and for cellular imaging applications.

Transition Metal Complex Catalysed Photo- and Electrochemical (De)hydrogenations Involving C=O- and C=N-Bonds

Synthesis ◽  
2021 ◽  
Author(s):  
Igor Fokin ◽  
Kai-Thorben Kuessner ◽  
Inke Siewert
Keyword(s):  
Transition Metal ◽  
Metal Complex ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Transition Metal Complex ◽  
Basic Principles

Herein, we summarize the photo- and electrochemical protocols for dehydrogenation and hydrogenations involving carbonyl and imine functions. The three basic principles that have been explored to interconvert such moieties with transition metal complexes are discussed in detail and the substrate scope is evaluated. Furthermore, we describe some general thermodynamic and kinetic aspects of such electro- and photochemically driven reactions.

scholarly journals Redox mediators accelerate electrochemically-driven solubility cycling of molecular transition metal complexes

2020 ◽  
Vol 11 (36) ◽  
pp. 9836-9851
Author(s):  
Katherine J. Lee ◽  
Kunal M. Lodaya ◽  
Cole T. Gruninger ◽  
Eric S. Rountree ◽  
Jillian L. Dempsey
Keyword(s):  
Transition Metal ◽  
Metal Complex ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Transition Metal Complex ◽  
Redox Mediators ◽  
Insoluble Material ◽  
Molecular Transition ◽  
Novel Strategy

We present an example of electrochemically-driven solubility cycling of a molecular transition metal complex and report a novel strategy for catalytically enhancing the oxidation of an insoluble material using homogeneous redox mediators.

scholarly journals Transition metal complexes of 5-bromosalicylidene-4-amino-3-mercapto-1,2,4-triazine-5-one: Synthesis, characterization, catalytic and antibacterial studies

2011 ◽  
Vol 76 (1) ◽  
pp. 75-83 ◽  
Author(s):  
A.S. Ramasubramanian ◽  
Ramachandra Bhat ◽  
Ramakrishna Dileep ◽  
Sandya Rani
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Pathogenic Bacteria ◽  
Magnetic Moments ◽  
Spectroscopic Techniques ◽  
Antibacterial Studies ◽  
Metal Precursors ◽  
Square Planar ◽  
Bactericidal Properties

Transition metal complexes of 5-bromosalicylidene-4-amino-3- mercapto-1,2,4-triazine-5-one with metal precursors, such as Cu(II), Ni(II), Co(II) and Pd(II), were synthesized and characterized by physicochemical and spectroscopic techniques. All the complexes are of the ML type. Based on analytical, spectral data and magnetic moments, the Co(II) and Ni(II) complexes were assigned octahedral geometries, while the Cu (II) and Pd(II) complexes square planar. A study on the catalytic oxidation of benzyl alcohol, cyclohexanol, cinnamyl alcohol, 2-propanol and 2- methyl-1-propanol was performed with N-methylmorpholine-N-oxide (NMO) and molecular oxygen as co-oxidants. All the complexes and their parent organic moiety were screened for their biological activity on several pathogenic bacteria and were found to possess appreciable bactericidal properties.

scholarly journals Resolving structures of transition metal complex reaction intermediates with femtosecond EXAFS

2020 ◽  
Vol 22 (5) ◽  
pp. 2660-2666 ◽  
Author(s):  
Alexander Britz ◽  
Baxter Abraham ◽  
Elisa Biasin ◽  
Tim Brandt van Driel ◽  
Alessandro Gallo ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Complex ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Transition Metal Complex ◽  
Complex Reaction ◽  
Reaction Intermediates ◽  
Intermediate States

Femtosecond EXAFS is implemented at an XFEL and can be used to observe short-lived intermediate states of photoexcited transition metal complexes in solution.

scholarly journals Preparation, Spectroscopic Characterization and Theoretical Studies of Transition Metal Complexes with 1-[(2-(1H-indol-3-yl)ethylimino)methyl]naphthalene-2-ol Ligand

2019 ◽  
Vol 31 (11) ◽  
pp. 2430-2438 ◽  
Author(s):  
Vian Yamin Jirjees ◽  
Veyan Taher Suleman ◽  
Abbas Ali Salih Al-Hamdani ◽  
Suzan Duraid Ahmed
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Spectroscopic Characterization ◽  
Bidentate Ligand ◽  
Spectroscopic Techniques ◽  
Theoretical Studies ◽  
Ft Ir ◽  
Uv Visible ◽  
Methyl Naphthalene

A new Schiff base [1-((2-(1H-indol-3-yl)ethylimino)methyl)naphthalene-2-ol] (HL) has been synthesized by condensing (2-hydroxy-1-naphthaldehyde) with (2-(1H-indol-3-yl)ethylamine). In turn, its transition metal complexes were prepared having the general formula; [Pt(IV)Cl2(L)2], [Re(V)Cl2(L)2]Cl and [Pd(L)2], 2K[M(II)Cl2(L)2] where M(II) = Co, Ni, Cu] are reported. Ligand as well as metal complexes are characterized by spectroscopic techniques such as FT-IR, UV-visible, 13C & 1H NMR, mass, elemental analysis. The results suggested that the ligand behaves like a bidentate ligand for all the synthesized complexes. On the other hand, theoretical studies of the ligand as well its metal complexes were conducted at gas phase using HyperChem 8.0. These metal complexes exhibited good antibacterial activity.

Synthesis, structural characterization, and reactivity of late transition-metal complexes bearing linked cyclopentadienyl–carboranyl ligands

2012 ◽  
Vol 90 (1) ◽  
pp. 108-117 ◽  
Author(s):  
Dongmei Liu ◽  
Zaozao Qiu ◽  
Hoi-Shan Chan ◽  
Zuowei Xie
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Structural Characterization ◽  
Molecular Structures ◽  
Spectroscopic Techniques ◽  
Late Transition Metal ◽  
X Ray ◽  
Elemental Analyses ◽  
Late Transition

Late transition-metal complexes bearing linked cyclopentadienyl/indenyl–carboranyl ligands were synthesized and their reactivities were examined. Reaction of Li2[Me2C(L)(C2B10H10)] (L = C5H4, C9H6, Me2NCH2CH2C5H3) with MCl2(PPh3)2 in Et2O afforded [η5:σ-Me2C(C5H4)(C2B10H10)]M(PPh3) (M = Co (4), Ni (5)), [η5:σ-Me2C(C9H6)(C2B10H10)]M(PPh3) (M = Co (6), Ni (7)), and [η5:σ-Me2C(Me2NCH2CH2C5H3)(C2B10H10)]Ni(PPh3) (8). Treatment of 4 or 5 with 2,6-dimethylphenylisocyanide, N-heterocyclic carbene (NHC), PCy3, or 1,2-bis(diphenylphosphino)ethane (dppe) gave the corresponding PPh3 displacement complexes [η5:σ-Me2C(C5H4)(C2B10H10)]M(2,6-Me2C6H3NC) (M = Co (9), Ni (10)), [η5:σ-Me2C(C5H4)(C2B10H10)]M[1,3-(2,6-i-Pr2C6H3)2C3N2H2] (M = Co (11), Ni (12)), [η5:σ-Me2C(C5H4)(C2B10H10)]Ni(PCy3) (13), or {[η5:σ-Me2C(C5H4)(C2B10H10)]Co}2(dppe) (14), respectively. These complexes were characterized by various spectroscopic techniques and elemental analyses. The molecular structures of 4–14 were further confirmed by single-crystal X-ray analyses.

Chiral transition-metal complexes as Brønsted-acid catalysts for the asymmetric Friedel–Crafts hydroxyalkylation of indoles

2014 ◽  
Vol 43 (29) ◽  
pp. 11260-11268 ◽  
Author(s):  
Daniel Carmona ◽  
M. Pilar Lamata ◽  
Antonio Sánchez ◽  
Fernando Viguri ◽  
Ricardo Rodríguez ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Complex ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Transition Metal Complex ◽  
Acid Catalysts ◽  
Bronsted Acid ◽  
Chiral Transition ◽  
Brönsted Acid ◽  
Bronsted Acid Catalysts

Water is the catalyst! The transition metal complex “only” modulates its acidity and provides a chiral environment.

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