scholarly journals Microencapsulation of Peppermint Oil by Complex Coacervation and Subsequent Spray Drying Using Bovine Serum Albumin/Gum Acacia and an Oxidized Starch Crosslinker

2021 ◽  
Vol 11 (9) ◽  
pp. 3956
Author(s):  
Wilhelm Robert Glomm ◽  
Peter Patrick Molesworth ◽  
Eugenia Mariana Sandru ◽  
Le Thuy Truong ◽  
Anders Brunsvik ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Spray Drying ◽  
Bovine Serum ◽  
Polymer Concentration ◽  
Core Material ◽  
Peppermint Oil ◽  
Complex Coacervation ◽  
Gum Acacia ◽  
Crosslinker Concentration

Most liquid food flavours such as essential oils are volatile and prone to degradation in the presence of oxygen, light, moisture and high temperatures. Microencapsulation of volatile ingredients prior to use in food or beverages is a commonly used process to limit loss and degradation of flavours and aromas during processing and storage. Here, peppermint essential oil was microencapsulated via complex coacervation using a combination of bovine serum albumin and gum Acacia as wall materials. The resulting core-shell microcapsules were chemically crosslinked with a modified food-grade starch, and subsequently spray dried, resulting in dry microcapsules which could be easily redispersed in aqueous solutions. Microcapsule formation and stability, as well as microencapsulation yield of peppermint oil, were investigated as a function of polymer concentration, core material load/wall thickness and crosslinker concentration. The crosslinked peppermint oil microcapsules were spherical and mononuclear both before and after spray drying and redispersion, whereas control coacervate samples without crosslinker did not withstand the spray drying process. Microencapsulation yield as analysed by GC-MS showed no loss of peppermint oil during or after complex coacervation, and 54% loss after spray drying for the best combination of Polymer:Oil ratio and crosslinker concentration used here, indicating good overall protection of the core material.

Mechanical and Tribological Studies of SU-8 Composites Filled With UHMWPE and Gum Acacia Under Dry and Bovine Serum Albumin Lubricated Conditions

2020 ◽  
Vol 143 (1) ◽  
Author(s):  
Jaswant K. Hirwani ◽  
Sujeet K. Sinha
Keyword(s):  
Bovine Serum Albumin ◽  
Wear Rate ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Normal Load ◽  
Specific Wear Rate ◽  
Fibrillar Structure ◽  
Cross Sectional ◽  
Microscopy Imaging ◽  
Gum Acacia

Abstract SU-8 polymer was mixed with ultrahigh-molecular weight polyethylene (UHMWPE) particles in various weight percentages (wt%) to make composites. Uniform distribution of filler material was confirmed by optical microscopy imaging. Cross-sectional scanning electron microscopy (SEM) analysis showed the formation of fibrillar structure of UHMWPE which helped bind UHMWPE particles with SU-8 matrix. Gum acacia made a coating on the UHMWPE particles and helped in binding with the matrix. The compressive Young’s modulus and strength of the composites were found to decrease with UHMWPE filler addition. The composites were tested in ball-on-disk tribometer using 12 mm diameter stainless steel (grade 304) ball under a normal load of 20 N and sliding speed of 32 mm/s. SU-8 with 25 wt% of UHMWPE showed coefficient of friction of 0.1 and specific wear-rate of 6.27 × 10−5 mm3/Nm which were 52% and 61%, respectively, lower in comparison with those of bulk UHMWPE tested in aqueous solution of bovine serum albumin (BSA). Adding 10 wt% of gum acacia to the SU-8/UHMWPE composite had beneficial effects on the wear-rate as the specific wear-rate of this hybrid composite further dropped to 4.6 × 10−5 mm3/Nm which was 71% lower than that of bulk UHMWPE.

scholarly journals Bovine serum albumin-based nanoparticles containing the flavonoid rutin produced by nano spray drying

2020 ◽  
Vol 56 ◽  
Author(s):  
Regiellen Cristina Pedrozo ◽  
Emilli Antônio ◽  
Najeh Maissar Khalil ◽  
Rubiana Mara Mainardes
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Spray Drying ◽  
Bovine Serum

scholarly journals PREPARATION AND IN VITRO EVALUATION OF METOPROLOL-LOADED BOVINE SERUM ALBUMIN NANOPARTICLES

2021 ◽  
pp. 213-217
Author(s):  
SHIVA KUMAR YELLANKI ◽  
SAI MANOJ A ◽  
MANGILAL T
Keyword(s):  
Particle Size ◽  
Bovine Serum Albumin ◽  
Drug Release ◽  
Zeta Potential ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Polymer Concentration ◽  
Entrapment Efficiency ◽  
Nanoprecipitation Method

Objective: The aim of the present research was to prepare metoprolol-loaded nanospheres. Metoprolol-loaded bovine albumin nanospheres were prepared by nanoprecipitation method. Metoprolol is beta-1-adrenergic receptor inhibitor specific to cardiac cells, thus producing negative chronotropic and ionotropic effect. Methods: Metoprolol nanospheres were prepared by nanoprecipitation method, using bovine serum albumin as polymer. The prepared nanospheres are evaluated for particle size evaluation, drug entrapment efficiency, and zeta potential. Drug-excipient compatibility was determined using Fourier-transform infrared spectroscopy. In vitro release and solubility of the drug from nanoparticles were determined. Results: The particle size of prepared metoprolol nanospheres was found to be always less than 200 nm. Maximum particle size was found to be 196±2.03 nm of batch 4 nanoparticles. Entrapment efficiency of prepared nanospheres was above 80% and maximum percentage entrapment efficiency was found to be 80.4±0.51%. It was found that the percentage entrapment efficiency and drug release were extended with increase in polymer concentration. Zeta potential of the optimized formulation was found to be −20.4 mV. In vitro drug release studies have shown the prolonged release of 94.5±0.54 up to 10 h. Drug release rate is extended with an increase in polymer concentration. Conclusion: Results have concluded that the albumin nanospheres loaded with metoprolol have reduced the blood pressure within 24 h and the prepared nanospheres are effective compared to other formulations and drug delivery.

Improvement of an artificial test substrate technique for evaluation of em immunocytochemical labeling

1987 ◽  
Vol 45 ◽  
pp. 762-763
Author(s):  
G. D. Gagne ◽  
M. F. Miller
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Artificial Substrate ◽  
Chemical Fixation ◽  
As If

We recently described an artificial substrate system which could be used to optimize labeling parameters in EM immunocytochemistry (ICC). The system utilizes blocks of glutaraldehyde polymerized bovine serum albumin (BSA) into which an antigen is incorporated by a soaking procedure. The resulting antigen impregnated blocks can then be fixed and embedded as if they are pieces of tissue and the effects of fixation, embedding and other parameters on the ability of incorporated antigen to be immunocyto-chemically labeled can then be assessed. In developing this system further, we discovered that the BSA substrate can also be dried and then sectioned for immunolabeling with or without prior chemical fixation and without exposing the antigen to embedding reagents. The effects of fixation and embedding protocols can thus be evaluated separately.

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