Polysorbate-Based Drug Formulations for Brain-Targeted Drug Delivery and Anticancer Therapy

Polysorbates (PSs) are synthetic nonionic surfactants consisting of polyethoxy sorbitan fatty acid esters. PSs have been widely employed as emulsifiers and stabilizers in various drug formulations and food additives. Recently, various PS-based formulations have been developed for safe and efficient drug delivery. This review introduces the general features of PSs and PS-based drug carriers, summarizes recent progress in the development of PS-based drug formulations, and discusses the physicochemical properties, biological safety, P-glycoprotein inhibitory properties, and therapeutic applications of PS-based drug formulations. Additionally, recent advances in brain-targeted drug delivery using PS-based drug formulations have been highlighted. This review will help researchers understand the potential of PSs as effective drug formulation agents.

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Drug-internalized bacterial swimmers for magnetically manipulable tumor-targeted drug delivery

Nanoscale ◽

10.1039/d0nr01892a ◽

2020 ◽

Vol 12 (25) ◽

pp. 13513-13522

Author(s):

Zhichu Xiang ◽

Gexuan Jiang ◽

Di Fan ◽

Jiesheng Tian ◽

Zhiyuan Hu ◽

...

Keyword(s):

Drug Delivery ◽

Targeted Drug Delivery ◽

Tumor Therapy ◽

Drug Carriers ◽

Targeted Drug

Tumor-targeted drug carriers are becoming attractive for precise drug delivery in anti-tumor therapy.

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Mini Review: Nano-Technology based Drug Deliveries

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v8i6.2053 ◽

2018 ◽

Vol 8 (6) ◽

pp. 268-271

Author(s):

Kuilong Wang

Keyword(s):

Drug Delivery ◽

Drug Resistance ◽

Targeted Drug Delivery ◽

Research Work ◽

Drug Carriers ◽

Nano Technology ◽

Treatment Conditions ◽

Nanoparticle Formulation ◽

Targeted Drug

Targeted drug delivery with nano-technology has been researched and identified as being efficient across many treatment conditions. This review assesses some of the existing research work and evidence practice in using nano-technology based drug carriers. Keywords: Nano-technology, drug delivery, nanoparticle formulation, nano-technology carriers, drug resistance

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Folic Acid Functionalized Zirconium‐Based Metal–Organic Frameworks as Drug Carriers for Active Tumor‐Targeted Drug Delivery

Chemistry - A European Journal ◽

10.1002/chem.201804153 ◽

2018 ◽

Vol 24 (64) ◽

pp. 17148-17154 ◽

Cited By ~ 29

Author(s):

Hong Dong ◽

Gui‐Xin Yang ◽

Xin Zhang ◽

Xiang‐Bin Meng ◽

Jing‐Li Sheng ◽

...

Keyword(s):

Drug Delivery ◽

Folic Acid ◽

Targeted Drug Delivery ◽

Metal Organic Frameworks ◽

Drug Carriers ◽

Metal Organic ◽

Targeted Drug

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The new frontiers of the targeted interventions in the pulmonary vasculature: precision and safety (2017 Grover Conference Series)

Pulmonary Circulation ◽

10.1177/2045893217752329 ◽

2017 ◽

Vol 8 (1) ◽

pp. 204589321775232 ◽

Cited By ~ 3

Author(s):

Jacob S. Brenner ◽

Raisa Yu. Kiseleva ◽

Patrick M. Glassman ◽

Hamideh Parhiz ◽

Colin F. Greineder ◽

...

Keyword(s):

Drug Delivery ◽

Targeted Drug Delivery ◽

Drug Carriers ◽

Pulmonary Vasculature ◽

Pulmonary Endothelium ◽

Targeted Interventions ◽

Safety Parameters ◽

Specific Affinity ◽

Targeted Drug ◽

High Doses

The pulmonary vasculature plays an important role in many lung pathologies, such as pulmonary arterial hypertension, primary graft dysfunction of lung transplant, and acute respiratory distress syndrome. Therapy for these diseases is quite limited, largely due to dose-limiting side effects of numerous drugs that have been trialed or approved. High doses of drugs targeting the pulmonary vasculature are needed due to the lack of specific affinity of therapeutic compounds to the vasculature. To overcome this problem, the field of targeted drug delivery aims to target drugs to the pulmonary endothelial cells, especially those in pathological regions. The field uses a variety of drug delivery systems (DDSs), ranging from nano-scale drug carriers, such as liposomes, to methods of conjugating drugs to affinity moieites, such as antibodies. These DDSs can deliver small molecule drugs, protein therapeutics, and imaging agents. Here we review targeted drug delivery to the pulmonary endothelium for the treatment of pulmonary diseases. Cautionary notes are made of the risk–benefit ratio and safety—parameters one should keep in mind when developing a translational therapeutic.

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Role of size of drug delivery carriers for pulmonary and intravenous administration with emphasis on cancer therapeutics and lung-targeted drug delivery

RSC Advances ◽

10.1039/c4ra02861a ◽

2014 ◽

Vol 4 (62) ◽

pp. 32673-32689 ◽

Cited By ~ 42

Author(s):

Chetna Dhand ◽

Molamma P. Prabhakaran ◽

Roger W. Beuerman ◽

R. Lakshminarayanan ◽

Neeraj Dwivedi ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Intravenous Administration ◽

Targeted Drug Delivery ◽

Cancer Therapeutics ◽

Drug Carriers ◽

Design Parameters ◽

Targeted Drug

The design of a drug delivery system and the fabrication of efficient, successful, and targeted drug carriers are two separate issues that require slightly different design parameters.

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A Review on Nanocarriers for Cancer Targeted Drug Delivery

Pakistan Journal of Scientific & Industrial Research Series A: Physical Sciences ◽

10.52763/pjsir.phys.sci.63.3.2020.239.246 ◽

2020 ◽

Vol 63 (3) ◽

pp. 239-246

Author(s):

Fariha Lrfan ◽

Tahir Lqbal ◽

Nafisa Malik ◽

Mohsin Ljaz

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Targeted Drug Delivery ◽

Drug Delivery Systems ◽

Drug Carriers ◽

Delivery Systems ◽

Effective Drug ◽

Targeted Drug

Nanoparticles in the drugs are useful for the treatment of cancer due to their unique properties and can act as drug carriers in different ways. Unlike the traditional chemotherapy, the entrance of nanotechnology enabled wide applications in treatment of cancer. Although nanoparticles provides safe and effective drug delivery systems but the factor of toxicity still limits the utilisation of several nanoparticles. The properties of nanodrug carriers are controllable by various factors. The use of nanoparticles in cancer therapy by drug delivery and their advantages as been reviewed.

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The Two Sweet Sides of Janus Lectin Drive Crosslinking of Liposomes to Cancer Cells and Material Uptake

Toxins ◽

10.3390/toxins13110792 ◽

2021 ◽

Vol 13 (11) ◽

pp. 792

Author(s):

Lina Siukstaite ◽

Francesca Rosato ◽

Anna Mitrovic ◽

Peter Fritz Müller ◽

Katharina Kraus ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Cells ◽

Targeted Drug Delivery ◽

Drug Carriers ◽

Lung Epithelial Cells ◽

Lung Epithelial ◽

Tumor Recognition ◽

Cancer Types ◽

Targeted Drug ◽

Extracellular Structures

A chimeric, bispecific Janus lectin has recently been engineered with different, rationally oriented recognition sites. It can bind simultaneously to sialylated and fucosylated glycoconjugates. Because of its multivalent architecture, this lectin reaches nanomolar avidities for sialic acid and fucose. The lectin was designed to detect hypersialylation—a dysregulation in physiological glycosylation patterns, which promotes the tumor growth and progression of several cancer types. In this study, the characteristic properties of this bispecific Janus lectin were investigated on human cells by flow cytometry and confocal microscopy in order to understand the fundamentals of its interactions. We evaluated its potential in targeted drug delivery, precisely leading to the cellular uptake of liposomal content in human epithelial cancer cells. We successfully demonstrated that Janus lectin mediates crosslinking of glyco-decorated giant unilamellar vesicles (GUVs) and H1299 lung epithelial cells. Strikingly, the Janus lectin induced the internalization of liposomal lipids and also of complete GUVs. Our findings serve as a solid proof of concept for lectin-mediated targeted drug delivery using glyco-decorated liposomes as possible drug carriers to cells of interest. The use of Janus lectin for tumor recognition certainly broadens the possibilities for engineering diverse tailor-made lectin constructs, specifically targeting extracellular structures of high significance in pathological conditions.

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Chitosan-Based Nanoparticles of Targeted Drug Delivery System in Breast Cancer Treatment

Polymers ◽

10.3390/polym13111717 ◽

2021 ◽

Vol 13 (11) ◽

pp. 1717

Author(s):

Yedi Herdiana ◽

Nasrul Wathoni ◽

Shaharum Shamsuddin ◽

I Made Joni ◽

Muchtaridi Muchtaridi

Keyword(s):

Breast Cancer ◽

Drug Delivery ◽

Cancer Cells ◽

Delivery System ◽

Targeted Drug Delivery ◽

Targeted Delivery ◽

Breast Cancer Cells ◽

Drug Carriers ◽

Efficient Treatment ◽

Targeted Drug

Breast cancer remains one of the world’s most dangerous diseases because of the difficulty of finding cost-effective and specific targets for effective and efficient treatment methods. The biodegradability and biocompatibility properties of chitosan-based nanoparticles (ChNPs) have good prospects for targeted drug delivery systems. ChNPs can transfer various antitumor drugs to targeted sites via passive and active targeting pathways. The modification of ChNPs has attracted the researcher to the loading of drugs to targeted cancer cells. The objective of our review was to summarize and discuss the modification in ChNPs in delivering anticancer drugs against breast cancer cells from published papers recorded in Scopus, PubMed, and Google Scholar. In order to improve cellular uptake, drug accumulation, cytotoxicity, and selectivity, we examined different kinds of modification of ChNPs. Notably, these forms of ChNPs use the characteristics of the enhanced permeability and retention (EPR) effect as a proper parameter and different biological ligands, such as proteins, peptides, monoclonal antibodies, and small particles. In addition, as a targeted delivery system, ChNPs provided and significantly improved the delivery of drugs into specific breast cancer cells (MDA-MB-231, 4T1 cells, SK-BR-3, MCF-7, T47D). In conclusion, a promising technique is presented for increasing the efficacy, selectivity, and effectiveness of candidate drug carriers in the treatment of breast cancer.

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