scholarly journals Mini Review: Nano-Technology based Drug Deliveries

2018 ◽  
Vol 8 (6) ◽  
pp. 268-271
Author(s):  
Kuilong Wang
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Targeted Drug Delivery ◽  
Research Work ◽  
Drug Carriers ◽  
Nano Technology ◽  
Treatment Conditions ◽  
Nanoparticle Formulation ◽  
Targeted Drug

Targeted drug delivery with nano-technology has been researched and identified as being efficient across many treatment conditions. This review assesses some of the existing research work and evidence practice in using nano-technology based drug carriers. Keywords: Nano-technology, drug delivery, nanoparticle formulation, nano-technology carriers, drug resistance

scholarly journals Folic Acid-Terminated Poly(2-Diethyl Amino Ethyl Methacrylate) Brush-Gated Magnetic Mesoporous Nanoparticles as a Smart Drug Delivery System

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 59
Author(s):  
Abeer M. Beagan ◽  
Ahlam A. Alghamdi ◽  
Shatha S. Lahmadi ◽  
Majed A. Halwani ◽  
Mohammed S. Almeataq ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Folic Acid ◽  
Drug Delivery System ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Ethyl Methacrylate ◽  
Mesoporous Nanoparticles ◽  
Targeted Drug ◽  
Mcf 7

Currently, chemotherapy is an important method for the treatment of various cancers. Nevertheless, it has many limitations, such as poor tumour selectivity and multi-drug resistance. It is necessary to improve this treatment method by incorporating a targeted drug delivery system aimed to reduce side effects and drug resistance. The present work aims to develop pH-sensitive nanocarriers containing magnetic mesoporous silica nanoparticles (MMSNs) coated with pH-responsive polymers for tumour-targeted drug delivery via the folate receptor. 2-Diethyl amino ethyl methacrylate (DEAEMA) was successfully grafted on MMSNs via surface initiated ARGET atom transfer radical polymerization (ATRP), with an average particle size of 180 nm. The end groups of poly (2-(diethylamino)ethyl methacrylate) (PDEAEMA) brushes were converted to amines, followed by a covalent bond with folic acid (FA) as a targeting agent. FA conjugated to the nanoparticle surface was confirmed by X-ray photoelectron spectroscopy (XPS). pH-Responsive behavior of PDEAEMA brushes was investigated by Dynamic Light Scattering (DLS). The nanoparticles average diameters ranged from ca. 350 nm in basic media to ca. 650 in acidic solution. Multifunctional pH-sensitive magnetic mesoporous nanoparticles were loaded with an anti-cancer drug (Doxorubicin) to investigate their capacity and long-circulation time. In a cumulative release pattern, doxorubicin (DOX) release from nano-systems was ca. 20% when the particle exposed to acidic media, compared to ca. 5% in basic media. The nano-systems have excellent biocompatibility and are minimally toxic when exposed to MCF-7, and -MCF-7 ADR cells.

Drug-internalized bacterial swimmers for magnetically manipulable tumor-targeted drug delivery

Nanoscale ◽  
2020 ◽  
Vol 12 (25) ◽  
pp. 13513-13522
Author(s):  
Zhichu Xiang ◽  
Gexuan Jiang ◽  
Di Fan ◽  
Jiesheng Tian ◽  
Zhiyuan Hu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Tumor Therapy ◽  
Drug Carriers ◽  
Targeted Drug

Tumor-targeted drug carriers are becoming attractive for precise drug delivery in anti-tumor therapy.

Biotinylated carboxymethyl chitosan/CaCO3 hybrid nanoparticles for targeted drug delivery to overcome tumor drug resistance

RSC Advances ◽  
2016 ◽  
Vol 6 (73) ◽  
pp. 69083-69093 ◽  
Author(s):  
Jin-Long Wu ◽  
Xiao-Yan He ◽  
Pei-Yuan Jiang ◽  
Meng-Qing Gong ◽  
Ren-Xi Zhuo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Tumor Cells ◽  
Targeted Drug Delivery ◽  
Carboxymethyl Chitosan ◽  
Hybrid Nanoparticles ◽  
Cancer Drug ◽  
Tumor Drug Resistance ◽  
Anti Cancer ◽  
Targeted Drug

A tumor targeted nano-sized self-assembled drug delivery system could efficiently co-deliver an anti-cancer drug and a drug resistance inhibitor to tumor cells and achieve an improved therapeutic efficiency through inhibition of P-gp function.

Folic Acid Functionalized Zirconium‐Based Metal–Organic Frameworks as Drug Carriers for Active Tumor‐Targeted Drug Delivery

2018 ◽  
Vol 24 (64) ◽  
pp. 17148-17154 ◽  
Author(s):  
Hong Dong ◽  
Gui‐Xin Yang ◽  
Xin Zhang ◽  
Xiang‐Bin Meng ◽  
Jing‐Li Sheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Targeted Drug Delivery ◽  
Metal Organic Frameworks ◽  
Drug Carriers ◽  
Metal Organic ◽  
Targeted Drug

scholarly journals The new frontiers of the targeted interventions in the pulmonary vasculature: precision and safety (2017 Grover Conference Series)

2017 ◽  
Vol 8 (1) ◽  
pp. 204589321775232 ◽  
Author(s):  
Jacob S. Brenner ◽  
Raisa Yu. Kiseleva ◽  
Patrick M. Glassman ◽  
Hamideh Parhiz ◽  
Colin F. Greineder ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Drug Carriers ◽  
Pulmonary Vasculature ◽  
Pulmonary Endothelium ◽  
Targeted Interventions ◽  
Safety Parameters ◽  
Specific Affinity ◽  
Targeted Drug ◽  
High Doses

The pulmonary vasculature plays an important role in many lung pathologies, such as pulmonary arterial hypertension, primary graft dysfunction of lung transplant, and acute respiratory distress syndrome. Therapy for these diseases is quite limited, largely due to dose-limiting side effects of numerous drugs that have been trialed or approved. High doses of drugs targeting the pulmonary vasculature are needed due to the lack of specific affinity of therapeutic compounds to the vasculature. To overcome this problem, the field of targeted drug delivery aims to target drugs to the pulmonary endothelial cells, especially those in pathological regions. The field uses a variety of drug delivery systems (DDSs), ranging from nano-scale drug carriers, such as liposomes, to methods of conjugating drugs to affinity moieites, such as antibodies. These DDSs can deliver small molecule drugs, protein therapeutics, and imaging agents. Here we review targeted drug delivery to the pulmonary endothelium for the treatment of pulmonary diseases. Cautionary notes are made of the risk–benefit ratio and safety—parameters one should keep in mind when developing a translational therapeutic.

Role of size of drug delivery carriers for pulmonary and intravenous administration with emphasis on cancer therapeutics and lung-targeted drug delivery

RSC Advances ◽  
2014 ◽  
Vol 4 (62) ◽  
pp. 32673-32689 ◽  
Author(s):  
Chetna Dhand ◽  
Molamma P. Prabhakaran ◽  
Roger W. Beuerman ◽  
R. Lakshminarayanan ◽  
Neeraj Dwivedi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Intravenous Administration ◽  
Targeted Drug Delivery ◽  
Cancer Therapeutics ◽  
Drug Carriers ◽  
Design Parameters ◽  
Targeted Drug

The design of a drug delivery system and the fabrication of efficient, successful, and targeted drug carriers are two separate issues that require slightly different design parameters.

scholarly journals A Review on Nanocarriers for Cancer Targeted Drug Delivery

2020 ◽  
Vol 63 (3) ◽  
pp. 239-246
Author(s):  
Fariha Lrfan ◽  
Tahir Lqbal ◽  
Nafisa Malik ◽  
Mohsin Ljaz
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Effective Drug ◽  
Targeted Drug

Nanoparticles in the drugs are useful for the treatment of cancer due to their unique properties and can act as drug carriers in different ways. Unlike the traditional chemotherapy, the entrance of nanotechnology enabled wide applications in treatment of cancer. Although nanoparticles provides safe and effective drug delivery systems but the factor of toxicity still limits the utilisation of several nanoparticles. The properties of nanodrug carriers are controllable by various factors. The use of nanoparticles in cancer therapy by drug delivery and their advantages as been reviewed.      

scholarly journals The Two Sweet Sides of Janus Lectin Drive Crosslinking of Liposomes to Cancer Cells and Material Uptake

Toxins ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 792
Author(s):  
Lina Siukstaite ◽  
Francesca Rosato ◽  
Anna Mitrovic ◽  
Peter Fritz Müller ◽  
Katharina Kraus ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
Drug Carriers ◽  
Lung Epithelial Cells ◽  
Lung Epithelial ◽  
Tumor Recognition ◽  
Cancer Types ◽  
Targeted Drug ◽  
Extracellular Structures

A chimeric, bispecific Janus lectin has recently been engineered with different, rationally oriented recognition sites. It can bind simultaneously to sialylated and fucosylated glycoconjugates. Because of its multivalent architecture, this lectin reaches nanomolar avidities for sialic acid and fucose. The lectin was designed to detect hypersialylation—a dysregulation in physiological glycosylation patterns, which promotes the tumor growth and progression of several cancer types. In this study, the characteristic properties of this bispecific Janus lectin were investigated on human cells by flow cytometry and confocal microscopy in order to understand the fundamentals of its interactions. We evaluated its potential in targeted drug delivery, precisely leading to the cellular uptake of liposomal content in human epithelial cancer cells. We successfully demonstrated that Janus lectin mediates crosslinking of glyco-decorated giant unilamellar vesicles (GUVs) and H1299 lung epithelial cells. Strikingly, the Janus lectin induced the internalization of liposomal lipids and also of complete GUVs. Our findings serve as a solid proof of concept for lectin-mediated targeted drug delivery using glyco-decorated liposomes as possible drug carriers to cells of interest. The use of Janus lectin for tumor recognition certainly broadens the possibilities for engineering diverse tailor-made lectin constructs, specifically targeting extracellular structures of high significance in pathological conditions.

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