scholarly journals Therapeutic Applications of Halloysite

2021 ◽  
Vol 12 (1) ◽  
pp. 87
Author(s):  
Mohammadmahdi Mobaraki ◽  
Sonali Karnik ◽  
Yue Li ◽  
David K. Mills
Keyword(s):  
Biomedical Application ◽  
Polymeric Nanoparticles ◽  
Mineralogical Composition ◽  
High Porosity ◽  
Sustained Drug Release ◽  
Future Directions ◽  
Clay Nanoparticles ◽  
Research Areas ◽  
Significant Research ◽  
Recent Trends

In recent years, nanomaterials have attracted significant research interest for applications in biomedicine. Many kinds of engineered nanomaterials, such as lipid nanoparticles, polymeric nanoparticles, porous nanomaterials, silica, and clay nanoparticles, have been investigated for use in drug delivery systems, regenerative medicine, and scaffolds for tissue engineering. Some of the most attractive nanoparticles for biomedical applications are nanoclays. According to their mineralogical composition, approximately 30 different nanoclays exist, and the more commonly used clays are bentonite, halloysite, kaolinite, laponite, and montmorillonite. For millennia, clay minerals have been extensively investigated for use in antidiarrhea solutions, anti-inflammatory agents, blood purification, reducing infections, and healing of stomach ulcers. This widespread use is due to their high porosity, surface properties, large surface area, excellent biocompatibility, the potential for sustained drug release, thermal and chemical stability. We begin this review by discussing the major nanoclay types and their application in biomedicine, focusing on current research areas for halloysite in biomedicine. Finally, recent trends and future directions in HNT research for biomedical application are explored.

Nanotechnology Based Delivery Systems of Drugs Currently Used to Treat Alzheimer’s Disease

2020 ◽  
Vol 10 (3) ◽  
pp. 228-247
Author(s):  
Niloufar Choubdar ◽  
Sara Avizheh
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Polymeric Nanoparticles ◽  
Biological Fluids ◽  
Delivery Systems ◽  
Original Research ◽  
Sustained Drug Release ◽  
The Past ◽  
Site Of Action ◽  
Therapeutic Compound

Alzheimer’s Disease (AD) is one of the most common forms of dementia affecting over 46 million people, according to AD International. Over the past few decades, there has been considerable interest in developing nanomedicines. Using nanocarriers, the therapeutic compound could be delivered to the site of action where it gets accumulated. This accumulation, therefore, reduces the required doses for therapy. Alternatively, using nanocarriers decreases the side effects. Nanotechnology has had a great contribution in developing Drug Delivery Systems (DDS). These DDS could function as reservoirs for sustained drug release or control the pharmacokinetics and biodistribution of the drugs. In the current review, we have collected 38 original research articles using nanotechnology as DDS for the clinically used cholinesterase inhibitor drugs donepezil (DPZ), Rivastigmine (Riv), and galantamine (Gal) used for AD treatment from 2002 to 2017 from Scopus and PubMed databases. Regarding DDS used for DPZ, most of the research in recent years dealt with polymeric nanoparticles (NPs) including Poly-D, L-Lactide-Co-Glycolide (PLGA), and chitosans (CHs), then Liposomes (LPs), nanogels, and natural products, respectively. In terms of Riv most of the research performed was focused on polymeric NPs including PLGA, polylactic acid (PLA), Poly-Ε-Caprolactone (PCL), poly-alkyl-cyanoacrylates, CH, gelatin and then LPs. The highest application of NPs in regard to Gal was related to modified LPs and polymeric NPs. Polymeric NPs demonstrate safety, higher stability in biological fluids and against enzymatic metabolism, biocompatibility, bioavailability, and improved encapsulation efficacy. LPs, another major delivery system used, demonstrate biocompatibility, ease of surface modification, and amphiphilic nature.

Forum: Dagmar Herzog's Sexuality in Europe

2013 ◽  
Vol 22 (2) ◽  
pp. 275-275
Keyword(s):  
Twentieth Century ◽  
History Of Sexuality ◽  
Future Directions ◽  
University Of Vienna ◽  
History Of ◽  
Recent Trends ◽  
East And West ◽  
Twentieth Century Europe

This discussion of Dagmar Herzog's Sexuality in Europe (2011) continues our new series of book fora. Herzog's new overview of changing European sexual mores and behaviour offers a jumping-off point for our panellists to discuss recent trends and future directions in the history of sexuality in twentieth-century Europe, East and West. Jeffrey Weeks (London South Bank University), Franz Eder (University of Vienna), Daniel Healey (University of Reading) and Victoria Harris (University of Birmingham) give their responses, and Herzog replies.

Improving the Stress Tolerance of Probiotic Cultures: Recent Trends and Future Directions

2011 ◽  
pp. 395-438 ◽  
Author(s):  
Aditya Upadrasta ◽  
Catherine Stanton ◽  
Colin Hill ◽  
Gerald F. Fitzgerald ◽  
R. Paul Ross
Keyword(s):  
Stress Tolerance ◽  
Future Directions ◽  
Recent Trends

scholarly journals A scientometric analysis and review of fall from height research in construction

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Vigneshkumar C ◽  
Urmi Ravindra Salve
Keyword(s):  
Construction Industry ◽  
Safety Management ◽  
Management Program ◽  
Research Community ◽  
Scientometric Analysis ◽  
Future Directions ◽  
Research Areas ◽  
Building Information ◽  
Fall From Height ◽  
Safety Knowledge

Fall from height (FFH) in the construction industry has earned much attention among researchers in recent years. The present review-based study introduced a science mapping approach to evaluate the FFH studies related to the construction industry. This study, through an extensive bibliometric and scientometric assessment, recognized the most active journals, keywords and the nations in the field of FFH studies since 2000. Analysis of the authors’ keywords revealed the emerging research topics in the FFH research community. Recent studies have been discovered to pay more attention to the application of Computer and Information Technology (CIT) tools, particularly building information modelling (BIM) in research related to FFH. Other emerging research areas in the domain of FFH include rule checking, and prevention through design. The findings summarized the mainstream research areas (e.g., safety management program), discussed existing research gaps in FFH domain (e.g., the adaptability of safety management system), and suggests future directions in FFH research. The recommended future directions could contribute to improving safety for the FFH research community by evaluating existing fall prevention programs in different contexts; integrating multiple CIT tools in the entire project lifecycle; designing fall safety courses to workers associated with temporary agents and prototype safety knowledge tool development. The current study was restricted to the FFH literature sample included the journal articles published only in English and in Scopus.

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