scholarly journals Metallomics Analysis for Assessment of Toxic Metal Burdens in Infants/Children and Their Mothers: Early Assessment and Intervention Are Essential

Biomolecules ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 6
Author(s):  
Hiroshi Yasuda ◽  
Toyoharu Tsutsui ◽  
Katsuhiko Suzuki

Accumulation of toxic metals in infants/children is of serious concern worldwide, from the viewpoint of their harmful effects on the normal growth and development. This metallomics study investigates the extent of toxic metal burdens in infants/children and the relationship to those in their mothers for 77 child/mother pair subjects. For mercury, its geometric mean concentration in infants/children was of similar level to that in their mothers, and a high-significant close correlation was observed between infants/children and their mothers (β = 0.758, r = 0.539, p < 0.0001). A significant but less intimate mother/child relationship was observed for arsenic (β = 0.301, r = 0.433), lead (β = 0.444, r = 0.471) and aluminum (β = 0.379, r = 0.451). Remarkably, the burden levels of lead, cadmium and aluminum in infants/children were approximately three times higher than those in their mothers (p < 0.0001), and the burden levels in some individuals were several tens of times higher than in the mothers. In contrast, some essential metal levels such as zinc, magnesium and calcium in infants/children were significantly lower than those in their mothers, and 29 individuals (37.7%) in the child subjects were estimated to be zinc-deficient. In addition, significant inverse correlations were observed between zinc and lead (r = −0.267, p = 0.019), and magnesium and arsenic (r = −0.514, p < 0.0001). These findings suggest that these toxic metal burdens and essential metal deficiencies in infants/children are of serious concern for their neurodevelopment, indicating that the early assessment and intervention are crucial. It is expected that larger epidemiological and intervention studies will provide a reasonable and essential pathway for intervention of neurodevelopment disorders.

2020 ◽  
Vol 3 (1) ◽  
pp. 50-59
Author(s):  
Xu Jianqin

This article analyses the evolution of the mother–daughter relationship in China, and describes the mothering characteristics of four generations of women, which in sequence includes “foot-binding mothers”, “mothers after liberation”, “mothers after reform and opening up”, and “mothers who were only daughters”. Referring to Klein’s ideas about the mother–child relationship, especially those in her paper “Some reflections on ‘The Oresteia’ ”, the author tries to understand mothers and their impact on their daughters in these various periods of Chinese history, so as to explore the mutual influence of the mother–daughter relationship in particular, and the Chinese cultural and developmental context in general.


2021 ◽  
pp. 002076402199118
Author(s):  
Marziyeh Khoshgoftar ◽  
Anahita Khodabakhshi-Koolaee ◽  
Mohammad Reza Sheikhi

Background and Aim: The mother as the first caregiver plays a significant role in the formation of the child’s behavior, growth, and communication. The present study aimed to analyze the early mother-child relationship in schizophrenic patients. Materials and Methods: This qualitative study employed a descriptive phenomenological approach. The participants were male patients with schizophrenia who were hospitalized in Qazvin Bahman Psychiatric Hospital from March to September 2020 with an age range of over 18 years. Given the objective of the study, the data were collected using semi-structured interviews. The participants were selected using purposive sampling and the sampling procedure continued until data saturation as the point when no new information is observed in the data. Accordingly, the data were saturated after interviewing 15 participants. The data were analyzed using Colaizzi’s seven-step method. Results: The analysis of the data revealed four main themes including ambivalent attachment to the mother, feelings of constant fear and worry, a sense of constant care for the mother, and a cold and emotionless relationship with the child. Conclusion: The present study suggested that schizophrenia is a disorder that affects the mother-child relationship, and does the term “schizophrenic mothers” need to be reconsidered? However, the result of this research has been done according to the nature and cultural context of Iranian society.


Author(s):  
Zurahanim Fasha Anual ◽  
Noraishah Mohammad Sham ◽  
Rashidah Ambak ◽  
Fatimah Othman ◽  
Rafiza Shaharudin

AbstractExposure to environmental pollutants in humans can be conducted through direct measurement of biological media such as blood, urine or hair. Assessment studies of metals and metalloids in Malaysia is very scarce although cross-sectional nationwide human biomonitoring surveys have been established by the USA, Canada, Germany, Spain, France, and Korea. This study aims to assess urinary metal levels namely cadmium (Cd), nickel (Ni), lead (Pb) and arsenic (As) among Malaysian adults. This was a cross-sectional study involving 1440 adults between the age of 18 and 88 years old. After excluding those with 24 h urine samples of less than 500 ml, urine creatinine levels < 0.3 or > 3.0 g/L and those who refuse to participate in the study, a total of 817 respondents were included for analysis. A questionnaire with socio-demographic information such as age, gender, occupation, ethnic, academic qualification and medical history was administered to the respondents. Twenty-four-hour urine samples were collected in a container before being transported at 4 °C to the laboratory. Samples were then aliquoted into 15 ml tubes and kept at − 80 °C until further analysis. Urine was diluted ten-fold with ultrapure water, filtered and analysed for metals and metalloids using Inductively Coupled Plasma-Mass Spectrometry (ICP-MS). The geometric mean of urinary As, Ni, Cd and Pb concentrations among adults in Malaysia was 48.21, 4.37, 0.32, and 0.80 µg/L, respectively. Males showed significantly higher urinary metal concentrations compared to females for As, Cd and Pb except for Ni. Those who resided in rural areas exhibited significantly higher As, Cd and Pb urinary concentrations than those who resided in urban areas. As there are no nationwide data on urinary metals, findings from this study could be used to identify high exposure groups, thus enabling policy makers to improve public health strategically.


Curationis ◽  
1992 ◽  
Vol 15 (1) ◽  
Author(s):  
A. Botha ◽  
G. Cleaver

The mother child relationship can help or hinder the social, emotional and intellectual development of the infant. Research has shown that the interaction between mother and child can affect the child’s cognitive development. Research has shown that mothers from the lower socio-economic groups do not stimulate their babies optimally and that this may affect the children negatively. In this study 86 underprivileged mothers from two different cultural backgrounds were asked to describe the ways in which they kept their infants occupied during the first year of their infants’ lives. The differences between the two groups are discussed and recommendations are made.


2005 ◽  
Vol 206 (2) ◽  
pp. 117-124 ◽  
Author(s):  
Syunichi Funakosi ◽  
Junko Hayashi ◽  
Takamichi Kamiyama ◽  
Takashi Ueno ◽  
Tomohiro Ishii ◽  
...  

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