Relationship between Levels of Pre-Stroke Physical Activity and Post-Stroke Serum Insulin-Like Growth Factor I

Physical activity (PA) and insulin-like growth factor I (IGF-I) have beneficial effects for patients who have suffered an ischemic stroke (stroke). However, the relationship between the levels of PA and IGF-I after stroke has not been explored in detail. We investigated the pre-stroke PA level in relation to the post-stroke serum IGF-I (s-IGF-I) level, at baseline and at 3 months after the index stroke, and calculated the change that occurred between these two time-points (ΔIGF-I). Patients (N = 380; 63.4% males; mean age, 54.7 years) with data on 1-year leisure-time pre-stroke PA and post-stroke s-IGF-I levels were included from the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS). Stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS). Pre-stroke, leisure-time PA was self-reported as PA1–4, with PA1 representing sedentary and PA2–4 indicating progressively higher PA levels. Associations between s-IGF-I and PA were evaluated by multiple linear regressions with PA1 as the reference and adjustments being made for sex, age, history of previous stroke or myocardial infarctions, cardiovascular risk factors, and stroke severity. PA correlated with baseline s-IGF-I and ΔIGF-I, but not with the 3-month s-IGF-I. In the linear regressions, there were corresponding associations that remained as a tendency (baseline s-IGF-I, p = 0.06) or as a significant effect (ΔIGF-I, p = 0.03) after all the adjustments. Specifically, for each unit of PA, ΔIGF-I increased by 9.7 (95% CI 1,1−18.4) ng/mL after full adjustment. This supports the notion that pre-stroke PA is independently related to ΔIGF-I.

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Association Between Levels of Serum Insulin-like Growth Factor I and Functional Recovery, Mortality, and Recurrent Stroke at a 7-year Follow-up

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/a-0833-8313 ◽

2019 ◽

Vol 128 (05) ◽

pp. 303-310 ◽

Cited By ~ 1

Author(s):

N. David Åberg ◽

Daniel Åberg ◽

Cecilia Lagging ◽

Lukas Holmegaard ◽

Petra Redfors ◽

...

Keyword(s):

Ischemic Stroke ◽

Growth Factor ◽

Functional Recovery ◽

Recurrent Stroke ◽

Serum Insulin ◽

Insulin Like Growth Factor ◽

Post Stroke ◽

Factor I ◽

Igf I ◽

Growth Factor I

Abstract Background The association of serum insulin-like growth factor I (s-IGF-I) with favorable outcome after ischemic stroke (IS) beyond 2 years is unknown. We investigated whether the levels of s-IGF-I 3 months post-stroke were associated with functional recovery up to 7 years after IS, considering also mortality and recurrent strokes. Methods Patients (N=324; 65% males; mean age, 55 years) with s-IGF-I levels assessed 3 months after the index IS were included from the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS). The modified Rankin Scale (mRS) was used to evaluate outcomes at 3 months, 2 and 7 years after IS, and recovery was defined as an improvement, no change, or deterioration in the shifts of mRS score. Baseline stroke severity was determined using the National Institutes of Health Stroke Scale (NIHSS). Results The mRS score distributions were better in the above-median s-IGF-I group (>146.7 ng/ml). The s-IGF-I level was not associated with recurrent stroke (N=79) or death (N=44), although it correlated with recovery (r=0.12, P=0.035). In the regression analysis, s-IGF-I associated with recovery between 3 months and 7 years (but not between 2 and 7 years). The associations did not withstand adjustment for age and sex. For comparison, the corresponding associations between 3 months and 2 years withstood all adjustments. Conclusion The association for s-IGF-I with long-term post-stroke recovery persists after 7 years, which is also reflected in the mRS score distributions at all time-points. The effects are however modest, and not driven by mortality or recurrent stroke.

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THE CHANGE IN CIRCULATING INSULIN-LIKE GROWTH FACTOR I (IGF-I) AFTER ISCHEMIC STROKE IS INDEPENDENTLY ASSOCIATED WITH OUTCOME

10.26226/morressier.5ab8f562d462b8029238d0d6 ◽

2018 ◽

Author(s):

David Åberg

Keyword(s):

Ischemic Stroke ◽

Growth Factor ◽

Insulin Like Growth Factor ◽

Factor I ◽

Igf I ◽

Growth Factor I

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The Effects of Physical Activity and Fitness in Adolescence on Cognition in Adulthood and the Role of Insulin-Like Growth Factor I

Journal of Physical Activity and Health ◽

10.1123/jpah.2014-0594 ◽

2016 ◽

Vol 13 (4) ◽

pp. 392-402 ◽

Cited By ~ 4

Author(s):

Doeschka A. Ferro ◽

Jan Berend Deijen ◽

Lando L. Koppes ◽

Willem van Mechelen ◽

Jos W. Twisk ◽

...

Keyword(s):

Physical Activity ◽

Working Memory ◽

Growth Factor ◽

Spatial Working Memory ◽

Insulin Like Growth Factor ◽

Factor I ◽

Visual Spatial ◽

Igf I ◽

Growth Factor I

Background:Physical activity and fitness in adolescence may improve cognition in adulthood by increasing insulin-like growth factor I (IGF-I).Methods:As part of the Amsterdam Growth and Health Longitudinal Study, following subjects from age 13 to 42 years, physical activity and fitness of 303 subjects were assessed annually between the ages 13 to 16. At mean age 36, physical activity, fitness and IGF-I were measured. At mean age 42, IGF-I and cognitive factors (ie, executive functioning and visual-spatial memory) were measured. The linear regression of physical activity and fitness in adolescence and IGF-I in adulthood on cognitive scores in adulthood was investigated.Results:A significant association was found in males between physical activity in adolescence and executive function in adulthood (Spatial Working Memory Between Errors: β = –.18, B = –.13, 95% CI = –.259 to –.010; Spatial Working Memory Strategy: β = –.20, B = –.08, 95% CI = –.147 to –.014). No association between physical activity or fitness in adolescence and cognitive function in adulthood was found in females, nor any intermediate role for IGF-I in either sex.Conclusions:The results suggest a stimulating effect of adolescent physical activity in males on executive functions in adulthood, emphasizing the importance of an active lifestyle among adolescent males.

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