scholarly journals Excessive Intake of High-Fructose Corn Syrup Drinks Induces Impaired Glucose Tolerance

Biomedicines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 541
Author(s):  
Hidemi Hattori ◽  
Yuma Hanai ◽  
Yuto Oshima ◽  
Hiroaki Kataoka ◽  
Nozomu Eto
Keyword(s):  
Insulin Secretion ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Caloric Intake ◽  
Soft Drinks ◽  
High Fructose Corn Syrup ◽  
Corn Syrup ◽  
High Fructose ◽  
Excessive Consumption ◽  
Excessive Intake

The number of patients with diabetes was approximately 463 million worldwide in 2019, with almost 57.6% of this population concentrated in Asia. Asians often develop type 2 diabetes (T2D), even if they are underweight and consume a smaller amount of food. Soft drinks contain large amounts of sweeteners, such as high-fructose corn syrup (HFCS). Excessive intake of HFCS drinks is considered to be one of the causes of T2D. In the present study, we investigated the effect of excessive consumption of HFCS–water on glucose tolerance and obesity under conditions of controlled caloric intake using a mouse model. Three-week-old male ICR mice were divided into two groups and given free access to 10% HFCS–water or deionized water. The caloric intake was adjusted to be the same in both groups using a standard rodent diet. The excess HFCS–water intake did not lead to obesity, but led to impaired glucose tolerance (IGT) due to insulin-secretion defect. It affected glucose and fructose metabolism; for example, it decreased the expression of glucokinases, ketohexokinase, and glucose transporter 2 in the pancreas. These results suggest that excessive consumption of HFCS drinks, such as soft drinks, without a proper diet, induces nonobese IGT due to insulin-secretion defect.

scholarly journals High-fructose corn syrup enhances intestinal tumor growth in mice

Science ◽  
2019 ◽  
Vol 363 (6433) ◽  
pp. 1345-1349 ◽  
Author(s):  
Marcus D. Goncalves ◽  
Changyuan Lu ◽  
Jordan Tutnauer ◽  
Travis E. Hartman ◽  
Seo-Kyoung Hwang ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Tumor Grade ◽  
Intestinal Lumen ◽  
High Fructose Corn Syrup ◽  
Moderate Dose ◽  
Corn Syrup ◽  
High Fructose ◽  
Increased Risk ◽  
Excessive Consumption ◽  
Support Tumor Growth

Excessive consumption of beverages sweetened with high-fructose corn syrup (HFCS) is associated with obesity and with an increased risk of colorectal cancer. Whether HFCS contributes directly to tumorigenesis is unclear. We investigated the effects of daily oral administration of HFCS in adenomatous polyposis coli (APC) mutant mice, which are predisposed to develop intestinal tumors. The HFCS-treated mice showed a substantial increase in tumor size and tumor grade in the absence of obesity and metabolic syndrome. HFCS increased the concentrations of fructose and glucose in the intestinal lumen and serum, respectively, and the tumors transported both sugars. Within the tumors, fructose was converted to fructose-1-phosphate, leading to activation of glycolysis and increased synthesis of fatty acids that support tumor growth. These mouse studies support the hypothesis that the combination of dietary glucose and fructose, even at a moderate dose, can enhance tumorigenesis.

scholarly journals Food texture affects glucose tolerance by altering pancreatic β-cell function in mice consuming high-fructose corn syrup

PLoS ONE ◽  
2020 ◽  
Vol 15 (5) ◽  
pp. e0233797
Author(s):  
Naoki Harada ◽  
Masayuki Nomura ◽  
Yasuhiro Yoda ◽  
Shigenobu Matsumura ◽  
Hiroshi Inui ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Cell Function ◽  
High Fructose Corn Syrup ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Corn Syrup ◽  
Food Texture ◽  
High Fructose ◽  
Β Cell Function

scholarly journals EXPLORING THE EFFECTS OF CONSUMERS’ NUTRITIONAL KNOWLEDGE AND INFORMATION INTEREST ON THE ACCEPTANCE OF ARTIFICIAL SWEETENER USAGE IN SOFT DRINKS

2019 ◽  
pp. 33-44 ◽  
Author(s):  
Yusuf Arslan
Keyword(s):  
Soft Drink ◽  
Food Additives ◽  
Well Being ◽  
Soft Drinks ◽  
Artificial Sweetener ◽  
High Fructose Corn Syrup ◽  
Nutritional Knowledge ◽  
Corn Syrup ◽  
The Public ◽  
High Fructose

Together with the increasing health awareness levels of consumers’, artificial food additives have been highly criticized by the public. However, these kinds of sweeteners are still being used widely all over the world. One of the sectors that prefer mostly these kinds of sweeteners is the soft drink industry. High fructose corn syrup, which has been associated with serious health problems recently, is one of these additives which is highly preferred in the soft drink industry. Upon examining the situation, it is understood that there is a conflict between the implementations of the soft drink industry and consumer attitudes towards them. However, it is seen that the consumers’ perspective is not clarified enough empirically in terms of this issue. This means that the players of the soft drink industry have a lack of insight in terms of consumer thoughts and attitudes regarding artificial sweetener usage in soft drinks. Owing to this research gap in the literature and the importance of the subject in terms of consumer well-being, this study aims to explore the antecedents for the acceptance of high fructose corn syrup usage in soft drinks. To reach this aim, four research questions represented to understand how frequent consumers prefer soft drinks containing high fructose corn syrup, to reveal consumers’ attitudes and acceptance towards high fructose corn syrup and to understand how nutritional knowledge and nutritional information interest affect consumers’ acceptance specifically on high fructose corn syrup usage in soft drinks. To answer these questions, a structured survey was developed and conducted on 888 soft drink consumers who are aware of high fructose corn syrup in soft drinks as an additive

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