Rare Sugar Syrup Containingd-Allulose but Not High-Fructose Corn Syrup Maintains Glucose Tolerance and Insulin Sensitivity Partly via Hepatic Glucokinase Translocation in Wistar Rats

In search of an adequate model for the human metabolic syndrome, the metabolic characteristics of Wistar rats were analysed after being submitted to different protocols of high fructose ingestion. First, two adult rat groups (aged 90 d) were studied: a control group (C1;n6) received regular rodent chow (Labina, Purina) and a fructose group (F1;n6) was fed on regular rodent chow. Fructose was administered as a 10 % solution in drinking water. Second, two adult rat groups (aged 90 d) were evaluated: a control group (C2;n6) was fed on a balanced diet (AIN-93G) and a fructose group (F2;n6) was fed on a purified 60 % fructose diet. Finally, two young rat groups (aged 28 d) were analysed: a control group (C3;n6) was fed on the AIN-93G diet and a fructose group (F3;n6) was fed on a 60 % fructose diet. After 4–8 weeks, the animals were evaluated. Glucose tolerance, peripheral insulin sensitivity, blood lipid profile and body fat were analysed. In the fructose groups F2 and F3 glucose tolerance and insulin sensitivity were lower, while triacylglycerolaemia was higher than the respective controls C2 and C3 (P < 0·05). Blood total cholesterol, HDL and LDL as well as body fat showed change only in the second protocol. In conclusion, high fructose intake is more effective at producing the signs of the metabolic syndrome in adult than in young Wistar rats. Additionally, diet seems to be a more effective way of fructose administration than drinking water.

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High fructose corn syrup supplementation progressively increased serum adenosine and inosine: Inosine raising blood pressure and heart rate in rats

Acta Universitaria ◽

10.15174/au.2021.2923 ◽

2021 ◽

Vol 31 ◽

pp. 1-9

Author(s):

Rafael Villalobos-Molina

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Wistar Rats ◽

Cardiovascular Function ◽

High Fructose Corn Syrup ◽

Long Term Effects ◽

Corn Syrup ◽

Arterial Blood ◽

High Fructose

High fructose corn syrup (HFCS) over-consumption underlies the obesity worldwide epidemics. Hepatic fructose metabolism includes fructolysis, lipogenesis, and purines degradation to uric acid. The aim of this study was to evaluate HFCS long-term effects on serum and hepatic adenosine (Ado) and inosine (Ino), as well as in vivo Ino effects on cardiovascular function. Fed male Wistar rats were subjected to 30% HFCS-enriched drinking water for five months (n = 15); every month, nucleosides were determined in serum and in isolated liver perfusate. Three months-old male naive Wistar rats were pithed and cannulated to record blood pressure and heart rate after Ino administration (n = 3). Rats consuming HFCS increased both Ado and Ino progressively in serum and livers’ perfusate; Ino increased cardiovascular function. The progressive Ado and Ino hepatic release by fructose-enriched diet suggests their contribution to raise glycemia through their gluconeogenic activation, and a higher serum Ino concentration might be related to increase in arterial blood pressure.

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Food texture affects glucose tolerance by altering pancreatic β-cell function in mice consuming high-fructose corn syrup

PLoS ONE ◽

10.1371/journal.pone.0233797 ◽

2020 ◽

Vol 15 (5) ◽

pp. e0233797

Author(s):

Naoki Harada ◽

Masayuki Nomura ◽

Yasuhiro Yoda ◽

Shigenobu Matsumura ◽

Hiroshi Inui ◽

...

Keyword(s):

Glucose Tolerance ◽

Cell Function ◽

High Fructose Corn Syrup ◽

Pancreatic Β Cell ◽

Β Cell ◽

Corn Syrup ◽

Food Texture ◽

High Fructose ◽

Β Cell Function

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Maternal Overconsumption of High Fructose Corn Syrup Causes Hypoxia in Placenta and Fetal Livers of Wistar Rats

The FASEB Journal ◽

10.1096/fasebj.2019.33.1_supplement.583.1 ◽

2019 ◽

Vol 33 (S1) ◽

Author(s):

Erum Ahmed ◽

Maria Alicia Carrillo‐Sepulveda

Keyword(s):

Wistar Rats ◽

High Fructose Corn Syrup ◽

Corn Syrup ◽

High Fructose

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5-LB: Consuming High-Fructose Corn Syrup or Sucrose-Sweetened Beverages Increases Hepatic Lipid Content and Decreases Insulin Sensitivity in Young Adults

Diabetes ◽

10.2337/db20-5-lb ◽

2020 ◽

Vol 69 (Supplement 1) ◽

pp. 5-LB

Author(s):

DESIREE SIGALA ◽

BETTINA HIERONIMUS ◽

CANDICE PRICE ◽

VIVIEN LEE ◽

MARINELLE NUNEZ ◽

...

Keyword(s):

Young Adults ◽

Insulin Sensitivity ◽

Lipid Content ◽

High Fructose Corn Syrup ◽

Corn Syrup ◽

Hepatic Lipid ◽

Sweetened Beverages ◽

High Fructose ◽

Hepatic Lipid Content

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Excessive Intake of High-Fructose Corn Syrup Drinks Induces Impaired Glucose Tolerance

Biomedicines ◽

10.3390/biomedicines9050541 ◽

2021 ◽

Vol 9 (5) ◽

pp. 541

Author(s):

Hidemi Hattori ◽

Yuma Hanai ◽

Yuto Oshima ◽

Hiroaki Kataoka ◽

Nozomu Eto

Keyword(s):

Insulin Secretion ◽

Glucose Tolerance ◽

Impaired Glucose Tolerance ◽

Caloric Intake ◽

Soft Drinks ◽

High Fructose Corn Syrup ◽

Corn Syrup ◽

High Fructose ◽

Excessive Consumption ◽

Excessive Intake

The number of patients with diabetes was approximately 463 million worldwide in 2019, with almost 57.6% of this population concentrated in Asia. Asians often develop type 2 diabetes (T2D), even if they are underweight and consume a smaller amount of food. Soft drinks contain large amounts of sweeteners, such as high-fructose corn syrup (HFCS). Excessive intake of HFCS drinks is considered to be one of the causes of T2D. In the present study, we investigated the effect of excessive consumption of HFCS–water on glucose tolerance and obesity under conditions of controlled caloric intake using a mouse model. Three-week-old male ICR mice were divided into two groups and given free access to 10% HFCS–water or deionized water. The caloric intake was adjusted to be the same in both groups using a standard rodent diet. The excess HFCS–water intake did not lead to obesity, but led to impaired glucose tolerance (IGT) due to insulin-secretion defect. It affected glucose and fructose metabolism; for example, it decreased the expression of glucokinases, ketohexokinase, and glucose transporter 2 in the pancreas. These results suggest that excessive consumption of HFCS drinks, such as soft drinks, without a proper diet, induces nonobese IGT due to insulin-secretion defect.

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Effects of dietary high fructose corn syrup on regulation of energy intake and leptin gene expression in rats

Revista de Nutrição ◽

10.1590/1415-52732015000600003 ◽

2015 ◽

Vol 28 (6) ◽

pp. 597-605 ◽

Cited By ~ 1

Author(s):

Guadalupe López-Rodríguez ◽

Silke Kotasek Osuna ◽

Marcos Galván García ◽

Teodoro Suárez Dieguez

Keyword(s):

Gene Expression ◽

Body Weight ◽

High Fat Diet ◽

Wistar Rats ◽

Fatty Acid Synthase ◽

High Fructose Corn Syrup ◽

High Fat ◽

Corn Syrup ◽

High Fructose ◽

The Brain

OBJECTIVE: To evaluate in Wistar rats the effect of chronic use of high fructose corn syrup on serum lipids, body weight, energy intake regulation, and expression of associated genes. METHODS: For 11 weeks, male rats were fed a standard diet with either water (control) or 15% high fructose corn syrup solution, or fed a high-fat diet. The rats' food intake and body weight were measured weekly. Expression of leptin and fatty acid synthase genes was quantified in their brain and adipose tissue upon sacrifice at age 119 days using real-time polymerase chain reaction. RESULTS: The intake of 15% high fructose corn syrup did not affect the rats' weight, only the rats on the high-fat diet gained significant weight. The rats in both diets had lower levels of leptin expression and high levels of fatty acid synthase in the brain, which were associated with high serum triglycerides. CONCLUSION: Fifteen percent high fructose corn syrup intake and the high-fat diet reduced leptin gene expression in the brain of Wistar rats, with differential effects on weight gain.

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