scholarly journals Post-Training Sleep Modulates Topographical Relearning-Dependent Resting State Activity

2021 ◽  
Vol 11 (4) ◽  
pp. 476
Author(s):  
Michele Deantoni ◽  
Thomas Villemonteix ◽  
Evelyne Balteau ◽  
Christina Schmidt ◽  
Philippe Peigneux
Keyword(s):  
Resting State ◽  
Low Frequency ◽  
Brain Structures ◽  
Resting State Fmri ◽  
Related Activity ◽  
State Activity ◽  
Before And After ◽  
Task Practice ◽  
Behavioural Performance ◽  
The Town

Continuation of experience-dependent neural activity during offline sleep and wakefulness episodes is a critical component of memory consolidation. Using functional magnetic resonance imaging (fMRI), offline consolidation effects have been evidenced probing behavioural and neurophysiological changes during memory retrieval, i.e., in the context of task practice. Resting state fMRI (rsfMRI) further allows investigating the offline evolution of recently learned information without the confounds of online task-related effects. We used rsfMRI to investigate sleep-related changes in seed-based resting functional connectivity (FC) and amplitude of low frequency fluctuations (ALFF) after spatial navigation learning and relearning. On Day 1, offline resting state activity was measured immediately before and after topographical learning in a virtual town. On Day 4, it was measured again before and after relearning in an extended version of the town. Navigation-related activity was also recorded during target retrieval, i.e., online. Participants spent the first post-training night under regular sleep (RS) or sleep deprivation (SD) conditions. Results evidence FC and ALFF changes in task-related neural networks, indicating the continuation of navigation-related activity in the resting state. Although post-training sleep did not modulate behavioural performance, connectivity analyses evidenced increased FC after post-training SD between navigation-related brain structures during relearning in the extended environment. These results suggest that memory traces were less efficiently consolidated after post-learning SD, eventually resulting in the use of compensatory brain resources to link previously stored spatial elements with the newly presented information.

scholarly journals Continued topographical learning- and relearning-dependent activity in the resting state after post-training sleep and wake

2020 ◽  
Author(s):  
Michele Deantoni ◽  
Thomas Villemonteix ◽  
Evelyne Balteau ◽  
Christina Schmidt ◽  
Philippe Peigneux
Keyword(s):  
Resting State ◽  
Low Frequency ◽  
Brain Structures ◽  
Resting State Fmri ◽  
Critical Element ◽  
Related Activity ◽  
Dependent Activity ◽  
Task Practice ◽  
Behavioural Performance ◽  
The City

AbstractContinuation of experience-dependent neural activity during offline periods of sleep and wakefulness is a critical element of memory consolidation. Using functional magnetic resonance imaging (fMRI), offline consolidation effects have been evidenced probing behavioral and neurophysiological changes during memory retrieval, i.e. in the context of task practice. Resting state fMRI (rfMRI) further allows investigating the offline evolution of recently learned information, without confounding task-related effects. In the present study, we used rfMRI to investigate offline changes in functional connectivity (FC) and Amplitude of Low Frequency Fluctuation (ALFF) associated with learning and relearning in a spatial navigation task, following an episode of post-training wake or sleep, respectively. Resting state activity was measured immediately (i) before and (ii) after topographical learning in a virtual town, (iii) 4 days later after regular sleep (RS) vs. sleep deprivation (SD) on the first post-learning night, and (iv) after topographical re-learning in an extended town encompassing the initial map. Task (navigation)-based fMRI activity was also recorded on Day 1 and Day 4 during target retrieval. Our results highlight the continuation of navigation-related activity in the subsequent resting state, as evidenced by changes in FC and ALFF in task-related neural networks. Behavioural performance was not modulated by post-training SD vs RS. However, in line with prior reports, post-training SD was associated with increased FC between navigation-related brain structures when faced to the task of learning a novel but related environment in the extended version of the city at Day 4. These results suggest the use of compensatory resources to link novel information with SD-related less efficiently consolidated memory traces.

scholarly journals Recovery-associated resting-state activity and connectivity alterations in Anorexia nervosa

2020 ◽  
Author(s):  
Leon D. Lotter ◽  
Georg von Polier ◽  
Jan Offermann ◽  
Kimberly Buettgen ◽  
Lukas Stanetzky ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Resting State ◽  
Low Frequency ◽  
Disease Status ◽  
Resting State Fmri ◽  
Grey Matter Volume ◽  
Cross Sectional ◽  
State Activity ◽  
Global Correlation ◽  
The Impact

AbstractBackgroundPrevious studies provided controversial insight on the impact of starvation, disease status as well as of underlying grey matter volume (GMV) changes on resting-state functional magnetic resonance imaging (rsfMRI) alterations in anorexia nervosa (AN). Here we adapt a combined longitudinal and cross-sectional approach to disentangle the effects of these factors on resting-state alterations in AN.MethodsOverall, 87 subjects were included in the study: adolescent patients with acute AN scanned at inpatient admission (N = 22) and at discharge (N = 21), 21 patients recovered from AN and two groups of healthy age-matched controls (both N = 22). Whole-brain measures of resting-state activity and functional connectivity were computed (Network Based Statistics, Global Correlation, Integrated Local Correlation, fractional Amplitude of Low Frequency Fluctuations) to assess rsfMRI alterations over the course of AN treatment before and after controlling for underlying GMV.ResultsPatients with acute AN displayed strong and widespread prefrontal, sensorimotor, parietal, temporal, precuneal and insular reductions of resting-state connectivity and activity. All alterations were independent of GMV and were largely normalized in short- and absent in long-term recovered AN.ConclusionsResting-state fMRI alterations in AN constitute acute and GMV independent presumably starvation-related phenomena. All alterations found here normalized over the course of recovery without evidence for possible preexisting trait- or remaining “scar”-effects.

Functional abnormalities in Broca’s area in adolescents with ADHD: A resting-state fMRI study

2015 ◽  
Vol 51 (1) ◽  
Author(s):  
Michał Pikusa ◽  
Rafał Jończyk
Keyword(s):  
Resting State ◽  
Low Frequency ◽  
Resting State Fmri ◽  
Broca’S Area ◽  
Broca's Area ◽  
Hyperactivity Disorder ◽  
Spontaneous Neural Activity ◽  
Fmri Study ◽  
Brodmann Areas ◽  
Underlying Causes

AbstractThere is evidence that attention-deficit/hyperactivity disorder (ADHD) is associated with linguistic difficulties. However, the pathophysiology underlying these difficulties is yet to be determined. This study investigates functional abnormalities in Broca’s area, which is associated with speech production and processing, in adolescents with ADHD by means of resting-state fMRI. Data for the study was taken from the ADHD-200 project and included 267 ADHD patients (109 with combined inattentive/hyperactive subtype and 158 with inattentive subtype) and 478 typically-developing control (TDC) subjects. An analysis of fractional amplitude of low-frequency fluctuations (fALFF), which reflects spontaneous neural activity, in Broca’s area (Brodmann Areas 44/45) was performed on the data and the results were compared statistically across the participant groups. fALFF was found to be significantly lower in the ADHD inattentive group as compared to TDC in BA 44, and in the ADHD combined group as compared to TDC in BA 45. The results suggest that there are functional abnormalities in Broca’s area with people suffering from ADHD, and that the localization of these abnormalities might be connected to particular language deficits associated with ADHD subtypes, which we discuss in the article. The findings might help explore the underlying causes of specific language difficulties in ADHD.

scholarly journals Altered hypothalamus functional connectivity with limbic system in fibromyalgia and the modulation effect of intervention

2020 ◽  
Author(s):  
Jian Kong ◽  
Yiting Huang ◽  
Jiao Liu ◽  
Siyi Yu ◽  
Ming Cheng ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Limbic System ◽  
Resting State ◽  
Tai Chi ◽  
Effective Connectivity ◽  
Resting State Fmri ◽  
Trial Registration ◽  
Modulation Effect ◽  
Resting State Functional Connectivity ◽  
Before And After

Abstract Background: This study aims to investigate the resting state functional connectivity (rsFC) changes of the hypothalamus in Fibromyalgia patients and the modulation effect of effective treatments. Methods: Fibromyalgia patients and matched healthy controls (HC’s) were recruited. Resting state fMRI data were collected from fibromyalgia patients before and after a 12-week Tai Chi intervention and once from HC’s. Results: Data analysis showed that fibromyalgia patients displayed significantly decreased medial hypothalamus (MH) rsFC with the thalamus and amygdala when compared to HC’s at baseline. After the intervention, fibromyalgia patients showed increased (normalized) MH rsFC in the thalamus and amygdala. Effective connectivity analysis showed disrupted MH and thalamus interaction in fibromyalgia, which nonetheless could be partially restored by Tai Chi. Conclusions: Elucidating the role of the diencephalon and limbic system in the pathophysiology and development of fibromyalgia may facilitate the development of new treatment methods for this prevalent disorder. Trial registration: Trial registration ClinicalTrials.gov Identifier: NCT02407665. Registered 3 April 2015 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02407665

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