White Matter Lesions as Possible Predictors of Audiological Performance in Adults after Cochlear Implantation

The presented prospective study investigated whether structural brain damage, measured with the Fazekas score, could predict hearing rehabilitation outcomes with cochlear implantation (CI). With a follow-up period of 24 months, this study included 49 bilaterally, postlingually hearing impaired CI candidates for unilateral CI (67.3 ± 8.7 years; 20 men, 29 women) older than 50 at the time of implantation. The differences in the predictive value between two age groups, 50–70 year-olds (mid-age; n = 26) and over 70-year-olds (elderly; n = 23), were analyzed. The patients were evaluated using speech perception (SP) measured in quiet (Freiburg monosyllabic test; FMT) and noise (Oldenburg sentence test; OLSA). The subjective hearing ability was assessed using Oldenburg inventory (OI). The Fazekas PVWM score predicted postoperative speech perception two years after CI in the mid-age population. The periventricular white matter lesions (PVWM) could explain 27.4% of the speech perception (FMT) variance. Our findings support the hypothesis about the influence of pre-existing WMLs on CI outcome. We recommend the evaluation of Fazekas score as a predictive factor for post-implantation hearing ability.

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P3-033 Cerebrospinal fluid Tau and periventricular white matter lesions in stable and progressive mild cognitive impairment

Neurobiology of Aging ◽

10.1016/s0197-4580(04)81187-4 ◽

2004 ◽

Vol 25 ◽

pp. S360-S361

Author(s):

Masahiro Maruyama ◽

Toshifumi Matsui ◽

Haruko Tanji ◽

Miyako Nemoto ◽

Naoki Tomita ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

White Matter ◽

White Matter Lesions ◽

Periventricular White Matter ◽

Periventricular White Matter Lesions

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Peak ependymal cell stretch overlaps with the onset location of periventricular white matter lesions

10.21203/rs.3.rs-635671/v2 ◽

2021 ◽

Author(s):

Valery Visser ◽

Henry Rusinek ◽

Johannes Weickenmeier

Keyword(s):

White Matter ◽

Ependymal Cell ◽

White Matter Lesions ◽

Magnetic Resonance Images ◽

Ependymal Cells ◽

Periventricular White Matter ◽

Ventricular Wall ◽

Imaging Data ◽

Lateral Ventricles ◽

Cell Stretch

Abstract Deep and periventricular white matter hyperintensities (dWMH/pvWMH) are bright appearing white matter tissue lesions in T2-weighted fluid attenuated inversion recovery magnetic resonance images and are frequent observations in the aging human brain. While early stages of these white matter lesions are only weakly associated with cognitive impairment, their progressive growth is a strong indicator for long-term functional decline. DWMHs are typically associated with vascular degeneration in diffuse white matter locations; for pvWMHs, however, no unifying theory exists to explain their consistent onset around the horns of the lateral ventricles. We use patient imaging data to create anatomically accurate finite element models of the lateral ventricles, white and gray matter, and cerebrospinal fluid, as well as to reconstruct their WMH volumes. We simulated the mechanical loading of the ependymal cells forming the primary brain-fluid interface, the ventricular wall, and its surrounding tissues at peak ventricular pressure during the hemodynamic cycle. We observe that both the maximum principal tissue strain and the largest ependymal cell stretch consistently localize in the anterior and posterior horns. Our simulations show that ependymal cells experience a loading state that causes the ventricular wall to be stretched thin. Moreover, we show that maximum wall loading coincides with the pvWMH locations observed in our patient scans. These results warrant further analysis of white matter pathology in the periventricular zone that includes a mechanics-driven deterioration model for the ventricular wall.

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Cerebral Hemodynamics in Patients with Periventricular White-Matter Lesions on Brain Imaging

Cerebral Ischemia and Dementia ◽

10.1007/978-3-642-76208-6_28 ◽

1991 ◽

pp. 247-254

Author(s):

F. Gotoh ◽

T. Amano ◽

M. Ichijo ◽

T. Shinohara ◽

Y. Terayama ◽

...

Keyword(s):

White Matter ◽

Brain Imaging ◽

White Matter Lesions ◽

Cerebral Hemodynamics ◽

Periventricular White Matter ◽

Periventricular White Matter Lesions

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Abstract P191: Association Between Blood Pressure And Brain Volumes Vary By Sex And Age.

Hypertension ◽

10.1161/hyp.78.suppl_1.p191 ◽

2021 ◽

Vol 78 (Suppl_1) ◽

Author(s):

Khawlah Alateeq ◽

Erin Walsh ◽

Walter Abhayaratna ◽

Nicolas Cherbuin

Keyword(s):

Blood Pressure ◽

Body Mass Index ◽

White Matter ◽

Body Mass ◽

Antihypertensive Medication ◽

Full Range ◽

Age Groups ◽

White Matter Lesions ◽

Hippocampal Volume ◽

Brain Volumes

Objective: To quantify the association between blood pressure (BP) across its full range and brain volumes and white matter lesions (WMLs) while investigating the effects of age, sex, body mass index (BMI), antihypertensive medication, and other risk factors. Methods: UK Biobank participants ( N =36,260) aged 40 to 70 years were included and stratified by sex and age into four groups (age ≤ 45, 46-55, 56-65 and > 65 years old). Multi-level regression analyses were used to assess the association between mean arterial (MAP), systolic (SBP), and diastolic (DBP) blood pressure, and brain volumes segmented using the FreeSufer software (gray matter [GMV], white matter [WMV], left [L] and right hippocampal volume [RHCV]) and WMLs. We also investigated the interaction effects between body mass index (BMI) and antihypertensive medication and BP in predicting brain volumes and WMLs. Results: Every 10-mmHg higher DBP was associated with lower brain volumes (GMV: -1300– -2800) [SE=34–90]; WMV: -903.44– -1171.7[SE=34.66–53.03]; LHCV: -7.7– -14.26 [SE=0.44–0.57]; RHCV: -6.25– -22.64[SE=0.32–0.95]) across all age groups. A similar pattern was detected in both sexes, although it was weaker, in men. Also, every 10-mmHg higher MAP was associated with larger WMLs across all age groups but peaked > 65 years (0.1 [SE=0.002]). Both lower BMI and anti-hypertensive medication appeared to afford a protective effect. Conclusion: Higher BP is associated with worse cerebral health across the full BP range from middle adulthood and across the life course. Therefore, it is important that prevention efforts be directed at younger adults with focus on achieving optimal BP to decrease future risk of developing dementia.

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