Immune-Related Mutational Landscape and Gene Signatures: Prognostic Value and Therapeutic Impact for Head and Neck Cancer

Immunotherapy by immune checkpoint inhibition has become a main pillar in the armamentarium to treat head and neck cancer and is based on the premise that the host immune system can be reactivated to successfully eliminate cancer cells. However, the response rate remains low and only a small subset of head and neck cancer patients achieves a durable clinical benefit. The availability of multi-omics data and emerging computational technologies facilitate not only a deeper understanding of the cellular composition in the tumor immune microenvironment but also enables the study of molecular principles in the complex regulation of immune surveillance versus tolerance. These knowledges will pave the way to apply immunotherapy more precisely and effectively. This review aims to provide a holistic view on how the immune landscape dictates the tumor fate and vice versa, and how integrative analysis of multi-omics data contribute to our current knowledge on the accuracy of predictive biomarkers and on a broad range of factors influencing the response to immunotherapy in head and neck cancer.

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A Compartmentalized Reduction in Membrane-Proximal Calmodulin Reduces the Immune Surveillance Capabilities of CD8+ T Cells in Head and Neck Cancer

Frontiers in Pharmacology ◽

10.3389/fphar.2020.00143 ◽

2020 ◽

Vol 11 ◽

Cited By ~ 2

Author(s):

Ameet A. Chimote ◽

Vaibhavkumar S. Gawali ◽

Hannah S. Newton ◽

Trisha M. Wise-Draper ◽

Laura Conforti

Keyword(s):

T Cells ◽

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Cd8 T Cells ◽

Immune Surveillance

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Establishment of a risk model for perineural invasion by integrative analysis of multi-omics data from head and neck cancer

10.1055/s-0041-1727959 ◽

2021 ◽

Author(s):

C Weusthof ◽

K Metzger ◽

S Burkart ◽

B Feng ◽

K Khorani ◽

...

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Perineural Invasion ◽

Risk Model ◽

Integrative Analysis ◽

Omics Data

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OC-0062 Potential predictive biomarkers for Nimorazole-modified radiochemotherapy in head and neck cancer

Radiotherapy and Oncology ◽

10.1016/s0167-8140(21)06756-6 ◽

2021 ◽

Vol 161 ◽

pp. S37-S38

Author(s):

M.J. Besso ◽

V. Bitto ◽

L. Koi ◽

W. Hadiwikarta ◽

R. Euler-Lange ◽

...

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Predictive Biomarkers

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Radiation Induced Xerostomia: Current Concepts and Future Trends

Defence Life Science Journal ◽

10.14429/dlsj.2.11669 ◽

2017 ◽

Vol 2 (3) ◽

pp. 256 ◽

Cited By ~ 1

Author(s):

Manu Krishnan ◽

Satish R Iyer ◽

Kanti Lal Chakraborti ◽

Saraswathy Seema ◽

Tarun Sekhri

Keyword(s):

Quality Of Life ◽

Head And Neck Cancer ◽

Salivary Gland ◽

Head And Neck ◽

Neck Cancer ◽

Current Knowledge ◽

Intensity Modulated Radiotherapy ◽

Chemical Derivatives ◽

Radiation Induced

Radiation induced xerostomia is a persistent clinical presentation that affects the quality of life in head and neck cancer patients even with the best of the intensity modulated radiotherapy protocols. Comprehensive review of the anatomic, histologic, developmental and neuronal entities of salivary glands from a regenerative perspective, ensuing radiation is taken. It also evaluates the systemic and glandular radiation responses that form the early and late clinical changes. From these, the article submits probable strategies; based on the current knowledge and future challenges involved, in reversing radiation induced xerostomia. Further, it elaborates on the status of radioprotectors and mitigators including the recently reported biologic and chemical derivatives and proposes the rationale of using combination radioprotector therapy in radiation injuries. A brief of palliative regimes, alternate treatment modes and technologic advancements in radiotherapy are also explained. Salivary gland histologic components, which need to be protected in the emerging radiotherapy protocols and can be targeted in different salivary gland regeneration therapies is highlighted. The paper contributes to an improved understanding in radiation induced xerostomia and deliberates on novel mechanisms towards enhancing quality of life in head and neck cancer radiotherapy patients.

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