scholarly journals Pathologic Characteristics of Pregnancy-Related Meningiomas

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3879
Author(s):  
Laura Giraldi ◽  
Emma Kofoed Lauridsen ◽  
Andrea Daniela Maier ◽  
Jørgen Vinsløv Hansen ◽  
Helle Broholm ◽  
...  

Meningiomas are the most common intracranial tumor. During pregnancy, explosive growth of a known meningioma occasionally occurs, but the underlying reasons remain unknown. Prolactin has been suggested as a possible key contributor to pregnancy-related meningioma growth. This study sets out to investigate prolactin and prolactin receptor status in 29 patients with pregnancy-related meningiomas in Denmark, from January 1972 to December 2016, as compared to 68 controls aged 20–45 years, also undergoing resection of a meningioma. Furthermore, we investigated potential differences in the progesterone and estrogen receptor statuses, WHO grade, Ki-67 labeling indices, and locations of the resected meningiomas between the cases and controls. Immunohistochemical analyses were performed, and histopathology and intracranial location were assessed with the investigator blinded for the case–control status. None of the samples stained positive for prolactin and very few samples stained positive for prolactin receptors, equally distributed among cases and controls. Estrogen and progesterone receptors generally followed the same distributional pattern between groups, whereas above cut-point Ki-67 labeling indices for both groups were observed. In conclusion, our results did not support the notion of prolactin as a key contributor to pregnancy-related meningioma growth. Rather, the similarities between the cases and controls suggest that meningiomas early in life may comprise a distinct biological entity.

2005 ◽  
Vol 99 (1) ◽  
pp. 36-42 ◽  
Author(s):  
Suleyman Engin Akhan ◽  
Ekrem Yavuz ◽  
Aysegul Tecer ◽  
Cem Ahmet İyibozkurt ◽  
Samet Topuz ◽  
...  

Genes ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 582
Author(s):  
Tatiana Kalinina ◽  
Vladislav Kononchuk ◽  
Efim Alekseenok ◽  
Darya Obukhova ◽  
Sergey Sidorov ◽  
...  

In ~70% of breast cancer (BC) cases, estrogen and progesterone receptors (ER and PR) are overexpressed, which can change during tumor progression. Expression changes of these receptors during cancer initiation and progression can be caused by alterations in microRNA (miR, miRNA) expression. To assess the association of BC progression with aberrant expression of miRNAs that target ER and PR mRNAs, we quantified miR-19b, -222, -22, -378a, and -181a in BC samples (n = 174) by real-time PCR. Underexpression of miR-222 and miR-378a in stage T2–T4 BC was characteristic for HER2-overexpressing tumors. In addition, the expression of miR-181a and miR-378a was higher in these tumors than in tumors with a HER2 IHC score of 0 or 1+. In tumors with a Ki-67 index ≥ 14%, all tested miRNAs were underexpressed in BC with a high Allred PR score (6–8). In ER-and-PR–negative tumors, miR-22, miR-222, miR-181a, and miR-378a underexpression was associated with Ki-67 index > 35% (median value). MiR-19b and miR-22 underexpression could be a marker of lymph node metastasis in ER- and/or PR-positive tumors with HER2 IHC score 0. Thus, the association of miR-19b, miR-22, miR-222, miR-378a, and miR-181a levels with BC characteristics is influenced by the status of tumor ER, PR, HER2, and Ki-67.


2017 ◽  
Vol 47 (6) ◽  
Author(s):  
Lorena Ferreira Silva ◽  
Luiz Antonio Franco da Silva ◽  
Rogério Elias Rabelo ◽  
Wanessa Patrícia Rodrigues da Silva ◽  
Geovanni Dantas Cassali ◽  
...  

ABSTRACT: This manuscript described the anatomopathological and immunohistochemical findings in a rare case of mammary fibroadenomatoid hyperplasia in a 12-month-old Holstein heifer. A yellow, multilobulated, firm 20cm x 9cm x 6.5cm mass affecting the right quarters of the udder was observed. Total mastectomy was performed. Microscopic evaluation revealed severe hyperplasia of the mammary epithelium and numerous well-differentiated and mildly pleomorphic acini. Additionally, moderate proliferation of the fibrous connective tissue and the myoepithelial cells near the proliferating acini was evident. About 50% of the proliferating epithelial cells showed positive nuclear labeling for estrogen and progesterone receptors, and approximately one-third were positive for Ki-67. In addition, the myoepithelial cells exhibited diffuse nuclear immunoreactivity for p63. Based on the clinical, morphologic, and immunohistochemical findings, a diagnosis of mammary fibroadenomatoid hyperplasia with probable influence of ovarian steroids was made.


2005 ◽  
Vol 59 (1) ◽  
pp. 36-40 ◽  
Author(s):  
Hüsnü Gökaslan ◽  
Levent Türkeri ◽  
Zehra Neşe Kavak ◽  
Funda Eren ◽  
Alper Şişmanoğlu ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document