scholarly journals A Systematic Review of the Safety, Feasibility and Benefits of Exercise for Patients with Advanced Cancer

Cancers ◽  
2021 ◽  
Vol 13 (17) ◽  
pp. 4478
Author(s):  
Nico De Lazzari ◽  
Timo Niels ◽  
Mitra Tewes ◽  
Miriam Götte
Keyword(s):  
Systematic Review ◽  
Adverse Events ◽  
Cancer Patients ◽  
Advanced Cancer ◽  
Exercise Intervention ◽  
Cochrane Library ◽  
Controlled Trials ◽  
Advanced Cancer Patients ◽  
Exercise Interventions ◽  
Positive Effects

Exercise therapy is a common supportive strategy in curative cancer treatment with strong evidence regarding its positive effects on, for example, cancer-related fatigue, health- related quality of life, and physical function. In the field of advanced cancer patients, knowledge about exercise as a useful supportive strategy is missing. The aim of this systematic review was to evaluate the feasibility and safety of exercise interventions as well as its effects on lowering the symptom burden. We included randomized controlled trials and nonrandomized controlled trials with advanced cancer patients receiving any type of exercise intervention. After an extensive literature search (in accordance to PRIMSA guidelines) in PubMed, Cochrane Library, and SPORTDiscus, 14 studies including 940 participants with different cancer entities were eligible. The results indicated the safety of exercise. In total, 493 participants received exercise interventions, with nine adverse events and no severe adverse events. The median recruitment rate was 68.33%, and adherence to exercise intervention was 86%. Further research with a high-quality and larger sample size is needed to clarify the potential of exercise with advanced cancer patients. Different advanced cancer entities have distinguished symptoms, and future research should construct entities-specific trial populations to figure out the best supportive exercise interventions.

scholarly journals Exercise as an Alternative Approach for Treating Smartphone Addiction: A Systematic Review and Meta-Analysis of Random Controlled Trials

2019 ◽  
Vol 16 (20) ◽  
pp. 3912 ◽  
Author(s):  
Shijie Liu ◽  
Tao Xiao ◽  
Lin Yang ◽  
Paul D. Loprinzi
Keyword(s):  
Systematic Review ◽  
Motor Skills ◽  
Exercise Intervention ◽  
Meta Analysis ◽  
Cost Effective ◽  
Public Health Issue ◽  
Smartphone Addiction ◽  
Controlled Trials ◽  
Exercise Interventions ◽  
Positive Effects

Background: With the emergence of electronic products, smartphones have become an indispensable tool in our daily life. On the other hand, smartphone addiction has become a public health issue. To help reduce smartphone addiction, cost-effective interventions such as exercise are encouraged. Purpose: We therefore performed a systematic review and meta-analysis evaluating existing literature on the rehabilitative effects of exercise interventions for individuals with a smartphone addiction. Methods: We searched PubMed, Web of Science, Scopus, CNKI, and Wanfang from inception to September 2019. Nine eligible randomized controlled trials (RCT) were finally included for meta-analysis (SMD represents the magnitude of effect of exercise) and their methodological quality were assessed using the PEDro scale. Results: We found significant positive effects of exercise interventions (Taichi, basketball, badminton, dance, run, and bicycle) on reducing the total score (SMD = −1.30, 95% CI −1.53 to −1.07, p < 0.005, I2 = 62%) of smartphone addiction level and its four subscales (withdrawal symptom: SMD = −1.40, 95% CI −1.73 to −1.07, p < 0.001, I2 = 81%; highlight behavior: SMD = −1.95, 95% CI −2.99 to −1.66, p < 0.001, I2 = 79%; social comfort: SMD = −0.99, 95% CI −1.18 to −0.81, p = 0.27, I2 = 21%; mood change: SMD = −0.50, 95% CI 0.31 to 0.69, p = 0.25, I2 = 25%). Furthermore, we found that individuals with severe addiction level (SMD = −1.19, I2 = 0%, 95%CI:−1.19 to −0.98) benefited more from exercise engagement, as compared to those with mild to moderate addiction levels (SMD = − 0.98, I2 = 50%, 95%CI:−1.31 to −0.66); individuals with smartphone addiction who participated in exercise programs of 12 weeks and above showed significantly greater reduction on the total score (SMD = −1.70, I2 = 31.2%, 95% CI −2.04 to −1.36, p = 0.03), as compared to those who participated in less than 12 weeks of exercise intervention (SMD = −1.18, I2 = 0%, 95% CI−1.35 to −1.02, p < 0.00001). In addition, individuals with smartphone addiction who participated in exercise of closed motor skills showed significantly greater reduction on the total score (SMD = −1.22, I2 = 0 %, 95% CI −1.41 to −1.02, p = 0.56), as compared to those who participated in exercise of open motor skills (SMD = −1.17, I2 = 44%, 95% CI−1.47 to −0.0.87, p = 0.03). Conclusions: Exercise interventions may have positive effects on treating smartphone addiction and longer intervention durations may produce greater intervention effects.

scholarly journals Effectiveness of workplace exercise interventions in the treatment of musculoskeletal disorders in office workers: a protocol of a systematic review

BMJ Open ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. e038854
Author(s):  
Carlos Tersa-Miralles ◽  
Roland Pastells-Peiró ◽  
Francesc Rubí-Carnacea ◽  
Filip Bellon ◽  
Esther Rubinat Arnaldo
Keyword(s):  
Systematic Review ◽  
Musculoskeletal Disorders ◽  
Exercise Intervention ◽  
Meta Analysis ◽  
Office Workers ◽  
Cochrane Library ◽  
Exercise Interventions ◽  
Physical Strength ◽  
Prolonged Sitting ◽  
Randomised Controlled

IntroductionPhysical inactivity due to changes in our society towards more sedentary behaviours is leading to health problems. Increasing physical activity might be a good strategy to improve physical strength and reduce the prevalence of illnesses associated with prolonged sitting. Office workers exhibit a sedentary lifestyle with short rest periods or even without pauses during the workday. It is important to perform workplace interventions to treat musculoskeletal disorders caused by prolonged sitting and lack of movement adopted on the office setting. This article describes a protocol for a systematic review to evaluate the effectiveness of exercise interventions on office workers in their work environment.Methods and analysisA literature search will be performed in the PubMed, CINAHL Plus, Cochrane Library, Scopus, ISI WoS and PeDRO databases for randomised controlled trials and studies published from 1 January 2010 to 31 July 2020 in English or Spanish. The participants will be office workers who spend most of their work time in a sitting position. The interventions performed will include any type of exercise intervention in the workplace. The outcome measures will vary in accordance with the aim of the intervention observed. The results of the review and the outcomes from the studies reviewed will be summarised with a narrative synthesis. The review protocol was developed according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols guidelines.Ethics and disseminationEthical approval is not required. The review outcomes and the additional data obtained will be disseminated through publications and in scientific conferences.PROSPERO registration numberCRD42020177462.

scholarly journals LB743 Cutaneous immune-related adverse events are undertreated in advanced cancer patients

2021 ◽  
Vol 141 (9) ◽  
pp. B10
Author(s):  
M. Chang ◽  
T. Otto ◽  
T. Jacoby ◽  
L. Thompson ◽  
K. Reynolds ◽  
...  
Keyword(s):  
Adverse Events ◽  
Cancer Patients ◽  
Advanced Cancer ◽  
Advanced Cancer Patients

scholarly journals Efficacy and safety of omalizumab in chronic rhinosinusitis with nasal polyps: a systematic review and meta-analysis of randomised controlled trials

BMJ Open ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. e047344
Author(s):  
Qingwu Wu ◽  
Lianxiong Yuan ◽  
Huijun Qiu ◽  
Xinyue Wang ◽  
Xuekun Huang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Adverse Events ◽  
Chronic Rhinosinusitis ◽  
Randomised Controlled Trials ◽  
Nasal Polyps ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Controlled Trials ◽  
Efficacy And Safety ◽  
Randomised Controlled

ObjectivesTo assess the efficacy and safety of omalizumab for chronic rhinosinusitis with nasal polyps (CRSwNP) and to identify evidence gaps that will guide future research on omalizumab for CRSwNP.DesignSystematic review and meta-analysis.Data sourcesA comprehensive search was performed in PubMed, Embase, Web of Science and the Cochrane Library on 13 October 2020.Eligibility criteriaRandomised controlled trials (RCTs) comparing omalizumab with placebo, given for at least 16 weeks in adult patients with CRSwNP.Data extraction and synthesisTwo independent authors screened search results, extracted data and assessed studies using the Cochrane risk of bias tool. Data were pooled using the inverse-variance method and expressed as mean differences (MDs) with 95% CIs. Heterogeneity was assessed by the χ2 test and the I2 statistic.ResultsA total of four RCTs involving 303 participants were identified. When comparing omalizumab to placebo, there was a significant difference in Nasal Polyps Score (MD=−1.20; 95% CI −1.48 to −0.92), Nasal Congestion Score (MD=−0.67; 95% CI −0.86 to −0.48), Sino-Nasal Outcome Test-22 (MD=−15.62; 95% CI −19.79 to −11.45), Total Nasal Symptom Score (MD=−1.84; 95% CI −2.43 to −1.25) and reduced need for surgery (risk ratio (RR)=5.61; 95% CI 1.99 to 15.81). Furthermore, there was no difference in the risk of serious adverse events ((RR=1.40; 95% CI 0.29 to 6.80), adverse events (RR=0.83; 95% CI 0.60 to 1.15) and rescue systemic corticosteroid (RR=0.52; 95% CI 0.17 to 1.61).ConclusionsThis was the first meta-analysis that identified omalizumab significantly improved endoscopic, clinical and patient-reported outcomes in adults with moderate to severe CRSwNP and it was safe and well tolerated.PROSPERO registration numberCRD42020207639.

The Prognostic Role of Phase Angle in Advanced Cancer Patients: A Systematic Review

2018 ◽  
Vol 33 (6) ◽  
pp. 813-824 ◽  
Author(s):  
Mayane Marinho Esteves Pereira ◽  
Mariana dos Santos Campello Queiroz ◽  
Nathália Masiero Cavalcanti de Albuquerque ◽  
Juliana Rodrigues ◽  
Emanuelly Varea Maria Wiegert ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cancer Patients ◽  
Advanced Cancer ◽  
Phase Angle ◽  
Prognostic Role ◽  
Advanced Cancer Patients

scholarly journals Revisiting the association between skin toxicity and better response in advanced cancer patients treated with immune checkpoint inhibitors

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Nicholas Gulati ◽  
Douglas Donnelly ◽  
Yingzhi Qian ◽  
Una Moran ◽  
Paul Johannet ◽  
...  
Keyword(s):  
Adverse Events ◽  
Cancer Patients ◽  
Advanced Cancer ◽  
Immune Checkpoint ◽  
Skin Toxicity ◽  
Institutional Review Board ◽  
Advanced Cancer Patients ◽  
Institutional Review ◽  
Immunosuppressive Medications ◽  
Multivariable Analyses

Abstract Background Immune checkpoint inhibition (ICI) improves survival outcomes for patients with several types of cancer including metastatic melanoma (MM), but serious immune-related adverse events requiring intervention with immunosuppressive medications occur in a subset of patients. Skin toxicity (ST) has been reported to be associated with better response to ICI. However, understudied factors, such as ST severity and potential survivor bias, may influence the strength of these observed associations. Methods To examine the potential confounding impact of such variables, we analyzed advanced cancer patients enrolled prospectively in a clinicopathological database with protocol-driven follow up and treated with ICI. We tested the associations between developing ST, stratified as no (n = 617), mild (n = 191), and severe (n = 63), and progression-free survival (PFS) and overall survival (OS) in univariable and multivariable analyses. We defined severe ST as a skin event that required treatment with systemic corticosteroids. To account for the possibility of longer survival associating with adverse events instead of the reverse, we treated ST as a time-dependent covariate in an adjusted model. Results Both mild and severe ST were significantly associated with improved PFS and OS (all P < 0.001). However, when adjusting for the time from treatment initiation to time of skin event, severe ST was not associated with PFS benefit both in univariable and multivariable analyses (P = 0.729 and P = 0.711, respectively). Receiving systemic steroids for ST did not lead to significant differences in PFS or OS compared to patients who did not receive systemic steroids. Conclusions Our data reveal the influence of time to event and its severity as covariates in analyzing the relationship between ST and ICI outcomes. These differences in outcomes cannot be solely explained by the use of immunosuppressive medications, and thus highlight the importance of host- and disease-intrinsic factors in determining ICI response and toxicity. Trial registration: The patient data used in this manuscript come from patients who were prospectively enrolled in two institutional review board-approved databases at NYU Langone Health (institutional review board #10362 and #S16-00122).

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