A Multicenter Epidemiological Study on Second Malignancy in Non-Syndromic Pheochromocytoma/Paraganglioma Patients in Italy

No studies have carried out an extensive analysis of the possible association between non-syndromic pheochromocytomas and paragangliomas (PPGLs) and other malignancies. To assess the risk of additional malignancy in PPGL, we retrospectively evaluated 741 patients with PPGLs followed-up in twelve referral centers in Italy. Incidence of second malignant tumors was compared between this cohort and Italian patients with two subsequent malignancies. Among our patients, 95 (12.8%) developed a second malignant tumor, which were mainly prostate, colorectal and lung/bronchial cancers in males, breast cancer, differentiated thyroid cancer and melanoma in females. The standardized incidence ratio was 9.59 (95% CI 5.46–15.71) in males and 13.21 (95% CI 7.52–21.63) in females. At multivariable analysis, the risk of developing a second malignant tumor increased with age at diagnosis (HR 2.50, 95% CI 1.15–5.44, p = 0.021 for 50–59 vs. <50-year category; HR 3.46, 95% CI 1.67–7.15, p < 0.001 for >60- vs. <50-year). In patients with available genetic evaluation, a positive genetic test was inversely associated with the risk of developing a second tumor (HR 0.25, 95% CI 0.10–0.63, p = 0.003). In conclusion, PPGLs patients have higher incidence of additional malignant tumors compared to the general population who had a first malignancy, which could have an impact on the surveillance strategy.

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Hepatocyte ultrastructural alterations in perimetastatic areas

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100166300 ◽

1996 ◽

Vol 54 ◽

pp. 768-769

Author(s):

H. J. Finol ◽

M. E. Correa ◽

L.A. Sosa ◽

A. Márquez ◽

N.L. Díaz

Keyword(s):

Malignant Tumor ◽

Malignant Tumors ◽

Surrounding Tissue ◽

Ultrastructural Changes ◽

Pancreas Carcinoma ◽

Duct Carcinoma ◽

Tissue Samples ◽

Primary Malignant Tumor ◽

Transmission Electron ◽

Remote Sites

In classical oncological literature two mechanisms for tissue aggression in patients with cancer have been described. The first is the progressive invasion, infiltration and destruction of tissues surrounding primary malignant tumor or their metastases; the other includes alterations produced in remote sites that are not directly affected by any focus of disease, the so called paraneoplastic phenomenon. The non-invaded tissue which surrounds a primary malignant tumor or its metastases has been usually considered a normal tissue . In this work we describe the ultrastructural changes observed in hepatocytes located next to metastases from diverse malignant tumors.Hepatic biopsies were obtained surgically in patients with different malignant tumors which metatastized in liver. Biopsies included tumor mass, the zone of macroscopic contact between the tumor and the surrounding tissue, and the tissue adjacent to the tumor but outside the macroscopic area of infiltration. The patients (n = 5), 36–75 years old, presented different tumors including rhabdomyosarcoma, leiomyosarcoma, pancreas carcinoma, biliar duct carcinoma and colon carcinoma. Tissue samples were processed with routine techniques for transmission electron microscopy and observed in a Hitachi H-500 electron microscope.

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THE PROGNOSTIC VALUE OF PD-L1 EXPRESSION IN TUMOR AND IMMUNE CELLS IN SQUAMOUS CELL CARCINOMA OF THE ORAL MUCOSA

Problems in oncology ◽

10.37469/0507-3758-2017-63-5-759-765 ◽

2017 ◽

Vol 63 (5) ◽

pp. 759-765

Author(s):

Svetlana Kutukova ◽

Natalya Belyak ◽

Grigoriy Raskin ◽

Marina Mukhina ◽

Georgiy Manikhas ◽

...

Keyword(s):

Oral Mucosa ◽

Malignant Tumor ◽

Immune Cells ◽

Prognostic Value ◽

Hard Palate ◽

Malignant Tumors ◽

Small Cell ◽

Alveolar Process ◽

Small Cell Lung ◽

Lower Jaw

The most frequent of malignant tumor cites of the oral mucosa are tongue - 55 %, mucosa of the cheek - 12 %, the fundus of the oral cavity - 10 %, the alveolar process of the upper jaw and the hard palate - 9 %, the alveolar process of the lower jaw - 6 %, the soft palate - 2 %. Malignant tumor cells carry PD-L1 ligands on their surface and its expression level is often correlated with an unfavorable prognosis in particular for such tumors as melanoma, kidney cancer and non-small cell lung cancer. It is relevant to evaluate the correlation between overexpression of PD-L1 and overall survival in patients with malignant tumors of the oral mucosa.

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Influence of the primary malignant tumor site on the incidence and features of metastatic ovarian tumors

Vojnosanitetski pregled ◽

10.2298/vsp0710691s ◽

2007 ◽

Vol 64 (10) ◽

pp. 691-696 ◽

Cited By ~ 1

Author(s):

Zorica Stanojevic ◽

Biljana Djordjevic ◽

Danijela Zivanovic

Keyword(s):

Malignant Tumor ◽

Malignant Tumors ◽

Statistical Significance ◽

Menopausal Status ◽

Ovarian Tumors ◽

Metastatic Tumors ◽

Primary Tumors ◽

Primary Malignant Tumor ◽

Group A ◽

Group B

Background/Aim. Ovary is the organ of the female reproductive system most commonly affected by metastases. The aim of the study was to determine the frequency and features of metastatic ovarian tumors (MOT) depending on the site of the primary malignant tumor. Methods. The study group consisted of 488 patients with histopathologically confirmed ovarian cancers treated at the Clinic of Oncology, Clinical Center Nis, in the period from 1 January 1998 to 31 December 2005. MOT were found in 41 patients. Regarding the site of the primary malignant tumor, those with secondary ovarian tumor were divided into two groups: group A - primary malignant tumor involving the genital organs (n = 30) and group B - primary malignant tumor of extragenital origin (n = 11). Results. MOT were confirmed in 8.40% (41/488) of the patients. Secondary ovarian malignancies were the consequence of endometrial carcinoma spreading in 73.17%, breast carcinoma in 19.51%, stomach carcinoma in 4.88% and colon carcinoma in 2.44% of the cases. No significant differences were found between the group A and group B by the factors of age, body mass index, parity and menopausal status. Contrary to the group A, metastatic tumors in the group B patients were more commonly asymptomatic (p < 0.001), bilateral (p < 0.05), with larger ovarian diameter (p < 0.05), associated with ascites (p < 0.001) and abdominal metastases (p < 0.01), all of statistical significance. Conclusions. Metastatic tumors made up 8.40% of ovarian neoplasmas. With non-genital primary tumors, secondary ovarian deposits were frequently asymptomatic, bilateral, associated with larger ovarian diameter, ascites and abdominal metastatic deposits, compared to malignant tumors of genital origin.

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Metastasis of missed cholangiocarcinoma in the left lobethrough abdominal wall laparoscopic port-site and umbilicus after laparoscopic cholecystectomy: case report and literature review

10.21203/rs.3.rs-45597/v1 ◽

2020 ◽

Author(s):

Lesheng Huang ◽

Hongyi Li ◽

Jun Chen ◽

Jinghua Jiang ◽

Wanchun Zhang ◽

...

Keyword(s):

Laparoscopic Cholecystectomy ◽

Abdominal Wall ◽

Malignant Tumor ◽

Malignant Tumors ◽

Abdominal Cavity ◽

Left Lobe ◽

Port Site ◽

Laparoscopic Port ◽

Missed Diagnosis ◽

Upper Abdominal

Abstract Introduction: Laparoscopic cholecystectomy (LC) has been widely used by surgeons. However, a serious but rare condition may be happened, which is the missed diagnosis of intraperitoneal malignant tumor. If the malignancy exists, the changes of the abdominal environment or the laparoscopic operation might brought the cancer cells to the abdominal cavity or the abdominal wall. The missed laparoscopic malignant tumors are prone to metastasis, especially at the laparoscopic port-site. More extreme condition will be located in the navel, which is known as Sister Mary Joseph’s nodule(SMJN).Case presentation: A 63-year-old female who had undergone cholecystectomy and choledocholithotomy ten months ago was hospitalized for upper abdominal pain. Laboratory examination indicated that the most of tumor markers were increased. CT scan revealed that there was a diffused irregular and progressively enhanced mass around the left lobe bile duct, multiple enlarged lymph nodes in the abdominal cavity and multiple nodular lesions were found under the costal margin of the right upper abdominal wall, right lower abdominal wall and the umbilicus. Biopsy of the nodules under the original surgical scar showed an infiltrative or metastatic middle differentiated adenocarcinoma. So the diagnosis was left lobe cholangiocarcinoma of the liver, multiple lymph nodes metastasis in the abdominal cavity and multiple implant metastasis in abdominal wall laparoscopic port-site and umbilical.Conclusion: In laparoscopic cholecystectomy, surgeons should not only focus on the local lesions, like gallstone in biliary system, but also look around other the tissues and organs to avoid missing the abdominal malignant tumor or other lesions. When atypical symptoms or abnormalities have been found pre-operation, all abdominal organs should be evaluated in detail to avoid missed diagnosis of potential malignant tumors. On the other hand, when there is a nodule in the umbilicus, all the organs and tissues in abdomen should be examined to find the potential malignant tumor. Finally, multiple cholelithiasis in the left lobe of the liver should be regarded as a high risk factor for cholangiocarcinoma.

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Third Ventricle Choroid Plexus Carcinoma

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/s0317167100046011 ◽

1984 ◽

Vol 11 (4) ◽

pp. 461-465 ◽

Cited By ~ 14

Author(s):

R.W. Broad ◽

P.B.R. Allen

Keyword(s):

Choroid Plexus ◽

Malignant Tumor ◽

Malignant Tumors ◽

Third Ventricle ◽

Literature Survey ◽

Choroid Plexus Carcinoma ◽

Diagnosis And Management

ABSTRACTBenign and malignant tumors of the choroid plexus in infancy are extremely uncommon. Diagnosis and management of a malignant tumor is described and the literature survey of the problem is presented.

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Accuracy of Frozen Section Diagnosis of the Salivary Gland

Otolaryngology ◽

10.1177/019459988709600404 ◽

1987 ◽

Vol 96 (4) ◽

pp. 325-330 ◽

Cited By ~ 9

Author(s):

Douglas R. Gnepp ◽

Willa Rae Rader ◽

Stewart F. Cramer ◽

Linda L. Cook ◽

James Sciubba

Keyword(s):

Salivary Gland ◽

Malignant Tumor ◽

Benign Tumor ◽

Malignant Tumors ◽

Frozen Section ◽

Frozen Sections ◽

Acinic Cell ◽

Frozen Section Examination ◽

Permanent Section ◽

Frozen Section Diagnosis

Three hundred and one salivary gland lesions (162 benign, 72 malignant, and 67 benign non-neoplastic) of 677 cases were evaluated by use of intraoperative frozen sections by 66 pathologists. In seven patients, the diagnosis was deferred for permanent sections. In four cases (1.3%), the diagnosis at permanent section changed from one category of benign tumor to another, and in five cases (1.7%), from one category of malignant tumor to another. In four tumors, a frozen section diagnosis of benign was changed to malignant on permanent sectioning; all four involved acinic cell carcinomas. Only two tumors were incorrectly diagnosed as malignant. We conclude that diagnoses of most salivary gland lesions based on frozen section examination are reliable and accurate. However, the literature does indicate that caution should be exercised when malignant tumors are dealt with.

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A Simple Method for Diagnosing Gallbladder Malignant Tumors with Subserosa Invasion by Endoscopic Ultrasonography

10.21203/rs.3.rs-67710/v1 ◽

2020 ◽

Author(s):

Mitsuru Sugimoto ◽

Hiroki Irie ◽

Mika Takasumi ◽

Minami Hashimoto ◽

Yuka Oka ◽

...

Keyword(s):

Endoscopic Ultrasonography ◽

Malignant Tumor ◽

Tumor Invasion ◽

Malignant Tumors ◽

Muscularis Propria ◽

Trial Registration ◽

Tumor Depth ◽

Simple Method ◽

Surgical Method ◽

Imaging Parameters

Abstract Background: If the depth of gallbladder malignant tumor (GBMT) invasion is deeper than the subserosa (ss), cholecystectomy is insufficient. In past reports that used endoscopic ultrasonography (EUS) to diagnose the depth of tumor invasion, it was difficult to diagnose GMBT invasion in the ss without a narrow or disrupted lateral hyperechoic layer (LHEL). Therefore, we developed a simple preoperative method to diagnose GBMTs with ss invasion. Methods: Forty-nine GBMT patients who underwent both EUS and surgery were enrolled: 15 patients whose tumors invaded the mucosa (m) or muscularis propria (mp) were classified as the “shallow group”, and 34 patients whose tumors invaded the ss were classified as the “deep group”. The EUS findings were compared between the two groups.Results: An irregular (narrow or thickened) LHEL was significantly more frequently observed on EUS in the deep group than in the shallow group. The diagnosis of ss invasion based on an irregular LHEL had the highest sensitivity and accuracy among the EUS imaging parameters (sensitivity 97.1% (33/34), specificity 86.7% (13/15), accuracy 93.8% (46/49)). When the deep group was limited to patients with a tumor depth of ss, the results were similar. When an irregular LHEL was used, the diagnosability of GBMTs with ss invasion was not significantly different between EUS specialists and beginners.Conclusions: An irregular (thickened or narrow) LHEL observed on EUS could be a reliable and simple method of diagnosing GBMTs with ss invasion and could contribute to choosing an appropriate surgical method.Trial Registration: not applicable

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Primary Cardiac Rhabdomyosarcoma in a child -- A case report

10.22541/au.160674686.67846790/v1 ◽

2020 ◽

Author(s):

KRISHNA PRASAD MARAM ◽

Vikram Kudumula ◽

Dilip Ratti

Keyword(s):

Case Report ◽

Left Ventricle ◽

Right Ventricle ◽

Malignant Tumor ◽

Right Atrium ◽

Malignant Tumors ◽

Benign Tumors ◽

Cardiac Tumors ◽

Cardiac Rhabdomyosarcoma ◽

Primary Cardiac Tumors

Primary cardiac tumors are rare in children, usually consist of benign tumors like rhabdomyomas and fibromas that may spontaneously regress. Primary malignant tumors are extremely rare even in adults and very few paediatric cases were reported in literature. Rhabdomyosarcoma is a rare primary malignant tumor in children and most of the reported cases occur in right ventricle, left atrium and right atrium. We report a 15 month old child with primary rhabdomyosarcoma of left ventricle presenting in cardiac tamponade and circulatory failure.

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The Impact of Post-Operative Radiotherapy in Early Stage (pT1-pT2N0M0) Oral Tongue Squamous Cell Carcinoma in Era of DOI

Cancers ◽

10.3390/cancers13194851 ◽

2021 ◽

Vol 13 (19) ◽

pp. 4851

Author(s):

Daniela Alterio ◽

Pasqualina D’Urso ◽

Stefania Volpe ◽

Marta Tagliabue ◽

Rita De Berardinis ◽

...

Keyword(s):

Malignant Tumors ◽

Early Stage ◽

Postoperative Radiotherapy ◽

Multivariable Analysis ◽

Disease Free Survival ◽

Free Survival ◽

Multivariable Analyses ◽

Tumors Classification ◽

The Impact

Background: This study investigated the role of depth of infiltration (DOI) as an independent prognosticator in early stage (T1-T2N0M0) oral cavity tumors and to evaluate the need of postoperative radiotherapy in the case of patients upstaged to pT3 for DOI > 10 mm in the absence of other risk factors. Methods: We performed a retrospective analysis on patients treated with surgery and re-staged according to the 8th edition of malignant tumors classification (TNM). The role of DOI as well as other clinical/pathological features was investigated at both univariable and multivariable analyses on overall survival (OS), disease free survival (DFS), relapse free survival (RFS), and local RFS. Results: Among the 94 included patients, 23 would have been upstaged to pT3 based on DOI. Multivariable analysis showed that DOI was not an independent prognostic factor for any of the considered outcomes. The presence of perineural invasion was associated with a significant worse RFS (p = 0.02) and LRFS (p = 0.04). PORT was found to be significantly associated with DFS (p = 0.04) and RFS (p = 0.06). Conclusions: The increasing DOI alone was not sufficient to impact the prognosis, and therefore, should not be sufficient to dictate PORT indications in early-stage patients upstaged on the sole basis of DOI.

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Metabolism in experimental malignant tumors. (Problems of Oncology, 1928, No. 1)

Kazan medical journal ◽

10.17816/kazmj78439 ◽

1929 ◽

Vol 25 (1) ◽

pp. 104-104

Keyword(s):

Tumor Cells ◽

Malignant Tumor ◽

Water Exchange ◽

Malignant Tumors ◽

Experimental Studies ◽

The Body ◽

Dramatic Effect ◽

Enzymatic Nature ◽

Nitrogenous Metabolism

Experimental studies have convinced Professor A.V. Repreva (Vopr. Oncology, 1928, No. 1) that inoculation of the smallest pieces of a malignant tumor to an animal has a dramatic effect on the metabolism in the body of the latter and, above all, on water exchange, then on salt metabolism, nitrogenous metabolism, etc. Obviously, tumor cells contain substances close to bodies of an enzymatic nature.

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